Clinical trials: Mouth Diseases
Asthma
Study to Assess the Safety, Tolerability and Pharmacokinetic Profile of PBF-680 After Multiple Oral Doses"
To assess the safety and tolerability of five doses of PBF-680 (5 mg, 10 mg, 20 mg, 40 mg and 60mg) after repeated (8 days) single daily oral dose administration in young male and female healthy subjects.
- Trial name
- NCT02208973
- Testing
- PBF-680
- Where
- 2 sites in Spain
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
Parkinson Disease
Pharmacokinetic Profile of BIA 6-512 in Healthy Elderly Subjects Versus Healthy Young Subjects
the purpose of the study was to the compare pharmacokinetic profile of BIA 6-512 in healthy elderly subjects versus healthy young subjects after single and repeated oral administration of 200 mg BIA 6-512.
- Trial name
- NCT03095105
- Testing
- 200 mg BIA 6-512
- Where
- Germany
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Bial - Portela C S.A.
COVID-19, Microbial Colonization
Role of the Oral Microbiome & Mucosal Immunity in COVID-19 Disease
Determining whether in the mouth there are differences between the participant groups in the nature and activity of mucosal innate immunity, in immune responses to SARS-COV2 antigens, or in the oral microbiome
- Conditions
- COVID-19, Microbial Colonization, Oral Disease, Periodontal Diseases
- Trial name
- MIMSA (NCT05212766)
- Testing
- COVID infection, COVID vaccination, Oral examination
- Where
- United Kingdom
- Volunteers
- 750 people, healthy volunteers welcome
- Sponsor
- King's College London
Gingivitis, Plaque, Dental
Gingivitis Reduction After Use of 0.45% Stannous Fluoride Toothpaste
The 6-month clinical study was designed to investigate clinical efficacy on plaque and gingivitis for the stannous fluoride containing toothpaste (SNAP) compared to Colgate Cavity Protection Toothpaste after 3 and 6 months of…
- Trial name
- NCT06300866
- Testing
- Test, Control
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Colgate Palmolive
Renal Impairment
Phase 1 Study of PK and Safety of Tebipenem Pivoxil Hydrobromide (TBPM-PI-HBr) in Subjects With Various Degrees Of Renal Function
Evaluation of the pharmacokinetics (PK) of TBPM-PI-HBr in subjects with normal renal function, subjects with various degrees of renal insufficiency, and subjects with end-stage renal disease (ESRD) receiving hemodialysis (HD)…
- Trial name
- NCT04178577
- Testing
- Tebipenem pivoxil hydrobromide (TBPM-PI-HBr)
- Where
- 2 sites in United States
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- Spero Therapeutics
Opiate Withdrawal Syndrome
A Study of Oral Ibogaine in Opioid Withdrawal
Study DMX-IB 201 is a Phase 1/2a study of ibogaine consisting of an initial single ascending dose escalation stage to determine the maximum tolerated dose (MTD) or treat-to-target dose (TTD) in healthy volunteers, followed by a…
- Trial name
- NCT05029401
- Testing
- DMX-1002
- Where
- 2 sites in United Kingdom
- Volunteers
- 116 people, healthy volunteers welcome
- Sponsor
- atai Therapeutics, Inc.
Depressive Disorder, Major
Study of the Efficacy and Safety of Initial Administration of 17 mg Vortioxetine Intravenously With 10 mg/Day Vortioxetine Orally in Patients With Major Depressive Disorder
To evaluate the early onset of efficacy of vortioxetine 17 mg intravenously (IV) and vortioxetine 10 mg/day oral dose regimen versus placebo IV and vortioxetine 10 mg/day oral dose regimen on depressive symptoms
- Trial name
- NCT02919501
- Testing
- Vortioxetine (IV), Vortioxetine (tablet)
- Where
- 7 sites in Estonia, Finland
- Volunteers
- 55 people
- Sponsor
- H. Lundbeck A/S
Type 2 Diabetes
WelChol® With Metformin in Treating Patients With Type 2 Diabetes
The purpose of the study is to see how safe and effective and tolerable the use of colesevelam hydrochloride is for type 2 diabetes when added to metformin alone or in combination with other anti-diabetic drugs.
- Trial name
- NCT00147719
- Testing
- Colesevelam hydrochloride
- Where
- 48 sites in United States, Mexico and 1 more
- Volunteers
- 300 people
- Sponsor
- Daiichi Sankyo
Gingival Diseases
Clinical Study to Examine Brushing on Dental Implants
The efficacy of two dentifrices in controlling gingivitis and plaque in adults with implants
- Trial name
- NCT00762619
- Testing
- Fluoride, Triclosan, fluoride
- Where
- 2 sites in United States, Israel
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- Colgate Palmolive
Jaw, Edentulous, Partially
Short Implants - An Alternative to Bone Grafting?
The study, with the ASTRA TECH Implant System, is comparing short implants (OsseoSpeed™) to standard length implants (OsseoSpeed™) in combination with bone grafting.
- Trial name
- NCT01030523
- Testing
- ASTRA TECH Implant System, OsseoSpeed™ 4.0 S (length: 6 mm), ASTRA TECH Implant System, OsseoSpeed™ implants (lengths: 11, 13, 15 mm) in combination with bone grafting
- Where
- 5 sites in United States, Austria and 3 more
- Volunteers
- 101 people
- Sponsor
- Dentsply Sirona Implants and Consumables
Oral Microbiota, Pancreatitis
The Characteristics of Oral Microbiota in Chronic Pancreatitis and Autoimmune Pancreatitis
There are more than 700 different bacteria colonized in human oral cavity, which are collectively referred to as oral microbiota.
