Clinical trials: Mother-to-Child Transmission
Hepatitis B, Chronic
Observational Study on Pregnant Women With Chronic Hepatitis B and Their Infants
The study was conducted to observe the clinical features during pregnancy in women with chronic hepatitis B virus infection and mother-to-child transmission of hepatitis B virus.
- Trial name
- NCT03539016
- Where
- 10 sites in China
- Volunteers
- 1,000 people
- Sponsor
- Nanfang Hospital, Southern Medical University
Acquired Immunodeficiency Syndrome
Open Label Study of NVP+CBV Treatment in Women Who Have Received sdNVP for the pMTCT of HIV
To determine the response to treatment with NVP, ZDV and 3TC in HIV positive women, who previously received NVP for the prevention of mother to child transmission.
- Trial name
- NCT00144157
- Testing
- Nevirapine, Zidovudine, 3TC
- Where
- 3 sites in South Africa
- Volunteers
- 53 people
- Sponsor
- Boehringer Ingelheim
HIV
Strategies to Optimize Antiretroviral Therapy Services for Maternal & Child Health: the MCH-ART Study
The purpose of this study is to understand how to improve health care services for HIV-positive women during their pregnancy and after delivery.
- Trial name
- MCH-ART (NCT01933477)
- Testing
- MCH-focused ART services
- Where
- South Africa
- Volunteers
- 1,554 people
- Sponsor
- University of Cape Town
HIV
Texting to Improve Testing (TextIT):
Early accurate diagnosis is one of the first crucial steps in care for infants born to HIV-infected mothers. Early initiation of antiretroviral therapy (ART) relies upon early diagnosis and results in significant reductions in…
- Trial name
- TextIT (NCT02350140)
- Testing
- Text messaging from beginning, Text messaging after 6 months of control
- Where
- Kenya
- Volunteers
- 2,508 people
- Sponsor
- University of Washington
HIV Infection
Zambia Exclusive Breastfeeding Study
The study is designed as a randomized, controlled trial with specific observational objectives. All HIV-seropositive pregnant subjects electing to breastfeed their child will be counselled to exclusively breastfeed through 4…
- Trial name
- NCT00310726
- Testing
- abrupt weaning at 4 months, Continued exclusive breastfeeding
- Where
- Zambia
- Volunteers
- 1,435 people
- Sponsor
- Boston Medical Center
Mother to Child Transmission, Breast Feeding
Trauma-informed Obstetric Care for Perinatal Health: a Pilot Study
The study will test trauma-informed obstetric care training and supervision for obstetric clinicians in relation to prenatal mental health and attachment formation (early predictors of child development) in women presenting for…
- Conditions
- Mother to Child Transmission, Breast Feeding, Trauma
- Trial name
- NCT07195058
- Testing
- Trauma Informed Obstetric Care (TIOC)
- Where
- Argentina
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Columbia University
HIV Infections
Nevirapine (NVP) Use to Prevent Mother-to-Child Transmission of HIV
HIV can be transmitted from an HIV infected mother to her infant through her breast milk. The purpose of this study is to determine whether giving infants of HIV infected mothers the anti-HIV drug nevirapine (NVP) for six weeks…
- Trial name
- NCT00074399
- Testing
- Nevirapine
- Where
- Ethiopia
- Volunteers
- 775 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Hepatitis B, Tenofovir
Tenofovir in Pregnancy to Prevent Mother to Child Transmission of Hepatitis B.
Hepatitis B virus (HBV) can be asymptomatic for years but can also lead to chronic hepatitis, hepatocellular carcinoma, and liver failure and death and cannot be eradicated with the current therapy.
- Conditions
- Hepatitis B, Tenofovir, Pregnancy
- Trial name
- PK-TDF (NCT04114890)
- Testing
- Tenofovir Disoproxil Fumarate
- Where
- Thailand
- Volunteers
- 27 people
- Sponsor
- University of Oxford
Hiv
Stepped Care to Optimize PrEP Effectiveness in Pregnant and Postpartum Women
To reach HIV-uninfected pregnant and breastfeeding women in South Africa, who are at very high risk of HIV, researchers will test a new and innovative package of interventions: 1) pre-exposure prophylaxis (PrEP), which is a daily…
- Trial name
- SCOPE-PP (NCT05322629)
- Testing
- PrEP adherence biofeedback, Standard of care counseling
- Where
- South Africa
- Volunteers
- 650 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Mother to Child Transmission, Pregnancy in Adolescence
Digital Intervention to Address Stigma Among Pregnant Adolescents Living With HIV
Pregnant adolescents living with HIV (ALHIV) in Kenya frequently experience stigma and difficulty telling a family member about their HIV and pregnancy status.
- Conditions
- Mother to Child Transmission, Pregnancy in Adolescence, Social Stigma, Self Disclosure
- Trial name
- NCT05383755
- Testing
- Digital intervention for pregnant adolescents living with HIV
- Where
- Kenya
- Volunteers
- 169 people, healthy volunteers welcome
- Sponsor
- Pacific Institute for Research and Evaluation
Hepatitis B
Maternal Antiviral Treatment and Infants Immunoprophylaxis in the Prevention of Mother-to-child Transmission
The effective control of nucleos(t)ide analogues for patients infected with hepatitis B has significantly curbed the horizontal transmission of hepatitis B.
