Clinical trials: Multiple Trauma/Injuries
Incomplete Spinal Cord Injury (SCI), SCI - Spinal Cord Injury
FES-assisted Gait Training for Incomplete Spinal Cord Injury
Spinal cord injuries (SCI) impair neural communication, leading to difficulties in walking due to muscle weakness, altered reflexes, and impaired muscle activation below the injury.
- Trial name
- FES-SCI (NCT07645144)
- Testing
- FES-assisted gait training
- Where
- Netherlands
- Volunteers
- 30 people
- Sponsor
- Stichting Reade
Healthy Volunteers
A Phase I Study Comparing the Safety, Pharmacokinetics and Renal Effects of VRP-034 and Marketed Polymyxin B in Healthy Volunteers
This is a Phase 1, single-center, randomized, double-blind, active-controlled clinical study designed to evaluate the safety, tolerability, pharmacokinetics (PK), and nephrotoxicity attenuation potential of VRP-034 compared with…
- Trial name
- VRP-034 (NCT07502144)
- Testing
- VRP-034 (Polymyxin B 500,000 IU), Commercially available Polymyxin B 500,000 IU (Poly-MxB)
- Where
- India
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Venus Remedies Limited
Osteoarthritis, Hip, Osteoarthritis
The Hip Arthroplasty Positioning Improvement Study
The primary objective of this study is to determine whether the Corin Optimised Positioning System (Corin, U.K.) reduces the rate of hip dislocation at one-year post-operatively compared with standard templating in patients…
- Conditions
- Osteoarthritis, Hip, Osteoarthritis, Arthritis, Musculoskeletal Diseases or Conditions
- Trial name
- HAPI (NCT03560063)
- Testing
- Corin Optimised Positioning System, Standard templating
- Where
- United Kingdom
- Volunteers
- 460 people
- Sponsor
- University of Oxford
Other and Unspecified Injury to Hip and Thigh
CONSERVE Plus Post-Approval Study (PAS)
The objective of this post-approval study is to provide scientifically valid and reliable evidence that supports claims of longer term safety and effectiveness with regard to Month 120 device survivorship rates.
- Trial name
- NCT01367899
- Where
- United States
- Volunteers
- 199 people
- Sponsor
- MicroPort Orthopedics Inc.
Ventricular Septal Defect, Atrioventricular Septal Defect
A Study Evaluating the Efficacy and Safety of IV L-Citrulline for the Prevention of Clinical Sequelae of Acute Lung Injury Induced by Cardiopulmonary Bypass in Pediatric Patients Undergoing Surgery for Congenital Heart Defects
This is a randomized, double-blind, placebo controlled, multicenter study to compare the efficacy and safety of L-citrulline versus placebo in patients undergoing surgery for congenital heart defects.
- Conditions
- Ventricular Septal Defect, Atrioventricular Septal Defect, Primum Atrial Septal Defect
- Trial name
- NCT05253209
- Testing
- L-citrulline, Plasmalyte A
- Where
- 10 sites in United States
- Volunteers
- 64 people
- Sponsor
- Asklepion Pharmaceuticals, LLC
Surgical Wound
AMBULATE: Cardiva Mid-Bore VVCS vs. Manual Compression for Multiple Femoral Venous Access Sites, 6 - 12F ID
The objective of the trial is to demonstrate the safety and effectiveness of the Cardiva Mid-Bore Venous Vascular Closure System (VVCS) in sealing femoral venous access sites and providing reduced times to ambulation (TTA)…
- Trial name
- NCT03193021
- Testing
- Cardiva Mid-Bore VVCS, Manual compression
- Where
- 13 sites in United States
- Volunteers
- 204 people
- Sponsor
- Cardiva Medical, Inc.
Wounds
A Post-marketing Observational Study of Cell Therapy for Chronic Wounds
A post-marketing multi-center observational study to provide data describing the safety and effectiveness of CUREXCELL™ as it is applied in a real-life setting for treatment in patients with chronic and/or refractory wounds.
- Trial name
- NCT01038986
- Testing
- CureXcell
- Where
- 3 sites in Israel
- Volunteers
- 70 people
- Sponsor
- Macrocure Ltd.
Ankle Sprain
Safety and Efficacy of Generic Diclofenac Epolamine Acute Pain Due to Minor Ankle Sprain
To demonstrate the therapeutic efficacy of a generic diclofenac epolamine patch against Flector patch in the treatment of pain in subjects with minor ankle sprain
- Trial name
- NCT02324270
- Testing
- Diclofenac epolamine
- Where
- 31 sites in United States
- Volunteers
- 658 people, healthy volunteers welcome
- Sponsor
- Actavis Inc.
Multiple Trauma
Proteomics in Multiple Trauma to Identify Organ Failure
To analyse differences in protein expression in multiple trauma patients for identification of potential biomarkers to predict organ dysfunction.
- Trial name
- NCT02030327
- Where
- Germany
- Volunteers
- 85 people, healthy volunteers welcome
- Sponsor
- Universitätsklinikum Köln
Venous Thrombosis Deep (Limbs), Surgical Blood Loss
Pre-operative Enoxaparin in the Surgical Management of Multi-trauma Patients Undergoing Orthopedic Surgical Procedures
All trauma patients receive Lovenox or other prophylactic medication to prevent deep vein clots from forming. For the trauma patients with orthopedic injuries requiring surgery there is controversy over safety and efficacy when…
- Trial name
- NCT05081375
- Testing
- Enoxaparin Injectable Product, Sodium chloride
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Valleywise Health
Ankle Sprain
Efficacy and Safety of Diclofenac Potassium 25 mg Tablet Taken Three Times Daily in Subjects With Acute Joint Pain
The purpose of this study is to evaluate the efficacy of diclofenac potassium 25 mg tablet compared with placebo taken three times a day in subjects with acute ankle sprains under 'in-use' conditions, in particular with regard to…
- Trial name
- NCT01666197
- Testing
- diclofenac potassium 25 mg tablet
- Where
- 4 sites in Germany
- Volunteers
- 100 people
- Sponsor
- Novartis
Pressure Ulcers, Multi-disciplinary Wound Care Teams
Pressure Ulcer Multi-disciplinary Teams Via Telemedicine (PUMTT): A Trial in Long Term Care
The purpose of this study is to evaluate the effectiveness of 'enhanced' multi-disciplinary wound care teams (MDTs) vs. 'usual' care teams in Long Term Care (LTC) facilities in Ontario for the treatment of pressure ulcers.
