Clinical trials: Movement Disorders, open to volunteers
Wilson's Disease
A Registered Cohort Study on Wilson's Disease
The aim of this study is to determine the clinical spectrum and natural progression of Wilson's Disease in a prospective multicenter natural history study, to assess the clinical, genetic, epigenetic features and biomarkers of…
- Trial name
- NCT04012658
- Testing
- No intervention
- Where
- China
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Wan-Jin Chen
Parkinson's Disease (PD)
Clinical Study of Chemogenetic Gene Therapy With AAV for Parkinson's Disease Using Stereotactic Surgery in the Subthalamic Nucleus
The investigators propose a gene therapy strategy for Parkinson's disease - a chemogenetic inhibition technique to intervene in the abnormal activity of the subthalamic nucleus in Parkinson's patients.
- Trial name
- CGTPD (NCT07533591)
- Testing
- gene therapy
- Where
- China
- Volunteers
- 6 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Parkinson Disease
Parkinson Progression Marker Initiative Online (PPMI Online)
Parkinson Progression Marker Initiative Online (PPMI Online) is an observational study collecting participant reported information from people with and without Parkinson's disease (PD), for the goal of better understanding risk…
- Trial name
- NCT05065060
- Testing
- Observation
- Where
- United States
- Volunteers
- 500,000 people, healthy volunteers welcome
- Sponsor
- Michael J. Fox Foundation for Parkinson's Research
PARKINSON DISEASE (Disorder), Parkinson s Disease
Effects of Accelerated rTMS On Motor and Cognitive Function in Parkinson's Disease
Parkinson's disease (PD) is a brain disorder that causes progressive problems with movement, such as slowness, stiffness, tremor, and difficulty walking. Many people with PD also develop problems with thinking and memory.
- Trial name
- NCT07554833
- Testing
- TMS
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- San Francisco Neurology and Sleep Center
Parkinson Disease
Determination of the Minimal Detectable Change of the Parkinson's Disease Questionnaire-8
This study is conducted to determine how many units of improvement the Parkinson's Disease Questionnaire-8 (PDQ-8), used to evaluate the quality of life of Parkinson's patients, should have to express a significant change in the…
- Trial name
- NCT06487364
- Testing
- Rehabilitation
- Where
- Turkey (Türkiye)
- Volunteers
- 39 people
- Sponsor
- Emre Şenocak
Tourette Syndrome
Strengthening Tourette Treatment OPtions Using TMS to Improve CBIT, a Double-blind, Randomized, Controlled Study
This pilot study will investigate the clinical and neurophysiological effects of repetitive transcranial magnetic stimulation (rTMS) followed by comprehensive behavioral intervention for tics (CBIT) in adult patients with…
- Trial name
- STOP-TIC (NCT05705999)
- Testing
- transcranial magnetic stimulation
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- West Virginia University
Parkinson Disease
Deep Brain Stimulation (DBS) of the Pedunculopontine Nucleus (PPN)
This is a mechanistic study to determine the differential effects of the dopaminergic and cholinergic systems on attention, gait, and balance.
- Trial name
- PPNGB01 (NCT04605263)
- Testing
- STN-PPN DBS Surgery, Deep Brain Stimulation Surgery (DBS)
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- St. Joseph's Hospital and Medical Center, Phoenix
Essential Tremor
Magnetoencephalography (MEG) Pilot Study
The purpose of this research is to learn more about how the brain works in people with essential tremor, and how it changes after treatment with High-Intensity Focused Ultrasound (HiFU).
- Trial name
- MEG (NCT07446192)
- Testing
- MRI and fMRI scans, MEG, Sensor-based motor assessments
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of Florida
Mitral Valve Disease
Evaluation of the Elasticity of the Mitral Valve
There is no information in the literature on the mechanobiological characteristics of mitral valve chords in living humans. All examinations were carried out on tissues taken from animals, either from cadavers or from frozen…
- Trial name
- NCT06153563
- Testing
- Data collection on patient history and intraoperative results.
- Where
- France
- Volunteers
- 30 people
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Parkinson's Disease (PD), Parkinson Disease 6, Early-Onset
Phase Ⅲ Clinical Trial to Evaluate the Efficacy and Safety of TJ0113 Capsules in Patients With Early-Onset Parkinson's Disease
This study is a randomized, double-blind, multicenter, placebo-controlled Phase III clinical trial designed to evaluate the efficacy, safety, and Pop PK characteristics of TJ0113 Capsules in treating EOPD patients.
- Trial name
- NCT07741045
- Testing
- TJ0113 200mg, TJ0113 400mg
- Where
- 21 sites in China
- Volunteers
- 300 people
- Sponsor
- Hangzhou PhecdaMed Co., Ltd.
