Clinical trials: Morphine
Postoperative Pain, Thyroidectomy
Celecoxib for Reducing Morphine Requirement After Thyroid Surgery: A Randomized Controlled Trial
The purpose of this study is to determine whether celecoxib is effective in the treatment postoperative pain after thyroidectomy.
- Conditions
- Postoperative Pain, Thyroidectomy, Cyclooxygenase 2 Inhibitors
- Trial name
- NCT00520338
- Testing
- celecoxib
- Where
- Thailand
- Volunteers
- 80 people
- Sponsor
- Mahidol University
Multiple Sclerosis
12-week Study to Evaluate RebiSmart™ Suitability for Self Injection in Relapsing Multiple Sclerosis.
The Electronic Device - The RebiSmart™ is an electronic injection device that is being studied for the delivery of Merck Serono's Rebif® New Formulation.
- Trial name
- NCT00735007
- Testing
- Rebif® New Formulation (RNF) using RebiSmartTM
- Where
- 6 sites in United States, Canada and 4 more
- Volunteers
- 106 people
- Sponsor
- EMD Serono
Major Depressive Disorder
Comparative Effectiveness Clinical Trial of MST Compared to ECT in Major Depressive Disorder
This study was a prospective, open-label comparative effectiveness clinical trial, comparing magnetic seizure therapy (MST) to ECT in patients with Major Depressive Disorder (MDD).
- Trial name
- NCT04216095
- Testing
- Electroconvulsive Therapy (n=30), Magnetic Seizure Therapy (n=30)
- Volunteers
- 60 people
- Sponsor
- Tanta University
Postoperative Pain
Morphine Consumption in Thoracotomy
Importance of effective postoperative pain management is well known. The undesired effects of pain can be prevented with multimodal analgesia for the patient. Thoracotomy operations are associated with high levels of pain.
- Trial name
- NCT04999319
- Testing
- PVB, ESPB
- Where
- Turkey (Türkiye)
- Volunteers
- 44 people
- Sponsor
- Kocaeli University
Type 2 Diabetes Mellitus
Study To Compare Single Dose Of Three Modified Release Formulations Of PF-04937319 With Immediate Release Material-Sparing-Tablet (IR MST) Formulation Previously Studied In Adults With Type 2 Diabetes Mellitus.
Study B1621015 will characterize bioavailability, tolerability and pharmacodynamics of three modified release formulations of PF-04937319 compared with the immediate release material-sparing-tablet (IR MST) formulation in adults…
- Trial name
- NCT02206607
- Testing
- PF-04937319 IR MST, PF-04937319 MR 1, PF-04937319 MR 2
- Where
- 2 sites in United States
- Volunteers
- 39 people
- Sponsor
- Pfizer
Pain, Cancer
Clinical Study of KW-2246 in Patients With Cancer Pain
This study is a Phase II open-label study to investigate the recommended conversion ratio (oral morphine dose to KW-2246) when switching oral morphine or oxycodone to KW-2246 in cancer patients.
- Trial name
- NCT00355628
- Testing
- KW-2246 (fentanyl citrate)
- Where
- Japan
- Volunteers
- 40 people
- Sponsor
- Kyowa Kirin Co., Ltd.
Acute Pulmonary Edema
MIdazolam Versus MOrphine in Acute Pulmonary Edema (MIMO Trial)
Acute pulmonary edema (APE) is a common condition in the emergency room, associated with considerable mortality. The use of intravenous morphine in the treatment of APE remains controversial and Benzodiazepines have been…
- Trial name
- MIMO (NCT02856698)
- Testing
- Midazolam, Morphine
- Where
- 8 sites in Spain
- Volunteers
- 111 people
- Sponsor
- Alberto Dominguez-Rodriguez
Obesity
Intravenous Ibuprofen for Laparoscopic Bariatric Surgery
Primary objective of this study is to test hypothesis that IV ibuprofen decreases 24 hours morphine requirement using IV PCA in patients after laparoscopic bariatric surgery.
- Trial name
- NCT01707251
- Testing
- Intravenous Ibuprofen, Saline
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Jacobi Medical Center
Analgesic Drug Dependence, Sensory Disorders
Intrathecal Morphine Microdose Method Sensory Changes
Following the retrospective study on the effectiveness of the microdose method of intrathecal morphine therapy, the investigators are interested in measuring the sensory changes at 4 time points during the microdose method.
- Conditions
- Analgesic Drug Dependence, Sensory Disorders, Chronic Pain
- Trial name
- NCT03395275
- Testing
- Quantitative Sensory Tests, surveys
- Volunteers
- healthy volunteers welcome
- Sponsor
- The University of Texas Medical Branch, Galveston
Postoperative Pain
NSAIDs With Morphine-PCA Compared to Epidural Analgesia in Thoracotomy Pain
The investigators investigated whether a strictly controlled pain management with patients participating in a clinical study can attenuate persistence of post-thoracotomy pain.
- Trial name
- NCT01541137
- Testing
- Diclofenac, parecoxib/ valdecoxib, patient controlled epidural analgesia
- Where
- Finland
- Volunteers
- 30 people
- Sponsor
- Helsinki University Central Hospital
Cesarean Delivery
BUprenorphine Versus Morphine for Postcesarean Analgesia (BUMP)
In this study the researchers are randomizing pregnant patients coming for elective cesarean delivery to receive either intrathecal buprenorphine or morphine for their analgesia.
