Clinical trials: Morphine
Child Behavior Disorders
Using Mobile Technology to Enhance Multisystemic Therapy (MST) Outcomes
The goal of the current trial is to assess the feasibility of a newly developed prototype of a cell phone app called VillageWhere.
- Trial name
- VillageWhere (NCT02320903)
- Testing
- VillageWhere App
- Where
- United States
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- Evidence-Based Practice Institute, Seattle, WA
Opioid Use Disorder
A Study to Assess the Effect of AZD4041 on Respiratory Drive in Recreational Opioid Users.
This is a Phase 1, single-centre, randomized, double-blind, placebo-controlled, 2 fixed sequences, multiple dose study in healthy male and/or female recreational opioid users.
- Trial name
- NCT05587998
- Testing
- Morphine, AZD4041
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
Postdural Puncture Headache
2 Dose Neuraxial Morphine for Prevention of PDPH
Neuraxial analgesia (most commonly continuous epidural or combined spinal epidural) is the most effective modality available for pain relief during labor.
- Trial name
- NCT02473276
- Testing
- Morphine, Sterile normal saline
- Where
- 4 sites in United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Columbia University
Labor Pain, Post-cesarean Delivery
Mu-Opioid Receptor Genetic Polymorphism and Intrathecal Analgesia
Pharmacogenetics has allowed clinicians to identify associations between an individual's genetic profile and his/her response to drugs.
- Trial name
- NCT00418015
- Testing
- Blood Draw
- Where
- United States
- Volunteers
- 293 people, healthy volunteers welcome
- Sponsor
- Northwestern University
Pain, Cesarean Section
Intrathecal Hydromorphone for Pain Control After Cesarean Section
The use of intrathecal opioids for analgesia in the setting of cesarean section has become standard obstetric anesthesia practice. Currently, two opioids are commonly used. These opioids are fentanyl and morphine (Duramorph).
- Trial name
- NCT02096003
- Testing
- Intrathecal morphine, Intrathecal hydromorphone
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Icahn School of Medicine at Mount Sinai
Healthy
Analgesics in the Pre-hospital Setting: Implications on Hemorrhage Tolerance - Morphine
We are examining how morphine (a commonly used pain medication) will alter responses to simulated blood loss in humans. To simulate blood loss in our research laboratory, participants will complete a test with their lower body in…
- Trial name
- NCT04138615
- Testing
- Morphine
- Where
- United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
Postdural Puncture Headache, Post-Lumbar Puncture Headache
Incidence of Headache Following an Unintentional Dural Puncture
The purpose of this study is to evaluate the use of intrathecal morphine administration following an unintentional dural puncture, to decrease the incidence of post dural puncture headaches (PDPH) in obstetric patients.
- Conditions
- Postdural Puncture Headache, Post-Lumbar Puncture Headache, Cerebrospinal Fluid Leaks
- Trial name
- NCT01977898
- Testing
- Morphine, Saline
- Where
- United States
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Northwestern University
Obstructive Sleep Apnea
Fentanyl Test in Children's Adenotonsillectomy
The purpose of this study is to discuss the relationship between the result of fentanyl test and required dosage of morphine for children with OSAS after adenotonsillectomy；and to evaluate the ability of predicting requested…
- Trial name
- NCT02484222
- Testing
- Fentanyl
- Where
- China
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Children's Hospital of Fudan University
Acute Pain, Fractures
Comparing Ketamine and Morphine in the Treatment of Acute Fracture Pain
Opioid pain medications such as morphine and dilaudid are commonly used in emergency departments to treat pain in patients. Physicians are familiar with the side effects of these medications; the most concerning of which is…
- Trial name
- NCT02430818
- Testing
- ketamine, morphine
- Where
- United States
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Knee Injuries
Femoral/Sciatic Block for Knee Surgery
Knee arthroplasty has a high potential for postoperative pain. This study compares analgesia and postoperative bleeding from intrathecal morphine with the continuous femoral and a single-shot sciatic nerve blockades.
- Trial name
- NCT02882152
- Testing
- femoral nerve blockade, morphine
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo General Hospital
Respiratory Monitoring
Comparison of Non-Invasive Respiratory Monitoring System (RMS)
The goal of this clinical trial is to compare the performance of a novel non-invasive respiratory monitoring system against the gold standard methods (manual counting) in healthy human subjects.
