Clinical trials: Multiple Sclerosis, completed
Multiple Sclerosis, Muscle Spasticity
Comparison of Safety and Efficacy of Tizanidine Hydrochloride Capsules Versus Zanaflex® (Tizanidine Hydrochloride Tablets) Taken While in the Fed State (Just After a Meal) and in the Fasted State (Before a Meal) in Patients With Moderate to Severe Spasticity.
This study is being conducted to compare the impact of somnolence (sleepiness) on cognition (awareness) as well as the safety and effectiveness of tizanidine hydrochloride capsules versus Zanaflex® (tizanidine hydrochloride…
- Conditions
- Multiple Sclerosis, Muscle Spasticity, Spinal Cord Injury, Stroke
- Trial name
- NCT00047580
- Testing
- tizanidine hydrochloride capsule
- Where
- 16 sites in United States
- Volunteers
- 120 people
- Sponsor
- Elan Pharmaceuticals
Multiple Sclerosis, Multiple Sclerosis, Relapsing-Remitting
Success of Titration, Analgesics, and B.E.T.A Nurse Support on Acceptance Rates in Early Multiple Sclerosis (MS) Treatment With Betaseron
The primary aim of this study is to evaluate the impact of titration, analgesics, and 12 month telephone follow-up period from the B.E.T.A nurse program upon adherence to treatment with Betaseron in patients with a first clinical…
- Trial name
- START (NCT00461396)
- Testing
- Interferon-1beta (Betaseron, BAY86-5046)
- Where
- 19 sites in United States
- Volunteers
- 104 people
- Sponsor
- Bayer
Multiple Sclerosis
Impact Study of 2 Therapeutic Strategy for Aggressive Remitting Multiple Sclerosis
Cost-effectiveness study of 2 disease-modifying therapies (natalizumab versus mitoxantrone followed by immunomodulator) in the management of aggressive remitting multiple sclerosis
- Trial name
- IQUALYSEP (NCT01065727)
- Testing
- mitoxantrone - immunomodulator, natalizumab
- Where
- 2 sites in France
- Volunteers
- 144 people
- Sponsor
- Rennes University Hospital
Multiple Sclerosis, Internuclear Ophthalmoplegia
Study and Treatment of Visual Dysfunction and Motor Fatigue in Multiple Sclerosis
Primary fatigue represents a major cause of disability in patients with multiple sclerosis (MS), being reported in about 90% of cases.
- Conditions
- Multiple Sclerosis, Internuclear Ophthalmoplegia, Fatigue
- Trial name
- NCT02391961
- Testing
- Dalfampridine
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- VA Office of Research and Development
Multiple Sclerosis
Open-Label Extension Study to Evaluate the Safety, Tolerability and Activity of Oral Fampridine-SR Tablets in Multiple Sclerosis Patients Who Participated in the MS-F203 Trial
The purpose of this study is to evaluate the safety, tolerability and activity of Fampridine-SR when administered for up to 36 additional months, or until it becomes commercially available whichever comes first, in subjects who…
- Trial name
- NCT00648908
- Testing
- Fampridine-SR
- Where
- 32 sites in United States, Canada
- Volunteers
- 269 people
- Sponsor
- Acorda Therapeutics
Multiple Sclerosis
My MS Toolkit: a Symptom Self-management Program for Multiple Sclerosis
My MS Toolkit is a web-based symptom self-management program for persons with multiple sclerosis. This study is evaluating various aspects of My MS Toolkit and how it impacts symptom self-management in multiple sclerosis.
- Trial name
- NCT03708276
- Testing
- My MS Toolkit
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Michigan
Multiple Sclerosis
Bright Light Therapy for Sleep Disturbance in People With Multiple Sclerosis
Sleep disturbance is common in people with multiple sclerosis (MS) and contributes to diminished quality of life. Bright light therapy may be an innovative strategy to reduce sleep disturbance in MS, possibly through its effects…
- Trial name
- NCT04054050
- Testing
- Light therapy
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- Johns Hopkins University
Multiple Sclerosis
Validation of a Self-questionnaire in French on the Use of the Upper Limbs in Patients With Multiple Sclerosis
Multiple sclerosis (MS) is an inflammatory and demyelinating disease of the central nervous system that causes disability in young adults.
