Clinical trials: Mouth Disease
Marijuana Dependence
Effect of Lofexidine and Oral THC on Marijuana Withdrawal and Relapse
The purpose of this study is to investigate the interaction between marijuana and two potential treatment medications: lofexidine and oral THC, with the direct goal of using this information to improve marijuana treatment outcome.
- Trial name
- NCT00373503
- Testing
- Lofexidine, dronabinol, Marijuana
- Where
- United States
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- New York State Psychiatric Institute
Parkinson Disease
Safety and Efficacy of Pramipexole and Bromocriptine Combined With L-dopa in Parkinson's Disease
The objective of the study was to evaluate the efficacy and safety of SND 919 (pramipexole) tablets administered in combination with L-dopa in patients with Parkinson's disease using placebo and bromocriptine tablets as…
- Trial name
- NCT02172573
- Testing
- Pramipexole, Bromocriptine
- Volunteers
- 315 people
- Sponsor
- Boehringer Ingelheim
Atopic Dermatitis
Evaluate Efficacy and Safety of Oral SHR0302 in Subjects Aged 12 Years and Older With Moderate to Severe Atopic Dermatitis
This is a randomized, double-blind, placebo-controlled, multicenter Phase 3 study that will enroll approximately 330 subjects aged 12 to 75 years old with moderate to severe atopic dermatitis.
- Trial name
- NCT04875169
- Testing
- Core Treatment Active Experimental: SHR0302 Dose#1, Core Treatment Active Experimental: SHR0302 Dose#2, Extension Treatment Active Experimental: SHR0302 Dose#1
- Where
- 52 sites in Canada, China
- Volunteers
- 336 people
- Sponsor
- Reistone Biopharma Company Limited
Type 2 Diabetes Mellitus
A Phase 4, Randomized, Double-blind, Parallel-group, Comparative Study and a Phase 4, Open-label, Long-term Study of SYR-472 (100 mg) in Combination With Insulin in Patients With Type 2 Diabetes
The purposes of this study is to evaluate the efficacy and safety of SYR-472 when administered at a dose of 100 mg once weekly as an add-on to insulin therapy compared with placebo in patients with type 2 diabetes mellitus and…
- Trial name
- NCT02324569
- Testing
- SYR-472
- Where
- 65 sites in Japan
- Volunteers
- 240 people
- Sponsor
- Takeda
Idiopathic Pulmonary Fibrosis
Expanded Access Program of Nintedanib in Patients With Idiopathic Pulmonary Fibrosis (EAP)
To provide early access and to evaluate the safety and tolerability of nintedanib in patients with idiopathic pulmonary fibrosis (IPF).
- Trial name
- NCT02171156
- Testing
- nintedanib
- Where
- 7 sites in United States
- Sponsor
- Boehringer Ingelheim
Iron Deficiency Anemia
Efficacious Iron for Iron Deficiency Anemia in Adults Aged ≥18 Years
Iron deficiency anemia (IDA) is a widespread condition affecting many people globally. Despite the many cases of IDA, there are few studies that compare the effectiveness of different types of iron supplements with a greater…
- Trial name
- NCT06303531
- Testing
- Ferrous Fumarate, Polysaccharide Iron, Ferrous Ascorbate
- Where
- Canada
- Volunteers
- 111 people
- Sponsor
- Dr. Anil K. Gupta Medicine Professional Corporation
Polio
Pakistan Short Interval mOPV1 Compared With Standard Interval mOPV1 and bOPV 1,3
Globally, polio cases have decreased by over 99% since 1988. However, wild poliovirus cases continue in Pakistan. Conflict and lack of access to children due to on-going insecurity in tribal areas present special challenges in…
- Trial name
- SIAD (NCT01586572)
- Testing
- mOPV1, bOPV 1,3
- Where
- 2 sites in Pakistan
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Aga Khan University
Peri-Implantitis, Periodontitis
Cellular and Molecular Inflammatory Mechanisms Leading to Bone Resorption in Peri-implantitis Vs Periodontitis
Recent data found that peri-implantitis may differ from periodontitis at the histological level in terms of extent and composition of the cellular components.
- Trial name
- DUOROPA (NCT02664675)
- Testing
- Crown lengthening, Open Flap Debridement
- Where
- 2 sites in France
- Volunteers
- 33 people
- Sponsor
- University of Paris 5 - Rene Descartes
Essential Thrombocythemia, Polycythemia Vera
Arsenic Trioxide With or Without Ascorbic Acid in Treating Patients With Myelofibrosis
This phase I trial studies the side effects and best dose of arsenic trioxide with or without ascorbic acid in treating patients with myelofibrosis.
