Clinical trials: Mosquito-Borne Diseases
Malaria,Falciparum
Therapeutic Efficacy Study of AL and DP in Western Kenya
Artemether-lumefantrine (AL) was adopted as first-line antimalarial therapy in Kenya in 2006, and dihydroartemisinin-piperaquine (DP) as the second-line therapy in 2010.
- Trial name
- NCT05060198
- Testing
- Artemether-lumefantrine (AL), Dihydroartemisinin-piperaquine (DP)
- Volunteers
- 340 people
- Sponsor
- Kenya Medical Research Institute
Alpha and Beta Thalassemia, Sickle Cell Disease
Collection of Human Biospecimens for Basic and Clinical Research Into Globin Variants
Background: Blood disorders like sickle cell disease and malaria affect many people around the world. Researchers want to learn more about blood disorders.
- Conditions
- Alpha and Beta Thalassemia, Sickle Cell Disease, Malaria, Human Physiology
- Trial name
- NCT03937817
- Where
- United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Malaria, Falciparum
A Study by the Tracking Resistance to Artemisinin Collaboration (TRAC)
This study is an open-label randomised trial comparing standard ACT treatment with matching triple artemisinin-based combination therapies (TACTs), evaluating efficacy in safety and tolerability.
- Trial name
- TRACII (NCT02453308)
- Testing
- ACT, TACT
- Where
- 20 sites in Bangladesh, Burma and 6 more
- Volunteers
- 1,110 people
- Sponsor
- University of Oxford
Dengue
Evaluating the Clinical and Immune Response to Two Dengue Virus Vaccines in Healthy Adults
Dengue viruses infect millions of people throughout the tropics and subtropics each year. The development of a dengue vaccine is an important health priority.
- Trial name
- NCT02392325
- Testing
- rDEN1Δ30, rDEN2Δ30-7169
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Malaria
Efficacy of Combination Therapy for Prevention of Effects of Malaria During Pregnancy
This study is an investigation to compare the efficacy of two different intermittent sulfadoxine/pyrimethamine (SP) treatment regimens and intermittent sulfadoxine/pyrimethamine (SP) + artesunate (SP/AS) treatment of HIV negative…
- Trial name
- NCT00164255
- Testing
- sulfadoxine/pyrimethamine, sulfadoxine/pyrimethamine plus artesunate
- Where
- 2 sites in Tanzania
- Volunteers
- 1,614 people, healthy volunteers welcome
- Sponsor
- Centers for Disease Control and Prevention
Dengue Hemorrhagic
Resuscitation With Albumin 5% in Dengue Haemorrhagic Fever
Endothelial cell had important role in plasma leakage process. Plasma leakage occurs due to increased vascular permeability caused by disruption of endothelial glycocalyx showed by increased syndecan-1 level in serum.
- Trial name
- NCT04076254
- Testing
- Albumins, Fluid
- Where
- Indonesia
- Volunteers
- 84 people
- Sponsor
- Universitas Indonesia
Dengue
Educational Intervention to Promote Control Behaviors and Prevention of Dengue
This study will assess the effect of an educational nursing intervention in adults to promote dengue control and prevention behaviors, in comparison with the usual strategy of a health service provider institution.
- Trial name
- NCT05321264
- Testing
- Educational nursing intervention
- Where
- Colombia
- Volunteers
- 116 people
- Sponsor
- Universidad de Antioquia
Malaria
Community-led Responses for Elimination: Controlled Trial of Reactive Case Detection Versus Reactive Drug Administration
This study is designed to compare the effectiveness of reactive focal drug administration (RFDA) using dihydroartemisinin+piperaquine (DHAP) versus reactive focal test and treat (RFTAT) using artemether+lumefantrine (AL) as a…
- Trial name
- CORE Zambia (NCT02654912)
- Testing
- Reactive Focal Drug Administration
- Where
- Zambia
- Volunteers
- 8,682 people, healthy volunteers welcome
- Sponsor
- PATH
Intermittent Preventive Treatment, Placental Malaria
Sulphadoxine-Pyrimethamine for Intermittent Preventive Treatment of Malaria in Pregnancy in Uganda
The effectiveness of sulfadoxine-pyrimethamine (SP) as intermittent preventive treatment in pregnancy in malaria-endemic areas the effectiveness and efficacy of SP may be compromised by increased SP resistance.
- Trial name
- SP IPTp (NCT01184911)
- Testing
- Sulfadoxine-pyrimethamine
- Where
- Uganda
- Sponsor
- University of California, San Francisco
Yellow Fever
Trial of an Inactivated Yellow Fever Virus Vaccine
This trial will be a randomized, placebo controlled, double-blind (within dosing group), dose escalation Phase 1 trial, evaluating dosages of 1 mcg and 5 mcg of HydroVax-002 YFV vaccine given intramuscularly on Day 1 and Day 29…
- Trial name
- NCT05172544
- Testing
- HydroVax-002 YFV
- Where
- United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Najit Technologies, Inc.