- Trial name
- MS-SEP (NCT03655093)
- Testing
- Validation of AMSQ questionnaire
- Where
- France
- Volunteers
- 200 people
- Sponsor
- Rennes University Hospital
Multiple Sclerosis, Neuromyelitis Optica
Immunologic Biomarker Profile of Cerebrospinal Fluid
The aim of this study was the describe the Immunologic biomarker profile of cerebrospinal fluid in multiple sclerosis patients
- Trial name
- BIOMOG (NCT04202055)
- Testing
- Biomarker analysis
- Where
- France
- Volunteers
- 165 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Amyotrophic Lateral Sclerosis, Motor Neuron Disease
Phase 1 Dose Escalation and PK Study of Cu(II)ATSM in ALS/MND
Multicenter, open-label , single and multiple dose-escalation and pharmacokinetic study
- Trial name
- NCT02870634
- Testing
- Cu(II)ATSM
- Where
- 2 sites in Australia
- Volunteers
- 50 people
- Sponsor
- Collaborative Medicinal Development Pty Limited
Depression
Effectiveness of Web-based Treatment for Depression in Patients With Neurologic Disorders
200 persons (100 with multiple sclerosis and 100 with epilepsy) with depressive symptoms are recruited via the multiple sclerosis clinics of the University Medical Center Hamburg-Eppendorf and the epilepsy centre Alsterdorf and…
- Trial name
- NCT01663649
- Testing
- Deprexis, Wait-list
- Where
- 2 sites in Germany
- Volunteers
- 180 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Multiple Sclerosis, Muscle Spasticity
Effect of Cervical Mobilization on Balance and Plantar Pressure Distribution in Multiple Sclerosis
MS patients were randomly divided into traditional therapy and traditional therapy + cervical mobilization groups. While muscle strengthening, stretching, balance and coordination exercises were given to the traditional group…
- Conditions
- Multiple Sclerosis, Muscle Spasticity, Pressure Area, Cervical Region Disorder Nos
- Trial name
- NCT04543448
- Testing
- Traditional Rehabilitation for multiple sclerosis, Cervical mobilization for multiple sclerosis
- Where
- Turkey (Türkiye)
- Volunteers
- 12 people
- Sponsor
- Hasan Kalyoncu University
Multiple Sclerosis, Radiologically Isolated Syndrome
Prognostic Value of Three New Biomarkers of Multiple Sclerosis in Patients With Radiologically Isolated Syndrome
To look at the prognostic value of new biomarkers in CSF and serum for characterisation of multiple sclerosis
- Trial name
- T-RIS (NCT03357887)
- Testing
- Analysis of cerebrospinal fluid and serum
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Multiple Sclerosis, Lower Urinary Tract Symptoms
Multiple Sclerosis and Voiding Symptoms: How to Assess?
In multiple Sclerosis (MS), storage and voiding symptoms are well described. Urodynamic patterns underlying storage symptoms are clearly defined, but the assessment of voiding phase in neurological diseases is a sensitive topic.
- Conditions
- Multiple Sclerosis, Lower Urinary Tract Symptoms, Voiding Disorders
- Trial name
- NCT04928716
- Testing
- voiding phase evaluation
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Pierre and Marie Curie University
Multiple Sclerosis, Biotine
Study of Biomarkers of the Response to Biotine
Biotine is proposed by neurologists to patients with a progressive form of Multiple sclerosis (MS) in the context of a nominative temporary authorization for use (TAU) as a disease-modifying treatment for their MS.
- Trial name
- BIOMARBIOT (NCT03215433)
- Where
- France
- Volunteers
- 25 people
- Sponsor
- Centre Hospitalier Universitaire Dijon
Multiple Sclerosis
Effects of Inspiratory Muscle Training in Persons With Advanced Multiple Sclerosis
This study evaluates the effects of a 10-week inspiratory muscle training on the outcomes of respiratory muscle strength, fatigue, activity participation, and respiratory infection rates in persons with advanced Multiple…
- Trial name
- NCT03345199
- Testing
- Inspiratory Muscle Trainer (IMT)
- Where
- 2 sites in United States
- Volunteers
- 38 people
- Sponsor
- University of Michigan
Multiple Sclerosis
Simultaneous T2-FLAIR and T1 Brain MRI With ENRAGED FLAIR in Multiple Sclerosis
This study will evaluate a new brain MRI technique called ENRAGED FLAIR in patients with multiple sclerosis. MRI is central in the diagnosis and follow-up of multiple sclerosis because it can show inflammatory lesions in the…
- Trial name
- ENRAGED FLAIR (NCT07687693)
- Testing
- ENRAGED FLAIR MRI
- Where
- Sweden
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- Region Stockholm
Multiple Sclerosis
Study of the Tolerability and Pharmacokinetics of Oral Doses of SAR442168 With a Food Effect Investigation in Healthy Adult Participants
This is a randomized, placebo-controlled, four-part, Phase I, first in human (FIH) study to assess the tolerability and pharmacokinetics (PK) of ascending single and 14-day repeated oral doses of SAR442168 with a food effect…
- Trial name
- NCT06106074
- Testing
- Tolebrutinib
- Where
- United States
- Volunteers
- 71 people, healthy volunteers welcome
- Sponsor
- Sanofi
Multiple Sclerosis
Mapping the Longitudinal, Multidimensional Impact of MS in Relation to Variables Indicative of Neurological Reserve
Some MS patients quickly accumulate neurological deficits, while others remain well for decades. Even though associations with age, sex, health behaviors, comorbidities and social determinants of health are widely acknowledged…
- Trial name
- Resilience (NCT06410326)
- Where
- Belgium
- Volunteers
- 2,600 people
- Sponsor
- National MS Center Melsbroek
Multiple Sclerosis, Relapsing-Remitting, Multiple Sclerosis Relapse
Evaluation of Relapse Presence in Multiple Sclerosis
Purpose: This study aims to investigate the demonstrability of increased inflammation and neurodegeneration in multiple sclerosis (MS) patients in relapse period compared to MS patients in remission by cross-sectional analysis of…
- Trial name
- NCT05218317
- Testing
- in-vivo Corneal Confocal Microscopy
- Where
- Turkey (Türkiye)
- Volunteers
- 87 people, healthy volunteers welcome
- Sponsor
- Marmara University