Clinical trials: Mother-to-Child Transmission
Hepatitis B
Prevention of Hepatitis B Virus Mother-to-child Transmission by Serovaccination.
The prevalence of HBsAg carriage in pregnant women varies in France, according to the native country, with highest rates in those originating from sub-Saharan Africa and Asia (5 to 8 % in Parisian area).
- Trial name
- NCT01810835
- Where
- 2 sites in France
- Volunteers
- 28 people
- Sponsor
- Hopital Lariboisière
Vitamin A Deficiency, HIV
Single-dose Postpartum Vitamin A Supplementation of Mothers and Neonates
The ZVITAMBO PROJECT is testing whether giving mothers and infants a single large dose of vitamin A during the immediate post partum period will reduce: 1.
- Trial name
- ZVITAMBO (NCT00198718)
- Testing
- Vitamin A (retinyl palmitate)
- Volunteers
- 28,220 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins Bloomberg School of Public Health
HIV-infection/Aids, Breast Feeding
Promoting Exclusive Breastfeeding Among HIV Infected Women in a PMTCT Program
This study evaluates strategies aimed at promoting exclusive breast feeding for 6 months followed by continued breastfeeding for the next 6 months with introduction of complementary foods among HIV infected women in a resource…
- Trial name
- EBF (NCT03069235)
- Testing
- Family member / peer support, Enhanced intervention with counselor support, standard of care
- Volunteers
- 218 people
- Sponsor
- Johns Hopkins University
Caries, Dental
Prevention of Transmission of Bacteria That Cause Cavities From Mothers to Their Children
The purpose of this study is to control the levels of bacteria that causes cavities in mothers by a combination of treatments that include fluoride and chlorhexidine varnishes and xylitol-chewing gum before the appearance of…
- Trial name
- NCT00066040
- Testing
- Cervitec chlorhexidine varnish, Duraphat fluoride varnish, xylitol gum from Fennobon, Finland
- Where
- Brazil
- Volunteers
- 280 people
- Sponsor
- New York University
HIV/AIDS
Does Provision of Point of Care CD4 Technology and Early Knowledge of CD4 Levels Affect Early Initiation and Retention on Anti-retroviral Treatment (ART) in HIV Positive Pregnant Women in the Context of Option B+ for PMTCT?
The study will be conducted at 32 health care facilities in three provinces in Zimbabwe and will compare the impact of the provision Point of Care CD4 technology and early knowledge of CD4 levels on retention at 12 months, with…
- Trial name
- E4E (NCT02070900)
- Testing
- POC CD4, Programmatic Mentoring
- Where
- 32 sites in Zimbabwe
- Volunteers
- 704 people, healthy volunteers welcome
- Sponsor
- WHO, Department of Maternal, Newborn, Child and Adolescent Health
Hepatitis B, Chronic, Pregnancy Related
Maternal Therapy With TAF Versus TDF to Prevent Vertical Transmission of Hepatitis B
Immunoprophylaxis failure of hepatitis B (HBV) remains a concern and has been reported in approximately 10-30% of infants born to highly viremic mothers with HBeAg-positive.
- Trial name
- NCT04211805
- Testing
- Tenofovir Alafenamide 25 MG for arm (A), Tenofovir Disoproxil Fumarate 300mg for arm (B)
- Where
- 11 sites in China
- Volunteers
- 450 people
- Sponsor
- New Discovery LLC
Hepatitis B, Chronic, Mother to Child Transmission
Preventing Mother-to-child Transmission of Hepatitis B Virus With Tenofovir Alafenamide (TAF)
The purpose of this study is to evaluate the efficacy and safety of Tenofovir alafenamide (TAF) for prevention of mother-to-child transmission of hepatitis B virus among pregnant women with high level HBV DNA.
- Trial name
- NCT05177926
- Testing
- antiviral prophylaxis with Tenofovir Alafenamide Fumarate
- Where
- 13 sites in China
- Volunteers
- 330 people
- Sponsor
- Nanfang Hospital, Southern Medical University
Prevention of Mother-to-child Transmission of HIV, Antenatal Health Care Utilization
Effectiveness of an HIV-adapted IMCI Training and Supervision Programme for Community Health Workers
This is a cluster randomized controlled trial (C-RCT) to evaluate the effectiveness of a Community-Integrated Management of Childhood Illness (C-IMCI) training for community caregivers (CCGs), adapted to include HIV-related…
- Conditions
- Prevention of Mother-to-child Transmission of HIV, Antenatal Health Care Utilization, Postnatal Health Care Utilization, Infant Feeding Practices
- Trial name
- NCT01774136
- Testing
- Enhanced HIV and MCH training for CHW
- Where
- South Africa
- Volunteers
- 1,342 people, healthy volunteers welcome
- Sponsor
- University of KwaZulu
HIV Infections, Pregnancy Related
DTG Plus 3TC for Prophylaxis of Mother-to-child Transmission of HIV Infection in Pregnant Women
The study aims to evaluate the safety and efficacy of a 2 drugs ART regimen (lamivudine plus dolutegravir) for prevention of mother to child transmission in pregnant women with HIV.
- Conditions
- HIV Infections, Pregnancy Related, Mother to Child Transmission
- Trial name
- PREGNANCY (NCT04808973)
- Testing
- Dolutegravir plus lamivudine in a FDC
- Where
- Brazil
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Fundação Bahiana de Infectologia
Hepatitis C, Transmission
Vertical Transmission of Hepatitis C Virus
Vertical HCV Transmission has been extensively studied, with a risk around 5% (range: 3 to 10%). Spontaneous viral clearance in infected children during childhood can occur, but data about this phenomenon are scarse, justifying…
- Trial name
- NCT02044042
- Where
- France
- Volunteers
- 120 people
- Sponsor
- Hopital Lariboisière
Virus-HIV
Becoming HIV-Exposed, Uninfected Children Born to HIV-Positive Mothers Followed at Bichat Claude Bernard Hospital
"The strategies for the Prevention of Mother-to-Child Transmission of the Human Immunodeficiency Virus (HIV) are very effective and have become common practices in many contexts.
