Clinical trials: Multiple Trauma/Injuries
Primary Progressive Multiple Sclerosis
Tear Analysis in the Diagnosis of Multiple Sclerosis
In the primary progressive multiple sclerosis, the detection of oligoclonal bands in cerebrospinal fluid is critical for the diagnosis.
- Trial name
- LARMES (NCT02016222)
- Testing
- tears sampling
- Where
- 13 sites in France
- Volunteers
- 80 people
- Sponsor
- Lille Catholic University
Aortic Aneurysm, Abdominal, Aortic Aneurysm, Thoracoabdominal
Clinical Application of the Medyria TrackCath System in Endovascular Repair of Abdominal Aortic Aneurysms (AAA)
Pre-market, single-arm, prospective, open-label, multi-center clinical trial aimed at assessing the safety and the performance of the Medyria TrackCath system in patients undergoing endovascular intervention.
- Conditions
- Aortic Aneurysm, Abdominal, Aortic Aneurysm, Thoracoabdominal, Acute Renal Failure, Acute Kidney Injury
- Trial name
- ACCESS (NCT04190979)
- Testing
- Medyria TrackCath System
- Where
- 4 sites in Germany
- Volunteers
- 40 people
- Sponsor
- Medyria AG
Brain Injuries, Traumatic
The Prophylactic Hypothermia Trial to Lessen Traumatic Brain Injury
Traumatic brain injury (TBI) is a leading cause of death and long term disability, particularly in young adults. Studies from Australia have shown that approximately half of those with severe traumatic brain injury will be…
- Trial name
- POLAR-RCT (NCT00987688)
- Testing
- Hypothermia
- Where
- 15 sites in Australia, France and 4 more
- Volunteers
- 511 people
- Sponsor
- Australian and New Zealand Intensive Care Research Centre
Acute Spinal Cord Injury of Traumatic Origin (tSCI)
Surgical Treatment for Spinal Cord Injury
Despite many years of research, an incomprehensible amount of scientific efforts worldwide and billions of dollars invested, no effective therapy resulting in major neurological or functional recovery is available to date for…
- Trial name
- SCI-POEM (NCT01674764)
- Testing
- Early surgical intervention, Late surgical intervention
- Where
- 17 sites in Austria, Bulgaria and 10 more
- Volunteers
- 297 people
- Sponsor
- AOSpine Europe
Ventricular Septal Defect, Atrioventricular Septal Defect
A Study Evaluating the Efficacy and Safety of IV L-Citrulline for the Prevention of Clinical Sequelae of Acute Lung Injury Induced by Cardiopulmonary Bypass in Pediatric Patients Undergoing Surgery for Congenital Heart Defects
This is a randomized, double-blind, placebo controlled, multicenter study to compare the efficacy and safety of L-citrulline versus placebo in patients undergoing surgery for congenital heart defects.
- Conditions
- Ventricular Septal Defect, Atrioventricular Septal Defect, Primum Atrial Septal Defect
- Trial name
- NCT05253209
- Testing
- L-citrulline, Plasmalyte A
- Where
- 10 sites in United States
- Volunteers
- 64 people
- Sponsor
- Asklepion Pharmaceuticals, LLC
Trauma
The WikiTrauma Interrupted Time Series Protocol
The purpose of this study is to study the combined effect of WikiTrauma, a free collaborative database of clinical decision support tools, and Wiki101, a training course teaching participants how to use WikiTrauma, on the quality…
- Trial name
- WikiTrauma (NCT04035772)
- Testing
- Wiki101 and WikiTrauma
- Where
- Canada
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Laval University
Injury, Trauma
Management of Major Trauma Patients at Aarau Trauma Center - Evaluation of Processes and Patient Outcome
Quality control and improvement project: Assessment and analysis of processes and outcome in trauma emergency room and major trauma patients at the Aarau trauma center (cantonal hospital) with regard to initial emergency…
- Conditions
- Injury, Trauma, Major Trauma, Multiple Trauma
- Trial name
- NCT02165137
- Where
- Switzerland
- Volunteers
- 3,800 people
- Sponsor
- Kantonsspital Aarau
Spinal Cord Injuries, Multiple System Atrophy, Parkinson Variant
Transcutaneous Spinal Cord Stimulation Home Study
The goal of this pilot clinical trial is to examine the safety and feasibility of SCONE as home based therapy for orthostatic hypotension and bowel dysfunction in individuals with spinal cord injury or multiple system atrophy.
- Trial name
- NCT06838637
- Testing
- Spinal COrd NEuromodulation ("SCONE") Device
- Where
- Canada
- Volunteers
- 6 people
- Sponsor
- Michael Berger
Hip Osteoarthritis
OXINIUM◊ DH Total Hip Arthroplasty Pivotal Study
The purpose of this study is to monitor safety of the participants implanted with the OXINIUM◊ DH Hip System up to 10-years post-implantation
- Trial name
- NCT02353377
- Testing
- OXINIUM DH Hip System, BIOLOX◊
- Volunteers
- 413 people
- Sponsor
- Smith & Nephew, Inc.
Post Traumatic Pain, Post Traumatic Analgesic Treatment
Occurence of Pain and Use of Analgesic Treatment in Multi-trauma Patients of Intermediate Seveity
To register the perceived pain score during 0-14 days after multitrauma in conscious patients and to register the use (type and dose) of analgesic treatment in the same period.
