Clinical trials: Mouth Diseases
SARS-CoV-2, COVID-19
The Efficacy of Pre-procedural Mouth Rinses on COVID-19 Saliva Viral Load
Preoperative antiseptic mouth rinses have been widely used as a standard protocol before routine dental treatment reduces oral microorganism counts.
- Conditions
- SARS-CoV-2, COVID-19, Mouthwashes, Viral Load
- Trial name
- NCT04721457
- Testing
- Distilled Water, 1% Povidone Iodine (PVP-I), 1.5% Hydrogen Peroxide (H2O2)
- Where
- Saudi Arabia
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- King Abdulaziz University
Periodontitis, Biomarker in Early Diagnosis
Discovery and Validation of Periodontitis Biomarkers
Periodontitis is a major public health issue in China: it is responsible for loss of masticatory function in 60 million older adults, and 400-500 million adults are on the same disease trajectory.
- Conditions
- Periodontitis, Biomarker in Early Diagnosis, Saliva
- Trial name
- NCT07293481
- Testing
- Diagnostic procedures
- Where
- China
- Volunteers
- 228 people, healthy volunteers welcome
- Sponsor
- Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University
Primary Biliary Cirrhosis, Autoimmune Hepatitis
Oral Budesonide in the Treatment of Patients With Primary Biliary Cirrhosis and Overlap Features of Autoimmune Hepatitis
The purpose of the study is to find out the effects Budesonide, 9 mg daily for one year, has on patients with Primary Biliary Cirrhosis with features of autoimmune hepatitis.
- Trial name
- PBC (NCT00587119)
- Testing
- Budesonide
- Sponsor
- Mayo Clinic
Gingival Recession
A Clinical Trial Testing Root Coverage With Acellular Dermal Matrix in Thin and Thick Gingival Biotypes
Gingival recession is a common defect among the American population. It is also a major cause for root decay, hypersensitivity, contributes to tooth mobility and low self-esteem.
- Trial name
- NCT03057730
- Testing
- Acellular Dermal Matrix
- Where
- United States
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Tufts University
Child Allergy, IgE-Mediated Allergic Process
Observatory of the Lille Paediatric Allergy Unit
The goal of this study is to set up a paediatric observatory within the allergology department of The saint Vincent Hospital, Lille.
- Conditions
- Child Allergy, IgE-Mediated Allergic Process, Food Allergy
- Trial name
- PAUL (NCT06634992)
- Testing
- Oral immunotherapy
- Where
- France
- Volunteers
- 1,000 people
- Sponsor
- Lille Catholic University
Edentulous; Alveolar Process, Atrophy
Bone Healing at Non-submerged Implants Installed With Different Insertion Torques.
The objective of the study is to evaluate histomorphometrically the healing at implants installed with standard or very low insertion torque values.
- Trial name
- NCT04017156
- Testing
- implant installation
- Where
- Colombia
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- ARDEC Academy
Parkinson's Disease
Parcopa Versus Carbidopa-levodopa in a Single Dose Cross-over Comparison Study
To find out if a single dose of Parcopa®, a form of levodopa that dissolves in your mouth, works faster than regular oral levodopa which is swallowed, in fluctuating PD patients.
- Trial name
- NCT00590122
- Testing
- Parcopa, carbidopa-levodopa (Sinemet)
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Baylor College of Medicine
Ventilator Associated Pneumonia, Tracheobronchitis
Effect of Chlorhexidine-Induced Oral Care on Ventilator-Related Some Respiratory System Complications
Ventilator-associated pneumonia and ventilator-associated treakeabronchitis in respiratory tract infections associated with ventilator are common infections in intensive care unit and cause significant morbidity, mortality and…
- Trial name
- NCT04505202
- Testing
- 0.12% chlorhexidine gluconate
- Where
- Turkey (Türkiye)
- Volunteers
- 57 people, healthy volunteers welcome
- Sponsor
- Karabuk University
Head and Neck Cancer
Vaccine Therapy in Treating Patients With Head and Neck Cancer
RATIONALE: Vaccines made from a person's dendritic cells mixed with peptides may help the body build an effective immune response to kill tumor cells.
- Trial name
- NCT00404339
- Testing
- mutant p53 peptide pulsed dendritic cell vaccine, tetanus toxoid helper peptide, adjuvant therapy
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- Robert Ferris
Periodontitis
Oral Gel Containing PHTALOX® as an Adjuvant in the Treatment of Periodontal Disease
Periodontitis, a chronic inflammatory condition of the periodontal tissues, impacts not only the patient's oral and systemic health but also has significant social and economic implications.
- Trial name
- NCT06731777
- Testing
- Scaling and root planing plus PHTALOX® oral gel vehicle, Scaling and root planing plus 0.12% chlorhexidine oral gel, Scaling and root planing plus PHTALOX® oral gel
- Where
- Brazil
- Volunteers
- 45 people
- Sponsor
- Universidade Federal de Alfenas
Burning Mouth Syndrome
Study Evaluating the Laser Diode Effect Burning Mouth Syndrome
The aim of this study was to report the effect of laser diode on the treatment of burning mouth syndrome (BMS) Patients were randomly allocated to two different groups: the first one (group A) underwent Laser diode whereas the…
- Trial name
- laser (NCT02757612)
- Testing
- laser diode
- Where
- Spain
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Universidad de Murcia
Fasting
Bioequivalence Study of Etodolac Capsules USP 300 mg Under Fasting Condition
This is a open Label, balanced, randomized, single dose, two-treatment, two-sequence, two-period, crossover pivotal study. The purpose of this study is to assess the bioequivalence between Test Product and the corresponding…
- Trial name
- NCT01746719
- Testing
- Etodolac Capsules USP 300 mg, Etodolac
- Where
- India
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- IPCA Laboratories Ltd.
