Clinical trials: Multi-organ Failure
ICU Mortality (Survival Rate)
FOUR-Based Modification of ICU Severity Scores
The goal of this observational study is to evaluate whether the Full Outline of UnResponsiveness (FOUR) score can replace the Glasgow Coma Scale (GCS) as the neurologic component of established intensive care unit (ICU) severity…
- Trial name
- FOUR-ICU (NCT07832773)
- Where
- Iraq
- Volunteers
- 2,000 people
- Sponsor
- Al-Nahrain University
Burns, Trauma
Microcirculatory Assessment in Patients With Trauma and Severe Burns
Predict the development of multiple organ failure in patients with trauma and severe burns.
- Trial name
- NCT01922960
- Testing
- micro-imaging
- Where
- United States
- Sponsor
- University of South Alabama
Multi Organ Failure
Early Renal Replacement Therapy in COVID 19 Patients With AKI Does it Improve the Outcome?
patients will be divided into two equal groups, each group including 50 adult patients with a confirmed diagnosis of covid, patients with acute kidney injury, the first group will be treated with early hemodialysis, second group…
- Trial name
- NCT05274685
- Testing
- haemodialysis
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Sohag University
Trauma; Complications, Multiple Organ Failure
A Validation of a Genomics Based Prognostic in Severe Trauma
The purpose of this study is to learn more about how to treat patients with severe injuries related to trauma and to prevent failure of vital organs in this patient population.
- Trial name
- NCT01810328
- Testing
- Traumatized population, Healthy Volunteers
- Where
- 2 sites in United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of Florida
SARS-CoV-2, Coronavirus
Personalized Health Education Against the Health Damage of Novel Coronavirus (COVID-19) Outbreak in Hungary
The additional effect of personalized health education compared to general education following the internationally accepted principles will be evaluated in the prevention of the serious course of the novel coronavirus infection.
- Conditions
- SARS-CoV-2, Coronavirus, COVID-19, 2019-nCoV
- Trial name
- PROACTIVE-19 (NCT04321928)
- Testing
- Personalized health education, General health education
- Where
- Hungary
- Volunteers
- 449 people, healthy volunteers welcome
- Sponsor
- University of Pecs
Peritonitis, Sepsis
The Value of PSP in Predicting Outcome in ICU Surgical Peritonitis Patients
The purpose of this study is to determine the diagnostic accuracy of Pancreatic Stone Protein (PSP) in predicting patient outcomes with suspected peritonitis in the Intensive Care Unit after abdominal surgery and compare PPS with…
- Conditions
- Peritonitis, Sepsis, Multiple Organ Failure, Death
- Trial name
- NCT01465711
- Testing
- All abdominal surgical procedures, Intubation, Imaging
- Where
- Germany
- Volunteers
- 137 people
- Sponsor
- University of Magdeburg
Septic Shock, Multiorgan Failure
Effect of oXiris Hemofilter Use in Septic Shock: A Multicenter Retrospective Cohort Study
This study aims to evaluate the clinical effectiveness of the oXiris® hemofilter in patients with septic shock and acute kidney injury (AKI) requiring continuous renal replacement therapy (CRRT).
- Conditions
- Septic Shock, Multiorgan Failure, Sepsis
- Trial name
- NCT07539883
- Where
- South Korea
- Volunteers
- 360 people
- Sponsor
- Seoul National University Bundang Hospital
SARS-CoV 2 Pneumonia
Calcifediol in the Treatment of SARS-CoV-2 Disease (COVID-19).
Descriptive, retrospective, observational, anonymous, study to evaluate the potential effect of incorporating calcifediol into the therapeutic protocol of patients hospitalized for COVID-19 on mortality and other outcome…
- Trial name
- COVIDIOL (NCT06279910)
- Testing
- Calcifediol
- Where
- Spain
- Volunteers
- 230 people
- Sponsor
- Complejo Hospitalario Universitario de Albacete
Organ Failure, Multiple
Evaluation of Corrected Carotid Flow Time Variations During Passive Leg Lift to Predict Response to Filling.
Patients hospitalized in intensive care often require intravenous administration of fluid in order to optimize the functioning of the heart and thus ensure perfusion of vital organs such as the kidneys, the brain or the digestive…
- Trial name
- CAROT (NCT04732481)
- Testing
- passive leg lift test
- Where
- France
- Volunteers
- 21 people
- Sponsor
- Centre Hospitalier de Cornouaille
Acute Pancreatitis, Complication
Rectal Indomethacin as Early Treatment for Acute Pancreatitis (INDOMAP Trial)
Acute pancreatitis (AP) is an inflammatory condition of the pancreas following the activated pancreatic enzymes induced by varied causes, with or without other organ(s) dysfunction.
- Conditions
- Acute Pancreatitis, Complication, Mortality Rate, Organ Failure, Multiple
- Trial name
- INDOMAP (NCT03547232)
- Testing
- Indomethacin SR
- Where
- 17 sites in China
- Volunteers
- 1,504 people
- Sponsor
- Peking Union Medical College Hospital
Septic Shock
Treatment of Septic Shock by Inhibiting Autodigestion and Preserving Gut Integrity With Enteric LB1148
Septic shock is a potentially life-threatening condition that can result in multi-organ dysfunction syndrome (MODS) and mortality.