- Trial name
- NCT03730272
- Testing
- analgesic drugs and methods
- Where
- Norway
- Volunteers
- 40 people
- Sponsor
- Oslo University Hospital
Alzheimer's Disease, Mild Cognitive Impairment
Retinal Imaging in Neurodegenerative Disease
This study aims to develop and evaluate biomarkers using non-invasive optical coherence tomography (OCT) and OCT angiography (OCTA) as well as ultra-widefield (UWF) fundus photography to assess the structure and function of the…
- Conditions
- Alzheimer's Disease, Mild Cognitive Impairment, Parkinson's Disease, Multiple Sclerosis
- Trial name
- NCT03233646
- Testing
- Retinal and Choroidal Imaging
- Where
- United States
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Duke University
Rib Fracture
The Analgesic Effect of Retro-laminar Block Versus Paravertebral Block in Patients With Multiple Fracture Ribs
Rib fractures are a common injury, occurring in up to 10% of all trauma patients. Multiple rib fractures can be particularly painful and debilitating, making it difficult for patients to breathe and cough.
- Trial name
- NCT06757803
- Testing
- rertrolaminar block, paravertebral block
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Assiut University
Pressure Ulcers Stage II, Pressure Ulcers Stage III
Comparison of Transforming Powder Dressing to NPIAP Recommended Standard of Care Therapies in Stage 2, 3 and 4 Pressure Injuries
Pressure injuries, commonly known as pressure ulcers, affect over 2.5 million people in the United States. Pressure injuries are classified into four escalating stages, from intact skin to full thickness wounds with deep tissue…
- Conditions
- Pressure Ulcers Stage II, Pressure Ulcers Stage III, Pressure Ulcer, Stage IV
- Trial name
- NCT05496296
- Testing
- Altrazeal® Transforming Powder Dressing
- Where
- 14 sites in United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- ULURU Inc.
Traumatic Brain Injury
Comparative Effectiveness of Intervention in Multi-level Hospitals for Acute Traumatic Brain Injury(Metric-TBI)
A prospective, multicenter, observational cohort study is designed to compare the effectiveness of intervention in multi-grade hospitals for acute traumatic brain injury and to optimize clinical outcomes.
- Trial name
- NCT06429774
- Testing
- Neurological function, Mental State, cognitive function, and life quality assessment, Peripheral blood test
- Where
- 64 sites in China
- Volunteers
- 2,000 people
- Sponsor
- Beijing Tiantan Hospital
Post-traumatic Stress Disorder, Suicide
Effectiveness of PTSD Treatment For Suicidal and Multi-Diagnostic Clients
The present project has two primary aims: (1) to examine the effectiveness of a multi-component implementation strategy in improving adoption and adherence to the Dialectical Behavior Therapy Prolonged Exposure (DBT PE) protocol…
- Conditions
- Post-traumatic Stress Disorder, Suicide, Self-injurious Behavior
- Trial name
- NCT02615197
- Testing
- Dialectical Behavior Therapy, Dialectical Behavior Therapy Prolonged Exposure protocol
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- University of Washington
PTSD - Post Traumatic Stress Disorder
First-Line Intervention for PTSD - Intensive Treatment
The goal of this clinical trial is to learn if an intensive program can treat post-traumatic stress disorder (PTSD) in adults getting treatment for the first time, and whether it has lower societal costs.
- Trial name
- FLIP-IT (NCT06700590)
- Testing
- Intensive Treatment, Treatment as usual
- Where
- 4 sites in Netherlands
- Volunteers
- 186 people
- Sponsor
- ARQ National Psychotrauma Centre
Organ Failure, Multiple, Inflammation
Red Cell Rejuvenation for the Attenuation of Transfusion Associated Organ Injury in Cardiac Surgery
The REDJUVENATE Trial proposes to test the hypothesis that postoperative organ injury and inflammation will be less if patients undergoing cardiac surgery who are at risk of large volume blood transfusion (defined as the…
- Conditions
- Organ Failure, Multiple, Inflammation, Sepsis
- Trial name
- NCT03167788
- Testing
- rejuvesol Solution, Standard Care
- Where
- United Kingdom
- Sponsor
- University of Leicester
Multiple Sclerosis (MS)
Characterization of Cortical Injury in Early MS Patients: a 7T MRI Study
The main aim of the present study is to assess the prevalence, the topography and the clinical counterpart of cortical lesions in patient included early after the first clinical episode of multiple sclerosis.
- Trial name
- NCT03624296
- Testing
- MRI 7T, TEST EDSS, TEST MSFC
- Where
- France
- Volunteers
- 30 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Concussion
Cortical Plasticity Assessment in Athletes With a History of Concussion
The purpose of this research is to determine whether athletes with concussion have changes in cortical excitability. Single and paired transcranial magnetic stimulation (TMS) can be used as reliable neurophysiological marker of…
- Trial name
- NCT01112761
- Testing
- Transcranial direct current stimulation
- Where
- United States
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- Spaulding Rehabilitation Hospital
Head Trauma, Craniocerebral Injuries
Assessment of InfraScanner 2000™ in Detecting Subdural and Epidural Hematomas
The goal of this study is to determine the sensitivity, specificity, and positive and negative predictive values of the a portable near-infrared-based device (portable NIR-based device), the InfraScanner 2000™, to detect…
- Conditions
- Head Trauma, Craniocerebral Injuries, Crushing Skull Injury, Head Injuries
- Trial name
- NCT03353246
- Testing
- InfraScanner 2000™
- Where
- United States
- Volunteers
- 500 people
- Sponsor
- Duke University
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