Clinical trials: Movement, Abnormal, open to volunteers
Ataxia Telangiectasia
Safety and Efficacy of Mutation-targeted Precision Genetic Therapy for Ataxia-Telangiectasia (A-T)
This project aims to evaluate the safety and efficacy of precision genetic therapy for patients with Ataxia-telangiectasia (A-T), a rare neurodegenerative disease caused by mutations in the ATM gene.
- Trial name
- NCT07215416
- Testing
- Antisense oligonucleotide targeting the ATM gene
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Timothy Yu
Spinocerebellar Ataxia - All Sub-types
Evaluation of the Safety and Preliminary Efficacy of Neuroinduced Mesenchymal Stem Cells and Exosome Therapy in Patients With Spinocerebellar Palsy
This clinical study aims to evaluate the safety and preliminary therapeutic potential of mesenchymal stem cell-derived therapies in patients diagnosed with spinocerebellar palsy.
- Trial name
- NEURO-SCP (NCT07467733)
- Testing
- Intrathecal infusion, Intranasal infusion
- Where
- Poland
- Volunteers
- 90 people
- Sponsor
- Biocells Medical
Movement Disorder, Tremor
Natural History Protocol for Movement Disorders
Background: A movement disorder is a condition that causes a person s body to move in ways that are not normal. There are different types. Some disorders cause movements people can t control, such as tics or shaking.
- Conditions
- Movement Disorder, Tremor, Parkinson's Disease
- Trial name
- NCT05413291
- Where
- United States
- Volunteers
- 4,000 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Risk Behavior, Agitation
Detection of Risk Behaviors: Pilot Observational Study With Bedridden and Agitated Patients.
There is a risk of falls and injuries in bedridden hospitalized patients, increased in agitated or confused patients. In neurosurgery departments, brain damaged patients can present a loss of consciousness of risky behaviors and…
- Conditions
- Risk Behavior, Agitation, Hospitalization, Bedridden Patients
- Trial name
- DECORIPAA (NCT05522647)
- Where
- France
- Volunteers
- 20 people
- Sponsor
- University Hospital, Clermont-Ferrand
Ataxia
Can Acute Photobiomodulation Improve Balance and Cognition in Individuals With Ataxia: a Pilot Feasibility Placebo Randomized Controlled Trial.
Cerebellar ataxias cause progressive impairments in balance, gait coordination, motor timing, and cognitive functions such as attention and executive control (Buckner, 2013; Salmi et al., 2010; Timmann \& Daum, 2007).
- Trial name
- NCT07296068
- Testing
- Photobiomodulation
- Where
- United Kingdom
- Volunteers
- 20 people
- Sponsor
- University of Central Lancashire
Bradykinesia, Parkinson Disease
prTMS as an Intervention for Bradykinesia in Parkinson's Disease
This study investigates the use of patterned repetitive transcranial magnetic stimulation (prTMS) as an intervention for bradykinesia in Parkinson's Disease (PD).
- Trial name
- ADAPT-BK (NCT07397377)
- Testing
- Active patterned repetitive transcranial magnetic stimulation (prTMS)
- Where
- Denmark
- Volunteers
- 27 people
- Sponsor
- Danish Research Centre for Magnetic Resonance
Spinocerebellar Ataxia
Effects of Oral Administration of Antrodia Cinnamomea Products for Clinical Symptoms in Spinocerebellar Ataxia Patients
This study aims to assess the effect of Antrodia cinnamomea on clinical symptoms in spinocerebellar ataxia patients. To investigate the advancements in neurodegenerative diseases.
- Trial name
- NCT06633003
- Testing
- Antrodia cinnamomea Products
- Where
- Taiwan
- Volunteers
- 60 people
- Sponsor
- ALPS Biotech CO. LTD
Parkinson Disease, Essential Tremor
Clinical Outcomes for Deep Brain Stimulation
The object of this study is to longitudinally collect clinical outcomes of patients receiving deep brain stimulation for movement disorders with the objective of making retrospective comparisons and tracking of risks, benefits…
- Conditions
- Parkinson Disease, Essential Tremor, Dystonia
- Trial name
- NCT03992625
- Testing
- Deep Brain Stimulation
- Where
- United States
- Volunteers
- 1,000 people
- Sponsor
- Washington University School of Medicine
Tardive Dyskinesia, Repetitive Transcranial Magnetic Stimulation
Single-Center, Double-Blind, Randomized, Placebo-Controlled Study on Efficacy and Safety of rTMS (With Precise Localization) in Relieving Motor Symptoms of TD
# Brief Summary (English Version) Tardive Dyskinesia (TD) is a hyperkinetic movement disorder induced by long-term use of dopamine receptor blockers and related drugs.
- Trial name
- NCT07173920
- Testing
- repetitive Transcranial Magnetic Stimulation
- Where
- China
- Volunteers
- 62 people
- Sponsor
- Peking University Sixth Hospital
PARKINSON DISEASE (Disorder)
Virtual tES Device Treatment for Parkinson's Disease Motor Symptoms
This study tests a new, non-invasive brain stimulation device called Sphere V3.0 to help improve movement problems in people with Parkinson's disease.
