Clinical trials: Moyamoya Disease
Moyamoya Disease, Intracranial Atherosclerotic Stroke
Moyamoya Disease Biomarkers in Patients With Intracranial Atherosclerotic Stroke
The aim of this study is to investigate the proportion of patients with moyamoya disease among the patients who were diagnosed as having intracranial atherosclerotic stroke.
- Conditions
- Moyamoya Disease, Intracranial Atherosclerotic Stroke, Intracranial Steno-occlusive Disease
- Trial name
- NCT02074111
- Where
- South Korea
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Samsung Medical Center
CADASIL, CADASIL (Diagnosis)
RAre, But Not aLone: a Large Italian Network to Empower the Impervious diaGNostic Pathway of Rare cerEbrovascular Diseases (ALIGNED)
Cerebrovascular diseases (CVDs) are one leading cause of morbidity and mortality worldwide. Despite intensive investigations, more than 30% of strokes remain of undetermined origin.
- Conditions
- CADASIL, CADASIL (Diagnosis), Moya Moya Disease, Moyamoya
- Trial name
- ALIGNED (NCT06935578)
- Where
- 17 sites in Italy
- Volunteers
- 500 people
- Sponsor
- Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta
Moyamoya Disease
Neurocognitive and Radiological Assessments in Adult Moyamoya Undergoing Surgery
Adult patients with moyamoya disease (MMD) are reported to suffer from considerable impairment of executive function/attention. Although reduced cerebrovascular reserve (CVR) in frontal areas has been detected by perfusion MRI…
- Trial name
- NRAAMUS (NCT02305407)
- Testing
- Surgical Revascularization, Conservative treatment
- Where
- China
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Huashan Hospital
Moyamoya Disease
The Safety and Efficacy of RIC on Adult Moyamoya Disease
There are a series of symptoms such as ischemic stroke、transient ischemic attack 、hemorrhagic stroke、headache 、seizure and so on in moyamoya disease( MMD) patients .Nowadays, revascularization is the only effective way for…
- Trial name
- RIC-AMD (NCT04012268)
- Testing
- RIC, Aspirin
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Capital Medical University
Brain Neoplasm, Intracranial Aneurysm
Subclavian Vein catheterization_Seldinger Vs Modified Seldinger
Seldinger technique is a minimally invasive technique in which the practitioner accesses the target vessel with a small bore needle, then dilates to the size required for the catheter.
- Conditions
- Brain Neoplasm, Intracranial Aneurysm, Cerebrovascular Moyamoya Disease
- Trial name
- MS (NCT02090010)
- Testing
- Seldinger technique, Modified Seldinger technique
- Where
- South Korea
- Volunteers
- 418 people
- Sponsor
- Seoul National University Hospital
Pain
Goal-directed Analgesia Using ANI During General Anesthesia in Children With Moyamoya Disease
Analgesia Nociception Index (ANI) has been proposed for the evaluation of the nociception-antinociception balance in the perioperative period.
- Trial name
- NCT05672212
- Testing
- ANI (Analgesia/Nociception Index) monitoring, standard monitoring, Sufentanil
- Where
- South Korea
- Volunteers
- 40 people
- Sponsor
- Seoul National University Hospital
Moyamoya Disease
Direct Bypass Versus Indirect Bypass in Treatment of Adults Hemorrhagic Moyamoya Disease
The investigators conducted a prospective multi-center study assessing the effect of direct bypass and indrect bypass in treatment of hemorrhagic moyamoya disease.
- Trial name
- NCT02982135
- Testing
- bypass surgery and indrect bypass surgery
- Where
- China
- Volunteers
- 300 people
- Sponsor
- liuxingju
Moyamoya Disease
Long-term Outcomes of Conservative Management in Patients with Moyamoya Disease and Their First-degree Relatives (LAMORA)
The purpose of this study is to investigate the long-term outcomes of conservative management in patients with moyamoya disease and their first-degree relatives, and provide potential pathogenesis of moyamoya disease.
- Trial name
- NCT05332756
- Testing
- Conservative management
- Where
- China
- Volunteers
- 400 people
- Sponsor
- Beijing Tiantan Hospital
Moyamoya Disease, Remote Ischemic Preconditioning
Effects of Remote Ischemic Pre-Conditioning in Moyamoya Disease Patients
In the present study, investigators evaluated whether RIPC reduce the major neurological complications in adult moyamoya disease patients undergoing encephaloduroarteriosynangiosis (EDAS).
- Trial name
- RIME (NCT04064658)
- Testing
- Remote ischemic preconditioning, Encephaloduroarteriosynangiosis
- Where
- 2 sites in China
- Volunteers
- 328 people
- Sponsor
- Beijing Tiantan Hospital
Moyamoya Syndrome, Moyamoya Disease
A Study of Cerebral Perfusion With tDCS in Chronic Hypoperfusion
This study is being done to examine whether transcranial direct current stimulation (tDCS) will increase cerebral blood flow which may provide a clinical benefit such as improving cognitive impairment.
