Clinical trials: Movement Disorders in Children
Cerebral Palsy, Hemiplegia
Constraint-induced Movement Therapy (CIMT) and Bimanual Training (HABIT) in Children With Hemiplegic Cerebral Palsy
A randomized control trial of bimanual training. The protocols have been developed at Columbia University to be child friendly and draws upon our experience since 1997 with constraint-induced movement therapy in children with…
- Conditions
- Cerebral Palsy, Hemiplegia, Children, Pediatric
- Trial name
- NCT00305006
- Testing
- Constraint-Induced Movement Therapy (CIMT), Hand-Arm Bimanual Intensive Therapy (HABIT)
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- Teachers College, Columbia University
Tic Disorder, Provisional Tic Disorder
Let It TiC in Childhood Provisional Eye Tic
Clarify the effectiveness and safety of "Reduced-Attention Intervention Therapy" in treating children with Provisional tic disorder （PTD） who mainly exhibit abnormal blinking behavior
- Trial name
- LETITTIC (NCT07838428)
- Testing
- Reducing Attentional Interventions Therapy Treatment, Continue with the previous treatment plan
- Where
- China
- Volunteers
- 134 people
- Sponsor
- Zhongshan Ophthalmic Center, Sun Yat-sen University
Tic-Disorder
Efficacy of Psychotherapy Treatment of Children With Tics
The main purpose of this study is to evaluate the efficacy of a habit reversal based treatment programme compared to an alternative treatment which aims at the activation of resources in children and adolescents aged 8 to 18…
- Trial name
- NCT02144870
- Testing
- Habit Reversal Training, Resources activation
- Where
- Germany
- Volunteers
- 100 people
- Sponsor
- University of Cologne
Cerebral Palsy Infantile
Study of the Sensitivity to Change of a Bimanual 3D Analysis Protocol for the Assessment of Upper Limb Movement in Children With Cerebral Palsy Before and After Therapies
Cerebral Palsy is the most common cause of motor disability in children. It can lead to a deficit of the upper limb which alters the realization of daily activities, in particular in bimanual situations, and eventually leads to a…
- Trial name
- BE API CHANGE (NCT05691556)
- Testing
- HABIT ILE rehabilitation course, botulinum toxin injections
- Where
- France
- Volunteers
- 20 people
- Sponsor
- University Hospital, Brest
Tourette's Disorder
Safety and Tolerability Study of Once-weekly Oral Aripiprazole in Children and Adolescents With Tourette's Disorder
The goal of the current trial is to obtain long term efficacy, safety and tolerability data of once weekly aripiprazole in children and adolescents with Tourette's Disorder.
- Trial name
- NCT01416441
- Testing
- Aripiprazole
- Where
- 80 sites in United States, Bulgaria and 8 more
- Volunteers
- 170 people
- Sponsor
- Otsuka Pharmaceutical Development & Commercialization, Inc.
Developmental Coordination Disorder
Rhythmic Motor Learning in Children With Developmental Coordination Disorders
The importance of play and physical activity include many benefits on positively improving health and well-being, enhancing children's and young people's thinking and performance in school, improving their sleep and enabling…
- Trial name
- EPIC2 (NCT03150784)
- Testing
- EPIC Club
- Where
- 5 sites in United Kingdom
- Volunteers
- 87 people, healthy volunteers welcome
- Sponsor
- Oxford Brookes University
Neuromuscular Diseases, Cerebral Palsy
Hippotherapy to Improve the Balance of Children With Movement Disorders
The purpose of this study is to determine if adding hippotherapy treatment will improve balance for children ages 5-17 who have disabilities such as cerebral palsy and down syndrome.
- Conditions
- Neuromuscular Diseases, Cerebral Palsy, Down Syndrome, Autism
- Trial name
- HPOT (NCT01313325)
- Testing
- Hippotherapy
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Central Michigan University
Tic Disorders, Tourette Syndrome
Online Remote Behavioural Intervention for Tics (ORBIT)
Online Remote Behavioural Intervention for Tics (ORBIT). Primary objective: to evaluate the clinical effectiveness of BiP Tic, a therapist-guided, parent-assisted, internet-based behavioural therapy intervention for tics in young…
- Trial name
- ORBIT (NCT03483493)
- Testing
- Exposure Response Prevention for tics, Psychoeducation for tics
- Where
- United Kingdom
- Volunteers
- 224 people
- Sponsor
- Nottinghamshire Healthcare NHS Trust
Neurodevelopmental Outcomes, ADHD - Attention Deficit Disorder With Hyperactivity
Where Wild Things Grow: Nature- and Activity-based Group Interventions for Neurodivergent Children and Youth
The goal of this action research project is to develop and implement nature- and activity-based group interventions across health care, school and leisure settings in Southern Norway.
- Conditions
- Neurodevelopmental Outcomes, ADHD - Attention Deficit Disorder With Hyperactivity, Autism, Tourette Syndrome
- Trial name
- NCT07203469
- Testing
- Universal approach, Selective approach, Outdoor therapy
- Where
- 2 sites in Norway
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Sorlandet Hospital HF
Sleep Problems
Assessment of the Pharmacokinetics of Circadin® in Children With Neurodevelopmental Disorders and Sleep Disturbances
There is increasing evidence that chronic sleep disorders in children with autism spectrum disorder (ASD), Angelman Syndrome (AS) and Smith-Magenis syndrome (SMS) are associated with disturbed melatonin secretion and melatonin…
- Trial name
- NCT01903681
- Testing
- Circadin 2 mg, Circadin 10 mg
- Where
- Netherlands
- Volunteers
- 16 people
- Sponsor
- Neurim Pharmaceuticals Ltd.
