Clinical trials: Mouth Disease
Limbal Insufficiency, Symblepharon
The Application of Oral Mucosal Epithelial Cell Sheets Cultivated on Amino Membrane in Patients Suffering From Corneal Stem Cell Insufficiency or Symblepharon.
Since cultivated autologous oral mucosal epithelial sheets on amniotic membrane have been reported to have good clinical results in treating patients with ocular surface disorders in both human or animal studies, and such…
- Trial name
- NCT00491959
- Testing
- Cultured oral mucosa cell sheet transplantation
- Where
- Taiwan
- Sponsor
- National Taiwan University Hospital
Cutaneous T-Cell Lymphoma, Leukemia-Lymphoma, Adult T-Cell
Study of Oral LBH589 in Patients With Cutaneous T-cell Lymphoma and Adult T-cell Leukemia/Lymphoma
This study will assess the safety, efficacy and pharmacokinetics of oral LBH589 in Japanese adult patients with refractory cutaneous T-Cell Lymphoma and adult T-cell leukemia/lymphoma.
- Trial name
- NCT00699296
- Testing
- Panobinostat (LBH589)
- Where
- 7 sites in Japan
- Volunteers
- 4 people
- Sponsor
- Novartis Pharmaceuticals
Oral Health Related Quality of Life, Oral Disease
Oral Health Related Quality of Life
As oral health has a major impact on general health and quality of life, good oral health are essential. The aspects of oral health that are most important for each individual vary, and quality of life is subjective, and…
- Trial name
- NCT05923762
- Testing
- OHRQoL
- Volunteers
- 3,700 people
- Sponsor
- Dalarna County Council, Sweden
Rare Diseases
Oral Health Related Quality of Life of Patients With Rare Diseases: a Qualitative Approach
The main objective of the study is to assess the oral health-related quality of life of patients with rare diseases and followed in the rare disease centers of expertise at Necker Hospital in Paris by semi-structured interviews.
- Trial name
- RaroDentAXE3 (NCT05070988)
- Testing
- Semi-structured interview
- Where
- France
- Volunteers
- 28 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Aggressive Periodontitis, Generalized
Nonsurgical Periodontal Treatment Associated or Not With Systemic Antibiotics and Photodynamic Therapy
To assess the local effect of the antimicrobial therapy using clarithromycin association with photodynamic therapy (PDT) in the treatment of generalized aggressive periodontitis (GAgP).
- Trial name
- NCT03142776
- Testing
- periodontal debridement, photodynamic therapy, systemic clarithromycin
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Universidade Estadual Paulista Júlio de Mesquita Filho
Alveolar Bone Loss, Bone Density Increased
Minimally Invasive Ridge Augmentation
The present study is a human, prospective, randomised controlled clinical trial conducted to explore the outcome of a minimally invasive ridge augmentation technique with and without low level laser therapy.
- Trial name
- NCT04190576
- Testing
- Low Level Laser Therapy
- Where
- India
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Krishnadevaraya College of Dental Sciences & Hospital
Periodontal Pocket
The Use of Erythritol Powder and Metronidazole Gel for the Non-surgical Treatment of Periodontitis
Aim of the present study is evaluate the use of erythritol powder with/without the adjunct of local metronidazole in the treatment of periodontal pockets.
- Trial name
- NCT02023840
- Testing
- metronidazole gel, ultrasonics, erythritol
- Where
- Italy
- Volunteers
- 20 people
- Sponsor
- Proed, Torino, Italy
Atrial Fibrillation
AIHEMAF - P "An Innovative Healthcare Model for AF Patients"
Non-profit observational study on the role of the community pharmacist and "the pharmacy of services" in the case management of patients suffering from atrial fibrillation and being treated with new generation oral anticoagulants
- Trial name
- AIHEMAF - P (NCT05086991)
- Testing
- Follow up
- Where
- Italy
- Volunteers
- 50 people
- Sponsor
- Farmacia La Regina s.r.l.
Overweight and Obese Women
The Effect of Oral Iron Supplements on Insulin and Glucose Metabolism in Overweight and Obese Women
The study will be a randomized, double-blind, 17-day metabolic intervention trial including 14 days of high-dose or low-dose iron supplementation. A total of 70 overweight or obese (OW/OB) women will be enrolled.
- Trial name
- NCT07315282
- Testing
- 195 mg iron daily, 15 mg iron daily
- Where
- Lebanon
- Volunteers
- 70 people
- Sponsor
- Nicole Stoffel
Oral Lichen Planus
The Clinical and Biological Effects Of The Use Of Probiotic VSL#3 In Patients With Oral Lichen Planus
Oral Lichen Planus (OLP) is an inflammatory disease of mucosal and skin with unknown etiology. The prevalence rate in England is reported to be between 1-2.4%.
