Clinical trials: Mosquito-Borne Diseases
HIV Coinfection, Malaria
Optimizing Malaria Treatment for HIV-Malaria Co-infected Individuals
Optimal is a Randomized clinical trial to optimize treatment of malaria in HIV -malaria co infected patients. It has been demonstrated that, when the antimalarial drug Artemether Lumefantrine is co administered with Efavirenz…
- Trial name
- OPTIMAL (NCT04708496)
- Testing
- Artemether-lumefantrine
- Where
- 2 sites in Uganda
- Volunteers
- 888 people
- Sponsor
- Makerere University
Malaria,Falciparum
Study of the Transmission-Blocking Vaccine Pfs230D1-EPA/Matrix-M Against Malaria in Adults in Mali
Background: Researchers are trying to develop a vaccine that will safely reduce the spread of malaria in the community by preventing mosquitos from carrying malaria from person to person.
- Trial name
- NCT05135273
- Testing
- Pfs230D1-EPA/Matrix-M Vaccine, Verorab Rabies Vaccine
- Where
- Mali
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Falciparum Malaria
Safety and Efficacy Study of Adjunctive Rosiglitazone in the Treatment of Uncomplicated Falciparum Malaria
The purpose of this study is to examine the safety, tolerability, and efficacy of adjunctive rosiglitazone in the treatment of uncomplicated P.falciparum malaria.
- Trial name
- NCT00149383
- Testing
- Rosiglitazone
- Where
- Thailand
- Volunteers
- 140 people
- Sponsor
- Mahidol University
Malaria
Absolute BA and OZ439 PK Effect of Different OZ439 Dose Volumes and Cobicistat Co-administration Study
This study is an open-label, two-part study to determine the absolute bioavailability (BA) of OZ439 using simultaneous intravenous [14C]-OZ439 microdose/800mg oral dosing and to investigate the pharmacokinetics (PK) of OZ439…
- Trial name
- NCT04069221
- Testing
- Single oral dose of 800 mg OZ439, Single oral dose of 400 mg OZ439, Single oral dose of cobicistat
- Where
- Netherlands
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Medicines for Malaria Venture
Dengue, Zika Virus Infection
Applying Wolbachia to Eliminate Dengue
This cluster randomised trial will evaluate the efficacy of Wolbachia-infected Aedes aegytpi mosquitoes in reducing dengue cases in Yogyakarta City, Indonesia
- Conditions
- Dengue, Zika Virus Infection, Chikungunya Fever
- Trial name
- AWED (NCT03055585)
- Testing
- Wolbachia-infected Aedes aegypti mosquitoes, standard practice dengue control
- Where
- Indonesia
- Volunteers
- 8,173 people
- Sponsor
- Gadjah Mada University
Malaria
MULTIple Doses of IPTi Proposal: a Lifesaving High Yield Intervention
As efforts to control malaria are stalling, and the disease is particularly severe in children under the age of two, it is imperative for countries in sub-Saharan Africa, with areas of moderate-to-high transmissions, to implement…
- Trial name
- MULTIPLY (NCT05085340)
- Testing
- Intermittent preventive treatment of malaria in infants (IPTi) with sulfadoxine-pyrimethamine (SP)
- Where
- 3 sites in Mozambique, Sierra Leone and 1 more
- Volunteers
- 94,252 people, healthy volunteers welcome
- Sponsor
- Barcelona Institute for Global Health
Plasmodium Falciparum Malaria
A Safety and Efficacy Study of Concomitant Administration of ChAd63/MVA ME-TRAP + RTS,S
The purpose of this study is to assess two types of new malaria vaccines in different combinations. The study will enable us to assess: 1. The ability of the vaccines to prevent malaria infection. 2.
- Trial name
- NCT02252640
- Testing
- RTS,S/AS01B (50mcg of RTS,S and standard adult dose of AS01), RTS,S/AS01B (10mcg of RTS,S and one fifth of the standard dose of AS01), ChAd63 ME-TRAP (5 x 10^10 vp)
- Where
- 4 sites in United Kingdom
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Onchocerciasis (River Blindness), Schistosomiasis
Expanding Access to Preventive Chemotherapy Among Mobile and Migrant Populations
Neglected Tropical Diseases (NTDs) are among the most common groups of diseases affecting over one billion people globally and are disproportionately concentrated in remote, underserved, and marginalized communities.
- Conditions
- Onchocerciasis (River Blindness), Schistosomiasis, Soil Transmitted Helminth (STH) Infections, Lymphatic Filariasis
- Trial name
- MISSION (NCT07707817)
- Testing
- Modified Mass Administration of Medicines Strategy, Albendazole 400 mg, Praziquantel 40 mg/kg
- Where
- Nigeria
- Volunteers
- 5,760 people, healthy volunteers welcome
- Sponsor
- Uwemedimo Friday Ekpo
Lymphatic Filariasis
Impact of Albendazole -Ivermectin on Wuchereria Bancrofti in Mali
Lymphatic filariasis is a public health problem in Mali. The existing data are not up to date and most of them are more than 15 years old.
- Trial name
- NCT02784743
- Testing
- ''albendazole'' and ''ivermectin''
- Volunteers
- 1,139 people, healthy volunteers welcome
- Sponsor
- Centre d'Appui à la lutte contre la Maladie
Dengue
Evaluating the Safety of and Immune Response to a Dengue Vaccine (TV003) in Healthy Adults, Adolescents, and Children in Thailand
The purpose of this study is to evaluate the safety of and immune response to two doses of a dengue vaccine (TV003) given 6 months apart to healthy adults, adolescents, and children in Thailand.
- Trial name
- NCT02332733
- Testing
- TV003
- Where
- Thailand
- Volunteers
- 266 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Malaria
Genetic Association Mapping of Malaria Resistance in Anopheles Gambiae
This is a study of the genetics of malaria transmission by the mosquito vector in Africa, Anopheles gambiae. The study focuses on the mosquito vector, not the human subjects infected with malaria.
- Trial name
- NCT00850655
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Minnesota
Malaria
An Extended Follow up of a RTS,S/AS01E Malaria Vaccine Trial
Malaria is one of the leading causes of deaths in children below five years old. Despite antimalarial drugs and insecticide treated bed nets, the established means of treatment and protection, malaria still continues to affect…
- Trial name
- MAL059 (NCT00872963)
- Testing
- RTS,S/AS01E
- Where
- Kenya
- Volunteers
- 450 people, healthy volunteers welcome
- Sponsor
- KEMRI-Wellcome Trust Collaborative Research Program
Malaria, Pneumonia
A Comparison of Diagnostic Approaches for Malaria and Pneumonia
This research investigates the diagnostic accuracy of various diagnostic approaches for malaria and pneumonia in under-five children presenting to primary healthcare centres in Benin City, Nigeria.
- Trial name
- NCT02482116
- Testing
- malaria or pneumonia diagnosis
- Where
- Nigeria
- Volunteers
- 1,000 people
- Sponsor
- University of Nottingham
Malaria
Insecticide Treated Polyethylene Sheeting for Prevention of Malaria in Emergencies
A Phase III malaria prevention trial was conducted in two camps of Liberian refugees in Sierra Leone using Insecticide Treated Polyethylene Sheeting (ITPS) or untreated polyethylene sheeting (UPS) randomly deployed to defined…
- Trial name
- NCT01456858
- Testing
- Insecticide Treated Polyethylene Sheeting, Untreated Plastic Sheeting
- Where
- Sierra Leone
- Volunteers
- 222 people, healthy volunteers welcome
- Sponsor
- The Mentor Initiative
Zika
Safety and Immunogenicity of a Candidate ZIKV Vaccine (ZIKA001)
This is a FIH, open-label, dose escalation, phase I clinical trial to assess the safety and immunogenicity of the candidate ChAdOx1 Zika vaccine in healthy volunteers administered intramuscularly.
- Trial name
- NCT04015648
- Testing
- ChAdOx1 Zika
- Where
- United Kingdom
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Malaria, Malaria Vaccines
Study of Safety, Immunogenicity and Efficacy of a Candidate Malaria Vaccine in Tanzanian Infants
GSK Biologicals in partnership with the Malaria Vaccine Initiative at PATH is developing a candidate malaria vaccine GSK 257049 for the routine immunization of infants and children living in malaria endemic areas.
- Trial name
- NCT00289185
- Testing
- RTS,S/AS02D, Engerix-B®, TETRActHib™
- Where
- Tanzania
- Volunteers
- 340 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Malaria
Single Low-dose Primaquine Efficacy and Safety.
Background: The World Health Organization has recommended addition of a 0.25 mg/kg single-dose primaquine (PQ) to standard artemisinin-based combination therapy (ACT) for elimination of malaria in low transmission-settings and…
- Trial name
- ESSLDPQP4502D6 (NCT03352843)
- Testing
- Primaquine
- Where
- Tanzania
- Volunteers
- 157 people
- Sponsor
- Tropical Pesticides Research Institute, Tanzania
Dengue Shock Syndrome
Effect of Hypertonic Sodium Lactate on sVCAM-1 Level as Surrogate Marker of Endothelial Capillary Leakage in Pediatric Dengue Shock Syndrome Patients (DSS)
Dengue hemorrhagic fever (DHF) and dengue shock syndrome (DSS) are among the leading causes of pediatric hospitalization in Asia.Mortality rates range from 1% at centres experienced in fluid resuscitation, to upto 44% in…
- Trial name
- NCT00966628
- Testing
- Hypertonic sodium lactate, Ringer's lactate
- Where
- Indonesia
- Volunteers
- 50 people
- Sponsor
- Innogene Kalbiotech Pte. Ltd
Malaria in Pregnant HIV + Patients
A Comparative Study of Mefloquine and S-P as Prophylaxis Against Malaria in Pregnant HIV + Patients
Randomized controlled single blind prospective comparative study.
- Trial name
- NCT02524444
- Testing
- Mefloquine, Sulphadoxine-Pyrimethamine
- Where
- Nigeria
- Volunteers
- 142 people, healthy volunteers welcome
- Sponsor
- ORIYOMI OMOTOYOSI AKINYOTU
Malaria
Evaluation of Combined Use of ITN's and Insect Repellents Against Malaria
Insecticide Treated Nets (ITN's) offer good protection against malaria in Africa where the vector mosquitoes feed indoors late at night.
- Trial name
- NCT00144716
- Testing
- Insect Repellent plus Insecticide Treated Net
- Volunteers
- 4,250 people, healthy volunteers welcome
- Sponsor
- London School of Hygiene and Tropical Medicine
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