Malaria
Evaluation of Artesunate in Infants Being Treated for Severe Malaria
This is essentially a laboratory study that is an addendum to an ongoing prospective Phase 4 multicenter observational study titled: "Safety and Efficacy of Artesunate in Pregnant Women and Infants (ARTEMUM)" being conducted in…
- Trial name
- NCT06555809
- Testing
- Artesunate Injection
- Where
- France
- Volunteers
- 15 people
- Sponsor
- Amivas Inc.
Yellow Fever
Characterization of T Cell Responses Following Yellow Fever Virus Vaccination in Healthy Adults
The investigators at Rockefeller University are doing this research to study how the immune system responds to viruses and other infectious agents by using the yellow fever 17D vaccine as a model.
- Trial name
- NCT00616356
- Where
- United States
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Rockefeller University
Vivax Malaria, G6PD Deficiency
Short Course Primaquine for the Radical Cure of P. Vivax - Papua New Guinea
Significant gains have been made in reducing the overall burden of malaria worldwide, however these have been far greater for Plasmodium falciparum than P. vivax. P.
- Trial name
- SCOPE (NCT05874271)
- Testing
- Revised case management package
- Where
- 4 sites in Papua New Guinea
- Volunteers
- 794 people
- Sponsor
- Macfarlane Burnet Institute for Medical Research and Public Health Ltd
Malaria
A Cluster-randomised Trial of Interventions to Improve Antimalarial Prescribing With Malaria Tests
Background. Overdiagnosis of malaria is widespread in health facilities throughout Africa, a situation that is unsustainable given the relatively high cost of artemisinin combination therapy (ACTs) compared to older…
- Trial name
- TACT (NCT01292707)
- Testing
- Control, HW, HWC
- Where
- Tanzania
- Volunteers
- 1,152 people
- Sponsor
- London School of Hygiene and Tropical Medicine
Dengue, Vaccination
Dengue Vaccine Strategy in Children Aged 9 to 17 Years in the French Caribbean
Dengue fever, an arbovirus transmitted by the Aedes mosquito, is a public health problem in all tropical and subtropical regions of the world. There is currently no antiviral treatment and vector control has shown its limits.
- Conditions
- Dengue, Vaccination, Seroprevalence, Infectious Disease
- Trial name
- DengueSEA (NCT04839757)
- Where
- Martinique
- Volunteers
- 590 people
- Sponsor
- University Hospital Center of Martinique
Malaria
Studies of a Candidate Aminoquinoline Antimalarial (AQ-13)
This is an initial efficacy study of a candidate antimalarial in human subjects with uncomplicated malaria caused by the most common and most important parasite in Africa (Plasmodium falciparum).
- Trial name
- NCT01614964
- Testing
- AQ-13 Treatment, Coartem Treatment
- Where
- Mali
- Volunteers
- 66 people
- Sponsor
- Tulane University
Malaria, Falciparum, Malaria
Safety and Immunogenicity Study of the Malaria Vaccines FP9 PP and MVA PP
This study examines two new malaria vaccines (FP9-PP and MVA-PP) in healthy human volunteers to determine their safety and ability to induce a measurable immune response against malaria.
- Trial name
- NCT00374998
- Testing
- FP9-PP (FP9 polyprotein), MVA-PP (Modified Virus Ankara polyprotein)
- Where
- United Kingdom
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- European Vaccine Initiative
Malaria
Effectiveness of Seasonal Malaria Chemoprevention in Nampula Province, Mozambique: Type Two Hybrid Implementation Study
We describe a Type II hybrid effectiveness-implementation study design which evaluates the effects of a clinical intervention on relevant outcomes whilst collecting information on implementation.
- Trial name
- NCT05186363
- Testing
- Chemopreventive Agent - SPAQ, Control Test - no drugs given
- Where
- 2 sites in Mozambique
- Volunteers
- 3,156 people, healthy volunteers welcome
- Sponsor
- Malaria Consortium
Vector Transmission
Attractive Targeted Sugar Bait Trial in Mali
Globally, the female mosquitoes to be effective at transmitting malaria parasites, must have a number of characteristics including: abundance, longevity (individual mosquitoes must survive long enough after feeding on infected…
- Trial name
- NCT04149119
- Testing
- Attractive Target Sugar Baits (ATSB)
- Where
- Mali
- Volunteers
- 6,068 people, healthy volunteers welcome
- Sponsor
- University Clinical Research Center, Mali
Malaria
Getting Malaria "Off the Back" of Women and Children in Western Uganda
This is a two-phase, mixed-methods pilot study of insecticide-treated lesus to reduce the incidence of P. falciparum malaria among infants in a rural area of western Uganda.
- Trial name
- NCT04102592
- Testing
- Permethrin-treated Lesu (baby wrap), Untreated Lesu (baby wrap)
- Where
- Uganda
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
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