Clinical trials: Mucocutaneous Lymph Node Syndrome
Kawasaki Disease
Measurement of Antibodies in Adults With a History of Kawasaki Disease
Kawasaki disease (KD) is an acute systemic vasculitic syndrome with coronary tropism. It has been reported worldwide, but it is ten times more common in Asian population.
- Trial name
- KAWASAKI Ac (NCT02853266)
- Testing
- laboratory biomarker analysis
- Where
- France
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Hospices Civils de Lyon
Kawasaki Disease Refractory to Initial Therapy With Intravenous Immunoglobulin
Clinical Study of TA-650 in Patients With Refractory Kawasaki Disease
The purpose of this study is to evaluate the efficacy and safety of TA-650 in comparison with a control drug Polyethylene Glycol-treated Human Immunoglobulin (VGIH) in patients with Kawasaki disease refractory to initial therapy…
- Trial name
- NCT01596335
- Testing
- TA-650, Polyethylene Glycol-treated Human Immunoglobulin (VGIH)
- Where
- 8 sites in Japan
- Volunteers
- 31 people
- Sponsor
- Tanabe Pharma Corporation
Kawasaki Disease, Macrophage Activation Syndrome (MAS)
MASKd: a Study on Kawasaki Disease (KD) Complicated by Macrophage Activation Syndrome (MAS)
Kawasaki Disease (KD) is one of the most common vasculitides in childhood and represents a leading cause of acquired heart disease in developed countries.
- Trial name
- NCT07491926
- Where
- Italy
- Volunteers
- 150 people
- Sponsor
- Meyer Children's Hospital IRCCS
Kidney Transplant, Familial Hypercholesterolaemia
Cardiovascular Risk in Children With Chronic Conditions Study
Children living with chronic health conditions face a higher risk of developing cardiovascular diseases than their peers, largely due to the accelerated aging of the heart and blood vessels.
- Conditions
- Kidney Transplant, Familial Hypercholesterolaemia, Type 1 Diabetes Mellitus (T1DM), Type 2 Diabetes Mellitus (T2DM)
- Trial name
- CR3C (NCT07086989)
- Where
- 3 sites in Hungary
- Volunteers
- 300 people
- Sponsor
- Semmelweis University
Kawasaki Disease
Cardiovascular Risk Markers and Response to Statins After Kawasaki Disease
The purpose of this study is to determine whether Chilean children with history of Kawasaki disease have endothelial dysfunction years after the acute phase of the disease, and if this condition can be modified by treatment with…
- Trial name
- NCT00305201
- Testing
- pravastatin
- Where
- Chile
- Sponsor
- Pontificia Universidad Catolica de Chile
Kawasaki Disease
The Value of Cardiovascular Imaging in Kawasaki Disease
The goal of this observational study is to assess the cardiovascular injury of Kawasaki disease with multi-modal imaging combined with clinical data.
- Trial name
- NCT06641817
- Where
- China
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- West China Second University Hospital
Kawasaki Disease
Infliximab Plus Intravenous Immunoglobulin for the Primary Treatment of Kawasaki Disease
The purpose of this study is to determine whether the addition of infliximab to standard primary therapy of intravenous immunoglobulin (IVIG) and high dose aspirin will reduce resistance to therapy in acute Kawasaki disease (KD).
- Trial name
- NCT00760435
- Testing
- Infliximab
- Where
- 2 sites in United States
- Volunteers
- 196 people
- Sponsor
- University of California, San Diego
Kawasaki Disease, Cardiovascular Disease
Magnetic Resonance Myocardial Stress Perfusion in Pediatric Patients with Cardiovascular Disease
the goal of this observational study is to evaluate myocardial ischemia and myocardial microcirculation dysfunction in children with cardiovascular disease by myocardial stress perfusion imaging.
- Conditions
- Kawasaki Disease, Cardiovascular Disease, Anomalous Origin of Coronary Artery
- Trial name
- NCT06641843
- Where
- China
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- West China Second University Hospital
Diagnoses Disease
Role of Calcium Binding Protein S100A12 in Diagnosis and Prognosis of Kawasaki Disease
Recent studies showed that the value of c100A12 increased in children with Kawasaki disease, and decreased rapidly after treatment with gamma globulin.
- Trial name
- NCT05434611
- Testing
- S100A12
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- The First Affiliated Hospital of Yangtze University
Kawasaki Disease
Etiology Study of Kawasaki Disease
The purpose of this study is to investigate the infectious etiology of Kawasaki disease (KD); a prospective household and case control study for Kawasaki disease will be done.
- Trial name
- NCT00154596
- Where
- Taiwan
- Volunteers
- 700 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Kawasaki Disease, Pilot Study
Model-informed Dose Optimization for Rivaroxaban in Children With Giant Coronary Artery Aneurysm After Kawasaki Disease
Based on a population pharmacokinetic model-based dose optimization study, a 15 mg-equivalent, age-, and bodyweight-adjusted dosing regimen for Chinese children with giant coronary artery aneurysms after Kawasaki disease was…
- Conditions
- Kawasaki Disease, Pilot Study, Coronary Artery Aneurysm, Rivaroxaban
- Trial name
- NCT06978439
- Testing
- Rivaroxaban (Xarelto)
- Where
- China
- Volunteers
- 10 people
- Sponsor
- Children's Hospital of Fudan University
Kawasaki Disease
Prevalence and Early Markers of Atherosclerosis in Adults With a History of Kawasaki Disease
Kawasaki disease (KD) is an acute systemic vasculitic syndrome with coronary tropism. It has been reported worldwide, but it is ten times more common in Asian population.