- Trial name
- ENIVIH (NCT06666543)
- Testing
- Questionary
- Where
- France
- Volunteers
- 172 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
HIV Infections
HIV Treatment Reinitiation in Women Who Received Anti-HIV Drugs to Prevent Mother-to-Child Transmission of HIV
The purpose of this study is to determine if pregnancy-limited, short-term combination HIV treatment regimens -- which were used solely for the prevention of mother to child transmission of HIV and discontinued postpartum …
- Trial name
- Nearly Naive (NCT00442962)
- Testing
- Efavirenz, Emtricitabine/Tenofovir disoproxil fumarate
- Where
- 9 sites in United States, Brazil and 1 more
- Volunteers
- 54 people
- Sponsor
- Advancing Clinical Therapeutics Globally for HIV/AIDS and Other Infections
Dental Caries
Study on Use of Xylitol-wipes to Prevent Dental Caries
Mutans streptococci (MS) and lactobacillus species (LB) are the two groups of infectious cariogenic (caries-causing) bacteria most strongly associated with dental caries (dental decay).
- Trial name
- WIPE (NCT01468727)
- Testing
- xylitol wipe
- Where
- United States
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
HIV Infections, Syphilis Infection
Implementation of an Opt-Out Testing and Rapid Diagnostic Strategy for Syphilis and HIV in Pregnant Patients Presenting to the Emergency Department
The purpose of this study is to evaluate infection detection and treatment initiation rates for syphilis and HIV before and after integration of the Chembio DPP® HIV-Syphilis rapid POC test into an ongoing Emergency Department…
- Trial name
- NCT07525076
- Testing
- Chembio HIV/Syphilis rapid Point of Care (POC) test, Laboratory-based HIV and syphilis testing
- Where
- United States
- Volunteers
- 1,400 people
- Sponsor
- The University of Texas Health Science Center, Houston
HIV Infections
Pharmacokinetics Study on Nevirapine Resistance in Tanzania
Primary pharmacokinetics of single dose nevirapine the effect of single dose carbamazepine on the pk of single dose nevirapine resistance against nevirapine before and after.
- Trial name
- NCT00294892
- Testing
- carbamazepine and nevirapine, Nevirapine
- Where
- Tanzania
- Volunteers
- 144 people
- Sponsor
- Radboud University Medical Center
HIV Infections
Antiviral Responses to NNRTI-Based vs. PI-Based ARV Therapy in HIV Infected Infants Who Have or Have Not Received Single Dose NVP for Prevention of Mother-to-Child Transmission of HIV
A single dose of nevirapine (SD NVP) given to an HIV infected pregnant woman followed by a single dose to her infant has been shown to be an effective way of reducing the risk of mother-to-child transmission (MTCT) of HIV.
- Trial name
- P1060 (NCT00307151)
- Testing
- Lamivudine, Lopinavir/ritonavir, Nevirapine
- Where
- 10 sites in India, Malawi and 5 more
- Volunteers
- 452 people
- Sponsor
- International Maternal Pediatric Adolescent AIDS Clinical Trials Group
Pre-exposure Prophylaxis, HIV Prevention
UNCPM 22314 - Pregnancy, Infant and Maternal Health Outcomes Study
The primary purpose of this study is to assess the safety of long-acting injectable cabotegravir (CAB-LA) and oral pre-expose prophylaxis (PrEP) (FTC/TDF or 3TC/TDF) for the prevention of HIV during pregnancy and breastfeeding…
- Conditions
- Pre-exposure Prophylaxis, HIV Prevention, Pregnancy Related
- Trial name
- PrIMO (NCT06158126)
- Testing
- Initiating daily oral PrEP during pregnancy, Already using daily oral PrEP at the time of pregnancy diagnosis, Initiating injectable PrEP during pregnancy
- Where
- Malawi
- Volunteers
- 621 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
HIV
Male Engagement in PMTCT Services
The study employs a quasi-experimental design in 8 public health centers in southwest Uganda offering care and treatment (C\&T) services.
- Trial name
- NCT01903889
- Testing
- clinic based intervention, clinic and community based intervention
- Where
- 7 sites in Uganda
- Volunteers
- 3,806 people, healthy volunteers welcome
- Sponsor
- FHI 360
Gut Microbiome, Mother to Child Transmission
Mother-infant Microbiota Transmission and Its Link to the Health of the Baby
The human intestinal tract harbors a diverse and complex microbial community, known as gut microbiota, which is critical in sustaining physiology, metabolism, nutrition and immune function.
- Trial name
- NCT04117321
- Where
- China
- Volunteers
- 20,000 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong
Maternal Fetal Infection Transmission, COVID-19
Maternal-foetal Transmission of SARS-Cov-2
One case of maternal-fetal transmission of SARS Cov-2 was published (1). Ig M and Ig G were found at two hours after birth of a new born from a mother COVID-19.
- Conditions
- Maternal Fetal Infection Transmission, COVID-19, SARS-CoV 2
- Trial name
- TMF-COVID-19 (NCT04395924)
- Testing
- Diagnosis of SARS-Cov2 by RT-PCR and : IgG, Ig M serologies in the amniotoc fluid, the blood cord and the placenta
- Where
- France
- Volunteers
- 50 people
- Sponsor
- Centre Hospitalier Régional d'Orléans