- Conditions
- Essential Thrombocythemia, Polycythemia Vera, Primary Myelofibrosis
- Trial name
- NCT01014546
- Testing
- Arsenic Trioxide, Ascorbic Acid, Laboratory Biomarker Analysis
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Roswell Park Cancer Institute
Essential Hypertension
A Study to Evaluate the Pharmacokinetics and the Safety After Administration of BR1015-A and Co-administration of BR1015-1 and BR1015-2 Under Fed Conditions
The purpose of this clinical trial is to evaluate the pharmacokinetics and the safety after administration of BR1015-A and co-administration of BR1015-1 and BR1015-2 in healthy volunteers under fed conditions
- Trial name
- NCT07421388
- Testing
- BR1015-A, BR1015-1, BR1015-2
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Boryung Pharmaceutical Co., Ltd
Behcet Syndrome, Uveitis
Tocilizumab for the Treatment of Refractory Behcet's Uveitis
The aim of this single-center prospective study is to evaluate the efficacy and safety of Tocilizumab (TCZ), humanized monoclonal antibody against IL-6receptor, in the treatment of refractory Uveitis of Behçet's disease (BDU), to…
- Trial name
- NCT03554161
- Testing
- Tocilizumab (TCZ)
- Where
- China
- Volunteers
- 3 people
- Sponsor
- Wenjie Zheng
Skin Disease, Immune System Disease
A Study of HL40626S Tablets in Healthy Adults
This is a single-centre, randomized, double-blind, placebo-controlled Phase 1 study to assess safety, tolerability, pharmacokinetics (PK), pharmacodynamics (PD), and immunogenicity of HL40626S tablets following single and…
- Conditions
- Skin Disease, Immune System Disease, Skin Diseases, Papulosquamous, Psoriasis (PsO)
- Trial name
- NCT07736586
- Testing
- HL40626S tablets
- Where
- 2 sites in Australia
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- HighsLab Therapeutics Inc.
Alveolar Bone Loss
mp3 vs Apatos in Post-extractive Sockets
The primary aim of the present multicenter randomized controlled trial was to evaluate and compare the shortterm clinical and histological changes of extraction sockets after ridge preservation procedures with changes of…
- Trial name
- NCT02644070
- Testing
- alveolar bone preservation with mp3, alveolar bone preservation with apatos, stabilization with membrane
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Tuscan Dental Institute
Pregnancy Related, Anemia, Iron Deficiency
Early Antenatal Support for Iron Deficiency Anemia
This is a randomized, controlled multi-site trial of iron therapy in pregnancy. The purpose of this research is to see if second trimester initiation of intravenous (IV) iron therapy is better than oral iron therapy for treatment…
- Conditions
- Pregnancy Related, Anemia, Iron Deficiency, Anemia of Pregnancy
- Trial name
- EASI-A (NCT04278651)
- Testing
- Ferumoxytol, Ferrous Sulfate
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Thomas Jefferson University
Peripheral Vestibular Disorder, Benign Paroxysmal Positional Vertigo
Effect of Peripheral Vestibular Disease Location on Outcomes Following Home-based Virtual Reality Vestibular Therapy
This parallel-group randomized controlled trial aims to determine if the location of the lesion(s) in the vestibular system (unilateral versus bilateral, lateral semi-circular canal versus otolith) impacts the effectiveness of…
- Conditions
- Peripheral Vestibular Disorder, Benign Paroxysmal Positional Vertigo, Meniere Disease, Vestibular Neuritis
- Trial name
- VR-PVD-RCT (NCT05424302)
- Testing
- Standard Vestibular Rehabilitation with Adjunct At Home Virtual Reality Vestibular Rehabilitation, Standard Vestibular Rehabilitation with Adjunct Auditory Intervention
- Where
- Canada
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Peri-Implantitis, Implant Expulsion
Evaluation of the Novel Implant Disease Risk Assessment : a Retrospective Study (IDRA)
Given the novelty of this risk assessment tool, this study will be interested in evaluating its effectiveness through a retrospective approach.
- Trial name
- IDRA (NCT04888572)
- Testing
- Peri-Apical X-ray
- Where
- Lebanon
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Saint-Joseph University
Immune System and Related Disorders, Immune System Diseases
Study of Cannabidiol (CBD) in Healthy Volunteers
This was a prospective, single-centre, open label, randomized, two-arm, parallel design study to evaluate the effect of four-weeks consumption of active study product on primary endpoint in healthy adults
- Trial name
- NCT06286839
- Testing
- Cannabidiol (CBD)
- Where
- United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- NextEvo Inc.
Thymic Carcinoma
Phase II Study Of Oral PHA-848125AC In Patients With Thymic Carcinoma
The intent of the study is to assess the antitumor activity of PHA-848125AC as second-line treatment in patients with recurrent or metastatic, unresectable thymic carcinoma previously treated with chemotherapy.
- Trial name
- NCT01011439
- Testing
- Milciclib Maleate
- Where
- 6 sites in United States, France and 1 more
- Volunteers
- 72 people
- Sponsor
- Tiziana Life Sciences LTD
Major Depressive Disorder
Study to Assess the Effects of Oral NMRA-335140 in Participants With Major Depressive Disorder
This randomized, double-blind, placebo-controlled, multicenter study will evaluate the effects of NMRA-335140 (formerly BTRX-335140) on symptoms of depression in participants with Major Depressive Disorder (MDD).
- Trial name
- NCT06058039
- Testing
- NMRA-335140
- Where
- 71 sites in United States, Bulgaria and 6 more
- Volunteers
- 422 people
- Sponsor
- Neumora Therapeutics, Inc.
Gingival Recession, Localized
Impact of Microneedling on Coverage of RT1 Gingival Recession in Thin Phenotype.
Gingival Recession (GR) is a common finding among adults, regardless of the oral hygiene levels. When it is associated with esthetic impairment, dentin hypersensitivity, root caries, surgical treatment is indicated.
- Trial name
- NCT06432439
- Testing
- microneedling followed by CAF procedures, CAF procedure
- Where
- India
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Postgraduate Institute of Dental Sciences Rohtak
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