Clinical trials: Multiple Sclerosis Spasticity
Multiple Sclerosis
Use of Cannabinoids in Patients With Multiple Sclerosis
This is a 10-week, randomised, double blind, placebo-controlled, crossover trial to investigate the effect of Cannabis Based Medicine Extract (Sativex) on patterns of brain activation associated with movement in 20 MS patients…
- Trial name
- NCT00202423
- Testing
- Sativex
- Where
- Italy
- Volunteers
- 20 people
- Sponsor
- S. Andrea Hospital
Botulinum Toxin Injection, Stiff Knee Gait
Analysis of Balance Disorders After Botulinum Toxin Treatment in the Rectus Femoris in Patients With a Stiff Knee Gait
Patients who suffered a stroke, cranial traumatism, medullar lesions or multiple sclerosis can present spastic muscular complications, which is particularly impairing if it concerns muscles of the leg.
- Conditions
- Botulinum Toxin Injection, Stiff Knee Gait, Fall Risk, Rectus Femoris Muscle
- Trial name
- FEMFALLTOX (NCT07108920)
- Testing
- Functional clinical tests
- Where
- France
- Volunteers
- 15 people
- Sponsor
- Hopital Nord Franche-Comte
Multiple Sclerosis, Pelvic Floor Disorders
Acute Effect of Osteopathic Visceral Mobilization Techniques
Multiple Sclerosis (MS), caused by lesions in the white matter of the central nervous system, is an autoimmune inflammatory demyelinating chronic disease.
- Conditions
- Multiple Sclerosis, Pelvic Floor Disorders, Urinary Incontinence, Visceral Mobilization
- Trial name
- NCT05981339
- Testing
- breathing exercises, osteopathic manual therapy techniques
- Where
- Turkey (Türkiye)
- Volunteers
- 20 people
- Sponsor
- University of Gaziantep
Multiple Sclerosis, Spasticity
One Year, Open Label, Dose Escalation Long-term Safety Study in Multiple Sclerosis (MS) Subjects With Spasticity
Clinical protocol OS440-3003 is a multicenter, open-label, non-randomized, uncontrolled, dose escalation study to evaluate the safety and tolerability of Arbaclofen Extended Release Tablets over 1 year in Multiple Sclerosis (MS)…
- Trial name
- NCT01844232
- Testing
- arbaclofen
- Where
- 35 sites in United States, Russia and 1 more
- Volunteers
- 150 people
- Sponsor
- RVL Pharmaceuticals, Inc.
Central Neurogical Impairment
Interest of Immersive Virtual Reality on Stress During Botulinum Toxin Injections in Spasticity (RVTOX)
The main objective of the study is to investigate the effect of exposure to a virtual reality session during botulinum toxin injections on injection-induced stress.
- Trial name
- RVTOX (NCT05364203)
- Testing
- DEEPSEN virtual reality mask
- Where
- France
- Volunteers
- 42 people
- Sponsor
- University Hospital, Clermont-Ferrand
Multiple Sclerosis
Internet-based MOTOmed Exercise to Reduce Spasticity and Improve Physical Function in Persons With Multiple Sclerosis
In an RCT, the effect of the MOTOmed movement trainer (Reck, Germany) on spasticity and physical function in pwMS with EDSS score between 4,5 and 7 is investigated.
- Trial name
- NCT03548974
- Testing
- Treatment group 1, Treatment group 2
- Volunteers
- 57 people
- Sponsor
- University of Erlangen-Nürnberg
Multiple Sclerosis
Neurophysiological Study of Sativex in Multiple Sclerosis (MS) Spasticity
Aim of this randomized, double-blind, placebo-controlled, cross-over study is to investigate cannabinoid-induced changes in neurophysiological parameters in a group of 40 patients with secondary or primary progressive Multiple…
- Trial name
- NS-MSS (NCT01538225)
- Testing
- Sativex®
- Where
- Italy
- Volunteers
- 45 people
- Sponsor
- Almirall, S.A.
Multiple Sclerosis, Spasticity
Dry Needling in Multiple Sclerosis
The investigators are doing this study to see if a treatment called dry needling improves muscle spasticity (muscle tightness) in people who have Multiple Sclerosis.
- Trial name
- NCT06394310
- Testing
- Dry needling
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- University of Kansas Medical Center
Multiple Sclerosis, Spasticity
A Study of the Long-term Safety of Sativex Use
Subjects who had previously received GW-1000-02 in a GW study who opted to continue using it in the long-term were monitored for ongoing tolerability and evidence of clinical benefit.
- Conditions
- Multiple Sclerosis, Spasticity, Pain
- Trial name
- NCT01606137
- Testing
- GW-1000-02
- Where
- United Kingdom
- Volunteers
- 507 people
- Sponsor
- Jazz Pharmaceuticals
Multiple Sclerosis
Non-invasive Spinal Cord Stimulation for Spasticity Control and Augmentation of Voluntary Motor Control in Individuals With Multiple Sclerosis
Epidural spinal cord stimulation (SCS) is currently regarded as one of the most promising intervention methods to improve motor function in individuals with severe spinal cord injury.
- Trial name
- noSpasMS (NCT04486209)
- Testing
- transcutaneous spinal cord stimulation
- Where
- Austria
- Volunteers
- 15 people
- Sponsor
- Medical University of Vienna
Spasticity in People With Multiple Sclerosis
Study of VSN16R for the Treatment of Spasticity in Multiple Sclerosis
Phase II a Proof of concept study in Multiple Sclerosis (MS) patients with spasticity.
