Clinical trials: Motor Cortex
Brain Stimulation, Peripheral Nerve Stimulation
Glutamate Modulation of tDCS Over Premotor Cortex Combined With Peripheral Nerve Stimulation Promoted Observation-execution-related Cortical Excitability and Motor Learning
This study aimed to investigate whether concurrent tDCS over the PMC and PNS during action observation enhance observation-execution-related motor cortex excitability and improve motor performance, and to explore the underlying…
- Conditions
- Brain Stimulation, Peripheral Nerve Stimulation, Motor Observation, Cortical Excitability
- Trial name
- NCT06694909
- Testing
- tDCS + PNS with action observation, tDCS + PNS without action observation
- Where
- China
- Volunteers
- 128 people, healthy volunteers welcome
- Sponsor
- Beijing Sport University
Patient Compliance
Cognitive Regulation Training and Exercise
The purpose of this study is to compare CORTEX (Cognitive Regulation Training and Exercise), a multi-faceted, general and exercise-specific cognitive training program plus a 4-month exercise program, to an attention-control…
- Trial name
- CORTEX (NCT01837004)
- Testing
- CORTEX
- Where
- United States
- Volunteers
- 133 people, healthy volunteers welcome
- Sponsor
- University of Illinois at Urbana-Champaign
Neurodegenerative Disease, Behavioral Variant Frontotemporal Dementia (bvFTD)
Tracking and Predicting How Brain Damage Spreads in Neurodegenerative Diseases
Neurodegenerative diseases, including frontotemporal lobar degeneration (FTLD) spectrum syndromes, are characterized by the accumulation of insoluble protein aggregates in the central nervous system.
- Conditions
- Neurodegenerative Disease, Behavioral Variant Frontotemporal Dementia (bvFTD), Primary Progressive Aphasia(PPA), Progressive Supranuclear Palsy(PSP)
- Trial name
- NCT07567664
- Testing
- 3 Tesla MRI without contrast medium, Blood sample for genetic analysis, Cerebrospinal fluid sampling (CSF)
- Where
- Italy
- Volunteers
- 645 people, healthy volunteers welcome
- Sponsor
- IRCCS San Raffaele
Stroke, Motor Cortex; Lesion
Imaging Laterality in Chronic Stroke Patients
In healthy individuals, unimanual movement (with either the left or right hand) is associated with activity in a network of predominantly contralateral brain regions, including the primary motor cortex (PMC).
- Trial name
- NCT03584425
- Testing
- Rasch modified version of the Fugl-Meyer Motor assessment, Anatomical image acquisition, Functional MRI task and acquisition
- Where
- United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Medical University of South Carolina
Parkinson's Disease
Effect of Stimulus Rate on Cognitive and Motor Activity in Young Subjects, Elderly Subjects, and Patients With Parkinson's Disease
The purpose of this study is to investigate how changes in the brain associated with Parkinson's disease influence the control of motor and thinking speed.
- Trial name
- NCT00026598
- Where
- United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Tourette's Syndrome, Obsessive Compulsive Disorder
Evaluation of the HBDL Coil Transcranial Magnetic Stimulation (TMS) Device - Safety and Feasibility Study for the Treatment of Tourette Syndrome
This is an open study.approximately 20 patients diagnosed with tourette's syndrome and under pharmAcological or psychotherapy treatments will participate.patients will be recruited from Schneider hospital and all his extensions.
- Trial name
- NCT00965211
- Testing
- HBDL-coil Repetitive Deep Transcranial magnetic stimulation (rdTMS)
- Where
- 2 sites in Israel
- Volunteers
- 20 people
- Sponsor
- Shalvata Mental Health Center
Healthy
Brain Control of Blinking
This study will use transcranial magnetic stimulation (TMS) to study how the brain controls movement of muscles in the face-in particular, those involved in eye blinking.
- Trial name
- NCT00030199
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Mental Fatigue, Athletic Performance
Effects of Mental Fatigue Duration on Cortical Activity and Jump Performance
"This study investigates whether the length of time spent on a mentally demanding task affects brain activity and jumping performance in physically active young men.