- Trial name
- NCT06000852
- Testing
- Makani Science Respiratory Monitoring System
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Michael Chu
Anesthesia, Opioid Use
Opioid-Free Anesthetic for Tonsillectomy
Prospective randomized controlled trial to determine if opioid-free anesthetic for tonsillectomy is non-inferior to standard opioid-containing anesthetic
- Conditions
- Anesthesia, Opioid Use, Tonsillitis, Sleep Disorder
- Trial name
- NCT04528173
- Testing
- Ketorolac, Dexmedetomidine, Morphine
- Where
- 2 sites in United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Children's Hospital of Philadelphia
Pruritus, Pregnancy Related
Treatment of Pruritus With Intramuscular Promethazine
Neuraxial narcotics are commonly used in obstetric patients for cesarean delivery to help with pain control over the first 24 hours after the surgery.
- Trial name
- NCT04805073
- Testing
- Promethazine
- Where
- United States
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- University of Florida
Osteoarthritis, Knee
Postoperative Pain Control After Periarticular Injection During Total Knee Arthroplasty
This study will evaluate the use of a local injection around the knee (periarticular) during total knee replacement (TKR) surgery to see if it reduces postoperative pain levels.
- Trial name
- NCT02570503
- Testing
- Ropivacaine, Ketorolac, Clonidine
- Where
- United States
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Virginia Commonwealth University
Pain
Low Dose Ketamine Versus Morphine for Moderate to Severe Pain in the Emergency Department
The primary objectives of the study are to evaluate the efficacy of subdissociative dose intravenous ketamine compared with intravenous morphine in relieving acute pain in the ED.
- Trial name
- NCT01835262
- Testing
- Morphine, Ketamine
- Where
- United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Antonios Likourezos
Cesarean Section
Comparison of 0.1 and 0.05mg Intrathecal Morphine for Post-cesarean Analgesia.
The purpose of this study is to determine the ideal dose of spinal morphine for use in Cesarean section. Spinal anesthesia (single injection in the lower back to numb patients from the waist down) is commonly used in Cesarean…
- Trial name
- NCT03427463
- Testing
- receiving 0.1 mg IT morphine, recieving 0.05 mg IT morphine
- Where
- United States
- Volunteers
- 229 people, healthy volunteers welcome
- Sponsor
- Medical University of South Carolina
Cesarean Delivery
Intravenous Methadone Versus Intrathecal Morphine for Analgesia Following Cesarean Delivery
The purpose of this study is to determine if there is a difference in opioid requirements at 0-48 hours after scheduled cesarean delivery in patients receiving 150 mcg intrathecal morphine compared to 0.2 mg/kg (maximum 20 mg)…
- Trial name
- NCT06826742
- Testing
- Intravenous line (IV) Methadone, Intrathecal Morphine
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Healthy
Study To Assess The Effect Of Gabapentin, Diphenhydramine And Morphine On Cold Pain In Healthy Male Volunteers
Human experimental pain models are useful in understanding the mechanisms underlying clinical pain conditions and can be used to test the analgesic efficacy of drugs used in the management of pain.
- Trial name
- NCT01119222
- Testing
- Gabapentin, Diphenhydramine, Morphine
- Where
- Belgium
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Pfizer
Chronic Pain
A Comparison of the Addiction Liability of Hydrocodone and Sustained Release Morphine
Characterize the relative abuse liability of a short versus a long acting opioid in chronic pain patients.
- Trial name
- NCT00314340
- Testing
- Markers of Abuse Liability, Neuropsych Testing, and Cue Reactivity, ER Morphine, hydrocodone plus acetaminophen
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of California, Davis
Analgesia, Obstetrical, Postpartum Hemorrhage
Prospective Effect of Intravenous Ketorolac on Opioid Use, EBL and Complications Following Cesarean Delivery
In this randomized, double-blind control trial to evaluate the effect of ketorolac given at the time of cord clamp has on estimated blood loss and postcesarean pain control.
- Conditions
- Analgesia, Obstetrical, Postpartum Hemorrhage, Opioid Use, Nonsteroidals (NSAIDs)Toxicity
- Trial name
- NCT02509312
- Testing
- Ketorolac
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- University Hospitals Cleveland Medical Center