Clinical trials: Multiple Organ Dysfunction
Multi Organ Failure, Left Ventricular Dysfunction
Acute Cardiac Dysfunction in Critical Illnes
The overall aim of the study is to establish the clinical importance of cardiac dysfunction, by estimating its incidence and impact on short- and long-term outcomes, in a mixed population of critically ill patients with…
- Conditions
- Multi Organ Failure, Left Ventricular Dysfunction, Right Ventricular Dysfunction, Tako Tsubo Cardiomyopathy
- Trial name
- NCT05860504
- Testing
- Echocardiography, Cardiac magnetic resonance imaging, Coronary CT
- Where
- Sweden
- Volunteers
- 592 people
- Sponsor
- Sahlgrenska University Hospital
Abdominal Surgery, Respiratory Failure
Metabolites of Tramadol in the Postoperative Surgical Patients
Tramadol is opioid analgesic widely used to treat moderate to severe pain. It is metabolized by cytochrome CYP2D6 into two major metabolites: pharmacologically active metabolite O-desmethyltramadol (M1) and inactive…
- Conditions
- Abdominal Surgery, Respiratory Failure, Renal Failure, Liver Dysfunction
- Trial name
- METRAS (NCT04004481)
- Testing
- Postoperative analgesia using tramadol
- Where
- Croatia
- Volunteers
- 50 people
- Sponsor
- Osijek University Hospital
Multiple Organ Dysfunction Syndrome
6-Methyl-Prednisolone for Multiple Organ Dysfunction Syndrome
Background: Systemic corticosteroids are considered in patients with an adverse clinical course suffering from conditions like the acute respiratory distress syndrome (ARDS) and septic shock.
- Trial name
- NAIF (NCT00127985)
- Testing
- 6-methyl-prednisolone
- Where
- 6 sites in Spain
- Volunteers
- 240 people
- Sponsor
- Hospital Universitario Principe de Asturias
Heat Stroke
Mechanism Study of G Protein-coupled Receptor 81 in Multiple Organ Dysfunction of Heat Stroke
Heat stroke is one of the common acute and critical conditions in the ICU, characterized by a high incidence and mortality rate, and there is still a lack of effective and precise treatment methods.
- Trial name
- NCT07346443
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Second Affiliated Hospital of Wenzhou Medical University
Sepsis, Burn Injury
Surgical Critical Care Initiative (SC2i) Tissue and Data Acquisition Protocol (TDAP) in Burn Patients Improving the Robustness and Generalizability of Post-burn Sepsis Prediction With the Post-Burn Sepsis Digital Twin. Group 1
This study is following adult patients with serious burn injuries to better understand how their bodies respond to treatment and recovery.
- Conditions
- Sepsis, Burn Injury, Wound Healing, Critical Illness
- Trial name
- NCT07249762
- Testing
- Observational Cohort (No Intervention)
- Where
- 3 sites in United States
- Volunteers
- 40 people
- Sponsor
- Henry M. Jackson Foundation for the Advancement of Military Medicine
Sepsis, Multiple Organ Failure
Microcirculatory Alteration and Biomarkers: New Approach for Early Assessment of Septic Multi-organ Dysfunction
The aim of this study is to investigate associations between early structural cellular injury and microvascular alteration with progression of septic organ dysfunction according to total SOFA-Score (an ICU-scoring system - the…
- Trial name
- NCT02426645
- Where
- Germany
- Volunteers
- 25 people
- Sponsor
- Prof. Dr. Marc-H. Dahlke, Ph. D.
Pediatric Sepsis-induced Multiple Organ Dysfunction Syndrome
The Study Seeks to Determine Potential Correlations Between Ventilation and Hematological Alterations, Contributing to a Better Understanding of Its Physiological Effects and Optimizing Patient Management in Critical Care Settings.
The study seeks to determine potential correlations between ventilation and hematological alterations, contributing to a better understanding of its physiological effects and optimizing patient management in critical care…
- Trial name
- NCT07030114
- Testing
- complete blood tests, mechanical ventilation (MV)
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Assiut University
Pancreatitis, Acute
Resolution of Organ Injury in Acute Pancreatitis - RESORP
Acute pancreatitis (AP) is inflammation of the pancreas usually triggered by gallstones or drinking excessive alcohol. 80% of people who have an episode of AP will recover without complications.
- Trial name
- RESORP (NCT03342716)
- Where
- United Kingdom
- Volunteers
- 229 people
- Sponsor
- University of Edinburgh
Endotoxemia, Inflammation
The Effects of Atazanavir-induced Hyperbilirubinemia During Human Endotoxemia
Excessive inflammation, production of free radicals and vascular injury are considered the main contributors to the development of organ dysfunction in patients with severe infections and sepsis.
- Conditions
- Endotoxemia, Inflammation, Multi Organ Dysfunction Syndrome, Sepsis
- Trial name
- NCT00916448
- Testing
- Atazanavir, E. coli endotoxin
- Where
- Netherlands
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Sepsis, MODS
Early Recognition and Dynamic Risk Warning System of Multiple Organ Dysfunction Syndrome Caused by Sepsis
Background Sepsis still the main challenge of ICU patients, because of its high morbidity and mortality. The proportion of sepsis, severe sepsis, and septic shock in china were 3.10%, 43.6%, and 53.3% with a 2.78%, 17.69%, and…
- Trial name
- NCT04904289
- Testing
- All intervention of real world
- Where
- 18 sites in China
- Volunteers
- 60,000 people
- Sponsor
- Sun Yat-sen University
Multiple Organ Dysfunction Syndrome
Pediatric Immune Response to Multi-Organ Dysfunction
Multiple organ dysfunction (MOD) is defined by the association of at least two failures of vital organs, with various etiologies (septic shock, polytrauma, acute respiratory distress syndrome, etc.).
