Clinical trials: Multimorbidity, active
Chronic Heart Failure With Reduced and Mildly Reduced Ejection Fraction (HFrEF and HFmrEF)
Polypharmacy, Safety, and Medication Adherence in Patients With Chronic Heart Failure With Reduced and Mildly Reduced Ejection Fraction
This prospective registry study (FARAON) aims to assess the prevalence, structure, safety profile, and dynamics of polypharmacy, as well as its association with medication adherence, quality of life, and clinical outcomes in…
- Trial name
- FARAON (NCT07640854)
- Where
- Russia
- Volunteers
- 130 people
- Sponsor
- National Medical Research Center for Therapy and Preventive Medicine
Cardiovascular Diseases, Multimorbidity
Factors of Potentially Dangerous Drug Interactions in Patients With Cardiovascular Diseases and Multimorbidity
This prospective observational registry aims to evaluate the prevalence and clinical significance of potentially dangerous drug interactions in outpatients with cardiovascular diseases and multimorbidity.
- Conditions
- Cardiovascular Diseases, Multimorbidity, Drug Interactions
- Trial name
- FARMISS (NCT07607574)
- Where
- Russia
- Volunteers
- 120 people
- Sponsor
- National Medical Research Center for Therapy and Preventive Medicine
Myopia, Mental Health
Intervention for Preventing Myopia and Multimorbidity in Children
This study aims to develop and evaluate a scalable, hybrid intervention model for the co-prevention of myopia, obesity, and mental health issues among children.
- Conditions
- Myopia, Mental Health, Cardiovascular Health Status
- Trial name
- NCT07294222
- Testing
- Standard School Health Education, Multi-component Health Promotion Package
- Volunteers
- 4,000 people, healthy volunteers welcome
- Sponsor
- Fangbiao Tao
Multimorbidity
Living With Multimorbidity: Care Coordination and Symptom Management Program (COORDINATE)
The goal of this clinical trial is to learn if a new care program, called the COORDINATE Program, can help older adults with two or more chronic health conditions.
- Trial name
- NCT07157982
- Testing
- COORDINATE Program, Enhanced Usual Care
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Johns Hopkins University
Major Depressive Disorder (MDD), Breast Cancer Survivor
Moving on After Breast Cancer Trial for Depressed Breast Cancer Survivors in Pakistan
Breast cancer is the most common cancer among women worldwide, and many survivors experience comorbid mental health conditions such as depression and anxiety, which can significantly worsen health outcomes and increase mortality.
- Trial name
- Moving On ABC (NCT07015944)
- Testing
- Non-specialist delivered Low intensity guided self-help (Khushi and Khatoon), Moving on After Breast Cancer (ABC) plus, Standardised pharmacological treatment (antidepressants)
- Where
- Pakistan
- Volunteers
- 26,376 people
- Sponsor
- Pakistan Institute of Living and Learning
Stroke, Traumatic Brain Injury
Targeting Osteosarcopaenia and Multimorbidity for Frailty Prevention
The aging population and its accompanying burden from non-communicable chronic diseases predicts an increasing impact imposed by frailty on healthcare systems.
- Conditions
- Stroke, Traumatic Brain Injury, Knee Osteoarthritis, Breast Cancer
- Trial name
- OPTIMA-C (NCT06073106)
- Where
- Singapore
- Volunteers
- 500 people
- Sponsor
- Tan Tock Seng Hospital
Hypertension, Diabetes
Exercise Impact in Elderly With Multimorbidity: HbA1c and Blood Pressure
The main objective of the study is to compare the effect of two different types of physical exercise modalities on glycated hemoglobin and blood pressure in elderly individuals with multimorbidity.
- Conditions
- Hypertension, Diabetes, Osteoarthritis, Depression Disorders
- Trial name
- NCT06879639
- Testing
- Exercise, Control
- Where
- Portugal
- Volunteers
- 63 people
- Sponsor
- Universidade do Porto
Chronic Obstructive Pulmonary Disease (COPD), Asthma
Chronic Airway Disease and Multimorbidity Cohort
Background: Chronic airway diseases (CAD), including chronic obstructive pulmonary disease (COPD), asthma and bronchiectasis, are highly prevalent and cause serious disease burden.
- Conditions
- Chronic Obstructive Pulmonary Disease (COPD), Asthma, Bronchiectasis
- Trial name
- CAM Cohort (NCT06798077)
- Where
- 9 sites in China
- Volunteers
- 2,000 people
- Sponsor
- China-Japan Friendship Hospital
Diabetes Mellitus, Hypertension
Comparing Healthcare Visit Recording and Open Notes to Improve Chronic iLlness Care Experience in Older Adults
CHRONICLE is a randomized trial assessing the comparative effectiveness of providing written visit information via the patient portal (NOTES) versus NOTES plus visit audio recording (AUDIO) to older adult patients with chronic…
- Trial name
- CHRONICLE (NCT05955339)
- Testing
- NOTES, AUDIO
- Where
- 3 sites in United States
- Volunteers
- 1,022 people
- Sponsor
- Dartmouth-Hitchcock Medical Center
Complex Patient, Multimorbidity
Pursuing the Triple Aim in Hotspotters: Identification and Integrated Care
Hotspotters are patients with complex care needs, defined by problems in multiple life domains and high acute care use. These patients often receive mismatched care, resulting in overuse of care and increased healthcare costs.
