Clinical trials: Mother-to-Child Transmission
Hepatitis B Virus, Mother to Child Transmission
Study of Tenofovir Alafenamide Fumarate Tablets (TAF) in Blocking Mother-to-child Transmission of Hepatitis B Virus
This study is a single-group, multi-center and prospective clinical study designed to assess the efficacy and safety of TAF in blocking mother-to-child transmission of hepatitis B virus.Pregnant women whose HBsAg and HBeAg are…
- Trial name
- NCT04065230
- Testing
- Tenofovir Alafenamide Fumarate tablets
- Where
- China
- Volunteers
- 330 people
- Sponsor
- Southeast University, China
HIV Infection, HBV Infection
"Pregnancy and Viral Infections: Impact on Pregnant Women and Their Children. French Prospective Cohort"
The VIROPREG study is a French prospective multicenter cohort study that aims to assess the impact of viral infections and antiviral treatments received during pregnancy on maternal and child health.
- Conditions
- HIV Infection, HBV Infection, HDV Infection, HCV Infection
- Trial name
- VIROPREG (NCT07412977)
- Testing
- Blood sampling, Umbilical cord blood sampling, Survey using a questionnaire
- Where
- France
- Volunteers
- 5,160 people
- Sponsor
- ANRS, Emerging Infectious Diseases
HIV, HIV Infections
Mobile Phone Technology for Prevention of Mother-to-Child Transmission of HIV: Acceptability, Effectiveness, and Cost (Kenya)
Although gains have been made in achieving the health-related Millennium Development Goals (MDG), much is still needed in countries affected by high levels of HIV/AIDS.
- Conditions
- HIV, HIV Infections, AIDS, Antiretroviral Therapy
- Trial name
- NCT01645865
- Testing
- Control, Intervention
- Where
- Kenya
- Volunteers
- 600 people
- Sponsor
- Elizabeth Glaser Pediatric AIDS Foundation
HIV Infections
Effects of Maternal Anti-HIV Treatment on Infants Born to HIV-Infected Women
In clinical trials being conducted throughout the world, pregnant HIV-infected women are given anti-HIV drugs before, during, and after they give birth to prevent mother-to-child transmission of HIV.
- Trial name
- NCT00100867
- Where
- 23 sites in Botswana, Brazil and 6 more
- Volunteers
- 236 people, healthy volunteers welcome
- Sponsor
- Advancing Clinical Therapeutics Globally for HIV/AIDS and Other Infections
HIV Infections
Breastfeeding, Antiretroviral, and Nutrition Study
This is a comparative clinical trial among HIV-infected women and their infants to determine: 1. the benefit of nutritional supplementation given to women during breastfeeding 2.
- Trial name
- NCT00164736
- Testing
- Maternal zidovudine/lamivudine/lopinavir-ritonavir, Infant nevirapine, Maternal protein and calorie supplement
- Where
- Malawi
- Volunteers
- 2,369 people, healthy volunteers welcome
- Sponsor
- Centers for Disease Control and Prevention
Hepatitis B, Chronic, Mother to Child Transmission
Mother-to-child Transmission of HBV in China
In order to evaluate the feasibility of eliminating mother-to-child transmission (MTCT) of hepatitis B virus (HBV) by 2030, a multi-center, prospective cohorts study was conducted to investigate MTCT of HBV in China.
- Trial name
- NCT05172453
- Testing
- comprehensive management algorithm for preventing mother-to-child transmission of HBV
- Where
- 15 sites in China
- Volunteers
- 50,000 people
- Sponsor
- Nanfang Hospital, Southern Medical University
Hiv
Evaluation of Pre-exposure Prophylaxis Cascade in Pregnant and Breastfeeding Women in Cape Town (Formative Study)
The overarching goal of this proposal is to evaluate the feasibility and acceptability of integrating PrEP into antenatal and postnatal care, to describe the cascade in women initiating PrEP in this setting, and to evaluate the…
- Trial name
- PrEP-PP (NCT03826199)
- Testing
- TDF-FTC, Counselling on PrEP in antenatal and postnatal care
- Where
- South Africa
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
HIV
Vertical Transmission Study
Short courses of drugs can be given to HIV-infected pregnant women to reduce the chance of HIV infection being passed to her child either during pregnancy or during the labour process.
- Trial name
- VTS (NCT01948557)
- Testing
- Infant feeding counselling and support
- Where
- 2 sites in South Africa
- Volunteers
- 3,465 people, healthy volunteers welcome
- Sponsor
- University of KwaZulu
Anemia, Antenatal Care
Effects of Video-based Health Education on Maternal and Child Health in Ethiopia
Low adherence to recommended health and nutrition strategies during the critical 1000 day-window of opportunity is multifactorial but low quality communication is key limitation.
- Conditions
- Anemia, Antenatal Care, Birth Outcomes, Worm Infection
- Trial name
- MCH (NCT04414527)
- Testing
- Standard counselling, Health-Video
- Where
- Ethiopia
- Volunteers
- 675 people
- Sponsor
- University Ghent
HIV (Human Immunodeficiency Virus)
Safe Generations Plus: Swaziland PMTCT LTF Study
This study is to understand how to improve retention in care and treatment services to HIV positive pregnant women and their babies in Swaziland.
- Trial name
- SG+ (NCT02969161)
- Where
- 10 sites in Eswatini
- Volunteers
- 616 people
- Sponsor
- Columbia University
HIV Infections, HIV Seronegativity
A Study of the Effects of Giving Two Anti-HIV Vaccines to Babies of HIV-Positive Mothers
The purpose of this study is to see if giving the ALVAC vCP1452 anti-HIV vaccine alone or with another vaccine called AIDSVAX B/B to babies of HIV-positive mothers is safe.
