Clinical trials: Motor Cortex
Temporomandibular Joint Disorders
Motor Cortex as a Research & Therapeutic Target in TMD
The investigators are doing a study to learn about the effects of a type of low-energy non-surgical electrical brain stimulation (HD-tDCS) on chronic pain in people's jaw joints.
- Trial name
- NCT02247063
- Testing
- High-Definition Transcranial Direct Current Stimulation (HD-tDCS)
- Volunteers
- 24 people
- Sponsor
- University of Michigan
Transcranial Magnetic Stimulation
Effects of Cerebellum or Supplementary Motor Area Functional Inactivation on Gait and Balance Control
In human, the physiology of gait and balance is not clearly established. By using functional imaging and electrophysiological techniques, various brain regions from the cortex to the midbrain area, including the cerebellum, have…
- Trial name
- CERESMARCHE (NCT02976298)
- Testing
- transcranial magnetic stimulation
- Where
- France
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Neuropathic Pain, Facial Pain
Motor Cortex Stimulation for Chronic Neuropathic Pain
The purpose of this study is to evaluate the efficacy of cortical stimulation (CS) as an adjunctive treatment for chronic neuropathic pain.
- Conditions
- Neuropathic Pain, Facial Pain, Post-stroke Pain, Brachial Plexus Avulsion
- Trial name
- NCT01554332
- Testing
- Motor Cortex Stimulation using SJM EonC Stimulator
- Where
- Brazil
- Volunteers
- 38 people
- Sponsor
- Abbott Medical Devices
Migraine, Healty Controls
Motor Evoked Potential and Cortical Silent Period in Migraine
The primary objective of this study is to assess the level of inhibitory control in the motor cortex of migraine patients using objective and non-invasive methods.
- Trial name
- NCT07250464
- Testing
- Transcranial Magnetic Stimulation (TMS), Surface Electromyography (sEMG), Needle EMG / Single Motor Unit (SMU) Recording
- Where
- Turkey (Türkiye)
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Istanbul Gelisim University
Major Depressive Disorder, Recurrent, Mild, Depressive Disorder, Major
Cortical Excitability and Inhibition in MDD
The purpose of this study is to learn if measures of brain activity are different in children and adolescents with depression who are in different stages of treatment.
- Trial name
- NCT01718730
- Testing
- Transcranial Magnetic Stimulation (TMS), Magnetic Resonance Spectroscopy and Imaging
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- Mayo Clinic
Stuttering, Adult
The Effects of Brain Stimulation on Speech Fluency in Adults Who Stutter
The project is leading to investigate the effects of neuromodulation techniques on speech fluency among adults who stutter (AWS).
- Trial name
- NCT05472181
- Testing
- rTMS (Repetitive TMS), Speech training
- Where
- Hong Kong
- Volunteers
- 18 people
- Sponsor
- The University of Hong Kong
Parkinson's Disease
Biomarkers of Neurodegeneration and Neuroplasticity in Parkinson's Disease Patients Treated by Bilateral M1-iTBS
Intermittent theta-burst stimulation (iTBS) is a promising therapeutic option for Parkinson's disease patients. A study involving 24 patients will assess its effectiveness in alleviating clinical deficits.
- Trial name
- NCT06840145
- Testing
- repetitive transcranial magnetic stimulation
- Where
- Spain
- Volunteers
- 24 people
- Sponsor
- Instituto de investigación e innovación biomédica de Cádiz
Gliomas Benign, Glioma, Malignant
General Anesthesia Versus Awake Surgery in Resection of Gliomas and Metastases of Motor Areas
Objective of the study is to determine whether resection of gliomas and metastases of motor areas using awake surgery can achieve rarer motor deterioration after operation than using general anesthesia.
