Clinical trials: Mucosal Inflammation
Head and Neck Cancer, Oral Complications
Pilocarpine in Preventing Mucositis and Dry Mouth in Patients Receiving Radiation Therapy for Head and Neck Cancer
RATIONALE: Radiation therapy uses high-energy x-rays to damage tumor cells. Drugs such as pilocarpine may protect normal cells from the side effects of radiation therapy.
- Trial name
- NCT00003139
- Testing
- pilocarpine hydrochloride
- Where
- 232 sites in United States, Canada
- Volunteers
- 249 people
- Sponsor
- Radiation Therapy Oncology Group
Radiation-induced Oral Mucositis, Oral Malignancy
A Phase II Prospective, Open-Label, Randomized, Multicenter Study of Kangfu Spray for the Prevention of Radiation-Induced Oral Mucositis in Patients With Oral Malignancies Receiving Intensity-Modulated Radiotherapy
This is a prospective, open-label, randomized, controlled, multicenter phase II study evaluating the efficacy and safety of Kangfu Spray for the prevention of radiation-induced oral mucositis in patients with histologically…
- Trial name
- NCT07538934
- Testing
- Kangfu Spray, Standard Oral Care
- Volunteers
- 140 people
- Sponsor
- YE ZHANG
Peri-implant Mucositis, Peri-Implantitis
Peri-implant Disease and Prosthetic Cement: Cross-sectional Study
The main objective of the present clinical study project, of a cross-sectional observational nature, is to evaluate the presence of submucosal cement residues through endoscopic visualization in clinical situations with…
- Trial name
- NCT05945836
- Where
- Italy
- Volunteers
- 46 people
- Sponsor
- University of Bologna
Peri-Implantitis, Peri-implant Mucositis
Evaluation of the Patient's Risk Profile Using the Peri-implantitis Risk Diagram
Various risk factors defined in the literature should be eliminated in order for the patient to be able to use implant-supported prostheses for a longer period of time.
- Conditions
- Peri-Implantitis, Peri-implant Mucositis, Dental Implant Failed
- Trial name
- NCT05618171
- Testing
- Evaluation of the patient's pre- and post-treatment risk profile using the peri-implantitis risk diagram
- Where
- Turkey (Türkiye)
- Volunteers
- 170 people, healthy volunteers welcome
- Sponsor
- Berceste Guler
Recurrent Aphthous Stomatitis, Mouth Ulcer
The Preventive and Therapeutic Effects of Spirulina Preparations on Ulcers of Oral Mucosa
This is a prospective, randomized, double-blind, placebo-controlled clinical trial designed to evaluate the efficacy and safety of spirulina supplementation in patients with radiation-induced oral mucositis (RIOM) receiving…
- Trial name
- NCT07723612
- Testing
- Spirulina Tablets
- Where
- China
- Volunteers
- 40 people
- Sponsor
- The Fourth Affiliated Hospital of Zhejiang University School of Medicine
Dental Implant Failed, Peri-implant Mucositis
Erythritol vs Ultrasonic Scaler Prophylaxis Systems on Dental Implants With Crowns Made by Different Materials
The aim of the study is to assess which prophylaxis methods is the most suitable for peri-implant hygiene between erythritol and ultrasonic scaler with peek inserts. A randomized clinical trial will be conducted on the patient.
- Conditions
- Dental Implant Failed, Peri-implant Mucositis, Peri-Implantitis
- Trial name
- NCT06288919
- Testing
- Erythritol prophylactic powders, Ultrasonic scaler with peek inserts
- Where
- Italy
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of Pavia
Head and Neck Cancer
Nutritional Risk and Mucositis in Patients With Head and Neck Carcinoma Receiving Chemoradiation
This study is being conducted to define the specific nutritional biomarkers and nutritional risk during the course of chemoradiation therapy for cancers of the head and neck.
- Trial name
- NCT00577902
- Testing
- Observation
- Where
- United States
- Volunteers
- 37 people
- Sponsor
- University of Arkansas
Oral Mucositis
Effects for Oral Mucositis Care During Chemoradiotherapy in Cancer Patients: Evaluation of the Bee Products
Oral mucositis is common among cancer patients receiving radiotherapy and chemotherapy. 80-90% of the patients are suffering from the mucositis pain; poor nutrition and even treatment discontinued.
- Trial name
- Mucositis (NCT05625841)
- Testing
- Honey product, propolis, Usual care
- Where
- Taiwan
- Volunteers
- 135 people
- Sponsor
- Taipei Medical University
Transplant; Intestine, Transplant; Complication, Rejection
The Endoscopic Assesment of Intestinal Grafts
The study validates prospectively a new endoscopic scoring system (Gothenburg Intestinal Transplant Endoscopy Score, GITES) designed to summarize and stratify the abnormal ileal endoscopic findings after intestinal…
- Conditions
- Transplant; Intestine, Transplant; Complication, Rejection, Transplant; Failure, Bowel, Enteritis
- Trial name
- INTEGRATE (NCT03444675)
- Where
- 4 sites in United States, Argentina and 2 more
- Volunteers
- 80 people
- Sponsor
- Sahlgrenska University Hospital
Radiation-Induced Mucositis, Head and Neck Cancer
Curcumin Gel On Radiation Induced Oral Mucositis
The goal of this clinical study is to investigate the effect of a curcuma longa oral gel (curenext) on reducing radiation-induced oral mucositis severity in cancer patients and provide a context for understanding if there is a…
- Trial name
- NCT05982197
- Testing
- Curcumin Gel, Standard Preparation
- Where
- Iraq
- Volunteers
- 40 people
- Sponsor
- University of Baghdad
Radiation Induced Oral Mucositis
Benzydamine vs Supersaturated Calcium Phosphate Oral Rinses for Radiation Induced Oral Mucositis in Head and Neck Cancer Patients.
