Clinical trials: Muscle Atrophy
Muscle Loss, Fractures
Musculoskeletal Effects of Bicarbonate
With aging, men and women develop a mild and progressive metabolic acidosis. This occurs as a result of declining renal function and ingestion of acid-producing diets.
- Conditions
- Muscle Loss, Fractures, Osteoporosis, Age Related, Fall Injury
- Trial name
- NCT01475214
- Testing
- potassium bicarbonate
- Where
- United States
- Volunteers
- 244 people, healthy volunteers welcome
- Sponsor
- Tufts University
Aging, Sarcopenia
Resistance Exercise and Low-Intensity Physical Activity Breaks in Sedentary Time to Improve Muscle and Cardiometabolic Health
What are the effects of resistance exercise (RE) alone or RE plus low intensity physical activity (LPA) breaks in sedentary time (ST) on skeletal muscle health in older adults? What are the effects of resistance exercise (RE)…
- Conditions
- Aging, Sarcopenia, Disability Physical, Cardiovascular Diseases
- Trial name
- REALPA (NCT03771417)
- Testing
- Exercise Intervention
- Where
- 2 sites in United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Louisiana State University and A&M College
Sarcopenia
A Study of Muscle Strength Maintenance in Older Adults
This research study is being done to see whether losartan can prevent the decrease in strength associated with aging. Muscle loss is associated with aging and has multiple symptoms such as weakness, slowness, and fatigue…
- Trial name
- NCT01989793
- Testing
- Losartan
- Where
- United States
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Urinary Incontinence, Sarcopenia
The Urinary Incontinence Treatment Study
Investigators plan a prospective cohort study with an adaptive design based on physical function status. The design will involve tracking the number of women recruited with physical function impairment and those without any…
- Trial name
- UNITS (NCT03057834)
- Testing
- Pelvic floor muscle exercise
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
Sarcopenia
Nutritional Biomarkers of Sarcopenia
This study proposes to characterize skeletal muscle amino acid kinetics to an EAA challenge, i.e., an oral amino acid tolerance test (OATT), in order to determine the state of muscle health.
- Trial name
- NCT05117112
- Testing
- XS Muscle Multiplier
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Arkansas
Sarcopenia, Inflammation
Effect of Fermented Milk Containing Lactobacillus Casei Strain Shirota in Sarcopenia Elderly
Sarcopenia, which refers to the progressive loss of skeletal muscle mass and strength, shares many characteristics with other disease states typically associated with risks of falling and fracture, including osteoporosis…
- Conditions
- Sarcopenia, Inflammation, Aging
- Trial name
- NCT04985877
- Testing
- Yakult 300 LIGHT Fermented Milk
- Where
- 3 sites in Taiwan
- Volunteers
- 132 people, healthy volunteers welcome
- Sponsor
- Taipei Medical University
Frailty, Sarcopenia
FrAilty Care and wEll-funcTion in Community Dwelling Older Adults
This study is looking at whether older people could benefit from an online monitoring platform to support their individual ambitions to maintain or improve functional ability.
- Conditions
- Frailty, Sarcopenia, Aging
- Trial name
- FACET (NCT03707145)
- Testing
- Consultation, Online Support, Empowered
- Where
- United Kingdom
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- Aberystwyth University
Sarcopenia, Aging
Semi-Recumbent Vibration Therapy in Older Adults
This proposed prospective study will evaluate whether a novel exercise approach, seated vibration therapy, can improve function in the target population of older adults.
- Trial name
- NCT02533063
- Testing
- VibeTech One
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Aging, Vascular Endothelium
Vascular Dysfunction During Physical Inactivity
Prolonged periods of reduced activity are associated with decreased vascular function and muscle atrophy. Physical inactivity due to a sedentary lifestyle or acute hospitalization is also associated with impaired recovery…
- Conditions
- Aging, Vascular Endothelium, Skeletal Muscle
- Trial name
- NCT04872998
- Testing
- Step Count Reduction
- Where
- United States
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- University of Utah
Sarcopenia
Anabolic and Inflammatory Responses to Short-Term Testosterone Administration in Older Men
Skeletal muscle loss is a common consequence of aging and in some individuals reaches a level that compromises health and quality of life.
- Trial name
- NCT00957801
- Testing
- Testosterone injection, Testosterone gel, Medrol
- Where
- United States
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- The University of Texas Medical Branch, Galveston
Sarcopenia, High Blood Pressure
The Impact of a Resistance Training Intervention on Blood Pressure Control in Older Adults With Sarcopenia
Current prevention and treatment of high blood pressure (BP) in sarcopenia, by non-pharmacological approaches remain limited and are far from optimal.