- Trial name
- NCT02542787
- Testing
- VSN16R
- Where
- 4 sites in United Kingdom
- Volunteers
- 160 people
- Sponsor
- Canbex Therapeutics Ltd
Multiple Sclerosis
Effectiveness of TMS on Spasticity and Balance for Patients With MS
Recently, non-invasive brain stimulation modalities such as transcranial magnetic stimulation (rTMS) and transcranial direct current stimulation have become treatment options.
- Trial name
- NCT07451600
- Testing
- rTMS
- Where
- Turkey (Türkiye)
- Volunteers
- 24 people
- Sponsor
- Ankara Etlik City Hospital
Hemiplegia, Spasticity
Upper Limb Nerve Cryoneurolysis is Non Inferior to the Usual Care and Has Therapeutic Add Value in Dealing With Shoulder Pain and Functional Problems Caused by Spasticity and Motor Impairment
This trial is part of the spastiCRYO clinical research project. The primary objective of this clinical trial is to test the hypothesis: "Upper limb nerve cryoneurolysis is non inferior to the usual care and has therapeutic add…
- Conditions
- Hemiplegia, Spasticity, Shoulder Spasticity, Shoulder Stiffness
- Trial name
- spastiCRYO-UL (NCT06782464)
- Testing
- Treatment
- Where
- Luxembourg
- Volunteers
- 50 people
- Sponsor
- Centre National de Rééducation Fonctionnelle et de Réadaptation
Multiple Sclerosis
Cannabis for Spasticity in Multiple Sclerosis
The purpose of this study is to learn if the use of inhaled cannabis (marijuana) and oral cannabinoid (dronabinol, Marinol or THC, which is an active ingredient of marijuana) is safe and effective in reducing the symptoms of…
- Trial name
- NCT00260741
- Testing
- Smoked Cannabis
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Center for Medicinal Cannabis Research
Sclerosis, Multiple, MS (Multiple Sclerosis)
EXOPULSE Mollii Suit, Motor Function & Multiple Sclerosis (EXOSEP 2)
The goal of this clinical trial is to demonstrate the improvement of motor functions related symptoms in patients with MS and spasticity using Exopulse Mollii suit stimulation in Multiple Sclerosis patients with spasticity.
- Conditions
- Sclerosis, Multiple, MS (Multiple Sclerosis), Spasticity, Muscle, Spastic
- Trial name
- NCT05857280
- Testing
- EXOPULSE Mollii Suit Stimulation
- Where
- United Arab Emirates
- Volunteers
- 36 people
- Sponsor
- Sheikh Shakhbout Medical City
Spasticity
A Prospective Study of Spasticity in Individuals With Multiple Sclerosis
This study is expected to contribute to the body of knowledge on the benefits of individuals with MS taking glatiramer acetate (Copaxone®).
- Trial name
- NCT01111435
- Where
- United States
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Fraser, Cira, Ph.D., RN, ACNS-BC
Multiple Sclerosis
Botulinum Toxin in Patients With Spastic Lower Limb Paresis Associated With Multiple Sclerosis
Spastic paraparesis is one of the most disabling functional deficits in the population with multiple sclerosis between 18 and 80 years of age and at any functional level.
- Trial name
- NCT04595045
- Testing
- Botulinum toxin type A infiltrations
- Where
- 2 sites in Spain
- Volunteers
- 84 people
- Sponsor
- Aránzazu Vázquez Doce
Post Stroke, Post-Traumatic Headache
Aerobic Exercise and Transcranial Low Laser Therapy in Patients With Central Nervous System Injury
Objective of this protocol will be to evaluate the parameters related to the function of the musculoskeletal and cardiorespiratory system, through a rehabilitation and training program for people with acquired central nervous…
- Conditions
- Post Stroke, Post-Traumatic Headache, Spinal Injuries, Cerebral Palsy, Spastic
- Trial name
- NCT03751306
- Testing
- Transcranial Photobiomodulation, Cardiorespiratory Rehabilitation
- Where
- Brazil
- Volunteers
- 90 people
- Sponsor
- Universidade do Vale do Paraíba
Spasticity, Multiple Sclerosis
Evaluate the Maintenance of Effect After Long-term Treatment With Sativex® in Subjects With Symptoms of Spasticity Due to Multiple Sclerosis
The purpose of this study is to evaluate the maintenance of effect after long-term treatment with Sativex® in subjects with symptoms of spasticity due to Multiple Sclerosis (MS) who have been receiving long-term benefit from…
- Trial name
- NCT00702468
- Testing
- Sativex
- Where
- United Kingdom
- Volunteers
- 36 people
- Sponsor
- Jazz Pharmaceuticals
Muscle Spasticity, Hypertonia, Muscle
Single and Multiple Ascending Dose Study of MTR-601 in Healthy Individuals
To assess the safety and tolerability of single and multiple doses of MTR-601 in normal healthy volunteers under fed and fasted conditions. To evaluate the plasma and urine pharmacokinetics (PK) of MTR-601.
- Conditions
- Muscle Spasticity, Hypertonia, Muscle, Cerebral Palsy, Multiple Sclerosis
- Trial name
- NCT06117020
- Testing
- MTR-601
- Where
- United States
- Volunteers
- 89 people, healthy volunteers welcome
- Sponsor
- Motric Bio