Acne Vulgaris
A Study to Compare Efficacy and Safety of Trifarotene Cream When Used With an Oral Antibiotic for the Treatment of Severe Acne Vulgaris (AV)
The purpose of this study was to demonstrate that daily use of topical trifarotene (CD5789) 50 microgram per gram (mcg/g) cream when used in association with oral antibiotic is safe and effective for the treatment of severe AV.
- Trial name
- DUAL (NCT04451330)
- Testing
- Trifarotene cream, Doxycycline hyclate, Trifarotene Vehicle
- Where
- 26 sites in United States, Puerto Rico
- Volunteers
- 202 people
- Sponsor
- Galderma R&D
Dental Anxiety of Hearing Impairment
Effectiveness of Virtual Reality vs Show-Do Technique on Dental Anxiety in Children With Hearing Impairment
This randomized controlled clinical trial aims to compare the effectiveness of virtual reality (VR) eyewear used as a distraction method in combination with the Show-Do (SD) technique versus the traditional Show-Do technique…
- Trial name
- NCT07245030
- Testing
- virtual reality distraction, show-do technique
- Where
- Egypt
- Volunteers
- 54 people
- Sponsor
- October University for Modern Sciences and Arts
Type 2 Diabetes Mellitus
Efficacy and Safety of the Insulin Glargine/Lixisenatide Fixed Ratio Combination (LixiLan) to Insulin Glargine Alone on Top of Oral Anti-diabetic Drugs (OADs) With Type 2 Diabetes in Japan
Primary Objective: To compare LixiLan to insulin glargine in glycated hemoglobin (HbA1c) change from baseline to Week 26 in patients with type 2 Diabetes.
- Trial name
- LIXILAN JP-O2 (NCT02752828)
- Testing
- Insulin glargine/lixisenatide (HOE901/AVE0010), Insulin glargine (HOE901), Oral anti-diabetic drugs
- Where
- 113 sites in Japan
- Volunteers
- 521 people
- Sponsor
- Sanofi
Type 2 Diabetes Mellitus
Study of LX4211 in Subjects With Type 2 Diabetes Mellitus
The purpose of this study is to evaluate the safety, tolerability, and efficacy of LX4211 versus a placebo control in subjects with type 2 diabetes mellitus.
- Trial name
- NCT00962065
- Testing
- LX4211 Low Dose, LX4211 High Dose
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- Lexicon Pharmaceuticals
Allergic Contact Dermatitis
Red Grape Polyphenol Oral Administration to Women Affected by Nickel-mediated Allergic Contact Dermatitis
Nickel (Ni)-mediated allergic contact dermatitis (ACD) is a very common disease worldwide. Our previous findings demonstrated that in vitro supplementation of polyphenols, extracted from seeds of red grape (Nero di Troia…
- Trial name
- Grapolyphen (NCT03902392)
- Testing
- NaturOx Group (A)
- Where
- Italy
- Volunteers
- 50 people
- Sponsor
- University of Bari
Inferior Alveolar Nerve Injuries, Impacted Third Molar Tooth
The Impact of 3D-CBCT Imaging on Nerve Injuries During Wisdom Tooth Surgery
The investigators aim to investigate if the additional information available from a 3D scan of the wisdom tooth can reduce the risk of nerve injury during wisdom tooth surgery compared to conventional 2D images.
- Trial name
- IMPACTION (NCT06261853)
- Testing
- 3D-CBCT, 2D-OPG
- Where
- 2 sites in United Kingdom
- Volunteers
- 1,292 people
- Sponsor
- University of Aberdeen
Gingival Recessions
Influence of Keratinized Tissue Width and Attached Gingiva Width on Root Coverage in Patients With Recession Defects: A Prospective Clinical Study
To evaluate the association between the width of keratinized tissue and attached gingiva with root coverage outcomes in RT1 gingival recession defects of maxillary and mandibular anterior teeth treated with subepithelial…
- Trial name
- NCT07576439
- Testing
- Vestibular incision subperiosteal tunnel access with connective tissue graft in treating RT 1 gingival recession defects
- Where
- India
- Volunteers
- 30 people
- Sponsor
- Postgraduate Institute of Dental Sciences Rohtak
Periodontal Diseases, Wound Heal
Hyaluronic Acid and Polynucleotides for Supra-bony Defects
The goal of this pilot study is to describe the early wound healing molecular events and the vascularization pattern associated with the treatment of supra-bony defects with access flap alone or in association with a combined…
- Conditions
- Periodontal Diseases, Wound Heal, Periodontal Inflammation, Periodontal Pocket
- Trial name
- NCT06309719
- Testing
- Periodontal Access Flap (AF) + Combined Formulation of Hyaluronic acid and Polydeoxyribonucleotides (PNHA), Periodontal Access Flap (AF)
- Where
- 2 sites in United Kingdom
- Volunteers
- 24 people
- Sponsor
- Queen Mary University of London
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