- Conditions
- Complex Patient, Multimorbidity, Psychosocial Problem, Chronic Disease
- Trial name
- NCT05878054
- Testing
- Proactive, integrated and personalised care
- Where
- Netherlands
- Volunteers
- 41 people
- Sponsor
- Leiden University Medical Center
Myocardial Infarction (MI), Acute Cardiovascular Disease
To Develop and Introduce Into Polyclinic Practice a Register of Patients with Experience of Myocardial Infarction and Acute Cerebrovascular Disease
This is a retrospective observational study using the methodology of creating medical registries. The expected number of patients included in the registry is about 2000 patients with myocardial infarction and/or ACVD of any…
- Trial name
- NCT06815913
- Where
- Belarus
- Volunteers
- 2,000 people
- Sponsor
- State Institution "Republican Scientific and Practical Center" Cardiology, Belarus
Cardiometabolic Comorbidities
Self-management Intervention for People With Cardiometabolic Multimorbidity: A Pilot Randomized Controlled Trial
This pilot randomized controlled trial aims to evaluate the feasibility and preliminary effects of a telephone-based self-management intervention for adults with cardiometabolic multimorbidity.
- Trial name
- NCT07792785
- Testing
- Motivational interviewing, self-affirmation and problem-solving, Usual Care
- Where
- China
- Volunteers
- 72 people
- Sponsor
- The Hong Kong Polytechnic University
Cancer
Improving Adherence to Chronic Disease Medication Regimens Among Patients With Recently Diagnosed Cancer
This pilot study evaluates a pharmacist-led medication adherence intervention and Medisafe mobile application among patients with newly diagnosed cancer and multimorbidity.
- Trial name
- NCT07811258
- Testing
- Medisafe Medication Management Program, Pharmacist-Led Medication Review
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Duke University
Multimorbidities
How Complexity and Multiple Illnesses Affect Hospitalized Patients' Health: A Multicenter Study
The goal of this observational study is to evaluate the association between complexity and multiple illnesses of adult hospitalized internal medicine patient and mortality.
- Trial name
- SPIR (NCT06872632)
- Where
- 21 sites in Italy
- Volunteers
- 2,326 people, healthy volunteers welcome
- Sponsor
- Società Italiana di Medicina Interna
Chronic Non-communicable Diseases, Cardiovascular Diseases
RegiStry Of the multiFaceted medIcal cenTer
This study is a prospective medical registry (the SOFIT Registry) that enrolls all patients hospitalized in various departments of the Tula Regional Clinical Hospital in 2021.
- Conditions
- Chronic Non-communicable Diseases, Cardiovascular Diseases, COVID-19, Multimorbidity
- Trial name
- SOFIT (NCT06803862)
- Where
- 2 sites in Russia
- Volunteers
- 21,783 people
- Sponsor
- National Medical Research Center for Therapy and Preventive Medicine
Multimorbidity, Physical Deconditioning
Multicomponent Telerehabilitation to Engage Veterans in Effective Self-Management of Complex Health Conditions
Medically complex older Veterans are at greater risk for progressive declines in physical function, lower quality of life, and increasing care needs.
- Trial name
- NCT06288438
- Testing
- Motivational Interviewing Techniques, Physical Therapy Interventions, Education
- Where
- United States
- Volunteers
- 126 people
- Sponsor
- VA Office of Research and Development
Chronic Diseases
Evaluate the Effectiveness of a Virtual Community of Practice
Objective: To evaluate and compare the effectiveness and cost-effectiveness of a Virtual Community of Practice (VCoP) via a web-based application versus individual and self-administered online education to improve the activation…
- Trial name
- NCT06046326
- Testing
- virtual community of practice
- Where
- 3 sites in Spain
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Gerencia de Atención Primaria, Madrid
Multimorbidity
Trajectories and Experiences of People With Multimorbidity in Spain (LOXO-MULTIPAP) Project: a Mixed Methods Study
The overall objective of the study is to analyze the evolution of multimorbidity, its most relevant patterns and trajectories in the Spanish National Health System population, from 2012 to 2022, and to analyze the factors that…
- Trial name
- LOXO (NCT06478745)
- Testing
- Retrospective and prospective cohort, Focus group, semi-structured interviews and Photovoice, Systematic review
- Where
- Spain
- Volunteers
- 3,239,950 people
- Sponsor
- Gerencia de Atención Primaria, Madrid
Alzheimer s Disease, Vascular Dementia
Predictors of Emergency Department Use in Frail Patients
When admitted to the emergency department (ED), elderly non-autonomous patients show high risk of adverse health outcomes. The prompt identification of ED use risk factors in such population is hence needed.
- Conditions
- Alzheimer s Disease, Vascular Dementia, Frailty, Elderly
- Trial name
- THE-Spoke 10 (NCT07259499)
- Testing
- Plasma phosphorylated Tau 181
- Where
- Italy
- Volunteers
- 110 people
- Sponsor
- University of Pisa
Asthma Bronchiale, Breast Neoplasms
Digital Implementation of the German S3 Clinical Practice Guideline for Multimorbidity
The web application gp-multitool.de is a digital tool for implementing the German S3 clinical practice guideline for multimorbidity of the German Society of General Practitioners and Family Physicians in primary care.
- Conditions
- Asthma Bronchiale, Breast Neoplasms, Coronary Disease, Diabetes Mellitus, Type 2
- Trial name
- NCT06831994
- Testing
- gp-multitool.de
- Where
- Germany
- Volunteers
- 659 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf