Clinical trials: Multiple Chronic Health Conditions
Multiple Sclerosis, Long Covid
Fatigue Investigation Using Digital Outcomes
This study investigates objective methods to measure and monitor fatigue in patients with post-COVID-19 condition (long COVID) and multiple sclerosis (MS), and includes a group of healthy volunteers for comparison.
- Conditions
- Multiple Sclerosis, Long Covid, Healthy
- Trial name
- FIDO (NCT07783074)
- Where
- 6 sites in Switzerland
- Volunteers
- 122 people, healthy volunteers welcome
- Sponsor
- Liliana Barrios
Multiple Chronic Diseases Among Diabetes Mellitus, Chronic Obstructive Pulmonary Diseases and Heart Failure
Life-long Monitoring of Frail Patients With Chronic Diseases
The purpose of this study is to evaluate whether telemonitoring of frail patients with chronic diseases produces benefits in terms of reduced readmissions, improved health related quality of life, and improved health status.
- Trial name
- NCT01608932
- Testing
- Telemonitoring for frail patients with chronic diseases
- Where
- 7 sites in Italy
- Volunteers
- 152 people
- Sponsor
- Regione Veneto
Diabetes, Heart Disease
The CREATE Wellness Study
Cardiovascular disease (CVD) is the leading cause of death in the U.S. Efforts to improve CVD risk factors often fall short in complex patients with multiple co-morbid conditions, a growing, expensive, and high-risk segment of…
- Conditions
- Diabetes, Heart Disease, Hypertension, Dyslipidemia
- Trial name
- NCT02302612
- Testing
- CREATE Wellness, Usual Care Control
- Where
- United States
- Volunteers
- 647 people
- Sponsor
- Kaiser Permanente
COPD
Lung Health of Early COPD: A Multi-center Cohort Study
This is a multi-center, prospective, cohort study in early COPD patients. This study aims to elucidate the lung function decline and its association with smoking and other risk factors.
- Trial name
- LHEC (NCT05466396)
- Testing
- smoking
- Where
- 2 sites in China
- Volunteers
- 1,550 people, healthy volunteers welcome
- Sponsor
- Ting YANG
Hepatitis C, Medication Adherence
Patient-Centered Models of HCV Care for People Who Inject Drugs
People who inject drugs (PWID) have higher rates of hepatitis C virus (HCV) than do other groups. Effective, safe new treatments called direct-acting antiviral agents (DAAs) have been developed recently.
- Trial name
- HERO (NCT02824640)
- Testing
- Patient Navigation, modified Directly Observed Therapy
- Where
- United States
- Volunteers
- 755 people
- Sponsor
- Prisma Health-Upstate
Gastrointestinal Hemorrhage, Diabetes Complications
Therapeutic Conflicts and Multimorbidity
Clinical practice guidelines do not take into account multimorbidity and various potential therapeutic conflicts. Identifying and quantifying therapeutic conflicts is crucial in multimorbid patients having more than two acute or…
- Conditions
- Gastrointestinal Hemorrhage, Diabetes Complications, Multimorbidity
- Trial name
- NCT02928939
- Testing
- drug-drug or drug-disease interaction
- Where
- Switzerland
- Volunteers
- 1,101 people
- Sponsor
- University of Zurich
Cardiovascular Diseases, Osteoporosis
Guangzhou Nutrition and Health Study (GNHS)
Purpose: The Guangzhou Nutrition and Health Study (GNHS) project aims to assess the determinants of metabolic disease in nutritional aspects, as well as other environmental and genetic factors, and explore possible mechanisms…
- Conditions
- Cardiovascular Diseases, Osteoporosis, Diabetes Mellitus, Type 2, Metabolic Syndrome
- Trial name
- GNHS (NCT03179657)
- Volunteers
- 5,118 people, healthy volunteers welcome
- Sponsor
- Sun Yat-sen University
Chronic Disease
A Mobile Intervention Merging Yoga and Self-Management Skills
Chronic disease self-management interventions and meditative movement approaches (.e.g., yoga) can independently improve depressive symptoms.
- Trial name
- MYSkillsMobile (NCT04758312)
- Testing
- MY-Skills Mobile
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Physical Function, Multiple Chronic Conditions
Church-based Intervention to Improve Physical Function
This is a 12-month multi-level behavioral cluster randomized trial testing a church-based intervention to improve physical function (PF) in Americans with PF limitations.
- Trial name
- NCT05345041
- Testing
- Keep it Movin', Go 4 Life Self Guided Education
- Where
- United States
- Volunteers
- 360 people, healthy volunteers welcome
- Sponsor
- Rush University Medical Center
Multiple Chronic Conditions, Dementia
Patient Priorities Care for Hispanics With Dementia
Most persons living with dementia (PlwD) have multiple chronic conditions (MCC). Managing MCC typically involves adhering to clinical practice guidelines for single diseases.
