Clinical trials: Motor Control Impairment
Low Back Pain
Movement Control and Motor Unit Behavior Responses to Different Types of Stimulation
This study aims to determine the effect of different stimulations including 1) transcranial direct current stimulation (tDCS), 2) neuromuscular electrical stimulation (NMES), 3) motor control exercise (MCE), and 4) isometric…
- Trial name
- NCT06516770
- Testing
- Transcranial direct current stimulation, Neuromuscular electrical stimulation, Motor control exercise
- Where
- Thailand
- Volunteers
- 136 people, healthy volunteers welcome
- Sponsor
- Mahidol University
Intracerebral Hemorrhage, Motor Impairment
Fluoxetine for Motor Recovery After Acute Intracerebral Hemorrhage
This is a randomized, double-blind, placebo-controlled, multicenter clinical trial that will be carried out in Mexico. The purpose of this study is to test whether a 3-month treatment with fluoxetine enhances motor recovery in…
- Trial name
- FMRICH (NCT01737541)
- Testing
- Fluoxetine
- Where
- 4 sites in Mexico
- Volunteers
- 32 people
- Sponsor
- Universidad Autónoma de Aguascalientes
Vascular Cognitive Impairment
PROMOTE: Promotion of the Mind Through Exercise
The investigators will conduct a proof-of-concept study to provide preliminary evidence of efficacy of aerobic-based exercise training for maintaining cognitive function, executive function, and everyday function in adults with…
- Trial name
- NCT01027858
- Testing
- Aerobic-based exercise training, CON (control; usual care)
- Where
- Canada
- Volunteers
- 71 people
- Sponsor
- University of British Columbia
Breast Cancer, Locally Advanced Breast Cancer
Memantine and Exercise to Improve Cognitive Function and Modulate Biological Pathways of Cognitive Decline During Chemotherapy in Breast Cancer
This randomized, placebo-controlled trial aims to assess the feasibility, acceptability, and preliminary efficacy of memantine and the University of Carolina (UNC)'s Get Real \& Heel cancer exercise program (MEM+EX) in addressing…
- Conditions
- Breast Cancer, Locally Advanced Breast Cancer, Cognitive Impairment, Cognitive Decline
- Trial name
- NCT06727773
- Testing
- Memantine, Exercise Intervention, Exercise Control
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- UNC Lineberger Comprehensive Cancer Center
Prediabetic State
Can Structured Education Promote Physical Activity in Those Identified With an Increased Risk of Developing Diabetes
This study is a three-armed randomised controlled trial that aims to determine the effect of a structured educational programme on physical activity levels and glucose tolerance in individuals with impaired glucose tolerance…
- Trial name
- PREPARE (NCT00566319)
- Testing
- PREPARE with pedometer, PREPARE
- Where
- United Kingdom
- Volunteers
- 103 people
- Sponsor
- University Hospitals, Leicester
Chonic Stroke Patients With Motor Impairment of Upper Limb
Impact of rTMS on BCI Control in Upper Limb Motor Rehabilitation of Patients With Chronic Stroke
Cerebrovascular accidents (strokes) are a major public health issue. Stroke is the 3rd leading cause of death and the leading cause of disability and loss of autonomy.
- Trial name
- BCINET (NCT06951035)
- Testing
- Repetitive transcranial magnetic stimulation (rTMS)
- Where
- France
- Volunteers
- 50 people
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Communication Disorder, Healthy
Central Mechanisms in Speech Motor Control Studied With H215O PET
Positron Emission Tomography (PET) is a technique used to investigate the functional activity of the brain. The PET technique allows doctors to study the normal biochemical and metabolic processes of the central nervous system of…
- Conditions
- Communication Disorder, Healthy, Stuttering, Tourette Syndrome
- Trial name
- NCT00001308
- Where
- United States
- Volunteers
- 1,163 people, healthy volunteers welcome
- Sponsor
- National Institute on Deafness and Other Communication Disorders (NIDCD)
Metabolic Disorders, Physical Inactivity
Interactive Roles of Cardiorespiratory Fitness and Adiposity on Glucose and Vascular Control After Physical Inactivity
The far-reaching negative health effects of the reduced physical activity (RPA) epidemic are often overlooked by the general population and health professionals.
- Conditions
- Metabolic Disorders, Physical Inactivity, Vascular Disease Risk
- Trial name
- NCT06842225
- Testing
- reduced physical activity
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Miami University
Mild Cognitive Impairment, Old Age; Debility
Dual Task Perturbation Training for OAwMCI
Studies have determined that compared to cognitively intact older adults (CIOA), older adults with mild cognitive impairment (OAwMCI) exhibit more pronounced balance and gait impairments which lead to an increased risk of falls…
- Trial name
- NCT04938349
- Testing
- Dual task perturbation training
- Where
- United States
- Volunteers
- 142 people, healthy volunteers welcome
- Sponsor
- University of Illinois at Chicago
Sedentary Behavior, Motor Control Impairment
Lumbar Stabilization Exercises in Sedentary Adults
This pilot randomized controlled trial will examine the effects of a four-week lumbar spine stabilization exercise program on motor control, dynamic balance, and quality of life in healthy sedentary adults.
