Clinical trials: Morbidity;Newborn
Mortality, Morbidity
Sex-Differential Health Interventions In Low-Birth-Weight Infants
Our group has consistently found that the major interventions to reduce morbidity and mortality in low-income countries have sex-differential effects.
- Conditions
- Mortality, Morbidity, Growth, Neonatal Mortality
- Trial name
- NCT00625482
- Testing
- OPV, OPV plus BCG
- Where
- Guinea-Bissau
- Sponsor
- Bandim Health Project
Infant, Premature, Diseases, Perinatal Morbidity
Prognosis of Extremely Premature Birth
Pregnant women at risk of giving birth before 28 weeks' gestational age will be enrolled. Fetal circulation will be studied and blood for inflammatory parameters will be collected.
- Conditions
- Infant, Premature, Diseases, Perinatal Morbidity, Development, Problem;Growth
- Trial name
- BabyPEP (NCT01150396)
- Where
- 2 sites in Norway
- Volunteers
- 160 people
- Sponsor
- University of Bergen
Pre-eclampsia, Pregnancy, High Risk
Placental Growth Factor Assessment of Women With Suspected Pre-eclampsia
The primary aim is to establish the effectiveness of plasma PlGF measurement in reducing maternal morbidity (with assessment of perinatal safety in parallel) in women presenting with suspected pre-eclampsia prior to 37 weeks'…
- Conditions
- Pre-eclampsia, Pregnancy, High Risk, Pregnancy Complications
- Trial name
- PARROT (NCT02881073)
- Testing
- Maternal plasma PlGF quantification
- Where
- 7 sites in Ireland
- Volunteers
- 2,313 people
- Sponsor
- Irish Centre for Fetal and Neonatal Translational Research
Newborn Morbidity, Pain
Epidemiology of Painful Procedures in Neonates
Sick or premature neonates are exposed to frequent painful and stressful procedures during their stay in neonatal intensive care units.
- Conditions
- Newborn Morbidity, Pain, Procedures, Intratracheal Intubation
- Trial name
- EPIPPAIN (NCT01346813)
- Where
- 21 sites in France
- Volunteers
- 1,000 people
- Sponsor
- Hôpital Armand Trousseau
Preterm Birth
17OHP for Reduction of Neonatal Morbidity Due to Preterm Birth (PTB) in Twin and Triplet Pregnancies
Hypothesis: Among women with twin or triplet pregnancies, weekly injections of 17-alpha-hydroxyprogesterone caproate (17OHP), started before 24 weeks of gestation, will reduce neonatal morbidity by reducing the rate of preterm…
- Trial name
- 170HP (NCT00163020)
- Testing
- 17-alpha-hydroxyprogesterone caproate injectable
- Where
- 18 sites in United States
- Volunteers
- 321 people
- Sponsor
- Obstetrix Medical Group
Bacterial Vaginosis, Premature Birth
Probiotics for the Prevention of Premature Birth and Neonatal Related Morbidity
The trial intends to evaluate the efficacy of specially designed probiotics to prevent premature birth and related neonatal morbidity associated to intra-uterine infection.
- Conditions
- Bacterial Vaginosis, Premature Birth, Sepsis, Periventricular Leukomalacia
- Trial name
- NCT00303082
- Testing
- Lactobacillus rhamnosus GR1 and Lactobacillus reuteri RC-14
- Where
- 2 sites in Brazil
- Volunteers
- 645 people
- Sponsor
- Oswaldo Cruz Foundation
Cleft Lip and Palate, Maxillary Hypoplasia
Cleft Orthognathic Surgery Versus Distraction Osteogenesis - Which is Better?
Cleft lip and palate patients normally present with a sunken face due to collapse in the middle part of the face and inability of the upper and lower teeth to meet during chewing.
- Trial name
- NCT00930124
- Testing
- Orthognathic surgery, Distraction osteogenesis
- Where
- Hong Kong
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- The University of Hong Kong
Digestive
Determinants of Digestive Morbidity in Neonatal Jaundice
Objective To explore the factors associated with adverse digestive system outcomes in neonates with jaundice. Methods A retrospective analysis was conducted on clinical data of hospitalized neonates admitted to the Department of…
- Trial name
- NCT07475624
- Testing
- Observation (Retrospective Cohort Study)
- Where
- China
- Volunteers
- 3,218 people, healthy volunteers welcome
- Sponsor
- The First Hospital of Jilin University
Transient Tachypnea Newborn, Cesarean Delivery Affecting Fetus
Misoprostol Before Elective Caesarean Section for Decreasing the Neonatal Respiratory Morbidity
Neonatal respiratory distress may occur in either term or preterm newborns with a higher relative risk in preterm, and whether born vaginally or through caesarean section, but in a higher percentage after elective caesarean…
- Trial name
- NCT03031353
- Testing
- Misoprostol
- Where
- Egypt
- Volunteers
- 170 people
- Sponsor
- Ain Shams University
Neonatal Disease
Neonatal Admission in Assuit University Children Hospital
There are many causes of admission of neonates in Neonatal Intensive Care Unit.So knowing such causes and their outcomes will give us knowledge about different risk factors of each disease and the prognosis of each cause.
- Trial name
- NCT04279301
- Volunteers
- 120 people
- Sponsor
- Assiut University
Pregnancy, Primiparity
MorbiMortality Amelioration in Preeclamptic Primiparas Study. MoMA Pre Prim Study
The purpose of this study is to determine whether close monitoring of patients with a high sFlt1 plasma level between 25 and 28 weeks of gestation (i.e.
- Conditions
- Pregnancy, Primiparity, Hypertension, Preeclampsia
- Trial name
- MOMA (NCT00763672)
- Testing
- Transmission of sFlt-1 results to the investigator, No transmission of the sFlt-1 results to the investigator
- Where
- France
- Volunteers
- 1,040 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Misoprostol, Respiratory Distress Syndrome (RDS) of Neonate
Misoprostol Before Caesarean Section
The aim of our study is to evaluate the efficacy of Misoprostol before elective cesarean section in pregnant women with gestational age less than 38 weeks for preventing the occurrence of neonatal respiratory morbidity.
- Conditions
- Misoprostol, Respiratory Distress Syndrome (RDS) of Neonate, Caesarean Section
- Trial name
- Miso/CS (NCT06946914)
- Testing
- Misoprostol
- Where
- Egypt
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Kafrelsheikh University
Patent Ductus Arteriosus, Circulation
Liver Regional Oxygen Saturation in Preterm Patent Ductus Arteriosus
This study evaluates the usefulness of liver perfusion and oxygenation status using regional oxygen saturation (RSO2) values obtained via near-infrared spectroscopy in assessing the hemodynamical significance of patent ductus…
- Conditions
- Patent Ductus Arteriosus, Circulation, Newborn Morbidity, Premature Birth
- Trial name
- NCT05639309
- Testing
- near-infrared spectroscopy based cerebral/somatic oximeter system (INVOS™ system manufactured by Medtronics)
- Where
- South Korea
- Volunteers
- 40 people
- Sponsor
- Seoul St. Mary's Hospital
Preterm Infant, Body Temperature
Air vs. Cutaneous Control Mode for Preterm Infants ≤ 32 WG in Incubators: Impact on Body Growth and Morbidity
Previous studies have shown that mortality and morbidity in preterm neonates are correlated with the fall in body temperature on admission. Hypothermia can be decreased by reducing body heat losses to the environment.
- Trial name
- ThermoKPreterm (NCT03919188)
- Testing
- air temperature control (ATC), skin servocontrol (SSC)
- Where
- France
- Volunteers
- 164 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Pregnancy Related Complications
PRONTO: Obstetric and Neonatal Emergency Training Program: A Cluster-Randomized Trial to Measure Impact
Rates and causes of maternal mortality in Mexico have dropped only slightly; thus, reaching the internationally established Millennium Development Milestones (MDM) is still a distant goal.
- Trial name
- PRONTO (NCT01477554)
- Testing
- PRONTO training
- Volunteers
- 24 people
- Sponsor
- Instituto Nacional de Salud Publica, Mexico
Meconium-stained Amniotic Fluid, Chorioamnionitis
Comparing Infectious Morbidity Among Women With Meconium-stained Amniotic Fluid at Term, Between Those Treated With Prophylactic Antibiotics Zinacef vs. Placebo
Our randomized controlled double blind clinical trail aims to compare maternal and neonatal infectious morbidity between women with meconium-stained amniotic fluid treated with zinacef vs. placebo.
- Trial name
- NCT06849037
- Testing
- zinacef tretment
- Where
- Israel
- Volunteers
- 182 people, healthy volunteers welcome
- Sponsor
- Western Galilee Hospital-Nahariya
Neonatal Morbidity and Mortality, Intrauterine Growth Disorders (IUGR and Macrosomia)
Analysis on the Health of Newborns in Three Hospitals, 2008-2024
The objective of this observational study is to analyze the factors associated with neonatal morbidity and mortality in three hospitals in Quito, Ecuador, from January 2008 to June 2024.
- Conditions
- Neonatal Morbidity and Mortality, Intrauterine Growth Disorders (IUGR and Macrosomia), Prematurity Complications, Neonatal Infections
- Trial name
- NCT06758622
- Where
- Ecuador
- Volunteers
- 40,000 people
- Sponsor
- HOSPITAL GINECO OBSTETRICO ISIDRO AYORA
Neonatal Respiratory Distress Syndrome
Effect of Antenatal Corticosteroids on Neonatal Morbidity.
It will be a randomized controlled trial. There will be two study groups. Study group 1 will be given dexamethasone while study group 2 will be given betamethasone. The control group will be given placebo.
- Trial name
- NCT03446937
- Testing
- Dexamethasone Sodium Phosphate Injection, Betamethasone Sodium Phosphate Injection (Medication), Water for injection
- Where
- Nigeria
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Ahmadu Bello University Teaching Hospital
Familial Hypercholesterolemia, Hypercholesterolemia
Evaluation of a Digiphysical Screening Method to Identify and Diagnose Familial Hypercholesterolemia
Longitudinal and observational registry-based cohort study of individuals participating in the national digiphysical screening program for Familial Hypercholesterolemia.
- Trial name
- DigiLipids (NCT04929457)
- Where
- Sweden
- Volunteers
- 30,000 people
- Sponsor
- Karolinska Institutet
Prenatal Infection, Congenital Infection
Congenital CYtoMEgalovirus Infection in VIEtnam (CYMEVIE)
To estimate the prevalence of congenital CMV infection in Vietnamese neonates and relating morbidity within 2-year follow-up. Along with evaluating the predictive value of the presence and the level of CMV replication in the…
- Conditions
- Prenatal Infection, Congenital Infection, Neonatal Disease
- Trial name
- CYMEVIE (NCT04822142)
- Where
- Vietnam
- Volunteers
- 5,000 people, healthy volunteers welcome
- Sponsor
- Hanoi Obstetrics and Gynecology Hospital