Clinical trials: Motor Control Impairment
Stroke
A Study to Evaluate the Safety and Efficacy of Basmisanil in Adults With Severe Motor Impairment Following an Ischemic Stroke
This Phase IIa, randomized, double-blind, placebo-controlled, parallel group study will evaluate the safety, efficacy and pharmacodynamics of basmisanil in adult participants with severe motor impairment following an ischemic…
- Trial name
- NCT02928393
- Testing
- Basmisanil
- Where
- 13 sites in France, Spain
- Volunteers
- 5 people
- Sponsor
- Hoffmann-La Roche
Adrenomyeloneuropathy Without Cerebral Involvement
Epidural Spinal Cord Stimulation for Lower-limb Impairment in Adrenomyeloneuropathy
Adrenal spinal neuropathy (AMN) is a rare X-linked genetic disease caused by mutations in the ABCD1 gene, and belongs to a special type of adrenal leukodystrophy.
- Trial name
- EPIC-AMN (NCT06796920)
- Testing
- Spinal cord stimulation
- Where
- 4 sites in China
- Volunteers
- 10 people
- Sponsor
- Third Military Medical University
Postpartum Pelvic Floor Dysfunction, Postpartum Urinary Incontinence
Exercise-Based Sensorimotor Physiotherapy for Postpartum Pelvic Health and Functional Recovery
This study evaluated whether a 12-week exercise-based sensorimotor physiotherapy program could improve pelvic health and functional recovery in postpartum women.
- Conditions
- Postpartum Pelvic Floor Dysfunction, Postpartum Urinary Incontinence, Postpartum Functional Recovery, Lumbopelvic Motor Control Impairment
- Trial name
- NCT07702565
- Testing
- Exercise-Based Sensorimotor Physiotherapy Program, Standard Postpartum Education and Home Advice
- Where
- Turkey (Türkiye)
- Volunteers
- 160 people
- Sponsor
- Özge BAYKAN ÇOPUROĞLU
Cerebral Palsy
Investigation of Relations Between Edinburgh Visual Gait Score and Selective Motor Control for Children With CP
Children with Cerebral Palsy have generally limited selective motor control which affects their ability to complete functional tasks Selective Motor Control has been shown to correlate with specific characteristics of gait…
- Trial name
- NCT04686630
- Testing
- Video based observational gait analysis and SCALE Test
- Where
- Turkey (Türkiye)
- Volunteers
- 42 people
- Sponsor
- Yeditepe University
Chronic Ischemic Stroke
CC-101 (f/k/a NR1) Neural Stem Cell Transplantation for Adults With Chronic Ischemic Stroke
The suNR1se II Study is a Phase 2b randomized, controlled, multi-center clinical trial evaluating the efficacy and safety of stereotactic intracerebral administration of CC-101 (f/k/a NR1), an investigational allogeneic neural…
- Trial name
- suNR1se II (NCT07709845)
- Testing
- CC-101 (f/k/a NR1) Intracerebral Transplantation, Tacrolimus
- Volunteers
- 36 people
- Sponsor
- Clarion Cells, Inc.
Mild Cognitive Impairment (MCI), Parkinson's Disease (PD)
Mindfulness-Enhanced Dual-Task Training in PD-MCI
The goal of this clinical trial is to learn if Mindfulness-Enhanced Dual-Task Training work to treat PD-MCI in adults. The main questions it aims to answer are: Does Mindfulness-Enhanced Dual-Task Training improve the cognitive…
- Trial name
- NCT06930742
- Testing
- Cognitive-Motor Dual-Task Training, Mindfulness Training, Single-task Training
- Where
- China
- Volunteers
- 90 people
- Sponsor
- Nanjing Mingzhou Rehabilitation Hospital
Impaired Glucose Tolerance
Cognitive Effects of Aerobic Exercise for IGT Adults
The specific aims for the study will be to determine if aerobic exercise enhances cognition for older adults who are at risk for developing type II diabetes mellitus (T2DM), and to evaluate whether change in insulin sensitivity…
- Trial name
- NCT00220441
- Testing
- Aerobic exercise
- Where
- 2 sites in United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Seattle Institute for Biomedical and Clinical Research
Cognitive Impairment
The Effect of Upper Limb Low-intensity Motor Control Training Program on Cognitive Function in Healthy Older Adults
This healthy volunteer intervention study is designed to evaluate the effectiveness of upper limb motor control training (uMCT) on physical and cognitive functions in older adults.
- Trial name
- uMCON (NCT06962722)
- Testing
- Upper limb motor control training (uMCON)
- Where
- United Kingdom
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Sickle Cell Disease, Aging
SickleFit Exercise and Nutrition Study
To goal of this study is to pilot the SickleFit exercise and nutrition intervention in adults with sickle cell disease in a randomized control trial
- Trial name
- NCT07442851
- Testing
- SickleFit Exercise plus Nutrition
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Duke University
Sensory Integration Disorder
Sensory Integration for Infants With Cortical Visual Impairment
Our study examines the effect of sensory integration training on sensory, motor and oculomotor skills in infants with cortical vision impairment .
- Trial name
- NCT05431647
- Testing
- Sensory integration therapy
- Where
- Turkey (Türkiye)
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Hacettepe University
Parkinson Disease, Freezing of Gait
Use of CereGate Therapy for Freezing of Gait in PD
A Multi-Center, Controlled Study to Evaluate Use of CereGate Therapy to Reduce Freezing of Gait in Participants Diagnosed with Parkinson's Disease.
