Clinical trials: Moxifloxacin
Healthy
Influence of Pramipexole on the QT Interval of the ECG in Healthy Male and Female Volunteers
The objective of the study is to assess that pramipexole does not prolong the QT interval more than placebo
- Trial name
- NCT02262546
- Testing
- Pramipexole extended-release (ER) tablets, Pramipexole immediate-release (IR) tablets, Moxifloxacin
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Boehringer Ingelheim
HCV Infection
Study to Evaluate Effect of Sofosbuvir/Velpatasvir/GS-9857 Fixed-Dose Combination on the Pharmacokinetics of a Representative Hormonal Contraceptive Medication, Norgestimate/Ethinyl Estradiol
This study will evaluate the effect of sofosbuvir (SOF)/velpatasvir (VEL)/voxilaprevir (VOX) fixed-dose combination (FDC) + voxilaprevir on the pharmacokinetics (PK) of a representative hormonal contraceptive medication…
- Trial name
- NCT02533427
- Testing
- SOF/VEL/VOX, VOX, Norgestimate/ethinyl estradiol
- Where
- New Zealand
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Gilead Sciences
Pneumonia
A Study to Assess the Efficacy and Safety of IV/PO Moxifloxacin in Subjects With Community-acquired Pneumonia
The purpose of this study is to assess if a therapy with oral and intravenous moxifloxacin is as effective as a therapy with intravenous ceftriaxone + intravenous azithromycin followed by oral amoxicilline/clavulanate and oral…
- Trial name
- NCT00717561
- Testing
- Avelox (Moxifloxacin, BAY12-8039), Ceftriaxone; Azithromycin; Amoxicilline/clavulanate; Clarithromycin
- Where
- 23 sites in Italy
- Volunteers
- 60 people
- Sponsor
- Bayer
Non-alcoholic Steatohepatitis
A Thorough QTC Study to Assess the Effect of Cotadutide on Cardiac Repolarization in Healthy Participants
This study will investigate the effect of multiple doses of cotadutide on the cardiac activity (QTc interval) of healthy participants.
- Trial name
- NCT05668936
- Testing
- Cotadutide, Moxifloxacin
- Where
- Germany
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
Healthy Subjects
Study Evaluating The Effect of Bosutinib (SKI-606) On Cardiac Repolarization (Rhythms Of The Heart)
The purpose of this study is to examine the effect of SKI-606 on rhythms of the heart (cardiac repolarization)
- Trial name
- NCT00914121
- Testing
- SKI-606, Moxifloxacin
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Wyeth is now a wholly owned subsidiary of Pfizer
Myelofibrosis
QT Interval/Corrected QT Interval （QT/QTc） Clinical Study to Evaluate the Cardiac Safety of TQ05105 Tablets in Healthy Participants
Primary Objective: To evaluate the effect of single-dose TQ05105 on QTcF interval in healthy Chinese participants. Secondary Objectives: To evaluate the effects of single-dose TQ05105 on other cardiac parameters (heart rate, QT…
- Trial name
- NCT07708272
- Testing
- TQ05105 tablets, Moxifloxacin Hydrochloride Tablets
- Where
- China
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Chia Tai Tianqing Pharmaceutical Group Co., Ltd.
Diabetes, Healthy
A Thorough QTc Evaluation of the Effect of Semaglutide on Cardiac Repolarisation in Healthy Subjects
This trial is conducted in Europe. The aim of the trial is to evaluate the effect of semaglutide on cardiac repolarisation in healthy subjects.
- Trial name
- NCT02064348
- Testing
- semaglutide, moxifloxacin
- Where
- Germany
- Volunteers
- 168 people, healthy volunteers welcome
- Sponsor
- Novo Nordisk A/S
Healthy
A Study to Evaluate the Effects of Ibrutinib on Cardiac Repolarization in Healthy Participants
The purpose of this study is to assess the safety and tolerability of ibrutinib, to compare the pharmacokinetics of ibrutinib after single oral administration of 840 mg and 1680 mg and to assess the effects of a single dose of…
- Trial name
- NCT02271438
- Testing
- Ibrutinib, Moxifloxacin
- Where
- Belgium
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Janssen Research & Development, LLC
QT Interval
A Thorough QT Study of Telotristat Etiprate
The purpose of this study is to demonstrate that telotristat etiprate does not differ from placebo in the mean change from Baseline QT interval corrected for heart rate.
- Trial name
- NCT02155205
- Testing
- Telotristat etiprate, Moxifloxacin
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Lexicon Pharmaceuticals
Healthy Volunteers
Multiple-Dose Study of Effect of Bardoxolone Methyl on QT/QTC Interval Volunteers
This is a single-center, multiple-dose, randomized, double-blind, double-dummy, placebo-controlled, active-comparator, parallel study in healthy volunteers.