- Trial name
- NCT07182058
- Testing
- Transcranial Electrical Stimulation Device
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- U: The Mind Company
Cervical Dystonia
Effect of Vibro-tactile Stimulation Intensity on Head Posture in Cervical Dystonia
The primary goal of this clinical trial is to examine the effects of cervical vibrotactile stimulation intensity on abnormal head posture in people with cervical dystonia.
- Trial name
- (CD-VTS) (NCT07245615)
- Testing
- cervical vibrotactile stimulation
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Friedreich Ataxia
Friedreich Ataxia Global Clinical Consortium UNIFIED Natural History Study
This project is a global, multicenter, prospective, longitudinal, observational natural history study that can be used to understand the disease progression and support the development of safe and effective drugs and biological…
- Trial name
- UNIFAI (NCT06016946)
- Where
- 34 sites in United States, Australia and 15 more
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- Friedreich's Ataxia Research Alliance
Cervical Dystonia
Zinc as an Adjunctive Therapy for Cervical Dystonia
The goal of this clinical trial is to evaluate if supplemental zinc can prolong the duration of benefit of botulinum toxin injections in cervical dystonia patients receiving care at the University of Florida.
- Trial name
- NCT07140874
- Testing
- Zinc citrate
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- University of Florida
Parkinson Disease(PD)
Adaptive DBS for PD
The goal of this clinical trial is to evaluate the efficacy and safety of an adaptive deep brain stimulation (aDBS) system for managing Parkinson's disease symptoms.
- Trial name
- SMART-DBS (NCT07635823)
- Testing
- adaptive deep brain stimulation, conventional deep brain stimulation
- Where
- 9 sites in China
- Volunteers
- 60 people
- Sponsor
- Beijing Pins Medical Co., Ltd
Spinocerebellar Ataxia
The EUROSCA Natural History Study
The key goals of EUROSCA-NHS is to determine and compare the rate of disease progression in SCA1, SCA2, SCA3 and SCA6 including determination of the order and occurrence of non-ataxia symptoms, assessment of activities of daily…
- Trial name
- EUROSCA-NHS (NCT02440763)
- Where
- 16 sites in Austria, Belgium and 8 more
- Volunteers
- 400 people
- Sponsor
- Ataxia Study Group
Post Stroke Spasticity, Dystonia
Deep Anterior Cerebellar Stimulation in Treatment of Poststroke Spasticity and Motor Function Impairment.
The aim of this clinical trial is to determine whether deep brain stimulation (DBS) interventions improve rehabilitation and functional recovery in patients with post-stroke spasticity who meet the other inclusion criteria listed…
- Trial name
- NCT07190092
- Testing
- Deep brain stimulation electrode implantation with an electrode target in the dentate nucleus
- Where
- Poland
- Volunteers
- 12 people
- Sponsor
- Jan Biziel University Hospital No 2 in Bydgoszcz
Huntington Disease
Study to Evaluate Music Therapy on Irritability and Impulsivity in Patients With Huntington's Disease (MUSIC-HD)
The study is an open-label clinical trial evaluating whether music therapy combined with conventional management reduces irritability and impulsivity in 15 patients with early-stage Huntington's disease.
- Trial name
- MUSIC-HD (NCT06414967)
- Testing
- Music Intervention
- Where
- France
- Volunteers
- 15 people
- Sponsor
- Poitiers University Hospital
Irritable Bowel Syndrome, Gallstone Disease
Pharmacokinetics, Bioequivalence, and Safety Study of Trimedat® 76,95 mg Orally Disintegrating Tablets and Trimedat® 100 mg Tablets in Healthy Volunteers.
This study aims to evaluate pharmacokinetic profile, safety and establish bioequivalence of the investigational drug Trimedat® 76,95 mg orally disintegrating tablets compared to the reference drug Trimedat® 100 mg tablets in…
- Conditions
- Irritable Bowel Syndrome, Gallstone Disease, GERD, Biliary Dyskinesia
- Trial name
- NCT07421011
- Testing
- Trimedat®
- Where
- Russia
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Valenta Pharm JSC
Dementia
Individualized Music Playlist Based on ISO Principle for De-escalation of Agitation in Dementia
The goal of this clinical trial is to evaluate the efficacy of an Individualized Music Playlist (InMP) composed of preferred music genres sequenced according to the ISO-Principle, for the immediate de-escalation of agitation in…
- Trial name
- NCT06104436
- Testing
- Individualized music playlist, Preferred music, Usual care
- Where
- Hong Kong
- Volunteers
- 81 people
- Sponsor
- The Hong Kong Polytechnic University
Huntington Disease
Gut Microbiomes in HD
The purpose of this study is to find out if there is a connection between the naturally occurring bacteria in our bodies and the progression of Huntington disease.
- Trial name
- NCT06448546
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- University of Central Florida