Clinical trials: Mucosal Irritation
Female Dry Genital Mucosa
Clinical Study to Prove Safety in Use (Irritability and Sensitization in Genital Mucosa) of an Intimate Lubricating Gel
The purpose of this study is to check the safety under normal conditions of use through the emergence of signs of irritability and sensitization of the genital mucosa.
- Trial name
- CL STD SAF USE (NCT02441647)
- Testing
- KL029 Intimate Lubricant Gel
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Kley Hertz S/A
Irritable Bowel Syndrome, Food Allergy
Endomicroscopic Evaluation of Food-induced Gastrointestinal Mucosal Alteration
The overarching goal of this study is to establish a first ever registry in the U.S. to collect outcomes data to evaluate changes in the gastrointestinal (GI) mucosa following direct food application utilizing Confocal Laser…
- Trial name
- NCT06792838
- Testing
- Confocal Laser Endomicroscopy
- Volunteers
- 200 people
- Sponsor
- Cook Children's Health Care System
Irritable Bowel Syndrome, Inflammatory Bowel Diseases
Mucosal Innate Immune Activation in Chronic Intestinal Disorders
Crohn's disease and ulcerative colitis are types of chronic intestinal disorder called inflammatory bowel diseases (IBD) that can affect the small and large bowel causing symptoms of abdominal pain, diarrhea, blood in the stool…
- Trial name
- NCT03529318
- Testing
- Biopsies from endoscopy
- Where
- United States
- Sponsor
- University of Arkansas
Mucus Colitis, Inflammation, Colon
The Impact of Red Meat and Whole-grains Intake on the Colonic Mucosal Barrier
This study evaluates the impact of red meat and whole-grain intake on the colonic mucosal barrier and the dietary impact of these groups on the induced low-grade inflammation
- Conditions
- Mucus Colitis, Inflammation, Colon, Dietary Exposure
- Trial name
- NCT04235348
- Where
- Denmark
- Volunteers
- 161 people, healthy volunteers welcome
- Sponsor
- University of Southern Denmark
Irritable Bowel Syndrome
A Randomized Controlled Pilot Trial of Mesalazine in Patients With Irritable Bowel Syndrome
Emerging evidence indicates the presence of low-grade mucosal inflammation and its pathogenetic role in IBS. The aim of this pilot study is to provide that mesalazine treatment of IBS patients reduces low grade colonic…
- Trial name
- NCT00774007
- Testing
- mesalazine
- Where
- Italy
- Volunteers
- 20 people
- Sponsor
- SOFAR S.p.A.
Irritable Bowel Syndrome (IBS)
Confocal Endomicroscopy Utility (p-CLE) in Irritable Bowel Syndrome
Irritable bowel syndrome (IBS) is one of the most common gastrointestinal disorders. It has prevalence in general population of 5-20% and is more common in women and young adults.
- Trial name
- NCT02651532
- Testing
- Confocal Laser Endomicroscopy
- Where
- Ecuador
- Volunteers
- 74 people
- Sponsor
- Instituto Ecuatoriano de Enfermedades Digestivas
Oral Pain, Oral Pungent Sensation
Efficacy of Oral HA35 for Rapid Relief of Oral Pain and Pungent Sensation
This prospective, open-label, controlled pilot study evaluates oral 10% 35 kDa hyaluronan (HA35) versus four control interventions (C60 grapeseed oil，normal saline) for relief of capsaicin/AITC-induced oral pain and pungent…
- Conditions
- Oral Pain, Oral Pungent Sensation, Capsaicin-Induced Pain, AITC-Induced Irritation
- Trial name
- NCT07630571
- Testing
- Capsaicin Oral Challenge, Allyl Isothiocyanate (AITC) Oral Challenge, 10% 35 kDa Hyaluronan (HA35) Oral Solution
- Where
- China
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Nakhia Impex LLC
Mucosal Irritation, Image Quality
Lower Lugol's Solution Concentration on Reducing the Adverse Symptoms of Chromoendoscopy With Iodine Staining
This study was to test an optimal concentration of Lugol's solution which can reduce the mucosal irritation and provide high image quality to ensure endoscopy examination by a randomized blinded controlled trial.
- Trial name
- NCT03180944
- Testing
- 1.2% Lugol's solution, 1.0% Lugol's solution, 0.8% Lugol's solution
- Where
- China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Shandong University
Irritable Bowel Syndrome
Mucosal and Microbiota Changes During Acute Campylobacteriosis
Gastrointestinal (GI) infection with Campylobacter causes inflammation in the bowel and can change bacteria in the gut. Certain individuals with Campylobacter infection are also known to develop chronic bowel problems such as…
- Trial name
- NCT03223077
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- Mayo Clinic
Mucosa Associated Bacteria in Small Intestine
Changes of Microbiota in Irritable Bowel Syndrome Patients
To investigate the changes of gastrointestinal microbiota in irritable bowel syndrome patients by hydrogen breath test and molecular-based analysis of microbiota in gastrointestinal tract
- Trial name
- NCT01679730
- Where
- Taiwan
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Far Eastern Memorial Hospital