- Trial name
- NCT01689116
- Testing
- Bardoxolone Methyl 20mg, Bardoxolone Methyl 80mg, Moxifloxacin 400mg
- Where
- United States
- Volunteers
- 179 people, healthy volunteers welcome
- Sponsor
- Biogen
Asthma
Corrected QT (QTc) Study With Flucticasone Furoate and GW642444
A randomised, placebo controlled thorough QTc study to evaluate the effect of repeat dose FF/GW642444M combination, with moxifloxacin as a positive control, on the QTc interval in healthy male and female subjects.
- Trial name
- NCT01209026
- Testing
- Fluticasone furoate (200 mcg)/GW642444 (25mcg) combination, Fluticasone furoate (400 mcg)/GW642444 (50mcg) combination, Moxifloxacin 400mg
- Where
- United Kingdom
- Volunteers
- 85 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Healthy
A Study to Evaluate the Effect of JNJ-63623872 on Cardiac Repolarization Interval in Healthy Participants
The purpose of this study is to evaluate the effect of JNJ-63623872 on the QT/QTc interval at supratherapeutic exposure in healthy participants (Panel 2).
- Trial name
- NCT02658825
- Testing
- JNJ-63623872 2400 milligram (mg), JNJ-63623872 3000 mg, JNJ-63623872
- Where
- Belgium
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Janssen Research & Development, LLC
Alzheimer Disease, Healthy
Study Evaluating the Effect of Lecozotan SR on the QTc Interval
This is a randomized, double-blind, placebo- and moxifloxacin (open-label)-controlled, 4-period crossover study.
- Trial name
- NCT00499642
- Testing
- Lecozotan SR, Moxifloxacin
- Where
- 2 sites in France
- Volunteers
- healthy volunteers welcome
- Sponsor
- Wyeth is now a wholly owned subsidiary of Pfizer
Healthy Volunteers - Male and Female
A Study to Evaluate the Effects of KP-001 on the QT/QTc Intervals in Healthy Adults
This is a Phase 1, single-center, randomized, single-blind (participants are blinded), placebo controlled, four-way cross over TQT study (4×4 Williams square design) to investigate the effect of KP-001 on the QTc interval using…
- Trial name
- NCT06649942
- Testing
- KP-001, Moxifloxacin 400 mg
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Kaken Pharmaceutical
Cataract
Pharmacokinetic Evaluation of Moxifloxacin in Vigadexa® in Aqueous Humor Samples Following Preoperative Antibiotic/Steroid Dosing in Cataract Surgery Patients
The purpose of this study was to determine the moxifloxacin aqueous penetration when dosing with a combination drug Vigadexa preoperatively in cataract patients.
- Trial name
- NCT01859702
- Testing
- Moxifloxacin 0.5%/Dexamethasone 0.1% ophthalmic solution
- Volunteers
- 36 people
- Sponsor
- Alcon Research
Secondary Peritonitis, Abscess, Intra-Abdominal
Moxifloxacin i.v. in the Treatment of Complicated Intra-Abdominal Infection (cIAI)
This study is a local, prospective, open-label, company-sponsored, non interventional, multi-center study. Patients documented must suffer from a cIAI and take at least one dose of Moxifloxacin infusion.The primary objective is…
- Trial name
- NCT01096511
- Testing
- Moxifloxacin (Avelox, BAY12-8039)
- Where
- China
- Volunteers
- 1,001 people
- Sponsor
- Bayer
Maxillary Sinusitis
Trial to Evaluate Time to Symptom Relief and Elimination of Infecting Bacteria in Treating Sinusitis With Avelox
This study evaluated the time to bacteriological eradication of common pathogens during moxifloxacin therapy for acute bacterial maxillary sinusitis.
- Trial name
- SPEED (NCT00668304)
- Testing
- Avelox (Moxifloxacin, BAY12-8039)
- Where
- 35 sites in United States, Argentina
- Volunteers
- 192 people
- Sponsor
- Bayer
Healthy
Thorough QT Study to Evaluate the Effect of Rodatristat Ethyl, Rodatristat and Its Major Metabolites on the Heart
To evaluate whether Rodatristat Ethyl prolongs the QTc interval when orally administered to healthy volunteers.
- Trial name
- NCT05933447
- Testing
- Rodatristat Ethyl, Moxifloxacin
- Where
- United States
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Altavant Sciences GmbH
Infections, Respiratory Tract
Placebo and Moxifloxacin Controlled Cardiac Conduction Study of GSK2140944 in Healthy Volunteers
This is Phase I, 4-period, randomized, active-and placebo-controlled, double-blind crossover, single-dose study to evaluate the effects of a therapeutic (1000 milligram [mg]) and supratherapeutic (1800 mg) dose of GSK2140944 with…
- Trial name
- NCT02257398
- Testing
- GSK2140944, Moxifloxacin
- Where
- United States
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Hepatitis C
VX-950-TiDP24-C136 - A Trial to Evaluate the Effect of Telaprevir (TVR) on the Results of Electrocardiograms (Electric Recording of the Heart) in Healthy Volunteers
The purpose of this study is to evaluate the effect of telaprevir on the results of electrocardiograms in healthy volunteers. An electrocardiogram is an electric recording of the heart.
- Trial name
- NCT00973388
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Tibotec BVBA