Clinical trials: Mouth Diseases
Xerostomia Due to Hyposecretion of Salivary Gland, pH
Efficacy of a Dietary Supplement (Aqualief®) in Xerostomic Patients
Xerostomia is defined as the subjective complaint of dry mouth. Symptoms of dry mouth may range from mild oral discomfort to significant oral disease that can compromise patients' health, dietary intake and quality of life.
- Conditions
- Xerostomia Due to Hyposecretion of Salivary Gland, pH, Saliva, Quality of Life
- Trial name
- Aqualief (NCT03612414)
- Testing
- Aqualief
- Where
- Italy
- Volunteers
- 60 people
- Sponsor
- Università degli Studi dell'Insubria
Medication Associated Metallic Taste , Dysgeusia
Determination of the Safety and Effectiveness of an Oral Rinse in the Reduction of Medication Associated Metallic Taste
Patients taking chemotherapeutic agents often do not comply well with their dosing regiment since many of these medications cause a metallic taste in the mouth.
- Trial name
- NCT02992314
- Testing
- Metaqil™ Oral Rinse
- Where
- United States
- Volunteers
- 52 people
- Sponsor
- You First Services
Advanced / Metastatic Solid Tumor
A Study of SR-8541A (ENPPI Inhibitor) in Advanced/Metastatic Solid Tumors
This is an open-label, dose-escalation, multi-center phase 1 study evaluating the safety, tolerability, and pharmacokinetics (PK) of SR-8541A administered orally as a monotherapy or in combination with an immune checkpoint…
- Trial name
- NCT06063681
- Testing
- SR-8541A, Immune checkpoint inhibitor (ICI)
- Where
- 3 sites in Australia
- Volunteers
- 25 people
- Sponsor
- Stingray Therapeutics
Fibromyalgia
Effect of an Amino-Acid-Based Blend on Human Growth Hormone (hGH) and Fibromyalgia (FM) Symptoms
The purpose of the study is to investigate the effect of the amino acid-based blend on growth hormone levels (measured by IGF-1) and clinical symptoms in individuals with treatment-resistant FM and low-normal hGH.
- Trial name
- NCT04510181
- Testing
- amino acid-based blend
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Pekarovics, Susan, MD
Periodontitis
Change in Gingival Volume and Quality of Life Due to Initial Periodontal Therapy in Smokers
The aim of this study is to compare the dimensional changes of the gingiva due to initial periodontal therapy in non-smokers and cigarette smokers and to compare the oral health related quality of life of non-smokers and…
- Trial name
- NCT05719519
- Testing
- Initial periodontal therapy and 3D intraoral scanning
- Where
- Croatia
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Rijeka
Periodontitis
Biomarkers for Periodontitis Relapse
In this clinical study, we have collected GCF at diseased teeth and at the same time drawn blood, both before and at 3, 6 and 12 months after periodontal surgical treatment.
- Trial name
- NCT04663165
- Testing
- Periodontal surgery, Regenerative periodontal surgery
- Where
- 2 sites in Sweden
- Volunteers
- 21 people
- Sponsor
- Anders Holmlund
Pruritus, Atopic Dermatitis
Study to Evaluate the Efficacy and Safety of Oral Difelikefalin as Adjunct Therapy to a Topical Corticosteroid for Moderate to Severe Pruritus in Subjects With Atopic Dermatitis
This is a two-part, multicenter, randomized, double-blind study to evaluate the efficacy and safety of oral difelikefalin as adjunct therapy to a topical corticosteroid (TCS) for moderate-to-severe pruritus in adult subjects with…
- Trial name
- KIND-1 (NCT05387707)
- Testing
- difelikefalin 0.25 mg, difelikefalin 0.5 mg, TCS Cream
- Where
- 61 sites in United States
- Volunteers
- 287 people
- Sponsor
- Cara Therapeutics, Inc.
Residual Disease, Aggressive Periodontitis
Omega-3 Fatty Acids Plus Low-dose Aspirin Daily Supplementation in Surgical Therapy to Treat Aggressive Periodontitis
The aim of this randomized controlled clinical trial of superiority will be to evaluate the effect of 3 g of omega-3 polyunsaturated fatty acids and 100 mg of aspirin daily supplementation over a period of 180 days as adjunct to…
- Trial name
- NCT03093207
- Testing
- Open flap debridement, Omega-3 polyunsaturated fatty acids, Aspirin
- Where
- Brazil
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Universidade Estadual Paulista Júlio de Mesquita Filho
Periimplantitis
Evaluatıon of TREM-1, MMP-8 and TIMP-1 Levels in Perı-Implant Crevicular Fluıd of Perı-Implanted Indıvıduals
The aim of this study was to evaluate the relationship between Triggering Receptor Expressed on Myeloid Cells-1 (TREM-1), Matrix Metalloproteinases-8 (MMP-8) and Tissue Inhibitors of Metalloproteinases-1 (TIMP-1) levels in…
- Trial name
- NCT07379892
- Testing
- Collection of PICF samples
- Where
- Turkey (Türkiye)
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Aydin Adnan Menderes University
Crohns Disease
Oral N-acetylglucosamine in Crohn's Disease
Protein glycosylation is a critical post-translational modification that regulates protein trafficking and protein-protein interactions impacting a host of physiological processes.
