Clinical trials: Multiple Trauma/Injuries
Perinatal Depression, COVID19
Global Mental Health of Urban Mothers
Mental health disorders are common during pregnancy and the postnatal period, and can have serious adverse effects on the well-being of woman and child.
- Conditions
- Perinatal Depression, COVID19, Anxiety, PTSD
- Trial name
- MUM (NCT04363177)
- Testing
- Web-based psychosocial peer-to-peer support
- Where
- 2 sites in China, Hong Kong
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Karolinska Institutet
Social Functioning, Chronic Pain
Characteristics of Injury Claims by Chronic Pain Patients
Chronic pain is associated with injuries and disabilities. This prospective observational study explores the injury or disability claims made by chronic pain patients.
- Conditions
- Social Functioning, Chronic Pain, Injuries, Disabilities Multiple
- Trial name
- NCT06104384
- Testing
- Behavioral and supportive therapy
- Where
- Canada
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Salem Anaesthesia Pain Clinic
Mild Traumatic Brain Injury, Posttraumatic Stress Disorder
Imaging Biomarkers of Mild Traumatic Brain Injury: a Longitudinal Cohort Study
This longitudinal cohort study aims to detect the topographical nature of the white matter microstructure and resting state functional connectivity patterns across the whole brain in the evolution of pathology as a function of…
- Conditions
- Mild Traumatic Brain Injury, Posttraumatic Stress Disorder, Affective and Somatic Complaints, Cognitive Impairments
- Trial name
- NCT02868684
- Where
- China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- First Affiliated Hospital Xi'an Jiaotong University
Acute Blunt Soft Tissue Injuries/Contusions
Efficacy and Safety of Diclofenac Sodium Topical Gel 1% Applied Four Times Daily in Subjects With Acute Blunt Trauma Injuries
The purpose of this study is to evaluate the efficacy of DSG 1% compared with placebo applied four times a day in subjects with acute blunt soft tissue injuries/contusions of the limbs
- Trial name
- NCT01272947
- Testing
- Diclofenac sodium
- Where
- 6 sites in Germany
- Volunteers
- 204 people
- Sponsor
- Novartis
Neurocognitive Disorders, Cognitive Dysfunction
A Pilot Randomized Controlled Trial: CoINTEGRATE
The purpose of this study is to examine the feasibility of comprehensive multimodal individually tailored Cognitive Behavioral Therapy (CBT), Cognitive Rehabilitation Therapy (CRT), and modifiable lifestyle sessions.
- Conditions
- Neurocognitive Disorders, Cognitive Dysfunction, Traumatic Brain Injury, Multiple Sclerosis
- Trial name
- CoINTEGRATE (NCT05732285)
- Testing
- CRT, CBT, Modifiable lifestyle factors
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- University of Michigan
Distal Radius Fracture, Wrist Fracture
Proprioception and Multi Sensory Training After DRF
Distal radius fracture is the most common upper extremity fracture with peak incidence among older women after the fifth decade of life. Proprioception is one constituent of a complex Sensory motor control process.
- Trial name
- NCT04820114
- Testing
- Proprioceptive wrist exercises, Wrist exercises
- Where
- Spain
- Volunteers
- 62 people
- Sponsor
- University of Malaga
Trauma, Fracture;Elbow
Type II Pediatric Supracondylar Humerus Fracture Management and Outcomes: A Prospective Multi-centre Cohort Study
The treatment of pediatric supracondylar humerus fractures is controversial, but despite the injury's high incidence there is a lack of high level evidence to guide operative versus non-operative decision making for displaced…
- Trial name
- NCT02963233
- Testing
- Closed reduction and percutaneous pinning and immobilization, Non-operative reduction and immobilization
- Where
- 13 sites in Canada
- Volunteers
- 60 people
- Sponsor
- British Columbia Children's Hospital
Cartilage Injury, Defect of Articular Cartilage
BioPoly RS Knee Registry Study for Cartilage Defect Replacement
Information will be collected on the pre-op and post-op clinical status of patients with focal cartilage defects of the femoral condyles treated with the BioPoly RS Partial Resurfacing Knee Implant, a permanent orthopaedic…
- Conditions
- Cartilage Injury, Defect of Articular Cartilage, Cartilage Damage
- Trial name
- NCT01473199
- Testing
- BioPoly RS Partial Resurfacing Knee Implant
- Where
- 5 sites in United Kingdom
- Volunteers
- 38 people
- Sponsor
- BioPoly LLC
Persistent PostConcussion-Like Symptoms, Post-Traumatic Stress Disorder
Persistent PostConcussion-Like Symptoms and Post Traumatic Stress Disorder in Patients Presenting at the Emergency Room.
Promising results of an early EMDR (Eye Movement Desensitization and Reprocessing) intervention on PCLS (PostConcussion-Like Syndrome) at three months have been shown, suggesting that the availability of psychological care in…
- Trial name
- SOFTERIV (NCT04916678)
- Testing
- R-TEP EMDR intervention
- Where
- 7 sites in France
- Volunteers
- 2,897 people
- Sponsor
- University Hospital, Bordeaux
Family Relations, Psychological Trauma
Multifamily Healing Spaces for Family Resilience in Rwanda
This cluster-randomized waitlist-control trial evaluated Multifamily Healing Spaces (MFHS), a culturally adapted behavioral family intervention for genocide-affected communities in Rwanda.