- Trial name
- NCT00000879
- Testing
- ALVAC(2)120(B,MN)GNP (vCP1452), MN rgp120/HIV-1 and GNE8 rgp120/HIV-1, ALVAC-HIV MN120TMG (vCP205)
- Where
- 17 sites in United States
- Volunteers
- 48 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Hiv
Stepped Care to Optimize PrEP Effectiveness in Pregnant and Postpartum Women
To reach HIV-uninfected pregnant and breastfeeding women in South Africa, who are at very high risk of HIV, researchers will test a new and innovative package of interventions: 1) pre-exposure prophylaxis (PrEP), which is a daily…
- Trial name
- SCOPE-PP (NCT05322629)
- Testing
- PrEP adherence biofeedback, Standard of care counseling
- Where
- South Africa
- Volunteers
- 650 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Hepatitis B, Chronic, Pregnancy Related
Chronic HBV Infection in Pregnant Women Taking TAF to Prevent Vertical Transmission
Mother-to-child transmission is the main route of transmission of Hepatitis B Virus (HBV) in China, and about 30% - 50% of chronic HBV carriers are infected by this.
- Trial name
- NCT04237376
- Testing
- Tenofovir Alafenamide 25 MG, Tenofovir Disoproxil Fumarate 300 MG Oral Tablet
- Where
- 4 sites in China
- Volunteers
- 600 people
- Sponsor
- New Discovery LLC
HIV
Promoting Uptake and Retention of Option B+ in Malawi
The purpose of this study is to determine if enhanced support for women and their families within facilities and/or through community outreach will result in improved retention in the continuum of PMTCT care.
- Trial name
- PURE (NCT02005835)
- Testing
- Community based peer support, Facility-based Peer Support
- Where
- Malawi
- Volunteers
- 1,050 people
- Sponsor
- Lighthouse Trust
Maternal Fetal Infection Transmission, COVID-19
Maternal-foetal Transmission of SARS-Cov-2
One case of maternal-fetal transmission of SARS Cov-2 was published (1). Ig M and Ig G were found at two hours after birth of a new born from a mother COVID-19.
- Conditions
- Maternal Fetal Infection Transmission, COVID-19, SARS-CoV 2
- Trial name
- TMF-COVID-19 (NCT04395924)
- Testing
- Diagnosis of SARS-Cov2 by RT-PCR and : IgG, Ig M serologies in the amniotoc fluid, the blood cord and the placenta
- Where
- France
- Volunteers
- 50 people
- Sponsor
- Centre Hospitalier Régional d'Orléans
Mother-to-child HIV Transmission
The Kabeho Study: Kigali Antiretroviral and Breastfeeding Assessment for the Elimination of HIV
The study design includes an observational prospective cohort of HIV-positive pregnant/postpartum women and their infants enrolled during antenatal clinics (or immediately postpartum) from prevention of mother-to-child…
- Trial name
- Kabeho (NCT02295800)
- Testing
- Standard of care, Semi-structured interviews
- Where
- Rwanda
- Volunteers
- 1,216 people
- Sponsor
- Elizabeth Glaser Pediatric AIDS Foundation
Syphilis, HIV Infections
Spotting Syphilis: A Dual Point-of-Care Syphilis Screening Initiative in a Low-Resource Healthcare Setting
The purpose of this study is to determine if a strategy utilizing the Chembio HIV/syphilis rapid point-of-care (POC) test for diagnosis of HIV and syphilis in pregnant women attending prenatal clinics in Guatemala will increase…
- Trial name
- NCT07498153
- Testing
- Chembio HIV/Syphilis rapid POC test
- Where
- United States
- Volunteers
- 153 people
- Sponsor
- The University of Texas Health Science Center, Houston
HIV-infection/Aids, Breast Feeding
Promoting Exclusive Breastfeeding Among HIV Infected Women in a PMTCT Program
This study evaluates strategies aimed at promoting exclusive breast feeding for 6 months followed by continued breastfeeding for the next 6 months with introduction of complementary foods among HIV infected women in a resource…
- Trial name
- EBF (NCT03069235)
- Testing
- Family member / peer support, Enhanced intervention with counselor support, standard of care
- Volunteers
- 218 people
- Sponsor
- Johns Hopkins University
HIV Infections
A Study of Zidovudine/Lamivudine and Either Nevirapine or Nelfinavir for Reduction of Mother-to-child HIV Transmission During Breastfeeding
The purpose of the study is to demonstrate that a regimen using highly active antiretroviral therapy (HAART) to maximally suppress maternal viral load in the late antenatal period and during the first six months of lactation is…
- Trial name
- KiBS (NCT00146380)
- Testing
- Zidovudine/Lamivudine and either Nevirapine or Nelfinavir, Breastfeeding for 6 months postpartum
- Where
- Kenya
- Volunteers
- 520 people
- Sponsor
- Centers for Disease Control and Prevention
Male Reproductive Problem
Effect of Formal Letter of Invitation on Male Partner Involvement at Antenatal Care Clinic
Prevention of mother to child transmission (PMTCT) of human immune deficiency virus (HIV) program requires great male participation in achieving a sustained reduction of mother-to-child transmission of HIV.
- Trial name
- NCT06171503
- Testing
- letter of invitation on MI in PMTCT service
- Where
- Ethiopia
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Jimma University