Clinical trials: Mood Disorders, active
Irritability, Disruptive Mood Dysregulation Disorder
Psychotherapy for Irritability in Youth: Comparing Active Treatment to Nonactive Psychoeducation Supportive Psychotherapy
Background: Irritability is defined as proneness to anger that may impair a person's ability to function. It is a common reason for why some children need mental health care.
- Conditions
- Irritability, Disruptive Mood Dysregulation Disorder, Oppositional Defiant Disorder, Attention Deficit Hyperactivity Disorder
- Trial name
- NCT07640802
- Testing
- Psychotherapy
- Where
- United States
- Volunteers
- 410 people
- Sponsor
- National Institute of Mental Health (NIMH)
Fatigue, Low Mood
A Study to Evaluate the Effects of a Beef Liver Supplement on Energy, Mood, and Mental Clarity
This is a randomized, triple-blind, placebo-controlled clinical trial evaluating the effects of the Ancestral Supplements Grass Fed Beef Liver oral supplement on energy, mood, and mental clarity over 12 weeks.
- Conditions
- Fatigue, Low Mood, Mental Clarity, Iron Deficiency
- Trial name
- NCT07892911
- Testing
- Intervention
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Ancestral Supplements, LLC
Depression
Characterization and Treatment of Adolescent Depression
This research study seeks to find causes and treatments of depression in teenagers. The study goals are to increase our knowledge of treatments for depression and understand how the brain changes when teenagers have depression.
- Trial name
- NCT03388606
- Testing
- Growth Mindset
- Where
- 3 sites in United States
- Volunteers
- 4,100 people, healthy volunteers welcome
- Sponsor
- National Institute of Mental Health (NIMH)
Late Life Depression (LLD), Depression - Major Depressive Disorder
Accelerated vs. Conventional Theta Burst Stimulation for Late-life Depression
The purpose of this trial is to compare the treatment efficacy (improvement in depressive symptoms) of accelerated TBS protocol (where participants receive multiple TBS treatments daily) to conventional TBS protocol (where…
- Conditions
- Late Life Depression (LLD), Depression - Major Depressive Disorder, Depressive Disorder, Treatment-Resistant, Mood Disorders
- Trial name
- ACT-LLD (NCT06854367)
- Testing
- TBS
- Where
- 2 sites in Canada
- Volunteers
- 280 people
- Sponsor
- Centre for Addiction and Mental Health
Major Depressive Disorder, Bipolar I Disorder
Digital Phenotypes for Predicting Depression_Validation
This 12-month, single-site prospective observational study will prospectively monitor the recurrence of mood episodes while continuously collecting passive digital phenotypes in individuals with and without mood disorders.
- Conditions
- Major Depressive Disorder, Bipolar I Disorder, Bipolar II Disorder, Mood Disorders
- Trial name
- NCT07880015
- Where
- South Korea
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Korea University Anam Hospital
Mood Disorders, Anxiety Disorders
Development of Magnetic Resonance Imaging Techniques for Studying Mood and Anxiety Disorders
This study is intended to help develop new MRI imaging techniques for studying mood and anxiety disorders. Researchers believe that depression and anxiety disorders may cause structural and functional changes in the brain.
- Trial name
- NCT00397111
- Testing
- 7T Magnetic Resonance Imaging scanner
- Where
- United States
- Volunteers
- 390 people, healthy volunteers welcome
- Sponsor
- National Institute of Mental Health (NIMH)
Post-Traumatic Stress Disorder, Chronic, Depressed Mood
An Interrupted Time-Series Pilot Trial of LGBTQ-Affirming Cognitive Processing Therapy for Interpersonal and Developmental Trauma
The researchers are testing a single-group cognitive-behavioral intervention for treating traumatic stress related to interpersonal and developmental trauma in LGBTQ adults.
- Conditions
- Post-Traumatic Stress Disorder, Chronic, Depressed Mood, Depressive and Anxiety Disorders, Anxiety
- Trial name
- NCT07863817
- Testing
- Cognitive Processing Therapy
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- University of Alabama at Birmingham
Depression, Unipolar
FMRI-neurofeedback in Depression
Previous studies with fMRI-neurofeedback in depression have demonstrated a good safety profile and considerable symptom reduction.
