Clinical trials: Motor Impairments
Pain, Physical Impairment
Enhancement of Physical Fitness in Older Adults
Ageing is related to a decrease in physical fitness, disability and age related symptoms like nocturnal leg cramps (NLC). Our research is focused on the enhancement of physical activity and mobility to increase physical fitness…
- Trial name
- NLC2010 (NCT01421628)
- Testing
- Fitness exercise program
- Where
- Netherlands
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Hanze University of Applied Sciences Groningen
Traumatic Brain Injury
The Impact of Traumatic Brain Injury in the Elderly
A better understanding of the impact of Traumatic Brain Injury (TBI) in the elderly, in terms of brain damage, cognitive and motor functions, sleep quality and quality of life is necessary due to the increasing incidence and…
- Trial name
- NCT04070092
- Where
- Belgium
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Parkinson's Disease
Cognitive Impairment in Parkinson's Disease Categorised in Accordance to Motor Symptoms
Background: Approximately 40% of patients with Parkinson's disease (PD) have cognitive impairments. There is a lack of consensus as to the extent to which psychiatric symptoms, depression, age at disease onset, disease duration…
- Trial name
- NCT00476372
- Where
- Denmark
- Volunteers
- 107 people
- Sponsor
- University of Aarhus
Parkinson Disease
TMS-related Measures as Biomarker of Cognitive Impairment in PD
The goal of the present study is to explore the diagnostic and prognostic value of neurophysiological biomarkers obtained through paired-pulse Transcranial Magnetic Stimulation (TMS) techniques in individuals affected by…
- Trial name
- SAI-PD22 (NCT06835595)
- Testing
- Transcranial Magnetic Stimulation
- Where
- 3 sites in Italy
- Volunteers
- 52 people
- Sponsor
- Azienda Sanitaria Universitaria Integrata del Trentino
Mild Cognitive Impairment
The Combined Aerobic Exercise and Cognitive Training (ACT) Trial: The ACT Trial
This multi-site clinical trial occurs at the University of Minnesota and University of Rochester. It tests the efficacy and additive/synergistic effects of an ACT intervention on cognition and relevant mechanisms (aerobic…
- Trial name
- NCT03313895
- Testing
- Aerobic & Cognitive Training (ACT), Cycling Only, Cognitive Training Only
- Where
- 4 sites in United States
- Volunteers
- 146 people
- Sponsor
- Arizona State University
Mild Cognitive Impairment (MCI)
Assessment of Motor Reserve in the Preclinical Stages of Dementia
Mild Cognitive Impairment (MCI) is a clinical condition associated with an increased risk of progression to dementia. Although cognitive alterations have traditionally been the main focus of investigation, growing evidence…
- Trial name
- NCT07634055
- Testing
- Sensor-based medical device for kinematic assessment: Hand Test System (HTS)
- Where
- Italy
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Istituto per la Ricerca e l'Innovazione Biomedica
Multiple Sclerosis, Relapsing-Remitting
Targeting Subclinical Motor and Cognitive Impairment in Patients With Early Onset Multiple Sclerosis
Our project proposal is based on an individualized rehabilitation approach in patients with early stage relapsing remission (RR) MS.
- Trial name
- RELIABLE (NCT06303024)
- Testing
- personalized combined physical and cognitive intervention
- Where
- Italy
- Volunteers
- 140 people
- Sponsor
- Fondazione Don Carlo Gnocchi ETS
Parkinsons Disease
First-in-Human Study of ALN-SNCA in Adult Participants With Early Parkinson's Disease (PD)
This study is researching an experimental drug called ALN-SNCA (called "study drug"). The study is focused on people with early Parkinson's disease, a disorder of the nervous system that affects movement.
- Trial name
- NCT07216066
- Testing
- ALN-SNCA
- Where
- 3 sites in Canada, Netherlands
- Volunteers
- 46 people
- Sponsor
- Regeneron Pharmaceuticals
Physical Frailty, Mild Cognitive Impairment (MCI)
Effects of Music-with-Movement on Cognitive and Physical Performance of People With Potentially Reversible Cognitive Frailty: a Randomised Controlled Trial
This study aims to evaluate the effects of Music-with-Movement Simultaneous Cognitive-Motor Dual-Task Training (MM-SDTT) on cognitive and physical performance in older adults with cognitive frailty coexisting with mild cognitive…
- Conditions
- Physical Frailty, Mild Cognitive Impairment (MCI), Cognitive Frailty
- Trial name
- NCT06791720
- Testing
- music-based cognitive-motor dual-task training/exercise, Social Gatherings
- Where
- Hong Kong
- Volunteers
- 113 people
- Sponsor
- The Hong Kong Polytechnic University
Acute Stroke
Sensory-Motor Rehabilitation Post Stroke
Early after stroke, patients often have significant motor impairment and sensory deficit. Evidence has demonstrated heightened plasticity and significant recovery in the acute phase (first months) post stroke but there has been a…
- Trial name
- NCT02369770
- Testing
- stretching and active movement training
- Where
- United States
- Volunteers
- 140 people
- Sponsor
- University of Maryland, Baltimore
Spinal Cord Injury, Tetraplegia/Tetraparesis
MEP Up-conditioning to Target Corticospinal Plasticity
Individuals with chronic cervical spinal cord injury will complete a 10-week training protocol where participants receive non-invasive brain stimulation and feedback on the size of the corresponding muscle response (wrist…
- Trial name
- uMEP2 (NCT06989905)
- Testing
- Up-conditioning of the wrist extensor motor evoked potential
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Medical University of South Carolina
ALS (Amyotrophic Lateral Sclerosis), Postpoliomyelitis Syndrome
Impairments of Neuro-muscular Communication in Motor-Neuron Disease: A Bio-Marker for Early and Personalised Diagnosis
Motor neuron disease (MND) or ALS is a nervous system disease. ALS leads to a loss of movement ability that eventually leads to death. At the moment, there is no known treatment for ALS.