- Trial name
- PPC-HD (NCT05303194)
- Testing
- Patient Priorities Care (PPC) Approach, Adapted PPC
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- The University of Texas Medical Branch, Galveston
Type 1 Diabetes, T1D
DASH-Obesity: Explainable AI for Family-Centric Personalized Weight Control in Adolescents and Young Adults With Obesity and Chronic Conditions
This prospective single-arm feasibility study evaluates the Adhera Caring Digital Program for Obesity (ACDP-O), a family-centered digital health intervention designed to support adolescents and young adults with…
- Conditions
- Type 1 Diabetes, T1D, Obesity & Overweight, Obesity Type 2 Diabetes Mellitus
- Trial name
- DASH-Obesity (NCT07638345)
- Testing
- Adhera Caring Digital Program-Obesity (ACDP-O)
- Where
- Spain
- Volunteers
- 280 people, healthy volunteers welcome
- Sponsor
- Adhera Health, Inc.
Hypertension
SMBP Study: Improving High Blood Pressure in Older Adults With Multiple Chronic Diseases
Nearly half of adults in the United States (47 percent, or 116 million) have hypertension, also known as high blood pressure (BP).
- Trial name
- NCT06932029
- Testing
- SMBP with clinical pharmacist support
- Where
- 2 sites in United States
- Volunteers
- 930 people
- Sponsor
- Korey Kennelty
Medication Adherence, Medication Nonadherence
Identifying Reasons for Non-adherence in Patients With Multi-morbidity
The study will be carried out during pharmacist-conducted medication reconciliation. The pharmacist will ask how the patient has been taking the prescribed medicines and whether any over-the-counter medicines and food supplements…
- Conditions
- Medication Adherence, Medication Nonadherence, Chronic Disease
- Trial name
- NCT05167578
- Testing
- Medication reconciliation
- Where
- Finland
- Volunteers
- 250 people
- Sponsor
- Helsinki University Central Hospital
Disability Physical, Chronic Conditions, Multiple
Physical Activity and Social Engagement for Persons With Disabilities in an Underserved Community
Using a community-based participatory approach, this project aims to evaluate the feasibility, acceptability, and preliminary efficacy of two technology-driven group activity programs on socioemotional health and physical…
- Conditions
- Disability Physical, Chronic Conditions, Multiple, Aging
- Trial name
- NCT05247242
- Testing
- Lakeshore Online Fitness (Online), Get Active with Virtual Reality (VR)
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of Alabama at Birmingham
Chronic Conditions, Multiple, Chronic Conditions
Evaluating Covered California's Grocery Support Program
This is a pragmatic randomized controlled trial (RCT) of Covered California's Grocery Support Program. This pragmatic RCT will test the efficacy of providing a monthly food card benefit for adults with food insecurity, a chronic…
- Conditions
- Chronic Conditions, Multiple, Chronic Conditions, Food Insecurity, Low-Income Population
- Trial name
- NCT07215897
- Testing
- Grocery Support Monthly Program, Grocery Support One-Time Payment
- Where
- United States
- Volunteers
- 6,975 people
- Sponsor
- University of California, San Francisco
Polypharmacy
Care Planning for Older Persons With Multiple Conditions: Encouraging a Tailored Approach (COMET): Stage II
The purpose of the proposed project is to pilot-test in the clinic setting a computer-based clinical decision support system (CDSS) designed to optimize medication prescribing for older persons with multiple chronic conditions…
- Trial name
- COMET (NCT02501967)
- Testing
- COMET
- Where
- United States
- Volunteers
- 128 people
- Sponsor
- Yale University
Children With Medical Complexity
Self-management Intervention for Children With Chronic Medical Complexity: Pilot Feasibility Trial
The investigators have developed a tool to facilitate self-management for children with medical complexity (complex, multisystem chronic diseases) called MyChildCMC (My Child's Complex Medical Condition).
- Trial name
- NCT04470193
- Testing
- MyChildCMC app
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Utah
Stroke, Multiple Sclerosis
Health Promotion and Wellness Program for Adults With Disabling Conditions
The objective of this study is to conduct a randomized controlled pilot study to examine the efficacy, feasibility and safety of the SystemCHANGE™(SC) health promotion and wellness program in adults with disabling conditions.
- Conditions
- Stroke, Multiple Sclerosis, Rheumatoid Arthritis
- Trial name
- NCT01776034
- Testing
- SystemCHANGE Group Lifestyle counseling, Phone Lifestyle Counseling
- Where
- United States
- Volunteers
- 66 people
- Sponsor
- Case Western Reserve University
Hernia
Patient Priorities Aligned Discrete Decision Making for Older Adults With Multiple Chronic Conditions.
The purpose of the study is to to evaluate an artificial intelligence (AI) powered large language model (LLM) chatbot -PrioritiesAI -that assists patients in understanding, clarifying, and communicating their health priorities…
- Trial name
- NCT07848386
- Testing
- AI Chatbot
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- The University of Texas Health Science Center, Houston
Multiple Chronic Conditions
Patient Priorities Care-North Carolina
The long-term goal of this research is to re-engineer clinical decision-making for older adults with multiple chronic conditions (MCC) to focus on patients' self-identified health priorities.
- Trial name
- PPC-NC (NCT04233554)
- Testing
- Patient Priorities Care
- Where
- 5 sites in United States
- Sponsor
- University of North Carolina, Chapel Hill