Clinical trials: Multiple Trauma/Injuries
Wounds and Injuries, Multiple Trauma
Normal Saline Versus Plasmalyte in Initial Resuscitation of Trauma Patients
The purpose of this study is to determine whether an intravenous salt solution called "Plasmalyte" causes less abnormality of the body's acid levels than a solution called "Normal Saline."
- Conditions
- Wounds and Injuries, Multiple Trauma, Disorder of Fluid Balance
- Trial name
- NCT01270854
- Testing
- Plasmalyte A, Normal Saline
- Where
- United States
- Volunteers
- 46 people
- Sponsor
- University of California, Davis
Polytrauma Patients
Correlation Between Inferior Vena Cava Collapsibility Index and Serum Lactate in Poly-trauma Patients
Polytrauma is defined as the presence of multiple traumatic injuries that may cause systemic physiological derangements and life-threatening conditions.
- Trial name
- NCT07255456
- Testing
- Abdominal ultrasound and Serum Lactate Level
- Where
- Egypt
- Volunteers
- 126 people
- Sponsor
- Farid Esmael Haridy Mohamed
Intertrochanteric Fractures
Internal Fixation or Joint Replacement Therapy for Aged Hip Fracture Patients
To evaluate the efficacy and safety of internal fixation or arthroplasty for hip fracture patients over 75 years of age with multiple medical complications through the operation time, intraoperative bleeding, time to start weight…
- Trial name
- NCT03407131
- Testing
- Joint replacement surgery, Intramedullary nail fixation
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Peking University People's Hospital
Kidney Failure, Acute
Study to Evaluate the Safety and Efficacy of the Renal Assist Device in Patients With Acute Renal Failure
The purpose of this study is to evaluate the safety and efficacy of the RAD to determine whether the RAD is effective in reducing mortality in patients with Acute Renal Failure due to Acute Tubule Necrosis and to evaluate the…
- Trial name
- NCT00280072
- Testing
- Renal Assist Device
- Where
- 16 sites in United States
- Sponsor
- RenaMed Biologics
COVID-19, Organ Dysfunction Syndrome Sepsis
Mechanisms for Organ Dysfunction in Covid-19
The study aims to investigate organ dysfunction and biomarkers in patients with suspected or verified COVID-19 during intensive care at Uppsala University Hospital.
- Conditions
- COVID-19, Organ Dysfunction Syndrome Sepsis, Organ Dysfunction Syndrome, Multiple, Septic Shock
- Trial name
- UMODCOVID19 (NCT04316884)
- Where
- Sweden
- Volunteers
- 380 people
- Sponsor
- Uppsala University
Lumbar Muscle Strain
Clinical Study on Intensive Multi-acupuncture in the Treatment of Lumbar Muscle Strain.
Acupuncture is widely used as a routine treatment for lumbar muscle strain. The aim of this randomized controlled trial is to evaluate the effectiveness of the intensive multi-acupuncture method.
- Trial name
- NCT06286969
- Testing
- acupuncture
- Volunteers
- 108 people
- Sponsor
- Xu Xinnan
Bladder Outlet Obstruction, Multiple Sclerosis
GentleCath™ for Men Intermittent Catheter With FeelClean™ Technology
Male self catherterisng observational study.
- Conditions
- Bladder Outlet Obstruction, Multiple Sclerosis, Cauda Equina Syndrome, Enlarged Prostate With Lower Urinary Tract Symptoms
- Trial name
- NCT05470751
- Testing
- Intermittent self-catheterisation
- Where
- 16 sites in United States, France and 1 more
- Volunteers
- 72 people
- Sponsor
- ConvaTec Inc.
Ureter Injury
IS-001 Injection in Patients Undergoing Robotic-Assisted Colorectal Surgery
This study evaluates the safety and efficacy of intravenous injection of IS-001 to aid in intraoperative ureter structure delineation
- Trial name
- NCT07346066
- Testing
- filricianine
- Where
- 9 sites in United States
- Volunteers
- 146 people
- Sponsor
- Intuitive Surgical
Ultrasonography, Multiple Trauma
Keller Prehospital Ultrasound Study
The study is based on the premise that ultrasound is not commonly used in an ambulance. There are some departments that do deploy it into the field, but of those departments there is almost no data collected about its use.
- Conditions
- Ultrasonography, Multiple Trauma, Kidney Calculi, Aortic Aneurysm, Abdominal
- Trial name
- NCT01074112
- Testing
- EFAST exam, Pelvic Ultrasound, Ultrasound Guided Vascular Access
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Keller Fire Rescue
Neonatal Encephalopathy
Follow-up of Inflammatory Responses and Multiorgan Outcomes FoLlowing Neonatal Brain injurY
Babies who have brain injury also frequently have involvement of their kidneys, lung and heart. Although clinical care in the neonatal period is well defined there are few guidelines and evidence for developmental, heart and…
- Trial name
- FIREFLY (NCT04816331)
- Testing
- Medical records and clinical measurements
- Where
- 5 sites in Ireland
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of Dublin, Trinity College
Diabetic Ulcer
Evaluation of Topical Wound Oxygen (two2) Therapy
The purpose of this study is to evaluate the efficacy of the Topical Wound Oxygen (two2) therapy system on the healing of diabetic lower extremity ulcers.