- Conditions
- Moyamoya Syndrome, Moyamoya Disease, Atheroscleroses, Cerebral
- Trial name
- NCT06477107
- Testing
- Soterix® 4x1HD-TDCS, Soterix® 1x1 tDCS, Cognitive training program
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- Mayo Clinic
Cerebrovascular Accident, Moyamoya Disease
Quantifying Collateral Perfusion in Cerebrovascular Disease-Moyamoya Disease and Stroke Patients
Quantifying Collateral Perfusion in Cerebrovascular Disease-Moyamoya disease and stroke patients
- Trial name
- NCT01419275
- Testing
- Xenon contrast agent, Magnetic Resonance Imaging
- Where
- United States
- Volunteers
- 126 people, healthy volunteers welcome
- Sponsor
- Stanford University
Moyamoya Disease
Relationship Between Endothelial Progenitor Cells and Revascularization Effect of Moyamoya Disease
Moyamoya disease is a chronic cerebrovascular disease，The typical pathological manifestations are the stenosis or occlusion of the distal internal carotid artery and/or middle cerebral artery, and the proximal anterior cerebral…
- Trial name
- REPCREMMD (NCT03613701)
- Where
- China
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Affiliated Hospital to Academy of Military Medical Sciences
EEG With Periodic Abnormalities
EEG Monitoring in Children With Moyamoya Disease
EEG in moyamoya disease in children preoperatively
- Trial name
- NCT03173014
- Testing
- EEG
- Where
- 2 sites in South Korea
- Volunteers
- 10 people
- Sponsor
- Seoul National University Hospital
Moyamoya
Characteristics and Outcomes of Childhood Moyamoya in the UK
This is a study to ascertain the number of children with moyamoya in the UK, their presenting features, clinical course and outcomes.
- Trial name
- NCT02434302
- Where
- United Kingdom
- Volunteers
- 98 people
- Sponsor
- Great Ormond Street Hospital for Children NHS Foundation Trust
Moyamoya, Stroke
The Adult Hemorrhagic Moyamoya Surgery Study
The aim of this study is to investigate whether extracranial-intracranial(EC-IC) bypass surgery could prevent rebleeding and improve neurological function in adult moyamoya with hemorrhagic onset.
- Trial name
- AHMSS (NCT02319980)
- Testing
- Extracranial-intracranial bypass surgery
- Where
- China
- Volunteers
- 360 people
- Sponsor
- Huashan Hospital
Moyamoya
NIRS to Evaluate Haemodynamic Reserve in Paediatric Moyamoya
Near infrared spectroscpy is a validated method of evaluating cerebral blood flow. The aim in this pilot study to explore its use in children with moyamoya disease.
- Trial name
- NIRS moyamoya (NCT05160454)
- Testing
- near infrared spectroscopy
- Where
- United Kingdom
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Great Ormond Street Hospital for Children NHS Foundation Trust
Moyamoya Disease
Prognostic Prediction Model in Patients With Moyamoya Disease Undergoing Revascularization Surgery
Moyamoya Disease (MMD) is a rare chronic cerebrovascular disease characterized by progressive occlusion of the internal carotid artery or its major branches, with blood flow compensated by the formation of an abnormal vascular…
- Trial name
- NCT06051552
- Where
- China
- Volunteers
- 350 people
- Sponsor
- Beijing Tiantan Hospital
Stroke, Moyamoya Disease
Application of Digital Twins' Technology in Patients Who Had a Stroke, With Moyamoya Disease and With Cerebral Amyloid Angiopathy (CAA) During the Secondary Prevention Phase: A Proof of Concept Using a Randomized Control Trial (Clinical Study 6, STRATIF-AI Project)
The goal of this clinical trial is to obtain initial feedback on the implementation of the STRATIF-AI platform and digital twin in the secondary prevention phase in patients with stroke, Moyamoya disease and Cerebral amyloid…
- Conditions
- Stroke, Moyamoya Disease, Cerebral Amyloid Angiopathy
- Trial name
- SMART (NCT06714097)
- Testing
- AI, healthy dialogue
- Where
- Italy
- Volunteers
- 20 people
- Sponsor
- Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta
Moyamoya Disease
Study on Evaluating the Effectiveness of Statins in the Treatment of Moyamoya Disease
The purpose of this study is to investigate the effectiveness of statins in the treatment of moyamoya disease based on multimodal magnetic resonance imaging.
- Trial name
- SEST-MOYA (NCT06817434)
- Testing
- Revascularization/Conservative management
- Where
- China
- Volunteers
- 330 people
- Sponsor
- Beijing Tiantan Hospital
Ischemic Attack, Ischemic Stroke
Multiple Burrhole Therapy With Erythropoietin for Unstable Moyamoya
In this study, the investigators aim to evaluate the indirect revascularization outcomes of a new combination therapy of multiple burrhole procedure with promotion of arteriogenesis by intravenous (IV) erythropoietin (EPO)…
- Conditions
- Ischemic Attack, Ischemic Stroke, Moyamoya Disease, Burr Hole
- Trial name
- NCT03162588
- Testing
- erythropoietin
- Where
- South Korea
- Volunteers
- 37 people
- Sponsor
- Ajou University School of Medicine