- Trial name
- SSAIL (NCT02317549)
- Testing
- LB1148
- Where
- 34 sites in United States, Canada
- Volunteers
- 8 people
- Sponsor
- Leading BioSciences, Inc
COVID-19
TXA127 for the Treatment of Severe COVID-19
The purpose of this study is to determine if administration of angiotensin-(1-7) (TXA127) prevents acute kidney injury and deterioration into multi-organ failure in patients with severe COVID-19.
- Trial name
- NCT04401423
- Testing
- TXA127
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- Columbia University
Trauma
Metabonomics Fingerprinting of Multiple Trauma
The aim of this study is to establish plasma metabonomics fingerprinting atlas for severe multiple trauma patient using 1H nuclear magnetic resonance (NMR) based metabonomics methodology and advanced mathematics tools.
- Trial name
- NCT01279239
- Where
- China
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Sichuan Academy of Medical Sciences
COVID-19, Post Acute Sequelae of COVID-19
COVID-19 Outcome Prediction Algorithm
Severe acute respiratory syndrome coronavirus 2-mediated coronavirus disease (COVID-19) is an evolutionarily unprecedented natural experiment that causes major changes to the host immune system.
- Conditions
- COVID-19, Post Acute Sequelae of COVID-19, Long COVID, Organ Dysfunction Syndrome, Multiple
- Trial name
- COPA (NCT05471011)
- Testing
- Blood and nasal swab sampling
- Where
- 7 sites in United States
- Volunteers
- 600 people
- Sponsor
- University of California, Los Angeles
Critical Illness, Respiratory Failure
High-flow Nasal Oxygenation for Apnoeic Oxygenation During Intubation of the Critically Ill
Intubation in the intensive care unit is a standard procedure with a high risk of adverse events such as hypoxaemia and cardiovascular instability.
- Conditions
- Critical Illness, Respiratory Failure, Multi Organ Failure, Hypoxia
- Trial name
- HiPOXIC (NCT05883137)
- Testing
- Optiflow Switch
- Where
- Sweden
- Volunteers
- 150 people
- Sponsor
- Region Stockholm
Preventive Medicine, Multi Organ Failure
Efficacy and Safety of FP-1201-lyo (Interferon Beta-1a) in Prevention of Multi-Organ Failure on Patients After Open Surgery for a RAAA
A study to assess effectiveness and safety of a drug FP-1201-lyo (Recombinant Human Interferon Beta-1a) in the Prevention of Multi-Organ Failure on patients after Open Surgery for a Ruptured Abdominal Aortic Aneurysm
- Trial name
- INFORAAA (NCT03119701)
- Testing
- Interferon Beta-1A
- Where
- 9 sites in Estonia, Finland and 1 more
- Volunteers
- 40 people
- Sponsor
- Faron Pharmaceuticals Ltd
Septic Shock
REmote Ischemic COnditioning in Septic Shock
Septic shock remains a major public health problem in industrialized countries, with a mortality rate as high as 50%, largely related to multiple organ dysfunction.
- Trial name
- RECO-Sepsis (NCT03201575)
- Testing
- Remote Ischemic conditioning, Patients with no remote ischemic conditioning
- Where
- 6 sites in France
- Volunteers
- 180 people
- Sponsor
- Hospices Civils de Lyon
Respiratory Failure, Multiple Organ Failure
Prevention of Severe Acute Respiratory Failure in Patients With PROOFCheck
Severe acute respiratory failure (ARF) requiring prolonged mechanical ventilation is the most common form of acute organ dysfunction in the hospital, and is often associated with multiple organ failure (MOF), high mortality, and…
- Trial name
- PROOFcheck (NCT02488174)
- Testing
- PROOFcheck, Standard Care
- Where
- 3 sites in United States
- Volunteers
- 34,040 people
- Sponsor
- Albert Einstein College of Medicine
Respiratory Failure, Circulatory Failure
ICU Background Early Awareness for Critical deterioratiON
The study will compare ICU sub-units, those with additional support of a clinician awareness system, ICU Beacon, and those receiving the standard of care.
- Conditions
- Respiratory Failure, Circulatory Failure, Mortality, Organ Dysfunction
- Trial name
- BEACON (NCT07119411)
- Testing
- ICU Beacon
- Where
- Switzerland
- Volunteers
- 1,962 people, healthy volunteers welcome
- Sponsor
- ETH Zurich
Localized Infection, Sepsis
The Procalcitonin and Survival Study
This is a randomised, single blinded, multicentre trial to evaluate whether daily procalcitonin (PCT) measurements and immediate diagnostic and therapeutic responses to abnormal values and day-to-day changes can reduce the…
- Conditions
- Localized Infection, Sepsis, Multiple Organ Failure
- Trial name
- PASS (NCT00271752)
- Testing
- Earlier therapeutic changes regarding infection
- Where
- 9 sites in Denmark
- Volunteers
- 1,200 people
- Sponsor
- Danish Procalcitonin Study Group