- Conditions
- ALS (Amyotrophic Lateral Sclerosis), Postpoliomyelitis Syndrome, Spinal Muscular Atrophy
- Trial name
- MotorMarker (NCT05663008)
- Testing
- 128 electrode electroencephalography (EEG), Bipolar surface electromyography (sEMG), High-density electromyography (HD-EMG)
- Where
- Ireland
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- University of Dublin, Trinity College
Caregiver Burden, Depression
Neighborhood-based Physical and Social Activity for Older Black Caregivers and People Living With Dementia
The Sharing History through Active Reminiscence and Photo-imagery (SHARP) Program engages triads (primary caregiver, person living with dementia, caregiver support person) in walking and social reminiscence, using a group tablet…
- Conditions
- Caregiver Burden, Depression, Cognitive Impairment
- Trial name
- SHARP-CG (NCT05658328)
- Testing
- SHARP - Physical and social activity
- Where
- United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Oregon Health and Science University
Parkinson's Disease
Effects of Pallidal Deep Brain Stimulation Location on Motor Impairment in Parkinson's Disease
This protocol will characterize the effects of deep brain stimulation (DBS) location (both adverse and beneficial) on motor signs in people with Parkinson's disease (PD).
- Trial name
- NCT05557864
- Testing
- Deep Brain Stimulation
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- University of Minnesota
Stroke, Hemiparesis
Personalized Robotic Telerehabilitation for Upper Limb Functional Recovery After Stroke in a Home-Based Setting
Stroke is a leading cause of long-term disability worldwide, with upper-limb impairment representing a major determinant of functional limitation and reduced independence.
- Conditions
- Stroke, Hemiparesis, Upper Extremity Paresis, Motor Impairment
- Trial name
- ROBOHOME (NCT07590349)
- Testing
- Robotic-Assisted Telerehabilitation Virtual Reality-Based Telerehabilitation, Virtual reality-based rehabilitation platform without robotic assistance
- Volunteers
- 70 people
- Sponsor
- University of Campania Luigi Vanvitelli
Stroke, Hemiparesis
Telerehabilitation Through Serious Games in Virtual Reality in a Stroke Population (AutoRReVi)
After a stroke, individuals present with motor and/or cognitive impairments. These impairments limit activity, restrict participation and affect quality of life.
- Conditions
- Stroke, Hemiparesis, Cognitive Impairment, Healthy Subjects
- Trial name
- AutoRReVi (NCT04694833)
- Testing
- Motor and cognitive virtual reality-based assessments, Motor and cognitive virtual reality-based serious games
- Where
- Belgium
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Université Catholique de Louvain
Cerebral Palsy, Arthrogryposis
Effects of Power Mobility on Young Children With Severe Motor Impairments
The purpose this study is to determine the effects of power mobility on the development and function of young children of young children whose severe physical disabilities limit their exploratory behaviors and may unnecessarily…
- Conditions
- Cerebral Palsy, Arthrogryposis, Spinal Muscular Atrophy, Other Central Nervous System or Musculoskeletal Disorders
- Trial name
- NCT01028833
- Testing
- Power mobility
- Where
- United States
- Volunteers
- 41 people
- Sponsor
- University of Oklahoma
Older Adults, Multiple Sclerosis
Exercise Training, Cognition, and Mobility in Older Adults With Multiple Sclerosis
The overall objective of the proposed randomized controlled (RCT) is to determine the feasibility and efficacy of a 16-week theory-based, remotely-delivered, combined exercise (aerobic and resistance) training intervention for…
- Conditions
- Older Adults, Multiple Sclerosis, Cognitive Impairment, Walking Impairment
- Trial name
- NCT05930821
- Testing
- Aerobic and Resistance Exercise Program (GEMS program), Flexibility and Stretching Program (FLEX-MS program)
- Where
- United States
- Volunteers
- 51 people
- Sponsor
- University of Illinois Chicago
Cerebral Palsy (CP), Encephalitis
Effects of Combined Music Therapy and Occupational Therapy on Motor and Physiological Parameters in Children With Neurological Impairments: A Non-Randomized Controlled Trial
This study aims to explore the effects of an occupational therapy program combined with music therapy elements on children 5-12 years old with neurological disorders including those with neurogenic scoliosis.
- Conditions
- Cerebral Palsy (CP), Encephalitis, Brain Tumor (After Recovery)
- Trial name
- NCT07200687
- Testing
- Music therapy, occupational therapy
- Where
- Greece
- Volunteers
- 18 people
- Sponsor
- Armakola Filomeni
Breast Cancer
Cognitive Training and Exercise for Women With Breast Cancer and Cognitive Impairment
Chemotherapy-related cognitive impairment is a prevalent and distressing condition among breast cancer survivors, adversely affecting memory, attention, and overall cognitive function, thereby diminishing quality of life.
- Trial name
- CHEMO-CogEx (NCT07017530)
- Testing
- Cognitive training, Psychoeducational therapy
- Where
- Spain
- Volunteers
- 220 people
- Sponsor
- Universidad de Extremadura