- Trial name
- NCT03977987
- Testing
- nucleos(t)ide analogue
- Where
- China
- Volunteers
- 233 people
- Sponsor
- Huashan Hospital
HIV
Promoting Uptake and Retention of Option B+ in Malawi
The purpose of this study is to determine if enhanced support for women and their families within facilities and/or through community outreach will result in improved retention in the continuum of PMTCT care.
- Trial name
- PURE (NCT02005835)
- Testing
- Community based peer support, Facility-based Peer Support
- Where
- Malawi
- Volunteers
- 1,050 people
- Sponsor
- Lighthouse Trust
HIV Infections, Pregnancy Complications, Infectious
Prenatal and Postnatal Studies of Interventions for Prevention of Mother-To-Child Transmission
The purpose of this study is to collect and study clinical and laboratory information about a pregnant or new mother and her medical care that will increase our knowledge of the best care for HIV-infected pregnant women and their…
- Trial name
- NCT00028145
- Testing
- Adherence assessment
- Where
- 77 sites in United States, Puerto Rico
- Volunteers
- 3,090 people
- Sponsor
- International Maternal Pediatric Adolescent AIDS Clinical Trials Group
Chronic Hepatitis B
The Study of Short-range Antiviral Treatment During Pregnancy to Block Mother-to-child Transmission of Hepatitis B Virus and Withdrawal Time
Pregnant women carry high HBV DNA loads before delivery, which is the most important factor leading to mother-to-child transmission of HBV.
- Trial name
- NCT03209908
- Testing
- Tenofovir Disoproxil Fumarate
- Where
- China
- Volunteers
- 380 people
- Sponsor
- Beijing Ditan Hospital
Obesity, Obesity, Childhood
In-home Obesity Prevention to Reach Low-income Infants
Existing obesity prevention efforts have had limited success among underserved, low-income children. This study capitalizes on the strengths of a nationwide ongoing Home Visitation Program (HVP), which serves at-risk, low-income…
- Conditions
- Obesity, Obesity, Childhood, Obesity; Familial
- Trial name
- NCT03529695
- Testing
- Standard HVP Curriculum, Obesity Prevention
- Where
- United States
- Volunteers
- 77 people, healthy volunteers welcome
- Sponsor
- University of Southern California
HIV
Adapting the HITSystem to Support Prevention of Mother-to-child HIV Transmission
The purpose of this study is to modify the HITSystem to engage and retain HIV+ pregnant women before, during and after delivery and evaluate the HITSystem impact on prevention of mother-to-child transmission (PMTCT) related…
- Trial name
- NCT02726607
- Testing
- HIV Infant Tracking System (HITSystem) 2.0, Standard of PMTCT care
- Where
- 3 sites in United States, Kenya
- Volunteers
- 157 people
- Sponsor
- University of Kansas Medical Center
HIV
Healthy Beginning Initiative
The purpose of this study is to determine if providing free laboratory test to pregnant women and their spouses at churches, in addition to laboratories or hospitals, will increase the number of pregnant women and their spouses…
- Trial name
- HBI (NCT01795261)
- Where
- Nigeria
- Volunteers
- 5,400 people, healthy volunteers welcome
- Sponsor
- University of Nevada, Reno
Mother to Child Transmission of HIV
Prospective Observational Cohort Study on Mother to Child Transmission HIV1/HIV2 and Prevention
The purpose of this study is to describe over time the rate of mother to child transmission of HIV and its prevention (PMTCT), to identify risk factors for transmission and to evaluate the safety of PMTCT strategies on outcome of…
- Trial name
- EPF (NCT03235310)
- Where
- 28 sites in France
- Volunteers
- 18,200 people
- Sponsor
- French National Agency for Research on AIDS and Viral Hepatitis
HIV Infections
Comparison of Anti-HIV Drug Combinations to Prevent Mother-to-Child Transmission of HIV
Pregnant women infected with HIV who take anti-HIV medications during pregnancy lower the risk of passing HIV to their infants. This study will compare how well two different combinations of anti-HIV medications control HIV in…
- Trial name
- NCT00086359
- Testing
- Abacavir sulfate, lamivudine, and zidovudine, Lamivudine/zidovudine, Lopinavir/ritonavir
- Where
- 8 sites in United States, Puerto Rico
- Volunteers
- 19 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Male Reproductive Problem
Effect of Formal Letter of Invitation on Male Partner Involvement at Antenatal Care Clinic
Prevention of mother to child transmission (PMTCT) of human immune deficiency virus (HIV) program requires great male participation in achieving a sustained reduction of mother-to-child transmission of HIV.
- Trial name
- NCT06171503
- Testing
- letter of invitation on MI in PMTCT service
- Where
- Ethiopia
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Jimma University