Clinical trials: Motor Vehicle Accident
Malaria
A Safety and Efficacy Study of R21 +/- ChAd63/MVA ME-TRAP
The purpose of this study is to assess the safety and efficacy of adjuvanted R21 alone and in combination with a viral-vectored vaccine regimen (constituting adjuvanted R21 + ChAd63 and MVA encoding ME-TRAP) against malaria…
- Trial name
- NCT02905019
- Testing
- R21 with Matrix-M1, ChAd63 ME-TRAP, MVA ME-TRAP
- Where
- 3 sites in United Kingdom
- Volunteers
- 63 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Hemorrhagic Fever, Ebola
Safety, Tolerability and Immunogenicity Study of 2-dose Heterologous Regimens for Ebola Vaccines Ad26.ZEBOV/MVA-BN-Filo
The purpose of this study is to assess the safety, tolerability and immunogenicity of different vaccination schedules of Ad26.ZEBOV and MVA-BN-Filo administered intramuscularly (IM) as 2-dose heterologous regimens in healthy and…
- Trial name
- NCT02598388
- Testing
- Ad26.ZEBOV, MVA-BN-Filo
- Where
- 7 sites in United States, Kenya and 4 more
- Volunteers
- 578 people, healthy volunteers welcome
- Sponsor
- Janssen Vaccines & Prevention B.V.
Traumatic Stress Disorder
The Effect of Flash Technique Via Self-Therapy App on Depression, Anxiety, and Traumatic Symptoms
EMDR is a psychotherapy method utilized for treating psychological traumas, with the Flash technique being one of its quickest and most effective methods.
- Trial name
- NCT06419387
- Testing
- Self-Therapy Mobile App, Psycho-education Videos
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Academy of Therapeutic Sciences, Turkey
Multiple Trauma
Importance of Forces and Safety Features in Car Crash Multitrauma
The pupose of the study is a prospective evaluation of external and internal factors/causes of importance for the trauma and final outcome experienced by persons inside motor vehicles in serious car accidents.
- Trial name
- NCT00204204
- Where
- Norway
- Volunteers
- 200 people
- Sponsor
- University of Oslo
Healthy
A Safety and Immunogenicity Study of Heterologous Prime-Boost Ebola Vaccine Regimens in Healthy Participants
The purpose of this study is to test the safety and immunogenicity of MVA-BN-Filo and Ad26.ZEBOV as heterologous prime-boost vaccine regimens in healthy adult participants.
- Trial name
- NCT02313077
- Testing
- MVA-BN-filo, Ad26. ZEBOV
- Where
- United Kingdom
- Volunteers
- 87 people, healthy volunteers welcome
- Sponsor
- Crucell Holland BV
Safety, Immunogenicity
EMaBS TB Vaccine Study
The study will commence with a dose-escalation and age de-escalation study in healthy adults and adolescents from the previous Entebbe Mother and Baby Study (EMaBS) in Entebbe, Uganda, focusing on ChAdOx1 85A, to provide safety…
- Trial name
- NCT03681860
- Testing
- ChAdOx185A, MVA85A, BCG
- Where
- 2 sites in Uganda, United Kingdom
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- University of Oxford
IUD Threads Not Visible, IUD Removal Complication
A Randomized Controlled Trial of No Strings Intrauterine Device (IUD) Removal Techniques
The goal of this clinical trial is to compare success rates of two removal techniques for intrauterine devices (IUDs) that have missing or non-visible strings.
- Trial name
- NCT05702242
- Testing
- IUD removal with no visible strings, Alligator forceps, Manual Vacuum Aspirator
- Where
- United States
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Smallpox
MVA Post-Event: Administration Timing and Boost Study
The purpose of this study is to evaluate an investigational smallpox vaccine, called IMVAMUNE®, with respect to safety and immune (body's defense system) response.
- Trial name
- NCT00437021
- Testing
- Live vaccinia virus vaccine, MVA Smallpox Vaccine
- Where
- 7 sites in United States
- Volunteers
- 226 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Human Immunodeficiency Virus
Safety and Efficacy Study of Vaccine Schedule With Ad26.Mos.HIV and MVA-Mosaic in Human Immunodeficiency Virus (HIV)-Infected Adults
The purpose of the study is to assess: 1 safety and tolerability of adenovirus serotype 26 (Ad26) prime and Modified Vaccinia Ankara (MVA) boost versus placebo in participants on suppressive antiretroviral therapy (ART) that was…
- Trial name
- NCT02919306
- Testing
- Ad26.Mos.HIV, MVA-Mosaic
- Where
- Thailand
- Volunteers
- 27 people
- Sponsor
- Janssen Vaccines & Prevention B.V.
Traumatic Injury, Accidental Injury
Trottinettes Urgences 2019-2020
The purpose of the study was to evaluate the risk, consequences and epidemiology of electric scooter accidents admitted to the emergency room at St. Pierre University Hospital.
- Conditions
- Traumatic Injury, Accidental Injury, Alcohol Drinking, Traffic Accident
- Trial name
- NCT04778332
- Where
- Belgium
- Volunteers
- 170 people
- Sponsor
- Centre Hospitalier Universitaire Saint Pierre
Malaria
A Study of AdCh63 ME-TRAP Alone and With MVA ME-TRAP
This is an open label phase I study, to assess the safety of a novel malaria vaccine, AdCh63 ME-TRAP, simian adenovirus encoding Plasmodium falciparum antigens.