- Conditions
- Sedentary Behavior, Motor Control Impairment, Quality of Life
- Trial name
- NCT07447167
- Testing
- Ergonomic and Stretching Instructions, Lumbar Stabilization Exercise Program
- Where
- Greece
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of West Attica
Mild Cognitive Impairment
SYNchronizing Exercises, Remedies in GaIt and Cognition
The proposed SYNERGIC trial is uniquely designed to evaluate the effect of aerobic and progressive resistance training exercises, combined with cognitive training and Vitamin D3 supplementation, in cognition and mobility in older…
- Trial name
- SYNERGIC (NCT02808676)
- Testing
- Vitamin D3, Exercises (E), Cognitive Training (CT)
- Where
- 6 sites in Canada
- Volunteers
- 175 people, healthy volunteers welcome
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Breast Cancer
Exercise, Cancer and Cognition: The ECCO-Study
The "ECCO"-study evaluates the efficacy of simultaneous controlled exercise during neo/-adjuvant chemotherapy in breast cancer patients and its effects on neurocognition.
- Trial name
- ECCO (NCT04789187)
- Testing
- High-Intensity-Interval-Training, General Physical Activity Recommendations
- Where
- Austria
- Volunteers
- 126 people
- Sponsor
- Johannes Kepler University of Linz
Central Visual Impairment
Training Oculo-motor Control to Improve Vision When Using a Preferred Retinal Locus
When high-detail vision is lost due to a retinal disease such as macular degeneration, people see poorly, and have difficulty with eye movements (oculo-motor control).
- Trial name
- NCT05637385
- Testing
- Training of perception and oculo-motor control
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Russell L. Woods
Neurologic Disorder, Paralysis
SWITCH II Early Feasibility Study: Implantable BCI to Control a Digital Device for People With Paralysis
The Synchron Motor Neuroprosthesis (MNP) is intended to be used in subjects with severe motor impairment, unresponsive to medical or rehabilitative therapy and a persistent functioning motor cortex.
- Conditions
- Neurologic Disorder, Paralysis, Paralysis; Stroke, Amyotrophic Lateral Sclerosis
- Trial name
- NCT05041114
- Testing
- Motor Neuroprosthesis
- Where
- 3 sites in Australia
- Sponsor
- Synchron Medical, Inc.
Cerebral Palsy (CP), Encephalitis
Effects of Combined Music Therapy and Occupational Therapy on Motor and Physiological Parameters in Children With Neurological Impairments: A Non-Randomized Controlled Trial
This study aims to explore the effects of an occupational therapy program combined with music therapy elements on children 5-12 years old with neurological disorders including those with neurogenic scoliosis.
- Conditions
- Cerebral Palsy (CP), Encephalitis, Brain Tumor (After Recovery)
- Trial name
- NCT07200687
- Testing
- Music therapy, occupational therapy
- Where
- Greece
- Volunteers
- 18 people
- Sponsor
- Armakola Filomeni
Stroke, Stroke, Acute
Associative Peripheral Stimulation for Reduction of Motor Impairment During Acute Period of Stroke Recovery
Associative Peripheral Stimulation (APS) is a non-invasive therapy intended for stroke rehabilitation involving transcutaneous electrical muscle stimulation paired with voluntary movement.
- Conditions
- Stroke, Stroke, Acute, Stroke, Ischemic, Stroke, Hemorrhagic
- Trial name
- APS-PILOT (NCT06575140)
- Testing
- Associative Peripheral Stimulation (APS) 1.0, Peripheral Neuromuscular Stimulation
- Where
- 3 sites in Mexico
- Volunteers
- 20 people
- Sponsor
- Ahmed A. Rahim
Alzheimer's Disease, Mild Cognitive Impairment
Wisconsin Brain Donor Program
The Wisconsin Brain Donor Program (WBDP) stores brain and other tissues/samples (e.g. blood and CSF) from deceased individuals who have participated in longitudinal research studies, as well as other select participants.
- Trial name
- WBDP (NCT00585572)
- Where
- United States
- Volunteers
- 9,999 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Spinal Cord Injuries, Poliomyelitis
Comparing Functional Outcomes in Individuals Using Micro-processor Controlled Orthosis Versus Stance Control Orthosis
The study will specifically evaluate the potential of the C-Brace to improve the functional mobility and quality of life in individuals with lower extremity impairments due to neurologic or neuromuscular disease, orthopedic…
- Conditions
- Spinal Cord Injuries, Poliomyelitis, Post-polio Syndrome, Arthritis
- Trial name
- NCT02089880
- Testing
- C-brace, Stance control orthosis
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Shirley Ryan AbilityLab
Progressive Supranuclear Palsy (PSP)
Efficacy of RIVAstigmine on Motor, Cognitive and Behavioural Impairment in Progressive Supranuclear Palsy
Progressive supranuclear palsy (PSP) is a rare neurodegenerative disease from the parkinsonian syndrome group. It represents 5 to 10% of all parkinsonian syndromes and affects 3,000 to 10,000 persons in France.
- Trial name
- RIVA-PSP (NCT02839642)
- Testing
- Rivastigmine
- Where
- France
- Volunteers
- 106 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Stroke
Effects of Strategy Training for Physical Activity (STPA) on the Post-stroke Executive Dysfunction
The goal of this randomized controlled trial is to examine if combining strategy training and physical activity (STPA) works to improve executive function in community-dwelling adults with post-stroke cognitive impairment.
- Trial name
- STPA (NCT06790173)
- Testing
- Strategy training for physical activity, Physical activity, Education
- Where
- 5 sites in Taiwan
- Volunteers
- 120 people
- Sponsor
- Taipei Medical University