- Conditions
- Sarcopenia, High Blood Pressure, Hypertension
- Trial name
- INERTIA (NCT04255745)
- Testing
- progressive resistance training
- Where
- United States
- Volunteers
- 77 people, healthy volunteers welcome
- Sponsor
- University of Illinois Chicago
Obstructive Sleep Apnea, Amyotrophic Lateral Sclerosis
Transmembrane Electromyography (TM-EMG) for the Assessment of Neuromuscular Function in the Oropharynx
This is a pilot study to examine the diagnostic utility of a novel transmembrane surface sensor, and compare signals obtained with the transmembrane sensor to conventional needle EMG signals from healthy volunteers to those with…
- Conditions
- Obstructive Sleep Apnea, Amyotrophic Lateral Sclerosis, Muscular Dystrophies, Healthy
- Trial name
- NCT03986671
- Testing
- Transmembrane EMG Oropharynx Probe
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Powell Mansfield Inc.
Spinal Muscular Atrophy
A Drug-drug Interaction Study With Risdiplam Multiple Dose and Midazolam in Healthy Participants
This will be a Phase I, 2-part, open-label, non-randomized study to investigate the safety, tolerability, and pharmacokinetics (PK) of a multiple-dosing regimen of risdiplam (Part 1) and the effect of risdiplam on the PK of…
- Trial name
- NCT03988907
- Testing
- Risdiplam, Midazolam
- Where
- United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Hoffmann-La Roche
Sarcopenia, Aging
Immune Function and Muscle Adaptations to Resistance Exercise in Older Adults
The loss of muscle mass and strength due to aging leads to serious health problems for older adults. Muscle health can be improved by exercise training, but some people improve their strength substantially, whereas others improve…
- Conditions
- Sarcopenia, Aging, Immune Function
- Trial name
- TDAP2 (NCT02261961)
- Testing
- TDAP, Acute Resistance Exercise, Resistance Exercise Training
- Where
- United States
- Volunteers
- 59 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Hypertension With Complications and Secondary Hypertension, Overweight and Obesity
Study of the Long-term Effects of Exercise on Heath Indicators in Older People
Cardiovascular diseases (CVD) represent the most frequent cause of death among the elderly population. Hypertension, unfavorable lipid profile, obesity and physical inactivity are among the main risk factors for CVD.
- Conditions
- Hypertension With Complications and Secondary Hypertension, Overweight and Obesity, Lipid Metabolism Disorders, Sarcopenia
- Trial name
- NCT01874132
- Testing
- Exercise training
- Where
- Portugal
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- University of Trás-os-Montes and Alto Douro
Muscular Atrophy, Spinal
A Study to Investigate the Effect of Hepatic Impairment on the Pharmacokinetics and Safety and Tolerability of a Single Oral Dose of Risdiplam Compared to Matched Healthy Participants With Normal Hepatic Function
This is a multi-center, open-label, non-randomized, parallel-group, 2-part study to evaluate the effect of hepatic impairment on the PK and safety and tolerability of a single oral dose of risdiplam compared to matched healthy…
- Trial name
- NCT03920865
- Testing
- Risdiplam
- Where
- 3 sites in United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Hoffmann-La Roche
Age-Related Sarcopenia, Muscle Loss
Impact of Protein and Alkali Supplementation on Skeletal Muscle in Older Adults
The central hypothesis is that higher protein intake and a neutralizing alkaline salt supplement will improve muscle performance and mass, compared to their respective placebos, in older men and postmenopausal women.
- Trial name
- NCT04048616
- Testing
- whey protein isolate, potassium bicarbonate (KHCO3), microcrystalline cellulose
- Where
- United States
- Volunteers
- 141 people, healthy volunteers welcome
- Sponsor
- Tufts University
Male Hypogonadism, Muscle Atrophy
5-Alpha Reductase and Anabolic Effects of Testosterone
The purpose of this study is to determine whether a higher-than-replacement dose of testosterone and finasteride can be combined to safely increase muscle strength in older men who have a low blood concentration of testosterone.
- Conditions
- Male Hypogonadism, Muscle Atrophy, Sarcopenia, Benign Prostate Hypertrophy
- Trial name
- NCT00475501
- Testing
- Testosterone Enanthate, Finasteride
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Sarcopenia
Role of the Gut Microbiome on Lean Mass and Physical Function in Older Adults
The investigators recently published significant associations between circulating gut bacteria-related metabolites with lean and skeletal muscle mass and with measures of physical function in older adults, evidence that suggests…
- Trial name
- NCT02811445
- Where
- United States
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- Tufts University
Myotonic Dystrophy
Effects of SomatoKine (Iplex)Recombinant Human Insulin-like Growth Factor-1/Recombinant Human Insulin-like Growth Factor-binding Protein-3 (rhIGF-I/rhIGFBP-3) in Myotonic Dystrophy Type 1 (DM1)
The aim of this study is to investigate the safety and feasibility of daily subcutaneous injections of recombinant IGF1 complexed with IGF binding protein 3 (SomatoKine-INSMED) as a treatment for muscle wasting and weakness in…
- Trial name
- NCT00233519
- Testing
- SomatoKine/IPLEX
- Where
- United States
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- University of Rochester