Clinical trials: Movement Disorders, open to volunteers
Movement Disorder, Tremor
Natural History Protocol for Movement Disorders
Background: A movement disorder is a condition that causes a person s body to move in ways that are not normal. There are different types. Some disorders cause movements people can t control, such as tics or shaking.
- Conditions
- Movement Disorder, Tremor, Parkinson's Disease
- Trial name
- NCT05413291
- Where
- United States
- Volunteers
- 4,000 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Traumatic Brain Injury, Stroke
Long-term Brain Stimulation of the Motor Ventral Thalamus (VOP/VIM) to Improve Motor Function
This study aims to recruit patients already implanted with Deep Brain Stimulation (DBS) for movement disorders to complete tasks assessing parameters of motor output, speech, and swallowing functions, both with and without…
- Conditions
- Traumatic Brain Injury, Stroke, Brain Disease, Movement Disorders (Incl Parkinsonism)
- Trial name
- NCT07056348
- Testing
- Deep Brain Stimulation (DBS) of the Motor Thalamus
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Jorge Gonzalez-Martinez
Movement Disorders (Incl Parkinsonism), Stroke
Stimulating Specific Brain Areas (VOP/VIM) With Electricity to Improve Movement and Muscle Control
In this study the investigators aim to enroll patients scheduled to undergo deep brain stimulation (DBS) implantation for movement disorders for intra-operative testing.
- Conditions
- Movement Disorders (Incl Parkinsonism), Stroke, Traumatic Brain Injury, Brain Diseases
- Trial name
- NCT07056361
- Testing
- Direct cortical stimulation and deep brain stimulation of motor thalamus
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Jorge Gonzalez-Martinez
Multiple System Atrophy, Parkinson Variant
A Trial of ONO-2808 in Participants With the Parkinsonian Subtype of Multiple System Atrophy (MSA-P)
The main goal of this clinical trial is to learn if ONO-2808 works to treat adults with the Parkinsonian subtype of Multiple System Atrophy (MSA-P).
- Trial name
- NCT07825402
- Testing
- ONO-2808
- Volunteers
- 486 people
- Sponsor
- Ono Pharmaceutical Co., Ltd.
Neglect, Hemispatial, Stroke, Cardiovascular
Implementation of IVS3 for Upper Limb Motor Recovery
This study measures participant satisfaction and upper extremity function in outpatients with chronic stroke when exposed to the IVS3 device.
- Conditions
- Neglect, Hemispatial, Stroke, Cardiovascular, Mirror Movement, Motor Activity
- Trial name
- NCT06483230
- Testing
- Intensive Visual Stimulation Device
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Weill Medical College of Cornell University
Stroke, Spinal Cord Injuries
ZEPU-AI Series Limb Feedback Robot Training Study (ZEPUAISRCT)
The goal of this clinical trial is to learn whether robotic rehabilitation devices (ZEPU-AI2, AI4, AI6 Plus, and AI7A) are feasible, safe, and effective for adults with upper or lower limb motor problems.
- Conditions
- Stroke, Spinal Cord Injuries, Brain Injuries, Traumatic, Movement Disorder, Upper Extremity
- Trial name
- NCT07749625
- Testing
- ZEPU-AI2, ZEPU-AI4, ZEPU-AI6 Plus
- Where
- Bangladesh
- Volunteers
- 36 people
- Sponsor
- Bangladesh Medical University
Neurodegenerative Diseases, Parkinson Disease
Neurodegenerative Diseases Progression Markers (MARKERS-NDD)
MARKERS-NDD is a prospective, observational, longitudinal study, which aims to collect data from patients affected by neurodegenerative diseases (NDD) followed longitudinally for routine examinations performed as part of normal…
- Conditions
- Neurodegenerative Diseases, Parkinson Disease, Synucleinopathies, Lewy Body Disease
- Trial name
- MARKERS-NDD (NCT06596746)
- Testing
- Observation
- Where
- Italy
- Volunteers
- 600 people
- Sponsor
- Casa di Cura San Raffaele Cassino
Frontotemporal Degeneration (FTD), ALS (Amyotrophic Lateral Sclerosis)
Biofluid Research on Age-Related or Inherited Neurodegeneration
The aim of this study is to contribute to and continue to sustain a repository of blood samples, nucleic acid (DNA and/or RNA) samples, family history information, and other demographic information from individuals with…
- Conditions
- Frontotemporal Degeneration (FTD), ALS (Amyotrophic Lateral Sclerosis), Primary Progressive Aphasia (PPA), Familial Frontotemporal Lobar Degeneration (fFTLD)
- Trial name
- BRAIN (NCT07798700)
- Where
- United States
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Dyskinesia, Drug-Induced, Parkinson Disease
rTMS as an Intervention for Levodopa-induced Dyskinesia
The proposed study investigates the use of repetitive transcranial magnetic stimulation (rTMS) as a treatment for levodopa-induced dyskinesia (LID) in Parkinson's Disease (PD).
- Trial name
- ADAPT-LIDI (NCT06570824)
- Testing
- active TMS
- Where
- Denmark
- Volunteers
- 68 people
- Sponsor
- Danish Research Centre for Magnetic Resonance
PD - Parkinson's Disease
Transplantation of Human iPS Cell-derived Dopaminergic Progenitors (CT1-DAP001) for Parkinson's Disease (Phase I/II)
To evaluate the safety and efficacy of transplantation of human induced pluripotent stem cell-derived dopaminergic progenitors, CT1-DAP001, into the corpus striatum in patients with Parkinson's disease
- Trial name
- CT1-DAP001 (NCT06482268)
- Testing
- Human induced pluripotent stem cell-derived dopaminergic progenitors (CT1-DAP001)
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- University of California, San Diego
Parkinson Disease, Depression
Psilocybin Therapy for Depression in Parkinson's Disease
The purpose of this study is to understand whether people with Parkinson's Disease and depression have improvement in their symptoms after psilocybin therapy.