- Trial name
- NCT00890019
- Testing
- AdCh63 ME-TRAP, AdCh63 ME-TRAP; MVA ME-TRAP
- Where
- 2 sites in United Kingdom
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Chronic Hepatitis C Infection
Efficacy of the Therapeutic Vaccine TG4040 Combined With Pegylated Interferon and Ribavirin in Chronic HCV Patients
The primary objective of this protocol is to study the effect of the standard of care in hepatitis C (pegylated interferon and ribavirin) associated with therapeutic vaccine TG4040 on the viral load of treatment-naïve patients…
- Trial name
- HCVac (NCT01055821)
- Testing
- pegylated interferon and ribavirin, TG4040 + SOC
- Where
- Germany
- Volunteers
- 140 people
- Sponsor
- Transgene
Whiplash Injuries
Maastricht Neck Study: Cervical Range of Motion in Whiplash Patients
Rationale: Neck complaints are often caused by motor vehicle accidents and particular after rear-end collision. Patients complain about neck pain after a whiplash trauma, which lead to mobility restrictions of the cervical spine.
- Trial name
- MaNeS (NCT00952510)
- Where
- Netherlands
- Volunteers
- 100 people
- Sponsor
- Maastricht University Medical Center
Influenza
Efficacy of Candidate Influenza Vaccine MVA-NP+M1 in Adults
A Phase 2b Study to Determine the Efficacy of Candidate Influenza Vaccine MVA-NP+M1 in Adults aged 18 years and over. To assess the effect of MVA-NP+M1 on the reduction of laboratory confirmed influenza when given as an adjunct…
- Trial name
- NCT03880474
- Testing
- MVA-NP+M1, Saline
- Where
- 9 sites in Australia
- Volunteers
- 2,364 people, healthy volunteers welcome
- Sponsor
- Barinthus Biotherapeutics
Human Immunodeficiency Virus
A Study of 2 Different Regimens of Tetravalent Ad26.Mos4.HIV Prime Followed by Boost With Modified Vaccinia Ankara (MVA)-Mosaic OR Ad26.Mos4.HIV Plus a Combination of Mosaic and Clade C gp140 Protein in Human Immunodeficiency Virus (HIV) Type 1 Infected Adults on Suppressive Antiretroviral Treatment
The primary purpose of this study is to assess safety/tolerability of 2 different prime/boost regimens containing adenovirus serotype 26 (Ad26).Mos4.HIV, Modified Vaccinia Ankara (MVA) -Mosaic or adjuvanted Mosaic and Clade C…
- Trial name
- NCT03307915
- Testing
- Ad26.Mos4.HIV, MVA-Mosaic, Clade C gp140 + Mosaic gp140
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Janssen Vaccines & Prevention B.V.
Abortion, Incomplete
Misoprostol for the Treatment of Incomplete Abortion
This randomized study will examine the efficacy, safety and acceptability of misoprostol for treatment of incomplete abortion. Women diagnosed with incomplete abortion will be randomized to receive one of the following regimens…
- Trial name
- NCT00670761
- Testing
- misoprostol, MVA
- Where
- 6 sites in Burkina Faso, Madagascar and 3 more
- Volunteers
- 720 people, healthy volunteers welcome
- Sponsor
- Gynuity Health Projects
HIV
A Study to Assess Safety and Immunogenicity of Conserved Mosaic HIV-1 Vaccines
The object of the study is to assess the safety profile of candidate vaccines ChAdOx1.tHIVconsv1, MVA.tHIVconsv3 and MVA.tHIVcnsv4 administered sequentially in healthy HIV-1/2 negative adult volunteers.
- Trial name
- NCT04586673
- Testing
- ChAdOx1.tHIVconsv1 (C1), MVA.tHIVconsv3 (M3), MVA.tHIVconsv4 (M4)
- Where
- United Kingdom
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Whiplash Injuries
Interdisciplinary Value-based Cognitive Behavioral Treatment for People with Persistent Whiplash Associated Disorders.
The goal of this clinical trial is to address the critical need for effective interventions by developing and testing an interdisciplinary values-based cognitive behavioral therapy (V-CBT) program for individuals with persistent…
- Trial name
- VALIANT (NCT06386068)
- Testing
- Values-based Cognitive Behavioral Therapy (V-CBT)
- Where
- Denmark
- Volunteers
- 12 people
- Sponsor
- University of Southern Denmark
Malaria
Efficacy of Candidate Malaria Vaccines in Senegalese Adults
Malaria transmission is falling in some parts of Africa as bed nets and anti-malarials become more widely available. However, transmission still persists and it appears that additional control measures are required.
- Trial name
- NCT01658696
- Testing
- ChAd63 ME-TRAP and MVA ME-TRAP, Rabies vaccine
- Where
- Senegal
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Non-melanoma Skin Cancer, Basal Cell Carcinoma
Imvamune Vaccine for the Treatment of Non-melanoma Skin Cancer
This study examines the safety and efficacy of using the Imvamune smallpox vaccine in the treatment of non-melanoma skin cancers (basal cell carcinoma and squamous cell carcinoma).
- Conditions
- Non-melanoma Skin Cancer, Basal Cell Carcinoma, Squamous Cell Carcinoma
- Trial name
- MUSIC-01 (NCT04410874)
- Testing
- Imvamune
- Where
- Canada
- Volunteers
- 1 people
- Sponsor
- Ivan Litvinov