Parkinson Disease, Huntington Disease
A PET Brain Imaging Study of mGluR5 in Subjects With Neuropsychiatric Conditions
Measurement of metabotropic glutamate receptor type 5 (mGluR5) binding capacity in the brain, may be a valuable tool in the early detection, understanding, or evaluation of Parkinson disease (PD), Huntington disease (HD), Fragile…
- Conditions
- Parkinson Disease, Huntington Disease, Autistic Spectrum Disorders, Fragile X Syndrome
- Trial name
- FPEB (NCT00870974)
- Testing
- [18F]FPEB
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Institute for Neurodegenerative Disorders
Neurodevelopmental Disorders, Autism
Sertraline vs. Placebo in the Treatment of Anxiety in Children and AdoLescents With NeurodevelopMental Disorders
There are currently no approved medications for the treatment of anxiety in children and youth with neurodevelopmental disorders (NDDs), both common and rare.
- Conditions
- Neurodevelopmental Disorders, Autism, Autism Spectrum Disorder, Fragile X Syndrome
- Trial name
- CALM (NCT06081348)
- Testing
- Sertraline
- Where
- 7 sites in Canada
- Volunteers
- 130 people
- Sponsor
- Holland Bloorview Kids Rehabilitation Hospital
Tourette Syndrome, Obsessive Compulsive Disorder
Developmental Phenomenology of Obsessive Compulsive Disorder and Tourette Syndrome in Children and Adolescents
OBJECTIVES: I. Characterize the natural history, associated features, and severity of symptoms of obsessive compulsive disorder and Tourette syndrome in children and adolescents. II.
- Trial name
- NCT00004324
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- National Center for Research Resources (NCRR)
Infantile Hemiplegia, Constraint Induced Movement Therapy
Intensive Therapies to Improve Manipulation in Young Children With Hemiparesis
mCIMT and BIT are therapies applied in children with hemiplegia which have a great evidence, but not in a early age. This research has the objective to know the effects of this therapies in infants diagnosed of infantile…
- Conditions
- Infantile Hemiplegia, Constraint Induced Movement Therapy, Family, Bimanual Intensive Therapy
- Trial name
- NCT06191588
- Testing
- INFANT CIMT/BIT
- Where
- 2 sites in Spain
- Volunteers
- 10 people
- Sponsor
- University of Seville
Sleep Disorders
Efficacy and Safety of Circadin® in the Treatment of Sleep Disturbances in Children With Neurodevelopment Disabilities
The purpose of this study is to establish the efficacy and safety of Circadin in children with neurodevelopmental disorders and to determine the dose, this randomized, placebo-controlled study is planned to evaluate the efficacy…
- Trial name
- NCT01906866
- Testing
- Circadin 2/5/10 mg
- Where
- 28 sites in United States, Finland and 3 more
- Volunteers
- 125 people
- Sponsor
- Neurim Pharmaceuticals Ltd.
Attention Deficit Disorder With Hyperactivity, Tourette Syndrome
Methylphenidate for Treating Children With ADHD and Tourette Syndrome
This study will evaluate the safety and effectiveness of methylphenidate in treating attention deficit hyperactivity disorder in children with both attention deficit hyperactivity disorder and Tourette syndrome.
- Trial name
- NCT00441649
- Testing
- Methylphenidate
- Volunteers
- 71 people
- Sponsor
- Stony Brook University
Tourette Syndrome
Safety, Pharmacokinetics, and Pharmacodynamics of NBI-98854 in Children and Adolescents With Tourette Syndrome
This is a Phase 1b, open-label, multiple-dose study of the safety, pharmacokinetics (PK), and pharmacodynamics (PD) of NBI-98854 in a total of 36 pediatric subjects with Tourette syndrome (TS).
- Trial name
- T-FORCE (NCT02256475)
- Testing
- NBI-98854
- Where
- 10 sites in United States
- Volunteers
- 36 people
- Sponsor
- Neurocrine Biosciences
Tic Disorders
Mobile App-assisted Behavioral Treatment in Children and Adolescents With Tics
Chronic tic disorders are neurodevelopmental disorders affecting 0.5-1% of children and adolescents. Tics present as sudden, rapid, repetitive non-rhythmic movements or vocalizations or a combination.
- Trial name
- NCT05390268
- Testing
- Mobile app-assisted behavioral treatment, Mobile app-assisted psychoeducation
- Where
- Denmark
- Volunteers
- 60 people
- Sponsor
- Aarhus University Hospital
Tics, Tic Disorders
Clinical Characteristics and Temporal Properties of Individual Tics in Persistent Tic Disorder
The goal of this clinical study is to learn more about the timing of tics (sudden, fast movements and sounds that people do and make without meaning to) in people who have multiple tics that have been going on for more than one…
- Conditions
- Tics, Tic Disorders, Vocal Tic, Motor Tic
- Trial name
- PTD (NCT06385535)
- Testing
- Habit Reversal Training (HRT)
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- University of Utah
Angelman Syndrome
Nutritional Formulation for Angelman Syndrome
Low carbohydrate diets such as the ketogenic (KD) and low glycemic index (LGIT) diets have been shown to be effective in treating drug resistant seizures in children with Angelman syndrome (AS).
- Trial name
- FANS (NCT03644693)
- Testing
- Nutritional Formulation Containing Exogenous Ketones
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- University of Colorado, Denver