- Trial name
- NCT00871312
- Testing
- Topical wound oxygen therapy
- Where
- 3 sites in United States, Canada
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- AOTI Ltd.
Cerebrovascular Accident, Post-polio Syndrome
Nomad P-KAFO Study
The goal of this clinical trial is to evaluate the impact of using the Nomad powered KAFO in people who have had a musculoskeletal or neurological injury that has affected their ability to walk.
- Conditions
- Cerebrovascular Accident, Post-polio Syndrome, Spinal Cord Injuries, Multiple Sclerosis
- Trial name
- NCT05644522
- Testing
- Indego Nomad® Powered Knee-Ankle-Foot Orthosis (P-KAFO) (Parker Hannifin Corp., Cleveland, OH)
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- Shirley Ryan AbilityLab
Brain Metastases, Radiotherapy Side Effect
GM1 Prophylaxis for WBRT Related Cognitive Dysfunction
To evaluate the efficacy and safety of GM1 for preventing cognitive impairment related to whole brain radiotherapy in breast cancer patients with brain metastases.
- Conditions
- Brain Metastases, Radiotherapy Side Effect, Cognitive Impairment, Gangliosidosis, GM1
- Trial name
- GLORY (NCT04395339)
- Testing
- Monosialotetrahexosyl ganglioside (GM1), Control
- Where
- China
- Volunteers
- 51 people
- Sponsor
- Sun Yat-sen University
Acquired Bleeding Disorder, Trauma
Evaluation of Recombinant Factor VIIa in Patients With Severe Bleeding Due to Trauma
This trial is conducted in the United States of America (USA). The purpose of this study is to evaluate the treatment of Recombinant Faction VIIa in Patients with Severe Bleeding Due to Trauma Please note that this trial and…
- Trial name
- NCT00323570
- Testing
- activated recombinant human factor VII
- Where
- 42 sites in United States
- Sponsor
- Novo Nordisk A/S
Burns
Relationship Between Neutrophil Function and Sepsis in Adults and Children With Severe Thermal Injuries
The study aims to validate neutrophil function, immature granulocyte and plasma free DNA levels as predictive diagnostic biomarkers of sepsis in burn patients.
- Trial name
- SIFTI-2 (NCT04693442)
- Testing
- taking of blood, urine and blood samples and objective scar assessment
- Where
- United Kingdom
- Volunteers
- 245 people, healthy volunteers welcome
- Sponsor
- University Hospital Birmingham NHS Foundation Trust
Primary Progressive Multiple Sclerosis
Tear Analysis in the Diagnosis of Multiple Sclerosis
In the primary progressive multiple sclerosis, the detection of oligoclonal bands in cerebrospinal fluid is critical for the diagnosis.
- Trial name
- LARMES (NCT02016222)
- Testing
- tears sampling
- Where
- 13 sites in France
- Volunteers
- 80 people
- Sponsor
- Lille Catholic University
Multiple Sclerosis
Muscle Strain in Multiple Sclerosis Patients Measured by Ultrasound Speckle Tracking Technique
The primary study, as outlined in the original trial registration, aiming to use ultrasound speckle tracking (STU) to monitor muscle contractility in multiple sclerosis (MS) patients receiving vs.
- Trial name
- MUST (NCT03847545)
- Testing
- Fampridine
- Where
- Denmark
- Volunteers
- 48 people
- Sponsor
- University of Southern Denmark
Trauma Injury
Placebo Versus Oxandrolone Supplementation in Trauma
The primary aim of this study is to examine the effect of Oxandrolone supplementation after lower extremity high energy fracture on muscle volume recovery.
- Trial name
- NCT05516849
- Testing
- Oxandrolone
- Sponsor
- Sunnybrook Health Sciences Centre
Burns
The Dermisgraft Epithelialization and Late Scar Healing
Study Synopsis Title; The dermis graft: epithelialization and late scar evaluation A Clinical Prospective multicenter trial Objectives; The objective of this study is to compare a dermal graft with a conventional split thickness…
- Trial name
- NCT05189743
- Testing
- Skin transplantation to heal burn injuries
- Where
- Sweden
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- University Hospital, Linkoeping
Pelvic, Acetabular, Femur, or Diaphyseal Tibial Operative Orthopaedic Injuries
Patient-Specific Precision Injury Signatures in Multiply Injured Orthopaedic Patients
The purpose of this study is to evaluate the use of precision methods that quantify injury and response to injury to predict how short-term clinical outcomes are affected by initial and staged orthopaedic interventions in…
- Trial name
- PRECISE (NCT03772730)
- Where
- 8 sites in United States
- Volunteers
- 320 people
- Sponsor
- Major Extremity Trauma Research Consortium