- Conditions
- Mental Fatigue, Athletic Performance, Cognitive-Motor Interaction
- Trial name
- MF-CMJ-EEG (NCT07754604)
- Testing
- Nature Documentary (Control), 10-Minute Stroop Task, 15-Minute Stroop Task
- Where
- Turkey (Türkiye)
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Inonu University
Parkinson Disease, Transcranial Magenetic Stimualtion
The Efficacy of Repetitive Transcranial Magnetic Stimulation in Parkinson's Disease：A Randomized, Double-blind, Multicenter, Placebo-controlled Trial
Repetitive transcranial magnetic stimulation (rTMS) is a non-invasive and widely used neuromodulation technology. Small sample studies have shown that rTMS treatment can significantly improve the symptoms of Parkinson's…
- Conditions
- Parkinson Disease, Transcranial Magenetic Stimualtion, Supplementary Motor Area
- Trial name
- NCT06583278
- Testing
- transcranial magnetic stimulation
- Volunteers
- 312 people
- Sponsor
- Anhui Medical University
Stroke
Repetitive Bihemispheric Transcranial Direct Current Stimulation After Stroke
Non-invasive repetitive bi-hemispheric transcranial direct current stimulation (tDCS) may restore post-stroke bi-hemispheric balance by increase peri-lesional cortex activity and suppress abnormal inhibition from non-lesional…
- Trial name
- NCT02731508
- Testing
- Bihemispheric transcranial direct current stimulation
- Where
- Taiwan
- Volunteers
- 32 people
- Sponsor
- Taipei Veterans General Hospital, Taiwan
Diplegia, Spastic
Eye-Hand Coordination in Children With Spastic Diplegia
This study will examine how the brain controls eye-hand coordination (visuomotor skills) in children with spastic diplegia and will determine whether impairment of this skill is related to the learning difficulties in school that…
- Trial name
- NCT00024791
- Where
- United States
- Volunteers
- 144 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Healthy Subjects
Safety Study Based on Transcranial Electrical Stimulation in Chile: a Case Series Study
Transcranial direct current stimulation (tDCS) is a non-invasive neuromodulation technique that delivers low-intensity, direct current to cortical areas facilitating or inhibiting spontaneous neuronal activity.
- Trial name
- NCT04245059
- Testing
- Multi-channel Transcranial direct current stimulation
- Where
- Chile
- Volunteers
- 3 people, healthy volunteers welcome
- Sponsor
- Corporación de Rehabilitación Club de Leones Cruz del Sur
Second Language Acquisition in Healthy Young Adults
Recognition of Second Language Spoken Words, Signs, and Characters Via Perception and Production in Adults
Self-production facilitates acquisition of spoken words, signs, and characters from an unfamiliar second language. The proposed work investigates how motor cortex, a key part of the brain enabling body action, supports their…
- Trial name
- NCT05587218
- Testing
- Self-production
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of Alabama, Tuscaloosa
Healthy, Gait Disorders, Neurologic
Exoskeleton and Brain Activity With fNIRS
Background. Force control is one of the major parameter of motor activity. There is few study concerning the cortical activity imply for different levels of force during gait. Objective.
- Trial name
- ExoNIRS (NCT05298943)
- Testing
- walking in 4 situations
- Where
- France
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Régional d'Orléans
Stroke, Cardiovascular
Cortical Excitability Sequential Changes in Response to Transcranial Magnetic Stimulation Post Stroke
This study was conducted to investigate the cortical excitability changes per session in response to the application of low frequency repetitive transcranial magnetic stimulation *LF-rTMS* on the contralesional hemisphere and its…
- Trial name
- NCT03845595
- Testing
- (LF-rTMS) group, Control group
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Cairo University
Parkinson Disease
Direct Measurement of Motor Cortical Responses to tDCS
Transcranial direct current stimulation (tDCS) has shown the potential to improve symptoms in patients with movement deficits, such as Parkinson's disease and chronic stroke.
- Trial name
- NCT04759898
- Testing
- transcranial direct current stimulation (invasive recording)
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Medical University of South Carolina
Brain Tumor, Brain Cancer
A Study to Measure the Effect of Brain Stimulation on Hand Strength and Function in Patients With Brain Tumors
The neurosurgical standard of care for treating a patient with a tumor invading hand primary motor cortex (M1) includes performing a craniotomy with intraoperative direct electrical stimulation (DES) mapping and to resect as much…
- Conditions
- Brain Tumor, Brain Cancer, Motor Cortex; Lesion
- Trial name
- NCT05023434
- Testing
- Intraoperative Brain Simulation - Alternate Stimulation Parameters
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Medical College of Wisconsin
Bladder Hypersensitivity
The Effectiveness of Transcranial Magnetic Stimulation of Supplementary Motor Area (SMA) in Patients With Bladder Hypersensitivity and Bladder Pain
The main hypothesis of this study is that transcranial magnetic neuromodulation can correct the symptoms of hypersensitivity and bladder pain.
- Trial name
- NCT04721210
- Testing
- Transcranial magnetic stimulation
- Where
- Russia
- Volunteers
- 28 people
- Sponsor
- Joint-Stock Company North-West Center for Evidence-Based Medicine, Russian Federation
Stroke
The Relationship Between Motor Cortex Oxygenation and Motor Function Recovery in Stroke Patients
Stroke is the most common cause of motor function impairment. However, the functional impairment is not totally irreversible. Several mechanisms may involved in both the cortical and motor function recovery after onset of stroke…
- Trial name
- NCT01781689
- Testing
- Functional Electric Stimulation, Rehabilitation programs
- Where
- Taiwan
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Kaohsiung Veterans General Hospital.
Healthy
Effects of Different Intensities of Bilateral- and Cathodal Transcranial Direct Current Stimulation in Healthy Individuals
This study will separate study to investigate the effects of 1 mA, 1.5 mA, and 2 mA of 1) bilateral- and 2) cathodal tDCS on cortical activity and motor learning in healthy individuals
- Trial name
- NCT05929014
- Testing
- study 1) Active bilateral-tDCS, study 2) active cathodal-tDCS
- Where
- Thailand
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Mahidol University