- Trial name
- PDP2 (NCT06455293)
- Testing
- Psilocybin, Pimavanserin
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Joshua Woolley, MD, PhD
Essential Tremor, Essential Tremor (ET)
Circadian Adaptive DBS in Essential Tremor
Deep brain stimulation (DBS) of the thalamus is an effective treatment for medically refractory essential tremor (ET). DBS involves delivering continuous stimulation to the brain through electrodes permanently implanted in the…
- Conditions
- Essential Tremor, Essential Tremor (ET), Essential Tremor, Movement Disorders
- Trial name
- NCT06635811
- Testing
- Circadian Adaptive DBS, Conventional DBS
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- University of Florida
Parkinson Disease, Movement Disorders
Moderate Versus High Volume Light-Moderate Intensity Exercise for People With Moderate Parkinson's Disease
Veterans with mid to later stage Parkinson's disease (PD) may not be able to work out as hard as they need to, to prevent brain cell loss.
- Conditions
- Parkinson Disease, Movement Disorders, Neurodegeneration
- Trial name
- HI-LITE (NCT06088355)
- Testing
- HV-PDAE: High Volume Partnered Dance Aerobic Exercise, MV-PDAE: Moderate Volume Partnered Dance Aerobic Exercise, MV-WALK: Moderate Volume Walking
- Where
- United States
- Volunteers
- 123 people
- Sponsor
- VA Office of Research and Development
Spinal Cord Injuries and Disorders (SCI/D), Spinal Cord Injury
Motoneuron Recruitment and Motor Evoked Potential Up-Conditioning (MEP) in Spinal Cord Injury (SCI)
The purpose of this research study is to examine the effect of a brain stimulation training to improve the function of brain-spinal cord- muscle connections.
- Trial name
- NCT07179822
- Testing
- Motor Evoked Potential (MEP) Operant Conditioning
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Medical University of South Carolina
Parkinson's Disease (PD), Parkinsonian Disorders
ZR001 Chemogenetics Gene Therapy Study in Patients With Parkinson's Disease
This study aims to evaluate the safety, tolerability, and preliminary efficacy of ZR001, a novel chemogenetic gene therapy product, in patients with moderately advanced Parkinson's disease (PD).
- Trial name
- NCT07718659
- Testing
- ZR001
- Where
- China
- Volunteers
- 8 people
- Sponsor
- Qianfoshan Hospital
Movement Disorders
Neurophysiology of the Basal Ganglia, Thalamus, and Cerebellum in Patients With Movement Disorders
The research study is being conducted to better understand parts of the human brain called the cortex, basal ganglia, thalamus, and cerebellum in patients with movement disorders (such as Parkinson's disease, essential tremor…
- Trial name
- NCT06848530
- Testing
- Prescribed Medications, Deep brain stimulation adjustment
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of Pennsylvania
Movement Disorders in Children, Neuro Developmental Delay
Pediatric Movement Disorders of Unknown Etiology in Vietnam (VPeMD)
This observational patient registry aims to describe the clinical phenotypes and genetic findings of Vietnamese children with movement disorders of unknown etiology.
- Conditions
- Movement Disorders in Children, Neuro Developmental Delay, Neurogenetic Disorders
- Trial name
- VPeMD (NCT07695610)
- Testing
- Whole-Exome Sequencing
- Where
- 2 sites in Vietnam
- Volunteers
- 50 people
- Sponsor
- University of Medicine and Pharmacy at Ho Chi Minh City
Tardive Dyskinesia, Intellectual Disability
Deutetrabenazine Treatment for Tardive Dyskinesia in Intellectual/Developmental Disabilities
The primary goal of this study is to investigate the efficacy of deutetrabenazine treatment of TD in this previously untreated patient population.
- Conditions
- Tardive Dyskinesia, Intellectual Disability, Developmental Disabilities
- Trial name
- TD-AIDD (NCT06997198)
- Testing
- Deutetrabenazine Oral Capsule
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- University Hospitals Cleveland Medical Center
Cirrhosis of the Liver, Ascites
Ultrasound Assessment of Diaphragmatic Structure and Function in Patients With Liver Cirrhosis: A Point-of-Care Tool for Predicting Complications and Sarcopenia in Limited Resource Settings
The goal of this observational study is to learn how liver cirrhosis affects the diaphragm, the main muscle used for breathing, in adults.
- Conditions
- Cirrhosis of the Liver, Ascites, Pleural Effusion Disorder, Hepatocellular Carcinoma (HCC)
- Trial name
- NCT07667608
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Assiut University
Mild Cognitive Impairment (MCI), Virtual Reality
An AI-Based Prediction of Cognitive Capacity in Older Adults and Individuals With Mild Cognitive Impairment During Virtual Reality Driving Tasks
Driving ability in older adults is essential for independent mobility and social participation, yet declines under high cognitive load or distraction often lead to visual attention failures such as "look-but-fail-to-see,"…
- Conditions
- Mild Cognitive Impairment (MCI), Virtual Reality, Eye Movement Disorder, Multimodal Monitoring
- Trial name
- NCT07656389
- Where
- Taiwan
- Volunteers
- 192 people
- Sponsor
- National Cheng-Kung University Hospital