- Conditions
- Pressure Ulcers, Multi-disciplinary Wound Care Teams, Remote Support, Digital Wound Photography
- Trial name
- PUMTT (NCT01232764)
- Testing
- Exposure to multi-disciplinary wound care team
- Where
- Canada
- Volunteers
- 137 people
- Sponsor
- University of Toronto
Rib Fractures, Pain, Acute
Dexmedotomidine for Acute Pain Control in Patients With Multiple Rib FracturesRandomized Controlled Trial
Blunt chest trauma is the second most common form of unintentional trauma in the US and is associated with significant morbidity and mortality. Thoracic injuries are the third most common cause of death in trauma patients.
- Trial name
- NCT05321121
- Testing
- Dexmedetomidine
- Where
- United States
- Volunteers
- 41 people
- Sponsor
- University of California, Irvine
Acquired Bleeding Disorder, Trauma
Incidence/Magnitude-Haemorrhagic Progression-Cerebral Contusions and Identification (ID) of Safety Issues After Traumatic Brain Injury
This study is conducted in North America. The purpose of this study is to evaluate the occurrence and severity of bleeding in brain injury and to identify important safety issues following traumatic brain injury.
- Trial name
- NCT00124293
- Testing
- activated recombinant human factor VII
- Where
- 2 sites in United States, Canada
- Volunteers
- 63 people
- Sponsor
- Novo Nordisk A/S
Venous Leg Ulcers
Effectiveness of Aurix Therapy in Venous Leg Ulcers
The aim of this trial is to demonstrate the effectiveness of complete wound healing in a prospective, open-label, randomized trial in which venous leg ulcers (VLU)n will be treated using Aurix and compared to patients receiving…
- Trial name
- NCT02940587
- Testing
- Aurix
- Where
- United States
- Sponsor
- Cytomedix
Acute Kidney Injury, Multiple Myeloma
Biomarkers of AKI in Patients Receiving Daratumumab
The goal of this prospective observational study is to understand changes in urinary and blood biomarkers associated with acute kidney injury (AKI) in patients newly diagnosed with multiple myeloma and being treated with…
- Conditions
- Acute Kidney Injury, Multiple Myeloma, Light Chain Nephropathy
- Trial name
- NCT06549634
- Testing
- Daratumumab
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Brigham and Women's Hospital
Orthopaedic Trauma, Chronic Opioid Use
Low-Dose Short-Term Ketorolac to Reduce Chronic Opioid Use in Orthopaedic Polytrauma Patients
The goal of this randomized clinical trial is to learn if the use of a low-dose nonsteroidal anti-inflammatory drug (NSAID), ketorolac, reduces the rate of chronic opioid use in orthopaedic trauma patients.
- Trial name
- NCT06201676
- Testing
- Ketorolac Injection, Standard of Care (SOC) Multimodal Analgesia
- Where
- 2 sites in United States
- Volunteers
- 458 people
- Sponsor
- Massachusetts General Hospital
Neurological Conditions, Brain Diseases
NEO-REEDUC - Mixed Reality for Motor Rehabilitation: a Prospective, Multicenter, Controlled, Randomized, Open Study.
This study aims to assess the effectiveness of a motor rehabilitation protocol that includes mixed reality activities, compared to conventional rehabilitation, on postural stability in children and adult patients with…
- Conditions
- Neurological Conditions, Brain Diseases, Cerebral Palsy, Parkinson Disease (PD)
- Trial name
- NCT07063810
- Testing
- Mixed Reality Rehabilitation
- Where
- 5 sites in France
- Volunteers
- 76 people
- Sponsor
- Slb Pharma
Myocardial Infarction Postoperative, Myocardial Injury
Myocardial Infarction in the Perioperative Setting
Acute myocardial infarction (AMI) is a significant complication following non-cardiac surgery. The investigators sought to evaluate incidence of perioperative AMI, its preoperative and intraoperative risk factors and the outcomes…
- Conditions
- Myocardial Infarction Postoperative, Myocardial Injury, Intraoperative Complications, Intraoperative Hypotension
- Trial name
- MIPS (NCT03837535)
- Testing
- Surgery
- Where
- Sweden
- Volunteers
- 400,742 people
- Sponsor
- Karolinska University Hospital
Shoulder Dislocation
Electrothermal Arthroscopic Capsulorrhaphy (ETAC) and Open Inferior Capsular Shift in Patients With Shoulder Instability
This trial will compare the effectiveness of electrothermal arthroscopic capsulorrhaphy (ETAC) to the current reference standard procedure, open inferior capsular shift (ICS), for the treatment of shoulder instability caused by…
- Trial name
- NCT00251160
- Testing
- Electrothermal arthroscopic capsulorrhaphy (ETAC), Open inferior capsular shift (ICS)
- Where
- 7 sites in Canada
- Volunteers
- 58 people
- Sponsor
- University of Calgary