- Trial name
- CABRIO (NCT03052179)
- Testing
- Poly-biotic
- Where
- United Kingdom
- Volunteers
- 30 people
- Sponsor
- University College, London
Partial Edentulism
Digital and Conventional Clasp-retained Partial Dentures (DIGICLASP)
This single-center prospective observational cohort study evaluates two fabrication workflows already in routine clinical use for clasp-retained removable partial dentures (RPDs): a digital workflow (Group 1) and a conventional…
- Trial name
- DIGICLASP (NCT07903662)
- Where
- Switzerland
- Volunteers
- 70 people
- Sponsor
- University of Bern
Xerostomia Due to Hyposecretion of Salivary Gland
Hyaluronic Acid in the Treatment of Hyposalivation
The goal of this clinical trial is to learn if drug containing non-crosslinked hyaluronic acid and amino acids solution (Sunecos-200) works to treat hyposalivation in adults.
- Trial name
- NCT07309588
- Testing
- Sunecos-200 Injectable Hyaluronic acid and amino acids solution
- Where
- Poland
- Volunteers
- 100 people
- Sponsor
- Poznan University of Medical Sciences
Obstructive Sleep Apnea
Pilot Study of Negative Pressure Sleep Therapy System to Treat Obstructive Sleep Apnea
This is a pilot study to investigate the efficacy and safety of the Negative Pressure Sleep Therapy System for the treatment of obstructive sleep apnea.
- Trial name
- NCT02324790
- Testing
- iNAP® Sleep Therapy System
- Where
- 4 sites in Taiwan
- Volunteers
- 34 people
- Sponsor
- Somnics, Inc.
Dental Anxiety, Pain
Effectiveness of Hand/Eyes/Mouth Behavior Management Technique During Local Anesthesia in Preschool Children
This will be a randomized, controlled, parallel-group clinical trial. The aim of this studio will be to evaluate the effectiveness of "Hands/Eyes/mouth" behavior management technique versus a conventional technique (covering the…
- Conditions
- Dental Anxiety, Pain, Infant Behavior, Heart Rate and Rhythm Disorders
- Trial name
- NCT02591797
- Testing
- inferior alveolar and lingual nerve block procedure
- Where
- Spain
- Volunteers
- 52 people
- Sponsor
- Cardenal Herrera University
Hypogonadism, Male
Ambulatory Blood Pressure Monitoring (ABPM) Extension Study of Oral Testosterone Undecanoate in Hypogonadal Men
The purpose of this six-month treatment study is to assess feasibility of a lower starting dose of SOV2012-F1 (daily dose of 400 mg [200 mg with breakfast meal and 200mg with dinner meal]) to titrate individual doses to further…
- Trial name
- NCT04467697
- Testing
- SOV2012-F1
- Where
- 19 sites in United States
- Volunteers
- 155 people
- Sponsor
- Marius Pharmaceuticals
Furcation Defects
Restorations and Furcation Involvement on Molars
The aim of this study will be to analyze the relationship between the presence of second class restorations (interproximal fillings) or prostheses (crowns, bridges) on molar teeth and the presence of bone resorption between the…
- Trial name
- NCT05481580
- Testing
- Periodontal probing
- Where
- Italy
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of Cagliari
Osteomyelitis Acute, Septic Arthritis
Initial Oral Antibiotics for Bone and Joint Infections in Children
Initial oral antibiotic treatment for children and adolescents with uncomplicated bone and joint infections (BJI) has been found non-inferior to initial IV antibiotics in one randomized controlled trial (RCT).
- Conditions
- Osteomyelitis Acute, Septic Arthritis, Bone Infection, Joint Infection
- Trial name
- NCT06827496
- Testing
- Oral antibiotic treatment
- Where
- Denmark
- Volunteers
- 100 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Periodontitis, Peri-implant Mucositis
Biological Responses Affecting Early-stage Dental Implant Placement in Patients With History of Periodontitis
This prospective parallel, double-blind, four-arm randomised controlled clinical study is planned to assess the difference in the level of the inflammatory biomarkers expressed following the placement of the first dental implant…
- Conditions
- Periodontitis, Peri-implant Mucositis, Peri-Implantitis
- Trial name
- NCT05834946
- Testing
- Megagen implant placement, Biomate-Swiss implant
- Where
- Malaysia
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- University of Malaya
Hepatic Encephalopathy, Chronic Liver Disease
Effectiveness of Oral Lactulose Versus Lactulose Enema in Hepatic Encephalopathy
Patients with chronic liver disease due to hepatitis B or C viruses, Non-alcoholic fatty liver disease, autoimmune hepatitis, wilson disease, cryptogenic hepatitis etc are prone to develop complications.
- Trial name
- NCT05788627
- Testing
- Tap water, Lactulose
- Volunteers
- 100 people
- Sponsor
- Khyber Medical College, Peshawar
Intestinal Permeability, Gastrointestinal Irritation
The Effects of Probiotics on Intestinal Permeability in Gastrointestinal Cancer Patients in Chemotherapy
The aim of this study is to test the hypothesis that adjuvant administration of probiotics in cancer patients undergoing chemotherapy can reduce a chemo-induced increased intestinal permeability.
- Conditions
- Intestinal Permeability, Gastrointestinal Irritation, Mucositis
- Trial name
- NCT03704727
- Testing
- Probiotic
- Where
- Denmark
- Volunteers
- 5 people
- Sponsor
- University of Copenhagen
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