- Conditions
- Oral Microbiota, Pancreatitis, Pancreatic Cancer
- Trial name
- NCT07015580
- Testing
- 16S rRNA sequencing
- Where
- China
- Volunteers
- 360 people, healthy volunteers welcome
- Sponsor
- Ruijin Hospital
Non-Small Cell Lung Cancer, Solid Tumors
A Trial of Gefitinib in Combination With BKM120 in Patients With Advanced Non-Small Cell Lung Cancer, With Enrichment for Patients Whose Tumours Harbour Molecular Alterations of PI3K Pathway and Known to Overexpress EGFR
The safety, tolerability and recommended phase 2 dose (RP2D) of the combination of gefitinib and BKM120 will be determined.
- Trial name
- BKM120 (NCT01570296)
- Testing
- Gefitinib and BKM120
- Where
- Singapore
- Volunteers
- 38 people
- Sponsor
- National Cancer Centre, Singapore
Postoperative; Parotitis
Gender and Opioid Consumption
Opioids are widely used for pain relief after major abdominal surgeries[1]. Sex differences in the opioid analgesia have been reported and investigated in human subjects and animal models In this study, effects of sex difference…
- Trial name
- GenderOpioid (NCT03006627)
- Testing
- postoperative morphine
- Volunteers
- 100 people
- Sponsor
- Mansoura University
Shigella
Safety and Efficacy Challenge Study of CVD 1208S, a Live, Attenuated Oral Vaccine to Prevent Shigella: Phase IIb
The purpose of this study is to determine whether CVD 1208S (a live, attenuated, oral vaccine) is safe and effective in the prevention of Shigella infection.
- Trial name
- NCT00866242
- Testing
- CVD 1208S, Challenge strain of wild-type Shigella flexneri 2a
- Where
- 2 sites in United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Maryland, Baltimore
Hand, Foot and Mouth Disease, Infection Control
CHIPCAT and HFMD-PREP for HFMD Prevention in Childcare Centres in Kota Kinabalu
Hand, foot and mouth disease (HFMD) is endemic in Malaysia and disproportionately affects children in childcare settings, where institutional infection prevention and control (IPC) capacity is frequently inadequate.
- Trial name
- NCT07839442
- Testing
- HFMD-PREP (HFMD Prevention and Response Enhancement Programme)
- Where
- Malaysia
- Volunteers
- 780 people, healthy volunteers welcome
- Sponsor
- Helmy Sajali, MD, MPH
Myofacial Pain Syndrome, Botulinum Toxin
Botulinum Toxin A in Patients With Myofascial Pain Syndrome With and Without Zinc Supplementation
Research question: Dose the use of oral zinc supplement improve the effects of botulinum toxins injection in patients with myofascial pain dysfunction syndrome? Statement of the problem: MPDS Patients treated with botulinum toxin…
- Trial name
- NCT05605886
- Testing
- Solvazinc 50mg
- Where
- Egypt
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Cairo University
Hepatocellular Carcinoma
Study of Milciclib in Patients With Unresectable/Metastatic Hepatocellular Carcinoma
The primary aim of this exploratory study is to test the safety and tolerability of milciclib when administered orally at 100 mg in patients with recurrent or metastatic Hepatocellular Carcinoma.
- Trial name
- NCT03109886
- Testing
- Milciclib maleate
- Where
- 14 sites in Greece, Israel and 1 more
- Volunteers
- 31 people
- Sponsor
- Tiziana Life Sciences LTD
Alveolar Ridge Deficiency, Alveolar Bone Loss
Novel Synthetic Membrane for Horizontal Bone Augmentation: A Case Series
The goal of this clinical study is to learn if the Inox Nanoksa G-Plus membrane works to rebuild bone in the upper or lower jaw (ridge augmentation) for adults who need dental implants but do not have enough bone width or height.
- Trial name
- NCT07701473
- Testing
- Inox Nanoksa G-Plus Membrane, Particulate Bone Graft
- Where
- Egypt
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Cairo University
Obesity, Lipid Disorders
A Clinical Study to Evaluate the Safety,Tolerability and PK of ZYT1, Following Oral Administration in Healthy Volunteers
This is a clinical study to evaluate the safety, tolerability and pharmacokinetics of ZYT1, following oral administrations in healthy volunteers. The study shall be divided into four plans as given below: 1.
- Trial name
- NCT01543269
- Testing
- ZYT1
- Where
- India
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Zydus Lifesciences Limited
Cardioembolic Stroke, Anticoagulant Therapy
Keeping Oral o Parental AnticoaguLation in the Acute Phase of Cardioembolic Ischemic Stroke
This is an observational, prospective, multicenter, cohort study in patients with cardioembolic stroke and previous oral or parenteral anticoagulant therapy.
- Conditions
- Cardioembolic Stroke, Anticoagulant Therapy, Stroke Recurrence, Haemorrhagic Transformation Stroke
- Trial name
- KOALA-IS (NCT05486351)
- Testing
- Observation
- Where
- 3 sites in France, Spain
- Volunteers
- 318 people
- Sponsor
- Instituto de Investigación Hospital Universitario La Paz
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