- Conditions
- Gliomas Benign, Glioma, Malignant, Metastases to Brain
- Trial name
- GAMMA (NCT05485038)
- Testing
- Tumor resection in awake patient, Tumor resection in asleep patient
- Where
- Russia
- Volunteers
- 72 people
- Sponsor
- Sklifosovsky Institute of Emergency Care
Frontotemporal Degeneration (FTD), ALS (Amyotrophic Lateral Sclerosis)
Biofluid Research on Age-Related or Inherited Neurodegeneration
The aim of this study is to contribute to and continue to sustain a repository of blood samples, nucleic acid (DNA and/or RNA) samples, family history information, and other demographic information from individuals with…
- Conditions
- Frontotemporal Degeneration (FTD), ALS (Amyotrophic Lateral Sclerosis), Primary Progressive Aphasia (PPA), Familial Frontotemporal Lobar Degeneration (fFTLD)
- Trial name
- BRAIN (NCT07798700)
- Where
- United States
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Obsessive-Compulsive Disorder
Priming in Repetitive Transcranial Magnetic Stimulation in the Treatment of Obsessive Compulsive Disorder
Obsessive Compulsive Disorder results in high social impact, affecting quality of life and tending to a chronic course. A considerable proportion of patients, up tp 60%, remain with symptoms even thought treatment is…
- Trial name
- NCT06049706
- Testing
- Active Priming
- Where
- Brazil
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Suellen Andrade
Parkinson's Disease
Home-based Transcranial Static Magnetic Field Stimulation (tSMS) of the Supplementary Motor Area in Parkinson's Disease
This is a pilot open study to test the hypothesis that home-based transcranial static magnetic field stimulation (tSMS) of the supplementary motor area is safe and feasible to modulate corticostriatal activity in patients with…
- Trial name
- NCT06840678
- Testing
- Transcranial static magnetic field stimulation (tSMS) of the supplementary motor area
- Where
- Spain
- Volunteers
- 20 people
- Sponsor
- Fundación de investigación HM
Cerebrovascular Accident, Healthy
Interhemispheric Interactions Associated With Performance of Voluntary Movements in Patients With Stroke Motor Disability
This study will use transcranial magnetic stimulation (TMS) to identify interactions between the unaffected and affected side of the brain in stroke patients.
- Trial name
- NCT00029718
- Where
- United States
- Volunteers
- 57 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Stroke, Spinal Cord Injuries
Cortical Biomarkers of Hand Function and Recovery After Injury
This is a pilot study to collect data to support a VA grant submission to study fMRI and neurophysiological predictors of hand function and recovery during a robotic intervention in people with hand impairments due to stroke or…
- Trial name
- NCT03833518
- Testing
- Rehabilitation using motorized glove for stroke and spinal cord injury, Functional MRI for stroke and spinal cord injury, Transcranial magnetic stimulation (TMS) for stroke and spinal cord injury
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- VA Pittsburgh Healthcare System
Children With Autism Spectrum Disorder, Typical Developed Children
Investigating Handwriting Characteristics and Underlying Factor in Children With Autism Spectrum Disorder
The mechanism of the motor problem in children with autism spectrum disorder (ASD) in handwriting has been investigated in the following three aspects, including collecting dynamic handwriting performance, exploring the related…
- Trial name
- NCT06228885
- Testing
- handwriting experiment and motor ability test
- Where
- Taiwan
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- National Cheng-Kung University Hospital
Antisocial Behavior, Aggression
The Effect of Repeated Prefrontal Cortex Stimulation on Antisocial and Aggressive Behavior
This study investigates the relationship between prefrontal cortex activity and antisocial and aggressive behavior, and risk factors for such behavior.
- Trial name
- NCT02674516
- Testing
- Transcranial direct current stimulation
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Tourette Syndrome
tDCS in Tourette (TIC-TDCS)
Double-blind randomized, sham-controlled clinical trial of 1 mA bilateral supplementary motor area in adolescents/adults with Tourette syndrome (TS).
- Trial name
- TIC-TDCS (NCT03401996)
- Testing
- 1 mA tDCS over bilateral SMA
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- University of Calgary
Chronic Neuropathic Pain
Study of RTMS Analgesic Effect in Chronic Neuropathic Pain,
The purpose of this study is to compare the analgesic effectiveness of three modes of repetitive Transcranial Magnetic Stimulation (rTMS) in chronic neuropathic pain: Classical rTMS stimulation Deeper rTMS stimulation Sham rTMS…
- Trial name
- NEUROSTIM (NCT04936646)
- Testing
- RepetitiveTranscranial Magnetic Stimulation (rTMS)
- Where
- France
- Volunteers
- 45 people
- Sponsor
- University Hospital, Grenoble
Cognitive Disorders, Motor Disorders
Evaluation of Cognitive and Motor Neurological Disorders in the Short and Long Term After Surgery for the Removal of a Diffuse Low-grade Glioma of the Supplementary Motor Area
Background : The supplementary motor area is the most common/preferential brain location of LGG. This area plays an important role in many motor and cognitive functions such as motor initiation, bimanual coordination and…
- Conditions
- Cognitive Disorders, Motor Disorders, Low-grade Glioma
- Trial name
- POG-C (NCT05373394)
- Testing
- Test battery
- Where
- France
- Volunteers
- 22 people
- Sponsor
- University Hospital, Tours
Quadriplegia
Sensory Motor Transformations in Human Cortex
This research study is being conducted to develop a brain controlled medical device, called a brain-machine interface. The device will provide people with a spinal cord injury some ability to control an external device such as a…
- Trial name
- NCT01964261
- Testing
- Neural Prosthetic System 2 (NPS2)
- Where
- 4 sites in United States
- Volunteers
- 5 people
- Sponsor
- Richard A. Andersen, PhD