- Conditions
- Family Relations, Psychological Trauma, Stress Disorders, Post-Traumatic, Parent-Child Relation
- Trial name
- MFHS-CRT (NCT07621705)
- Testing
- Multifamily Healing Spaces
- Where
- 5 sites in Rwanda
- Volunteers
- 319 people
- Sponsor
- Alexandros Lordos, PhD
Rib Fractures, Rib Trauma
Investigation of the Effect of Age and Injury Severity on Short-term Intra-hospital Outcomes After Surgical Stabilized Rib Fractures
The study aims to investigate the effect of surgical stabilisation of rib fractures (SSRF) on clinical outcomes measured during the hospital stay (mortality, days on a mechanical ventilator, intensive care unit and hospital…
- Conditions
- Rib Fractures, Rib Trauma, Rib Fracture Multiple, Thorax; Fracture
- Trial name
- NCT06464302
- Testing
- Surgical stabilisation of rib fractures (SSRF), Non-operative management of rib fractures
- Where
- Germany
- Volunteers
- 1,064 people
- Sponsor
- University Hospital Muenster
Upper Limb Function, Upper Limb Pain
Upper Limb Functional Index
To translate and validate the Upper Limb Functional Index into Albanian for use in the Albanian-speaking population.
- Conditions
- Upper Limb Function, Upper Limb Pain, Upper Limb; Injury, Superficial, Multiple, Upper Limb Rehabilitation
- Trial name
- ULFI-A (NCT06834919)
- Testing
- Observational
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Universidad Católica San Antonio de Murcia
Rib Fracture Multiple, Flail Chest
Surgery for Unstable Chest Wall Injuries - How Many Fractures Should be Fixed?
The goal of this prospective, randomized study is to learn about the effects of two different surgical techniques for treating unstable chest wall injuries in adults.
- Trial name
- NCT07338656
- Testing
- Surgical stabilization of two fractures per rib, Surgical stabilization of one fracture per rib.
- Where
- Sweden
- Volunteers
- 100 people
- Sponsor
- Sahlgrenska University Hospital
Wound Infection, Surgical Site Infection
Prophylactic Closed Incision Negative Pressure Wound Therapy on Abdominal Wounds - Clinical and Economic Perspectives
This study evaluates whether specialist negative pressure dressings reduce the risk of wound infections after operations when compared to conservative dressings, and if one negative pressure dressings works better than another.
- Conditions
- Wound Infection, Surgical Site Infection, Surgical Wound, Surgical Incision
- Trial name
- ProNounCE (NCT04110353)
- Testing
- Wound dressings: Conservative dressings, Wound dressings: Prevena dressings, Wound dressings: ciVAC dressings
- Sponsor
- Imperial College London
Multiple Myeloma, Renal Injury
A Clinical Study on the Whole-course Management (BCD-KPD-AutoHSCT) Scheme for Patients With RIMM
Multiple myeloma (MM) is still an incurable hematological tumor, and renal involvement is the main factor of poor prognosis. The recovery of renal function can partially reverse its poor outcome.
- Trial name
- NCT06203145
- Testing
- Bortezomib
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Peking University First Hospital
Multiple Myeloma, Light Chain Nephropathy
Novel Treatments in Improving Renal Outcomes in Light Chain Cast Nephropathy
Objective 1: To test whether treatment with plasma exchange improves renal recovery in patients with light chain cast nephropathy Objective 2: To compare renal outcomes among patients treated with plasma exchange versus…
- Conditions
- Multiple Myeloma, Light Chain Nephropathy, Acute Kidney Injury
- Trial name
- NCT06483139
- Testing
- Plasma exchange, Daratumumab
- Where
- United States
- Volunteers
- 549 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Nasopharyngeal Carcinoma ,Xerostomia,Radiotherapy
Monitoring Salivary Gland Injury in Nasopharyngeal Carcinoma Patients After Radiotherapy Using Multi-Modal Radiomics
This prospective observational study aims to evaluate the role of intravoxel incoherent motion (IVIM) imaging and magnetic resonance fingerprinting (MRF) techniques in monitoring salivary gland injury in nasopharyngeal carcinoma…
- Trial name
- NCT06751381
- Testing
- IVIM Imaging MRF Imaging
- Volunteers
- 45 people
- Sponsor
- Hainan Medical College
Rib Fractures, Respiratory Complication
Oscillating Positive Expiratory Pressure (OPEP) Therapy in Trauma Patients With Multiple Rib Fractures
To determine the efficacy of oscillatory positive expiratory pressure (OPEP) therapy on patients admitted through the trauma service line for rib fractures, as compared to incentive spirometry (IS).
- Trial name
- NCT04100512
- Testing
- Oscillating Positive Expiratory Pressure Device, Incentive spirometry
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Poudre Valley Health System
Traumatic Hemorrhage, Hemorrhagic Shock
The Use of rFVIIa in Trauma Patients: A Multi-Center Case Registry
Trauma surgeons throughout the US have begun using recombinant activated factor VII (rFVIIa) to control severe hemorrhage following injury when traditional measures have failed.
- Trial name
- NCT00328133
- Where
- United States
- Volunteers
- 380 people
- Sponsor
- University of California, San Francisco
Drug/Agent Toxicity by Tissue/Organ, Leukemia
Growth Factor to Prevent Oral Mucositis in Patients With Hematologic Cancer
RATIONALE: Keratinocyte growth factor may prevent symptoms of mucositis in patients receiving radiation therapy and chemotherapy.
- Conditions
- Drug/Agent Toxicity by Tissue/Organ, Leukemia, Lymphoma, Multiple Myeloma and Plasma Cell Neoplasm
- Trial name
- NCT00004132
- Testing
- filgrastim, palifermin, cyclophosphamide
- Where
- United States
- Sponsor
- Jonsson Comprehensive Cancer Center
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