- Trial name
- NCT05640089
- Testing
- fMRI-based neurofeedback
- Where
- 3 sites in Netherlands
- Volunteers
- 120 people
- Sponsor
- Maastricht University Medical Center
Mental Disorders, Mood Disorders
Group Transdiagnostic Cognitive Behavioural Therapy for Intolerance of Uncertainty Versus Applied Relaxation
Many people find uncertainty distressing, but for some, it may become overwhelming and drive persistent anxiety, worry, and avoidance.
- Conditions
- Mental Disorders, Mood Disorders, Anxiety Disorders, Generalized Anxiety Disorder
- Trial name
- OBSCURA (NCT07866794)
- Testing
- Group Transdiagnostic Cognitive Behavioural Therapy for Intolerance of Uncertainty (CBT-IU), Group Transdiagnostic Applied Relaxation (AR)
- Where
- United Kingdom
- Volunteers
- 135 people
- Sponsor
- Medical Research Council Cognition and Brain Sciences Unit
Bipolar Disorder, Major Depression
NIMH Rhythms and Blues Study: A Prospective Natural History Study of Motor Activity, Mood States, and Bipolar Disorder
Background: Mood disorders, such as bipolar disorder, can have serious effects on a person s life. People with bipolar disorder are more likely to have heart disease and abuse substances.
- Conditions
- Bipolar Disorder, Major Depression, Migraine
- Trial name
- NCT05669703
- Where
- United States
- Volunteers
- 1,260 people, healthy volunteers welcome
- Sponsor
- National Institute of Mental Health (NIMH)
Bipolar Disorder (BD), Depression - Major Depressive Disorder
Epigenetic Enhancement of Cognitive Training in Aging Mood and Schizophrenia Spectrum Disorder Populations
The aim of this clinical trial is to investigate the effects of a three-week virtual reality-based cognitive remediation training (VR-CRT) programme in combination with daily intake of a histone deacetylase inhibitor (HDACi)…
- Conditions
- Bipolar Disorder (BD), Depression - Major Depressive Disorder, Cognitive Impairment, Schizophrenia Disorders
- Trial name
- EPIC (NCT07404085)
- Testing
- Virtual Reality-based cognitive remediation therapy (VR-CRT), Virtual Reality-based control treatment (VR-CT), HDACi butyrate
- Where
- Denmark
- Volunteers
- 160 people
- Sponsor
- Mental Health Centre Copenhagen, Bispebjerg and Frederiksberg Hospital
Depressive Disorder, Major
A Study of Brenipatide (LY3537031) in Adult Participants With Major Depressive Disorder
This study evaluates the safety and efficacy of brenipatide when administered with standard of care (SoC) compared to placebo plus SoC in delaying the return of major depressive symptoms.
- Trial name
- RENEW-MDD- 2 (NCT07775300)
- Testing
- Brenipatide
- Where
- 170 sites in United States, Australia and 13 more
- Volunteers
- 1,000 people
- Sponsor
- Eli Lilly and Company
Prader-Willi Syndrome, Excessive Daytime Sleepiness
Impact of Bright Light Therapy on Prader-Willi Syndrome
This is a placebo controlled clinical trial to assess the utility of light therapy as a sufficient treatment for excessive daytime sleepiness in patients with Prader-Willi Syndrome
- Conditions
- Prader-Willi Syndrome, Excessive Daytime Sleepiness, Hyperphagia, Body Weight
- Trial name
- PWS-LT (NCT05939453)
- Testing
- Bright Light Therapy
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Maimonides Medical Center
Major Depressive Disorder (MDD), Major Depressive Disorder With Anxious Distress
A Study to Evaluate the Efficacy and Safety of SPT-300 (GlyphAllo) in Participants With Major Depressive Disorder, With or Without Anxious Distress (BUOY-1 Study)
This is a randomized, parallel-group, double-blind, placebo-controlled, monotherapy study to evaluate the efficacy, safety, and tolerability of SPT-300 (GlyphAllo) in adults with major depressive disorder (MDD), with or without…
- Trial name
- NCT07065240
- Testing
- SPT-300
- Where
- 61 sites in United States, Bulgaria and 5 more
- Volunteers
- 360 people
- Sponsor
- Seaport Therapeutics
Major Depressive Disorder (MDD), Major Depressive Disorder With Anxious Distress
An Open-Label Extension Study to Evaluate the Safety and Tolerability of SPT-300 (GlyphAllo) in Participants With Major Depressive Disorder, With or Without Anxious Distress (BUOY-1 OLE Study)
This is an open-label, monotherapy, extension study to evaluate the safety and tolerability of SPT-300 (GlyphAllo) in adults with major depressive disorder (MDD), with or without anxious distress.