The goal of this clinical trial is to compare and correlate salivary macrophage migratory inhibitory factor levels with onset and severity of radiation induced mucositis in head and neck cancer patients by using super saturated…
- Trial name
- NCT07748442
- Testing
- Benzydamine hydrochloride mouthrinse, Super saturated calcium phosphate oral rinses
- Where
- Pakistan
- Volunteers
- 42 people
- Sponsor
- Postgraduate Medical Institute, Lahore
Peri-Implantitis, Peri-implant Mucositis
Comparison of the Accuracy of Different Periodontal Probes for Peri-implant Pocket Registration
Various types of periodontal probes (e.g., metal probes, plastic/bendable probes, electronic periodontal probes) are used for peri-implant pocket depth registration; however, depending on the shape and size of the prosthetic…
- Trial name
- NCT05332327
- Where
- Sweden
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Malmö University
Oral Mucositis
Multi-centre, Open-label, First-in-man Study With Mucopad HA
The device´s intended use is to treat defects and/or lesions of the oral mucosa, e.g. oral mucositis.To prove safety of the device in terms of clinical results.
- Trial name
- NCT06276270
- Testing
- Mucopad HA
- Where
- 5 sites in Czechia
- Volunteers
- 50 people
- Sponsor
- Contipro Pharma a.s.
Head and Neck Neoplasms, Chemoradiotherapy
Evaluation the Effects of Herbal Gargle for Chemoradiotherapy-induced Oral Mucositis of Head & Neck Cancer, a Pilot Study.
The aim of the study is to evaluate the effects of Herbal gargle on chemoradiotherapy-induced stomatitis in head \& neck cancer patients.
- Conditions
- Head and Neck Neoplasms, Chemoradiotherapy, Stomatitis and Ulceration
- Trial name
- NCT05341206
- Testing
- Herbal gargle, Normal saline
- Where
- Taiwan
- Volunteers
- 80 people
- Sponsor
- Chang Gung Memorial Hospital
Peri-Implantitis and Peri-implant Mucositis, Hypoxia
Analysis of HIF-1α, MDA, and GPX4 in Peri-Implant Crevicular Fluid
Peri-implant diseases, such as peri-implant mucositis and peri-implantitis, are inflammatory conditions that affect the tissues surrounding dental implants. If untreated, these diseases can lead to bone loss and implant failure.
- Conditions
- Peri-Implantitis and Peri-implant Mucositis, Hypoxia, Ferroptosis
- Trial name
- NCT06863116
- Where
- Turkey (Türkiye)
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Ege University
Oral Mucositis, Stomatitis
Prospective Study of Head and Neck Cancer Radiation Treatment With or Without Amifostine
The purpose of this study is to compare the incidence of stomatitis when treating with amifostine before radiation treatment.
- Trial name
- NCT01288625
- Testing
- Amifostine
- Sponsor
- Sun Pharmaceutical Industries Limited
Intestinal Mucositis, Inflammation
Semaglutide in Auto-HSCT
The primary objective of this clinical trial is to ievaluate the effect of semaglutide (GLP-1 receptor agonist) in reducing intensity of gastrointestinal (GI) mucositis in patients undergoing high-dosage chemotherapy followed by…
- Conditions
- Intestinal Mucositis, Inflammation, Chemotherapeutic Toxicity
- Trial name
- PROTECT (NCT06449625)
- Testing
- Semaglutide Pen Injector [Ozempic]
- Volunteers
- 40 people
- Sponsor
- Klaus Gottlob Müller
Oral Mucositis, Pain
Cryotherapy for Prevention of Oral Mucositis in Children Undergoing Hematopoietic Stem Cell Transplantation
Oral mucositis (OM) is a common adverse effect of chemotherapy, radiotherapy and conditioning regimens before Hematopoietic Stem Cell Transplantation (HSCT).
- Conditions
- Oral Mucositis, Pain, Infection, Nutrition Aspect of Cancer
- Trial name
- NCT01789658
- Testing
- Cryotherapy
- Where
- 5 sites in Sweden
- Volunteers
- 53 people
- Sponsor
- Uppsala University
Oral Mucositis
A Mouthwash Medicine for the Reduction or Prevention of Mouth Ulceration Caused by Radiotherapy for Head and Neck Cancer
This study is looking at a new medication called NG11-2 to see if it can reduce a side effect called severe Radiation-induced Oral Mucositis (RIOM) that can happen to people getting radiation treatment for head and neck cancer.
- Trial name
- NCT06669390
- Testing
- NG11-2
- Where
- 4 sites in United Kingdom
- Volunteers
- 15 people
- Sponsor
- VasoDynamics Ltd
Mucositis, Hematopoietic Stem Cell Transplantation
Cryotherapy in the Prevention of Chemotherapy-Induced Mucositis in Stem Cell Transplant
Oral mucositis is a common complication of cancer therapy. Mucositis results from damage to the mucosal epithelium after delivery of chemotherapy or radiation treatments designed to treat the cancer.
- Conditions
- Mucositis, Hematopoietic Stem Cell Transplantation, Peripheral Blood Stem Cell Transplantation, Stomatitis
- Trial name
- NCT02326675
- Testing
- Ice, Normal Saline Solution
- Where
- United States
- Volunteers
- 29 people
- Sponsor
- University of Florida