Frontotemporal Dementia, Amyotrophic Lateral Sclerosis
Investigating Complex Neurodegenerative Disorders Related to Amyotrophic Lateral Sclerosis and Frontotemporal Dementia
Background: Neurodegenerative disorders can lead to problems in movement or memory. Some can cause abnormal proteins to build up in brain cells.
- Conditions
- Frontotemporal Dementia, Amyotrophic Lateral Sclerosis, Progressive Supranuclear Palsy
- Trial name
- NCT03225144
- Where
- United States
- Volunteers
- 360 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Knee Osteoarthritis
Evaluation of Mobility in Subjects With Severe Knee Osteoarthritis Who Are to Undergo Total Knee Replacement
Osteoarthritis (OA) is the most common joint disease. It is characterized by a progressive destruction of all the components of the joint, especially the cartilage.
- Trial name
- MOUV-GOPRO (NCT05488093)
- Testing
- X-sens sensor
- Where
- France
- Volunteers
- 20 people
- Sponsor
- University Hospital, Montpellier
Parkinsonism, REM Sleep Behavior Disorder
A Multimodal Prospective Cohort Study of Parkinsonism
This is a single-center, prospective, observational cohort study designed to investigate the progression and differential diagnosis of Parkinsonism using a multimodal approach.
- Trial name
- NCT07553845
- Where
- China
- Volunteers
- 640 people, healthy volunteers welcome
- Sponsor
- Ruijin Hospital
Parkinson's Disease (PD)
STN-tTIS With Different Intervention Intervals Versus Standard Medical Treatment for Parkinson's Disease
The goal of this clinical trial is to compare the efficacy and safety of different Intervention Intervals of subthalamic nucleus-targeted transcranial temporal interference stimulation (STN-tTIS) in patients with Parkinson…
- Trial name
- NCT07774312
- Testing
- STN-tTIS Once Weekly, STN-tTIS Twice Weekly, STN-tTIS Five Times Weekly
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Ruijin Hospital
Movement Disorders, Neurorehabilitation
Towards Restoring Complex Movement After Paralysis: Algorithm Development With Healthy Participants
Participants will perform experiments with non-invasive activity recordings. The study will record from multiple non-invasive signal sources that reflect motor intent that may include: electroencephalography (EEG)…
- Conditions
- Movement Disorders, Neurorehabilitation, Non-invasive Activity Recording
- Trial name
- NCT07236892
- Testing
- Participants will perform experimental tasks while undergoing non-invasive activity recordings, which may include EEG, EMG, IMUs, fNIRS, eye gaze, or pupillometry.
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Parkinson Disease
Characterizing the Pathophysiological Role of the Pallido-thalamocortical Motor Pathway in Parkinson's Disease.
When a patient gets DBS surgery, the neurosurgeon makes a hole in the skull through which they can put the DBS lead down in deep parts of the brain that help control movement.
- Trial name
- NCT06692920
- Testing
- DBS stimulation
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- University of Minnesota
Meige Syndrome
Bilateral Single-Electrode VO Combined With STN-DBS for Treating Meige Syndrome
Meige syndrome is a rare and debilitating movement disorder characterized by blepharospasm, oromandibular dystonia, and cervical muscle contractions, often refractory to pharmacological therapies.
- Trial name
- NCT06912282
- Testing
- deep brain stimulation
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Huashan Hospital
Parkinson Disease, Constipation
Pyridostigmine for the Treatment of Constipation in Parkinson Disease
Constipation is a common and debilitating non-motor symptom of Parkinson disease (PD) that often precedes the onset of classic motor symptoms by decades.
- Trial name
- NCT05603715
- Testing
- Pyridostigmine Bromide
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- University of Vermont Medical Center
Stroke, Rehabilitation
Virtual Reality Mirror Therapy With Focused Object-Directed Attention System
In this study, the investigators hypothesized that Virtual Reality Mirror Therapy with Focused Object-Directed Attention (VRMTFOA) would yield superior therapeutic effects compared to conventional Virtual Reality Mirror Therapy…
- Conditions
- Stroke, Rehabilitation, Virtual Reality, Mirror Movement Therapy
- Trial name
- NCT07525713
- Testing
- task-oriented training
- Where
- Taiwan
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- National Cheng-Kung University Hospital
Cerebral Palsy
Home-Based Training With Feedback to Improve Outcomes in Adolescents and Young Adults With Cerebral Palsy..
This clinical trial aims to determine whether extrinsic feedback through music enhances the effects of home-based motor training for adolescents and young adults with cerebral palsy (CP) and whether feedback improves adherence to…
- Trial name
- THRIVE-CP (NCT06962618)
- Testing
- Music Motion Group, Control
- Where
- Denmark
- Volunteers
- 70 people
- Sponsor
- University of Copenhagen
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