- Trial name
- NCT07161700
- Testing
- SPT-300
- Where
- 42 sites in United States, Bulgaria and 5 more
- Volunteers
- 360 people
- Sponsor
- Seaport Therapeutics
Pediatric Pain, Anxiety
PURSUIT: A Technologically Augmented School-based Program to Improve Child Coping and Prevent Substance Use.
The study investigators aim to test an online support platform for Michigan youth aged 8-18 years enrolled in elementary, middle, or high school and their parent/caregiver.
- Conditions
- Pediatric Pain, Anxiety, Mood, Stress
- Trial name
- NCT07266740
- Testing
- PURSUIT
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Michigan State University
Low Mood, Depression - Major Depressive Disorder
PROMOTE: Effects of 5-HT4 Agonism on Cognition and Sleep in Peopl With Low Mood
Serotonin is a chemical in the brain that plays an important role in mood, sleep, and other functions. It works by attaching to different types of serotonin receptors on brain cells.
- Trial name
- PROMOTE (NCT07848477)
- Testing
- Prucalopride
- Where
- United Kingdom
- Volunteers
- 60 people
- Sponsor
- University of Oxford
Suicide, Depressive Disorder, Treatment-Resistant
Investigation of the Antidepressant Effects of (2R,6R)-HNK, an Enhancer of Synaptic Glutamate Release, in Treatment-Resistant Depression
Background: Major depressive disorder (MDD) is a serious mental illness that can put people at risk of self-harm and death. Many drugs are used to treat MDD, but it can take a long time for them to be effective.
- Conditions
- Suicide, Depressive Disorder, Treatment-Resistant, Ketamine, Molecular Mechanisms of Pharmacological Action
- Trial name
- NCT06511908
- Testing
- (2R,6R)-hydroxynorketamine (0.25 to 2.0 mg/kg)
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- National Institute of Mental Health (NIMH)
Depressive Disorder, Major
A Study of Brenipatide in Adult Participants With Major Depressive Disorder
This study evaluates the safety and efficacy of brenipatide when administered with standard of care (SoC) compared to placebo plus SoC in delaying the return of major depressive symptoms.
- Trial name
- RENEW-MDD-1 (NCT07412756)
- Testing
- Brenipatide
- Where
- 181 sites in United States, Australia and 13 more
- Volunteers
- 1,000 people
- Sponsor
- Eli Lilly and Company
Suicidal Ideation and Behavior, Mood Disorders
Videoconference-Based Brief Cognitive Behavioral Therapy for Patients With Mood Disorders at High Risk for Suicide
This study aims to investigate inflammatory biomarkers associated with suicide risk and to evaluate the efficacy of videoconference-based brief cognitive-behavioral therapy (V-BCBT) in patients with mood disorders at high risk…
- Conditions
- Suicidal Ideation and Behavior, Mood Disorders, Suicide Attempt, Cognitive Behavior Therapy
- Trial name
- V-BCBT-BIO (NCT07857291)
- Testing
- Videoconference-Based Brief Cognitive Behavioral Therapy, Treatment as Usual (TAU)
- Where
- South Korea
- Volunteers
- 320 people, healthy volunteers welcome
- Sponsor
- Hyung Keun Park