- Trial name
- PedIMOD (NCT04438460)
- Testing
- Blood test
- Where
- 2 sites in France
- Volunteers
- 186 people
- Sponsor
- Hospices Civils de Lyon
Septic Shock, Disseminated Intravascular Coagulation
Disseminated Intravascular Coagulation (DIC) Score and Organ Dysfunction in Septic Shock Patients
Septic shock is common complication in patients with critical illnesses, with higher incidence in low and medium income countries like ours.
- Trial name
- NCT06363149
- Where
- India
- Volunteers
- 60 people
- Sponsor
- Sanjay Gandhi Postgraduate Institute of Medical Sciences
Congenital Disease
Kids Intestinal Dysfunction in Congenital Heart Disease: the Kind Heart Study
Approximately 40,000 infants are born each year in the United States with congenital heart defects (CHD), and heart defects are the leading cause of birth defect-related deaths in the United States.
- Trial name
- NCT02824705
- Testing
- Congenital Heart Disease Surgery
- Where
- United States
- Volunteers
- 53 people
- Sponsor
- University of Arizona
Cardiac Disease, Multiple Organ Dysfunction Syndrome
Hemoperfusion Efferon LPS During Cardiac Surgery Using Cardiopulmonary Bypass
More than 1 million people undergo cardiac surgery each year worldwide. Cardiac surgeries still in most cases require cardiopulmonary bypass, use of myocardial protection against aortic clamping and creation of cardioplegic…
- Trial name
- NCT06659289
- Testing
- Efferon LPS
- Where
- Russia
- Volunteers
- 14 people
- Sponsor
- Efferon JSC
Multiple Organ Failure
Efficacy of Coenzyme Q10 Supplementation on Multi-Organ Dysfunction in Severely Burned Patients
This multi-center prospective intervention study is designed to develop coenzyme Q10 (CoQ10) supplementation as a cost-effective adjunctive therapy for burn injury.
- Trial name
- NCT03968640
- Testing
- CoQ10
- Where
- United States
- Sponsor
- American Burn Association
Liver Cirrhosis, Kidney Failure, Acute
Intermittent ADVOS vs. Hemodialysis in Non-intensive Care Patients With Liver Dysfunction
In the planned randomized controlled prospective pilot study, we aim to evaluate ADVOS compared with conventional hemodialysis regarding the elimination of protein-bound toxins in patients with therapy-refractory hepatorenal…
- Conditions
- Liver Cirrhosis, Kidney Failure, Acute, Kidney Replacement, Multi Organ Failure
- Trial name
- ADVOMITTENT (NCT06129617)
- Testing
- Hemodialysis, ADVOS
- Where
- Germany
- Volunteers
- 14 people
- Sponsor
- University Medical Center Mainz
Heat Stress Disorders, Wounds and Injuries
Effects of Environmental Heat Exposure on Human Multiple Organ Function
This is a randomized controlled human exposure crossover study. Investigators aims to assess the acute effects of high temperature exposure and the underlying mechanisms.
- Conditions
- Heat Stress Disorders, Wounds and Injuries, Body Temperature Changes, Multiple Organ Dysfunction
- Trial name
- NCT06938932
- Testing
- High temperature exposure, Moderate temperature exposure
- Where
- China
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Yinan Qu
Crohn Disease, Ulcerative Colitis
Safety and Efficacy of Fecal Microbiota Transplantation
The gut microbiota is critical to health and functions with a level of complexity comparable to that of an organ system. Dysbiosis, or alterations of this gut microbiota ecology, have been implicated in a number of disease…
- Conditions
- Crohn Disease, Ulcerative Colitis, Celiac Disease, Irritable Bowel Syndrome
- Trial name
- NCT04014413
- Testing
- Fecal Microbiota Transplantation
- Where
- Hong Kong
- Volunteers
- 450 people
- Sponsor
- Chinese University of Hong Kong
Endotoxemia, Inflammation
The Effects of Immunostimulation With GM-CSF or IFN-y on Immunoparalysis Following Human Endotoxemia
The human body knows a biphasic immunological reaction to sepsis. First, the pro-inflammatory reaction takes place, marked by the release of pro-inflammatory cytokines like TNF-α, as a reaction to the bacterial toxins.
- Conditions
- Endotoxemia, Inflammation, Multi Organ Dysfunction Syndrome, Sepsis
- Trial name
- NCT01374711
- Testing
- GM-CSF, IFN-Y, E.coli endotoxin
- Where
- Netherlands
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Acute Renal Failure, SIRS
BK Virus and Renal Dysfunction in Postoperative/Posttraumatic Critically Ill Patients
The purpose of this study is to find out whether acute renal failure is associated with BK virus reactivation in postoperative/posttraumatic critically ill patients with severe SIRS/sepsis and shock.
- Conditions
- Acute Renal Failure, SIRS, Sepsis, Critically Ill
- Trial name
- BICUK (NCT00736827)
- Where
- Germany
- Volunteers
- 51 people
- Sponsor
- University of Ulm