Clinical trials: Movement; Disorder, Treatment-Induced
Tardive Dyskinesia
Pyridoxal Kinase Activity in Tardive Dyskinesia
Objectives: The mechanisms of tardive dyskinesia (TD) remain unclear, although pathophysiologic theories have proposed mechanisms such as dopamine receptor supersensitivity, the degeneration of cholinergic striatal interneurons…
- Trial name
- NCT01908452
- Testing
- Pyridoxine
- Where
- 3 sites in Israel
- Sponsor
- Beersheva Mental Health Center
Tardive Dyskinesia
Treatment of Tardive Dyskinesia With Galantamine
Tardive dyskinesia (TD), a form of movement disorder, remains a problem for some patients who received antipsychotic medications.
- Trial name
- NCT00164242
- Testing
- Galantamine
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- Caroff, Stanley N., M.D.
Stroke
CIMT Versus HABIT in Late Sub-Acute Post-Stroke Rehabilitation
This study will compare the effects of Constraint Induced Movement Therapy and Hand-Arm Bimanual Intensive Training on upper extremity function in late sub-acute post-stroke patients. It will be a randomized controlled trial.
- Trial name
- CIMT-HABIT (NCT07626554)
- Testing
- Constraint Induced Movement Therapy, Hand-Arm Bimanual Intensive Training
- Where
- Pakistan
- Volunteers
- 34 people
- Sponsor
- Riphah International University
Rehabilitation, Recovery of Function
Constraint-induced Movement Therapy to Improve Gait and Mobility of People With Chronic Stroke
The purpose of this single-subject, concurrent mixed methods study is to investigate the relationship between the effect of the CIMT protocol on gait and mobility and participants' and caregivers' expectations and perceptions…
- Conditions
- Rehabilitation, Recovery of Function, Stroke, Lower Extremity Paresis
- Trial name
- NCT03114046
- Testing
- Lower extremity Constraint-induced movement therapy(LE-CIMT)
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- University of Alabama at Birmingham
Cerebral Palsy, Congenital
CIMT and BIMT Affect Functional Outcome in CP
The aim of this randomized controlled trial is to determine the effects of constraint induced movement therapy CIMT and BIM bimanual activities on functional outcome in hemiplegic CP.
- Trial name
- NCT04211623
- Testing
- Constraint induced movement therapy, Bimanual activities
- Where
- Pakistan
- Volunteers
- 38 people
- Sponsor
- Riphah International University
Stroke
Enhancing Participation of Chronic Stroke Patients by Constraint Induced Movement Therapy (HOMECIMT)
The aim of this study is to evaluate the efficacy of a modified approach of constraint induced movement therapy ("CIMT at home") for chronic stroke patients, compared to conventional physiotherapy and occupational therapy…
- Trial name
- HOMECIMT (NCT01343602)
- Testing
- mod. Constraint-Induced Movement Therapy, Therapy as usual
- Where
- Germany
- Volunteers
- 156 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Stroke, Stroke Rehabilitation
COMPERATIVE EFFECTS of CONSTRAINT- INDUCED MOVEMENT THERAPY and MIRROR THERAPY on FUNCTIONAL AMBULATION and QUALITY of LIFE in CHRONIC STROKE PATIENTS
Stroke is a global health issue as this happens when the blood flow to the brain is disrupted or reduced, depriving the brain tissue of sugar and oxygen.
- Conditions
- Stroke, Stroke Rehabilitation, Mirror Therapy, Quality of Life (QOL)
- Trial name
- NCT06807814
- Testing
- Constraint-Induced Movement Therapy (CIMT)), Mirror Therapy
- Where
- Pakistan
- Volunteers
- 56 people
- Sponsor
- University of Lahore
Hemiparesis, Cerebral Palsy
Children With Hemiparesis Arm and Hand Movement Project (CHAMP Study)
What is the CHAMP Study? The CHAMP Study is a multisite clinical trial funded by the National Institutes of Health that is comparing the efficacy of alternative therapies for young children with unilateral spastic cerebral palsy…
- Conditions
- Hemiparesis, Cerebral Palsy, Brain Injury
- Trial name
- CHAMP (NCT01895660)
- Testing
- Variations in Pediatric Constraint-Induced Movement Therapy (P-CIMT) versus usual and customary rehabilitation
- Where
- United States
- Volunteers
- 124 people
- Sponsor
- Virginia Polytechnic Institute and State University
Tardive Dyskinesia, Intellectual Disability
Deutetrabenazine Treatment for Tardive Dyskinesia in Intellectual/Developmental Disabilities
The primary goal of this study is to investigate the efficacy of deutetrabenazine treatment of TD in this previously untreated patient population.
- Conditions
- Tardive Dyskinesia, Intellectual Disability, Developmental Disabilities
- Trial name
- TD-AIDD (NCT06997198)
- Testing
- Deutetrabenazine Oral Capsule
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- University Hospitals Cleveland Medical Center
Levodopa Induced Dyskinesia in Patients With Parkinson's Disease
A Feasibility Study to Evaluate Safety and Initial Effectiveness of ExAblate Transcranial MR Guided Focused Ultrasound for Unilateral Pallidotomy in the Treatment of Dyskinesia of Parkinson's Disease
The proposed study is to evaluate the safety and initial effectiveness of the ExAblate Transcranial MRI-guided focused ultrasound (MRgFUS) treatment of patients with dyskinesia of Parkinson's Disease (PD) Safety: To evaluate the…
- Trial name
- NCT02003248
- Testing
- transcranial magnetic resonance guided focused ultrasound pallidotomy
- Where
- South Korea
- Volunteers
- 10 people
- Sponsor
- Yonsei University
Mania, Parkinson Disease
Deep Brain Stimulation-Induced Mania in Parkinson's Disease
Parkinson's Disease (PD) is a common and debilitating neurodegenerative disease. While medication can alleviate its symptoms, not all patients will adequately respond to medical therapy.