- Trial name
- Kawasaki (NCT01440075)
- Testing
- Cardiac evaluation
- Where
- France
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- Hospices Civils de Lyon
Kawasaki Disease, Steroid
A Trial to Evaluate the Efficacy of Immunoglobulin Plus Steroid for Prevention of Coronary Artery Abnormalities in Taiwanese Refractory Kawasaki Disease (RAST Study)
Background: Kawasaki disease (KD), most popular acquired heart disease in childhood, is characterized by diffuse vasculitis, especially on the middle-sized muscular arteries. IVIG and aspirin are currently standard treatment.
- Conditions
- Kawasaki Disease, Steroid, Immuoglobulin
- Trial name
- RAST (NCT03200561)
- Testing
- Prednisolone, immunoglobulin
- Where
- Taiwan
- Volunteers
- 100 people
- Sponsor
- National Taiwan University Hospital
Kawasaki Disease
Efficacy and Safety of Immunoglobulin Plus Firsekibart in Patients With Kawasaki Disease
This study evaluates the efficacy and safety of the addition of Firsekibart to standard initial treatment (intravenous immunoglobulin [IVIG] plus aspirin) in children with Acute Kawasaki Disease (KD) .
- Trial name
- NCT07686770
- Testing
- IVIG, Aspirin, Firsekibart
- Where
- 2 sites in China
- Volunteers
- 90 people
- Sponsor
- Children's Hospital of Fudan University
Mucocutaneous Lymph Node Syndrome, Kawasaki Disease
A Randomized, Double Blind, Placebo Controlled Study of Etanercept in Children With Kawasaki Disease
The purpose of this study is to determine whether Etanercept (Enbrel) when used in conjunction with IVIG and aspirin, improves treatment response to IVIG in patients with Kawasaki Disease. Funding Source- FDA/OOPD
- Trial name
- NCT00841789
- Testing
- Etanercept
- Where
- 8 sites in United States, Canada
- Volunteers
- 205 people
- Sponsor
- Michael Portman
Kawasaki Disease, Coronary Aneurysm
Doxycycline Treatment to Prevent Progressive Coronary Artery Dilation in Children With Kawasaki Disease
Kawasaki disease (KD) affects infants and young children causing inflammation of the skin and blood vessels including the coronary arteries of the heart.
- Trial name
- NCT01917721
- Testing
- Doxycycline
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- Hawaii Pacific Health
SARS CoV-2, Kawasaki Disease
Genome Analysis of Human Endogenous Retroviruses (HERVs)(COVID19)
Human Endogenous Retroviruses (HERVs) are ancient sequences that became integrated into our DNA during evolutionary processes. The significance of their presence in DNA is still being studied, but HERVs appear to be involved in…
- Conditions
- SARS CoV-2, Kawasaki Disease, Retrovirus Infection
- Trial name
- HERV_COVID (NCT06775457)
- Testing
- sample collection
- Where
- 5 sites in Italy
- Volunteers
- 120 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
Kawasaki Disease
A Multi-center, Randomized to Compare the Efficacy of IVIG Alone and IVIG Plus High-dose Aspirin in Kawasaki Disease
Kawasaki disease (KD) is an acute febrile systemic vasculitis most commonly seen in children under the age of 5 years old. This trial has been designed as a multi-center, prospective, randomized controlled, evaluator-blinded…
- Trial name
- NCT02951234
- Testing
- IVIG only, IVIG and Aspirin
- Where
- 5 sites in Taiwan
- Volunteers
- 278 people
- Sponsor
- Chang Gung Memorial Hospital
Kawasaki Disease
Clinical Precise Diagnosis and Treatment in the Kawasaki Disease
The purpose of this project is to explore the differential gene expression profile of Kawasaki disease, and will explore the diagnosis and treatment targets related to coronary artery injury or kawasaki disease susceptibility…
- Trial name
- NCT05347901
- Testing
- Echocardiography, Genomics NGS sequencing
- Where
- 4 sites in China
- Volunteers
- 800 people, healthy volunteers welcome
- Sponsor
- Affiliated Hospital of Nantong University
Kawasaki Disease, Coronary Artery Abnormalities
Statins Study in Children of Acute Kawasaki Disease With Coronary Artery Abnormalities
The goal of this observational study is to learn about the safety and effects of atorvastatin in treatment of Chinese Kawasaki disease (KD) children complicated with coronary artery abnormalities (CAA) in acute phase.
- Trial name
- NCT07530640
- Testing
- atorvastatin of dose level 1, atorvastatin of dose level 2, atorvastatin of dose level 3
- Where
- China
- Volunteers
- 9 people
- Sponsor
- Children's Hospital of Fudan University