Clinical trials: Mouth Diseases
Denture Stomatitis
Surface Roughness of Heat Cured Acrylic Resin Versus Acrylic Resin With Titanium Dioxide
Measurement of surface roughness of tow different material of denture base to find out which material is more hygienic by decreasing the amount of bacterial accumulation.
- Trial name
- NCT02950584
- Testing
- Titanium dioxide denture, Rapid heat denture
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Cairo University
Hepatitis C Viral
Oral Microbiome of Patients With Hepatitis C Virus Infection
Hepatitis C virus (HCV) infection is very common in Egypt and the middle east. The disease affects multiple body organs and may proceed to hepatocellular carcinoma.
- Trial name
- NCT03682549
- Testing
- Oral microbiome analysis
- Where
- Egypt
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Cairo University
Mouth Neoplasms
Vitamin D Plus Celecoxib Therapy to Stimulate Intratumoral Immune Reactivity
The poor survival of Veterans with oral cancer underscores the significance of identifying new treatment approaches. The proposed studies will test a new 2 pronged immunotherapeutic approach for oral cancer patients which lessen…
- Trial name
- NCT00953849
- Testing
- Celecoxib, Calcitriol, Celecoxib plus Calcitriol
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- VA Office of Research and Development
Asthma
Systemic Corticosteroids Avoidance Study in Severe Asthma Patients
The overall purpose of this study was to determine the efficacy of fevipiprant (150 mg and 450 mg once daily), compared with placebo, as add-on to standard-of-care asthma therapy, in terms of avoidance of corticosteroid use over…
- Trial name
- NCT03629249
- Testing
- QAW039 150 mg once daily, QAW039 450 mg once daily
- Where
- 120 sites in United States, Argentina and 19 more
- Volunteers
- 604 people
- Sponsor
- Novartis Pharmaceuticals
Thalassemia, Iron Overload
Oral Nifedipine to Treat Iron Overload
This study will determine if nifedipine, a medication used to treat high blood pressure, can help treat iron overload, a condition in which the body contains too much iron.
- Conditions
- Thalassemia, Iron Overload, Hemochromatosis
- Trial name
- NCT00712738
- Testing
- Nifedipine, Phlebotomy, Urinalysis
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Schizophrenia
A Long-term, Extended Treatment Study of Aripiprazole in Pediatric Patients With Schizophrenia
The objective of this study is to investigate the safety and efficacy of aripiprazole (initial dose 2 mg/day, maintenance dose 6-24 mg/day, maximum dose 30 mg/day) orally administered over a period of 52 weeks in subjects who…
- Trial name
- NCT01942148
- Testing
- Aripiprazole
- Where
- 8 sites in Japan
- Volunteers
- 68 people
- Sponsor
- Otsuka Pharmaceutical Co., Ltd.
Mouth, Edentulous
Conventionally vs. Digitally Fabricated Complete Dentures: Clinical Treatment Outcome Differences
Purpose: To compare complete denture outcomes between conventional and digital denture fabrication processes. Participants: Sixteen edentulous adult patients in the University of North Carolina School of Dentistry Student Clinic…
- Trial name
- NCT02521935
- Testing
- Complete traditional dentures, Complete CADCAM dentures
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Plaque Induced Gingivitis
Plaque and Gingivitis Evaluation of a U-Shaped Toothbrush in a 30-Day Model
The objective of this 30 day, randomized, two group, parallel, examiner-blind clinical trial is to assess the safety and efficacy of AutoBrush® 360° U-shaped Sonic Toothbrush on plaque and gingivitis, compared to an American…
- Trial name
- NCT06122376
- Testing
- U-shaped Power Toothbrush, Soft Manual Toothbrush
- Where
- United States
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Lander Enterprises, LLC
Carious and Non-carious Lesions of the Teeth
Comparative Evaluation of Dental Disease Prevention Programs
Relevance. The dental health of the Chapaevsk children's population and the risk factors for dental caries and periodontal disease were well studied in 1995-2009.
- Trial name
- NCT05767281
- Testing
- prevention program
- Where
- Russia
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Samara State Medical University
Fibromyalgia
Effect of an Amino-Acid-Based Blend on Human Growth Hormone (hGH) and Fibromyalgia (FM) Symptoms
The purpose of the study is to investigate the effect of the amino acid-based blend on growth hormone levels (measured by IGF-1) and clinical symptoms in individuals with treatment-resistant FM and low-normal hGH.
- Trial name
- NCT04510181
- Testing
- amino acid-based blend
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Pekarovics, Susan, MD
Trigeminal Neuropathy
Erenumab-aooe for the Management of Trigeminal Neuropathic Pain.
This study is a single center, placebo-controlled, double blind, randomized, phase II pilot to evaluate the efficacy of erenumab-aooe in the management of trigeminal neuropathic pain comparing erenumab-aooe vs Placebo.
- Trial name
- NCT05142228
- Testing
- Erenumab-Aooe
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- University of Maryland, Baltimore
Atrial Fibrillation, Stroke
AI-Assisted Workflow for Occult Atrial Fibrillation Detection After Ischemic Stroke: A Prospective Randomized Trial
We hypothesize that an AI-guided AF risk stratification approach, particularly when combined with intensified rhythm monitoring using wearable devices and extended ECG patches, will significantly increase AF detection rates…
- Conditions
- Atrial Fibrillation, Stroke, Artificial Intelligence
- Trial name
- AI-AFIS (NCT07540065)
- Testing
- Active Follow-up Group, Standard Follow-up Group
- Where
- Taiwan
- Volunteers
- 400 people
- Sponsor
- National Taiwan University Hospital
Gingival Recession, Localized
Assessment of Gingival Health Following Rubber-Dam Isolation
The aim of this study is to evaluate the effect of retraction techniques on gingival health. Four different method (212 clamp (Hu-Friedy, USA); Brinker B4 clamp (Coltene Hygenic, USA); dental floss using the simple knot tie…
- Trial name
- NCT05850065
- Testing
- Hu-Friedy 212 clamp, dental floss using the simple knot tie method, Coltene B4 clamp
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Marmara University
Arthritis, Rheumatoid
A Study Of The Taste Of Different Oral Liquid Preparations Of CP-690,550 In Trained Adult Product Testers
This study will test the palatability of several different CP-690,550 oral preparations in trained product tester healthy volunteers.
- Trial name
- NCT01023100
- Testing
- CP 690,550 oral solutions
- Where
- United States
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- Pfizer
Jaw, Edentulous
Multicenter Study to Evaluate the Clinical Outcome of the OmniTaper EV Implant in Single Tooth Restorations
This clinical study, funded by the company Dentsply Sirona, is being carried out to see if the newly developed tooth implant "OmniTaper EV" is safe, effective and functions as intended when replacing a lost or removed tooth.
- Trial name
- NCT05355792
- Testing
- OmniTaper EV implants
- Where
- 6 sites in Germany, Switzerland and 1 more
- Volunteers
- 139 people
- Sponsor
- Dentsply Sirona Implants and Consumables
Peripheral Vascular Diseases, Cardiovascular Diseases
Warfarin and Antiplatelet Vascular Evaluation
The purpose of this study is to evaluate whether the addition of warfarin (a blood-thinning medication) to an antiplatelet therapy like aspirin is better than antiplatelet therapy alone (i.e.
- Trial name
- NCT00125671
- Testing
- Warfarin
- Where
- Canada
- Volunteers
- 2,400 people
- Sponsor
- Anand, Sonia, M.D.
Behçet
Role of Femoral Vein Wall Thickness and Inflammatory Markers in Patients With Behcet Disease
Evaluation of femoral vein wall thickness and inflammatory indices in patients with Behcet disease and assessment of their relation to the disease activity and related some clinical manifestations
- Trial name
- NCT06721234
- Where
- Egypt
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Sohag University
Smoking, Periodontitis
The Effect of Smoking and Non-surgical Periodontal Treatment on Gingival Crevicular Fluid Cyclophilin A and EMMPRIN Levels
This study aimed to investigate the effect of smoking and non-surgical periodontal treatment on gingival crevicular fluid CyPA and EMMPRIN levels in patients with periodontitis.
- Conditions
- Smoking, Periodontitis, Non-surgical Periodontal Treatment
- Trial name
- NCT04430764
- Testing
- non-surgical periodontal treatment
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- Ege University
PreDiabetes, Diabetes Mellitus, Type 2
Oral Endocannabinoids in People With Prediabetes and Diabetes
This study evaluates the relationship of endocannabinoids in saliva with inflammation and oral dysbacteriosis present in people with periodontal disease and prediabetes/type 2 diabetes
- Conditions
- PreDiabetes, Diabetes Mellitus, Type 2, Obesity, Oral Dysbiosis
- Trial name
- SMILE (NCT06040164)
- Testing
- Observational study
- Volunteers
- 60 people
- Sponsor
- Fundación Pública Andaluza para la Investigación de Málaga en Biomedicina y Salud
Hypercholesterolaemia
Bioequivalence Study of Bempedoic Acid 180 mg Film Coated Tablet and Nilemdo® (Bempedoic Acid) 180 mg Film-coated Tablets
Single dose oral bioequivalence study of Bempedoic Acid 180 mg Film Coated Tablet and Nilemdo® (Bempedoic Acid) 180 mg Film-coated tablets in healthy adult human subjects under fasting conditions.
- Trial name
- NCT07170852
- Testing
- Bempedoic acid film coated tablet, Nilemdo® Film-coated tablets
- Where
- India
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Humanis Saglık Anonim Sirketi
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