- Trial name
- BPD_DBS (NCT05444907)
- Testing
- No Intervention / Exposure
- Where
- Portugal
- Volunteers
- 100 people
- Sponsor
- Albino Maia
Cerebral Palsy Spastic Hemiplegic
Investigation of the Effect of Constraint Induced Movement Therapy Applied to the Lower Extremity on Lower Extremity Functions in Individuals With Unilateral Cerebral Palsy
Lower extremity constraint induced movement therapy has been applied to individuals with multiple sclerosis, stroke, subacute and chronic hemiparesis in recent years and positive results have been reported.
- Trial name
- NCT06753812
- Testing
- constraint induced movement therapy, Control (Standard treatment)
- Where
- Turkey (Türkiye)
- Volunteers
- 36 people
- Sponsor
- Abant Izzet Baysal University
Cerebral Palsy
Modified Constraint Induced Movement Therapy With And Without Cross Education In Cerebral Palsy
A nonprogressive injury to the growing brain, cerebral palsy can impair a child's speech, intellectual ability, and motor development. The kind of impairment will correspond with the affected brain region.
- Trial name
- NCT06522464
- Testing
- Group A: mCIMT with cross-education, Group B: mCIMT without cross-education
- Where
- Pakistan
- Volunteers
- 22 people
- Sponsor
- Riphah International University
Stroke
Constraint Induced Movement Therapy for Walking in Individuals Post Stroke
To compare the effect of constraint induced movement therapy (CIMT) vs. treadmill training only on walking function in individuals post-stroke, a 6 week, single-blind, randomized training study will be conducted with three…
- Trial name
- NCT03264261
- Testing
- robotic training, treadmill training
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- Shirley Ryan AbilityLab
Parkinson Disease, Dyskinesia, Drug-Induced
Dipraglurant (ADX48621) for the Treatment of Patients With Parkinson's Disease Receiving Levodopa-based Therapy
This study is designed to evaluate the safety and efficacy of dipraglurant in PD patients with dyskinesia (randomized 1:1 to receive active or placebo) for 12 weeks (1 week at 150 mg per day and 11 weeks at 300 mg per day).
- Conditions
- Parkinson Disease, Dyskinesia, Drug-Induced, Dyskinesias
- Trial name
- NCT04857359
- Testing
- Dipraglurant
- Where
- 41 sites in United States
- Volunteers
- 25 people
- Sponsor
- Addex Pharma S.A.
Stroke
Efficacy of Modified Constraint-Induced Movement Therapy on the Upper Limb Function of Sub-acute Stroke Patients in Peshawar Pakistan
This RCT will also help the clinicians to provide the best treatment to their patients for better outcomes. The objective of the study is to determine the efficacy of Modified Constraint-induced movement therapy on the Upper Limb…
- Trial name
- NCT05570461
- Testing
- Modified Constraint-Induced Movement Therapy
- Where
- Pakistan
- Volunteers
- 46 people
- Sponsor
- NCS University System
Stroke, Spasticity as Sequela of Stroke
Different Treatment Methods Effect on Upper Extremity Spasticity and Decreased Functionality After Stroke
The aim of our study is to objectively and clearly determine the differences between the Spasticity and Decreased Functionality in the Upper Extremity Flexor Group Muscles After Stroke, the Vibration, mBZHT and Physiotherapy and…
- Conditions
- Stroke, Spasticity as Sequela of Stroke, Limitation, Mobility
- Trial name
- NCT05747950
- Testing
- Vibration, Modified Constraint-İnduced Movement Therapy, Conventional Therapy
- Where
- Turkey (Türkiye)
- Volunteers
- 45 people
- Sponsor
- Zuhal Şevval Gökdere
Acute Stroke
Feasibility of Constraint-induced Therapy Combined With Visual-spatial Cueing Strategy in Patients With Acute Stroke
The aim of this study is to test the feasibility of a constraint intervention combined with visual-spatial cueing strategy in patients with acute stroke to improve their daily life activities.
- Trial name
- ITHEMICAL (NCT03754166)
- Testing
- Constraint-induced movement therapy
- Where
- France
- Volunteers
- 8 people
- Sponsor
- Nantes University Hospital
Cerebrovascular Disorders
Treatment for Movement Problems in Elderly Stroke Patients
After a stroke, many patients are left with an impaired arm. Restricting the use of the good arm may improve the use of the bad arm.
- Trial name
- NCT00059696
- Testing
- Constraint-Induced Movement Therapy
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Tardive Dyskinesia
Levetiracetam Treatment of Tardive Dyskinesia
This is a placebo-controlled study designed to learn if levetiracetam is effective for tardive dyskinesia.
- Trial name
- NCT00291213
- Testing
- levetiracetam
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Yale University