- Trial name
- NAGIC (NCT07225998)
- Testing
- N-Acetylglucosamine (GlcNAc)
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Johns Hopkins University
Dry Eye, Sjogren's Syndrome
Pilot Study for Testing Safety of Repetitive Magnetic Stimulation for Treatment of Dry Eye
The study aims to test the safety of Repetitive Magnetic Stimulation (RMS) treatment for dry eye disease. Patients are asked to undergo a one-time treatment with Epitech Ocular Magnetic Stimulation Device on one eye in the first…
- Conditions
- Dry Eye, Sjogren's Syndrome, Aqueous Tear Deficiency, Meibomian Gland Dysfunction
- Trial name
- NCT03012698
- Testing
- Ocular Repetitive Magnetic Stimulation (RMS) treatment
- Where
- 3 sites in Israel
- Volunteers
- 29 people
- Sponsor
- Epitech Mag Ltd.
Pneumonia, Pneumocystis Carinii, HIV Infections
A Study of Trimetrexate in the Treatment of Pneumocystis Carinii Pneumonia (PCP) in Patients With AIDS Not Previously Treated for PCP
To evaluate the safety and effectiveness of trimetrexate (TMTX) given at increasing doses along with the leucovorin calcium (LCV) for treating Pneumocystis carinii pneumonia (PCP) in AIDS patients TMTX is an experimental new drug…
- Trial name
- NCT00000998
- Testing
- Trimetrexate glucuronate, Leucovorin calcium
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Anxiety Disorders
Bioequivalence Study of Paroxetine and PAXIL Under Fasting Conditions in Healthy Mexican Participants
This study will be conducted to evaluate and compare the single oral dose bioavailability of Paroxetine manufactured by GlaxoSmithKline (GSK) Pharmaceuticals S.A. for GlaxoSmithKline México, S.A. de C.V.
- Trial name
- NCT04311463
- Testing
- Paroxetine hydrochloride, PAXIL (Paroxetine hydrochloride )
- Where
- Mexico
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Anatomic Stage I Breast Cancer AJCC v8, Anatomic Stage IA Breast Cancer AJCC v8
RBX7455 Before Surgery for the Treatment of Operable Breast Cancer
This clinical trial studies the side effects and possible benefits of RBX7455 given before surgery in treating patients with breast cancer that can be removed by surgery (operable).
- Conditions
- Anatomic Stage I Breast Cancer AJCC v8, Anatomic Stage IA Breast Cancer AJCC v8, Anatomic Stage IB Breast Cancer AJCC v8, Anatomic Stage II Breast Cancer AJCC v8
- Trial name
- NCT04139993
- Testing
- Microbiota-based Formulation RBX7455
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Mayo Clinic
Transgender Individuals
Effects of Gender-Affirming Hormone Therapy on Cardiovascular, Metabolic, and Mental Health Outcomes in Transgender Adults.
The objective of this observational study is to examine the impact of gender-affirming hormone therapy (GAHT) on mood in transgender individuals and to explore its potential association with early atherosclerotic processes.
- Trial name
- NCT07394400
- Where
- Spain
- Volunteers
- 94 people, healthy volunteers welcome
- Sponsor
- Milagros Rocha Barajas
Peri-Implant Health, Peri Implant Mucositis
Impact of Smoking on Immune Responses in Peri-implant Health and Disease
Peri-implant diseases are inflammatory conditions affecting the gums and bone around dental implants. Peri-implant mucositis causes inflammation in the gums, while peri-implantitis can also lead to bone loss and, in severe cases…
- Conditions
- Peri-Implant Health, Peri Implant Mucositis, Peri-implantitis
- Trial name
- NCT07750171
- Where
- Turkey (Türkiye)
- Volunteers
- 216 people, healthy volunteers welcome
- Sponsor
- Gazi University
Trigeminal Neuralgia
The Alternative Effects of Electroacupuncture in the Treatment of Trigeminal Neuralgia
Trigeminal neuralgia (TN), characterized by its refractory nature and recurrence, frequently leads to anxiety, depression, and insomnia, thereby significantly diminishing patients' quality of life and potentially inducing…
- Trial name
- NCT06977932
- Testing
- Carbarmazepine, Electroacupuncture
- Volunteers
- 126 people
- Sponsor
- Yuanyuan Wu
Retinitis, Behcet's Syndrome
Stem Cell Transplantation in Ocular Lesions of Behcet's Disease
The purpose of this study is to find if autologous stem cell transplantation can stop the progression of intractable eye lesions of Behcet's Disease or even to improve it.
- Trial name
- NCT00550498
- Testing
- Autologous Stem Cell Transplantation
- Where
- Iran
- Volunteers
- 5 people
- Sponsor
- Tehran University of Medical Sciences
Post-osseointegration Biological Failure of Dental Implant, Alveolar Bone Loss
The Influence of Mucosal Tissue Thickness on Soft and Hard Tissue Changes Around Implants
Crestal bone and soft tissue stability around implants is an important issue in implant dentistry. Initial vertical mucosal tissue thickness was shown to be one of the factors having impact on bone stability.
- Trial name
- NCT02580721
- Testing
- Dentsply Astra Tech Implant System EV
- Where
- Turkey (Türkiye)
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Cukurova University
Cancer Screening, Oral Cancer
Application and Validation of a Smartphone-based Deep Learning System for Oral Potentially Malignant Disorders and Oral Cancer Screening
The goal of this clinical trial is to learn if smartphone-based deep learning system works to accurately detect oral potentially malignant disorders and oral cancer in adults.
- Conditions
- Cancer Screening, Oral Cancer, Oral Potentially Malignant Disorders
- Trial name
- NCT06862414
- Testing
- Smartphone-based deep learning system
- Where
- Taiwan
- Volunteers
- 954 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
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