- Trial name
- NCT07786012
- Testing
- buprenorphine, morphine
- Where
- United States
- Volunteers
- 180 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Other Specified Disorders of Kidney and Ureter, Benign Neoplasm of Ureter
Spinal Morphine or Intravenous Lidocaine in Robot-assisted Upper Urologic Surgery
The goal of this clinical trial is to learn whether the addition of spinal analgesia leads to superior recovery in patients undergoing robotic-assisted laparoscopic upper urinary tract surgery under general anesthesia.
- Conditions
- Other Specified Disorders of Kidney and Ureter, Benign Neoplasm of Ureter, Calculus of Kidney and Ureter, Ureter Cancer
- Trial name
- SMILe (NCT06349668)
- Testing
- spinal analgesia with morphine and bupivacaine, lidocaine infusion
- Where
- 3 sites in Sweden
- Volunteers
- 220 people
- Sponsor
- Hans Bahlmann
Postoperative Nausea and Vomiting, Postoperative Pain
Spinal Morphine and Atropine Added to General Anaesthesia for Nausea and Pain After Abdominal Laparoscopy
Laparoscopic abdominal surgery carries one of the highest risks of postoperative nausea and vomiting (PONV), and postoperative opioids given for pain are themselves emetogenic.
- Conditions
- Postoperative Nausea and Vomiting, Postoperative Pain, Anesthesia, Anesthesia Spinal
- Trial name
- NCT07851870
- Testing
- Intrathecal bupivacaine, morphine and atropine, General anaesthesia, Multimodal analgesia and antiemetic prophylaxis
- Where
- Indonesia
- Volunteers
- 63 people
- Sponsor
- Universitas Indonesia
Multiple Sclerosis
An Open-label Study of AZD0120 in Adults With Multiple Sclerosis
This trial is a Phase 1b, open-label, multi-center, clinical study of AZD0120, a BCMA/CD19 dual targeting CAR+ T-cell therapy, to evaluate the safety and tolerability in adult participants with Multiple Sclerosis.
- Trial name
- ZENITH (NCT07224373)
- Testing
- AZD0120 - Regimen 1, AZD0120 - Regimen 2
- Where
- 19 sites in United States, Australia and 3 more
- Volunteers
- 24 people
- Sponsor
- AstraZeneca
Pain
Influence of Patient Choice of Intrathecal Morphine on Post-cesarean Delivery Pain.
This is a randomized controlled study that will place patients into a "choice" and a "no choice" group. The choice group will be able to choose between receiving 100 mcg or 200 mcg intrathecal morphine.
- Trial name
- NCT01425762
- Testing
- Drug Dose
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Stanford University
Drug-drug Interaction
Determining the Clinical Relevance of the Interaction Between Enzalutamide and the Opioid Morphine and the DOAC Edoxaban
Enzalutamide is one of the oncolytic drugs that showed efficacy and safety in most of the features of prostate cancer. Approximately 17% of the patients treated with enzalutamide need pain control.
- Trial name
- MIND THE GAP (NCT05339672)
- Testing
- Blood sampling - Pharmacokinetic assessment
- Where
- 3 sites in Netherlands
- Volunteers
- 26 people
- Sponsor
- Radboud University Medical Center
Pain, Postoperative
Safety and Efficacy of Cocktail Periarticular Injection in Simultaneous Total Knee Arthroplasty
We investigated the safety and efficacy of the bilateral periarticular cocktail injection at a reduced dosage in patients undergoing simultaneous bilateral total knee arthroplasty.
- Trial name
- NCT02270437
- Testing
- ropivacaine, fentanyl, adrenaline
- Where
- China
- Volunteers
- 55 people
- Sponsor
- Peking Union Medical College Hospital
Pain, Huntington Disease
Evaluating the Relationship of Morphine Consumption and Pain-related Molecules in Hepatic Surgical Patients
According to above basic findings, it is important to confirm those results in clinic. In this branch, the investigators will use patient control analgesic (PCA) device to investigate the consumption of morphine for patients…
- Conditions
- Pain, Huntington Disease, Hepatic Surgery
- Trial name
- NCT01919034
- Where
- Taiwan
- Volunteers
- 15 people
- Sponsor
- National Cheng-Kung University Hospital
Multiple Sclerosis
Evaluation of the Relationship Between ABCG2 Mutation and Teriflunomide Exposure and Safety in Chinese RMS Patients Treated With Teriflunomide 14 mg Once Daily for 24 Weeks
Primary Objective: Evaluate the relationship between ABCG2 mutation (rs2231142) and teriflunomide exposure, during 6-month treatment with teriflunomide 14 mg Secondary Objective: Characterize the safety (AEs, such as ALT…
- Trial name
- TERI-PK (NCT04410965)
- Testing
- TERIFLUNOMIDE
- Where
- China
- Volunteers
- 82 people
- Sponsor
- Sanofi
COPD
Morphine or Fentanyl for Refractory Dyspnea in COPD
Rationale: The most important complaint in severe COPD is dyspnea which is associated with a diminished exercise tolerance, reduced quality of life and can lead to anxiety and depression.
- Trial name
- MoreFoRCOPD (NCT03834363)
- Testing
- Fentanyl, Morphine Retard
- Where
- 10 sites in Netherlands
- Volunteers
- 59 people
- Sponsor
- Huib A.M. Kerstjens