- Conditions
- Parkinson Disease, Freezing of Gait, Deep Brain Stimulation
- Trial name
- NCT05292794
- Testing
- CereGate Software; BSN cDBS Programmer; BSN Burst Programmer
- Where
- 7 sites in United States
- Volunteers
- 41 people
- Sponsor
- CereGate Inc.
Low Back Pain, Low Back Pain, Recurrent
Structural White and Gray Matter Correlates of Impaired Muscle Control and Deficient Pain Processing
Although the cause of persistent non-specific low back pain (LBP) remains unknown, structural and functional alterations of the brain, alterations in the lumbar muscles and dysfunction of the central nervous system have been…
- Conditions
- Low Back Pain, Low Back Pain, Recurrent, Low Back Pain, Chronic, Healthy Volunteers
- Trial name
- B~Maps (NCT06143319)
- Where
- Belgium
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University Ghent
Sedentary Behavior, Mild Cognitive Impairment
The DURATION Study: reDUcing sedentaRy behAviour to Maintain cogniTIve functiON.
Rationale: Older adults spend the majority of their time in sedentary behaviours (SB). High amounts of SB have been correlated with reduced cognitive performance.
- Conditions
- Sedentary Behavior, Mild Cognitive Impairment, Glucose Intolerance, Overweight and Obesity
- Trial name
- NCT04323423
- Testing
- interrupting sedentary behaviour with light physical activity
- Where
- Canada
- Sponsor
- Western University, Canada
Cerebral Palsy Hemiparetic Cerebral Palsy Spasticity Gait Disorders, Neurologic Postural Balance Impairment
Vibration Effects on Gait and Balance in CP
This randomized controlled study aims to investigate the acute effects of local vibration applied to the spastic medial gastrocnemius muscle on balance and spatiotemporal gait parameters in children with hemiparetic cerebral…
- Trial name
- NCT07045519
- Testing
- Local Vibration Therapy
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Kırıkkale University
Fall Prevention, Exercise
Perturbation-Based Treadmill Training to Prevent Unrecovered Falls in Geriatric Patients
The goal of this clinical trial is to determine the effectiveness of perturbation-based balance training (PBT) in preventing unrecovered falls among geriatric patients aged ≥70 years with a prospective fall risk of ≥40%.
- Conditions
- Fall Prevention, Exercise, Geriatrics, Cognitive Impairment
- Trial name
- TRAIL (NCT06652828)
- Testing
- Conventional Treadmill Walking (CTT), Perturbation-Based Balance Training (PBT)
- Where
- 3 sites in Germany
- Volunteers
- 396 people
- Sponsor
- University of Oldenburg
Acute Pain, Atrophic
Neurophysiology of Weakness and Exercise in Rotator Cuff Tendinopathy
The purpose of this study is to examine deficits in activation and motor patterns, as well as central drive in patients with rotator cuff tendinopathy.
- Conditions
- Acute Pain, Atrophic, Goals, Impairment
- Trial name
- NCT02971072
- Testing
- Subacromial injection, Physical Therapy
- Where
- United States
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- University of Oregon
Type 2 Diabetes
The Finnish Diabetes Prevention Study
The aim of this study is to clarify whether lifestyle intervention provided to people with high type 2 diabetes risk will lower the cumulative incidence of diabetes.
- Trial name
- DPS (NCT00518167)
- Testing
- Intensive lifestyle counselling
- Where
- 4 sites in Finland
- Volunteers
- 522 people, healthy volunteers welcome
- Sponsor
- Finnish Institute for Health and Welfare
Amyotrophic Lateral Sclerosis
Evaluation of the Early Use of the Pressure Relaxer in the Respiratory Impairment of Patients With Amyotrophic Lateral Sclerosis: Multicenter Randomized Controlled Study.
Amyotrophic lateral sclerosis (ALS) is a rare and serious neurodegenerative disease causing degeneration of motor neurons. . It leads to a progressive paralysis of the muscles involved in voluntary motricity.
- Trial name
- RELAX SLA (NCT05297487)
- Testing
- early use of intermittent positive pressure breathing
- Sponsor
- Centre Hospitalier Universitaire de la Réunion
Cognitive Impairment, Frailty
Smart Taiko-Drum Playing for Older Adults With Cognitive Frailty
The objective of this randomised controlled feasibility trial is to evaluate the feasibility of the Smart Taiko Drum-playing intervention embedding the cognitive-motor dual-task training concept for older adults with cognitive…
- Trial name
- NCT06115889
- Testing
- Smart Taiko Drumming
- Where
- Hong Kong
- Volunteers
- 60 people
- Sponsor
- The Hong Kong Polytechnic University
Stroke
Brain-behavior Associations of Sensorimotor Therapy Post Stroke
Stroke survivors often encounter impairments in the upper limb after stroke. Sensorimotor impairments are present in 67% of the stroke patients, resulting in problems with independency and performance of activities of daily life.
- Trial name
- NCT03236376
- Testing
- additional sensorimotor therapy for the upper limb, additional motor therapy for the upper limb after stroke
- Where
- Belgium
- Volunteers
- 59 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven