Clinical trials: Mosquito-Borne Diseases
Japanese Encephalitis, Varicella
Study of Japanese Encephalitis Chimeric Virus Vaccine (JE-CV) in Children Previously Immunized With JE-CV
The aim of the study is to investigate the memory immune response and the yearly persistence of the immunity against Japanese Encephalitis (JE) after vaccination with Japanese Encephalitis Chimeric Virus Vaccine (JE-CV) in…
- Trial name
- NCT01190228
- Testing
- JE-CV Vaccine, Varicella Vaccine
- Where
- Philippines
- Volunteers
- 454 people, healthy volunteers welcome
- Sponsor
- Sanofi Pasteur, a Sanofi Company
Dengue Fever
Safety and Immunogenicity With Two Different Serotype 2 Potencies of Takeda's Tetravalent Dengue Vaccine Candidate (TDV) in Adults in Singapore
The purpose of this study is to assess the post-vaccination neutralizing antibody response against each dengue serotype by vaccine group.
- Trial name
- NCT02425098
- Testing
- Takeda's Tetravalent Dengue Vaccine Candidate (TDV), Takeda's High-Dose Tetravalent Dengue Vaccine Candidate (HD-TDV)
- Where
- 3 sites in Singapore
- Volunteers
- 351 people, healthy volunteers welcome
- Sponsor
- Takeda
Zika Virus Disease
Zika Case Definition and Surveillance Study
This prospective, surveillance study will assess the operational Zika virus definition for use in future Zika purified inactivated virus (ZIKV) vaccine efficacy trials in order to identify Zika virus disease (ZVD) cases among the…
- Trial name
- NCT03158233
- Where
- 6 sites in Colombia, Honduras and 2 more
- Volunteers
- 2,400 people, healthy volunteers welcome
- Sponsor
- Sanofi Pasteur, a Sanofi Company
Dengue
Pilot Study to Detect DENGUE Virus in Sperm
The purpose of this study is to seek the presence of dengue virus in semen, to determine its localization and to assess the efficiency of spermatozoa processing methods to obtain virus free spermatozoa.
- Trial name
- DENGSPERM (NCT03612609)
- Testing
- blood, urine and semen sample
- Where
- Reunion
- Volunteers
- 10 people
- Sponsor
- University Hospital, Toulouse
Buddhist Monks, Health Education
Health Education by Buddhist Monks to Promote Malaria Knowledge and Preventive Practices in Rural Myanmar
Malaria is still a leading public health concern in Myanmar. However, people living in rural areas usually showed poor prevention practice despite residing in malaria hotspots.
- Conditions
- Buddhist Monks, Health Education, Malaria, Monastery-based
- Trial name
- NCT06386367
- Testing
- Monastery-based health education by Buddhist monks
- Where
- Burma
- Volunteers
- 501 people, healthy volunteers welcome
- Sponsor
- Myanmar Health Network Organization
Severe Falciparum Malaria
Safety and Preliminary Efficacy of L-arginine in Severe Falciparum Malaria
Background: Mortality from severe malaria remains ~15% despite the use of the most rapidly parasiticidal antimalarial therapy, artesunate. Adjunctive treatments may improve outcome.
- Trial name
- ARGISM (NCT00616304)
- Testing
- L-arginine hydrochloride, Normal saline
- Where
- Indonesia
- Volunteers
- 8 people
- Sponsor
- Menzies School of Health Research
Falciparum Malaria
Evaluation of the Gametocytocidal Efficacy and Safety of Primaquine in Uncomplicated Falciparum Malaria in Uganda
The purpose of this study is to evaluate the safety and efficacy of lower doses of primaquine compared to the dose recommended by the WHO for reducing P.
- Trial name
- NCT01365598
- Testing
- Primaquine
- Where
- Uganda
- Volunteers
- 468 people
- Sponsor
- London School of Hygiene and Tropical Medicine
Dengue
Homologous Re-infection With Dengue 1 or Dengue 3
Previous studies with one dengue infection in a controlled environment at Upstate generated data that has been important in understanding the clinical signs and symptoms and how a person's body reacts to dengue infection over…
- Trial name
- NCT05967455
- Testing
- Dengue virus 1 Live Virus Human Challenge (DENV-1-LVHC), Dengue virus 3 Live Virus Human Challenge (DENV-3-LVHC)
- Where
- United States
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- State University of New York - Upstate Medical University
Plasmodium Vivax Malaria, Vivax Malaria
Tafenoquine Drug Levels in Small Children
This study is an open label, single arm, pharmacokinetic trial. A total of 20 participants (children ≤12kg and >28 days old) will be enrolled.
- Trial name
- TQP (NCT07835321)
- Testing
- Chloroquine, Tafenoquine
- Where
- 2 sites in Thailand, Vietnam
- Volunteers
- 20 people
- Sponsor
- University of Oxford
Falciparum Malaria
Nitrite Infusion in Children With Malaria
The purpose of this study is to assess the safety of intravenous sodium nitrite in African children who have moderately severe malaria.
- Trial name
- NCT04289558
- Testing
- Sodium Nitrite
- Where
- Tanzania
- Sponsor
- Duke University
Malaria
Long-term Iron Supplements and Malaria Risk in Early Pregnancy: a Randomized Controlled Trial
A randomized double-blind controlled trial will be carried out in which young, nulliparous (having never given birth) women will be randomly assigned to receive weekly supplementation with either iron and folic acid or folic acid…
- Trial name
- PALUFER (NCT01210040)
- Testing
- Folic Acid, Folic Acid and Iron
- Where
- Burkina Faso
- Volunteers
- 1,959 people, healthy volunteers welcome
- Sponsor
- Liverpool School of Tropical Medicine
Venezuelan Equine Encephalitis
Safety, Tolerability and Immunogenicity of the Venezuelan Equine Encephalitis (VEE) Attenuated Live-Virus Vaccine
This study is being done to determine the safety and tolerability of a new investigational vaccine referred to as VEE IA/B V3526, which may induce production of specific antibodies in vaccinated humans, and may protect them…
- Trial name
- NCT00109304
- Testing
- VEE 3526
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- DynPort Vaccine Company LLC, A GDIT Company
Malaria, Falciparum, Anemia
Liberia Insecticide Treated Durable Wall Linings Study: Protocol for a Cluster Randomised Trial (DL)
A cluster-randomized control trial will study the effect of insecticide-treated wall lining on malaria transmission in Bomi County, Liberia.
- Trial name
- NCT02448745
- Testing
- Insecticide treated wall lining
- Where
- Liberia
- Volunteers
- 6,317 people, healthy volunteers welcome
- Sponsor
- The Mentor Initiative
Vivax Malaria
A Revised Tafenoquine Dose to Improve Radical Cure for Vivax Malaria
The goal of this clinical trial is to assess the efficacy and safety or a revised weight band tafenoquine dose in vivax malaria patients.
- Trial name
- TADORE (NCT06148792)
- Testing
- Tafenoquine, Primaquine
- Where
- 4 sites in Brazil, Ethiopia and 2 more
- Volunteers
- 1,090 people
- Sponsor
- Menzies School of Health Research
Mortality, Malaria
Improved Management and in-Hospital Mortality
The study intend to evaluate whether the use of standardised malaria case management protocol plus financial incentives added to the availability of free drugs reduce the case-fatality at the paediatric ward.
- Trial name
- MTV (NCT00465777)
- Testing
- Guideline adherence and financial incentive
- Where
- Guinea-Bissau
- Volunteers
- 950 people
- Sponsor
- Bandim Health Project
Plasmodium Infection
Reducing Malaria Transmission in Forest-going Mobile and Migrant Populations in Lao PDR and Cambodia
This stepped-wedge cluster-randomized controlled trial with nested mixed methods study will assess the effectiveness, acceptability, feasibility and cost-effectiveness of a personal protection package to reduce malaria…
- Trial name
- NCT05117567
- Testing
- Personal protection package
- Volunteers
- 5,868 people, healthy volunteers welcome
- Sponsor
- Macfarlane Burnet Institute for Medical Research and Public Health Ltd
Malaria
Surveillance of Effectiveness/Safety of Artemether-lumefantrine in Patients With Malaria
The purpose of this study is to describe the pediatric and adult patients (U.S. and foreign residents) diagnosed with malaria and treated with artemether-lumefantrine with regard to their demographics, including evaluation of…
- Trial name
- NCT01228344
- Testing
- Artemether-lumefantrine
- Where
- United States
- Volunteers
- 324 people
- Sponsor
- Novartis Pharmaceuticals
Malaria
A Randomised Efficacy Study of Combination Antimalarials to Treat Uncomplicated Malaria
The purpose of this study is to compare the efficacy of sulfadoxine-pyrimethamine plus artesunate with that of sulfadoxine-pyrimethamine on its own for the treatment of uncomplicated malaria.
- Trial name
- NCT00203736
- Testing
- Sulfadoxine-pyrimethamine, Artesunate plus sulfadoxine-pyrimethamine
- Where
- 2 sites in Mozambique
- Volunteers
- 240 people
- Sponsor
- University of Cape Town
Eastern Equine Encephalitis
Safety and Immunogenicity Study of the Eastern Equine Encephalitis (EEE) Vaccine
This study is being conducted to collect safety and immunogenicity data for the Eastern Equine Encephalitis (EEE) vaccine.
- Trial name
- NCT02654509
- Testing
- Eastern Equine Encephalitis Vaccine, Inactivated, Dried, TSI-GSD 104
- Where
- United States
- Volunteers
- 138 people, healthy volunteers welcome
- Sponsor
- U.S. Army Medical Research and Development Command
Systemic Lupus, Rheumatoid Arthritis
Yellow Fever Vaccine in Patients With Rheumatic Diseases
According to World Health Organization (WHO), since December 2016, Brazil is showing a significant increase in cases of yellow fever in humans.
- Conditions
- Systemic Lupus, Rheumatoid Arthritis, Spondyloarthritis, Inflammatory Myopathy
- Trial name
- NCT03430388
- Testing
- Yellow Fever vaccine (17D)
- Where
- Brazil
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo General Hospital