Clinical trials: Muscle Degeneration
Achilles Tendon Rupture, Achilles Tendinopathy
Degenerative Achilles Tendon Rupture Repair With Regeneten Augmentation
Retrospective Case Series to investigate the effect a bovine collagen patch to augmented repair in acute Achilles tendon rupture with pre-existing tendinopathy
- Trial name
- NCT06252389
- Testing
- Achilles Tendon Repair augmented with Bioinductive Collagen Patch
- Where
- Hong Kong
- Volunteers
- 9 people
- Sponsor
- Chinese University of Hong Kong
Other Intervertebral Disc Degeneration, Lumbar Region
Trunk Muscles and Lumbar Intervertebral Disc Degeneration in Combat Sports
This study examined whether there is an association between the presence of lumbar intervertebral disc degeneration (LDD) and the size and symmetry of the cross-sectional areas (CSAs) of the trunk muscles in combat sports…
- Trial name
- NCT02744781
- Testing
- Lumbar disc degeneration; LDD
- Volunteers
- 69 people, healthy volunteers welcome
- Sponsor
- National Institute of Technology, Hiroshima College
Healthy, Muscular Dystrophy
Studies of Patients With Skin Disease, Patients With Neurological Degenerations, and Normal Volunteers
It is proposed that patients with skin disease due to presumed immunologic, genetic or viral-induced abnormalities, patients with neurological degenerations, and normal controls be evaluated with various in vitro studies of…
- Conditions
- Healthy, Muscular Dystrophy, Retinal Degeneration, Skin Diseases
- Trial name
- NCT00001164
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- National Cancer Institute (NCI)
Sarcopenia, Connective Tissue Diseases in Old Age
RCT of Combination Effect of Vibration Treatment and HMB Supplementation on Myosteatosis and NMJ Degeneration
The investigators' pre-clinical study confirms the positive effects of combined treatment (VT + HMB) on reducing fat-to-lean tissue ratio, intramuscular fat infiltration and increasing muscle strength in sarcopenia animal model.
- Conditions
- Sarcopenia, Connective Tissue Diseases in Old Age, Musculoskeletal Abnormalities
- Trial name
- NCT05525039
- Testing
- Low-magnitude High-frequency Vibration, β-hydroxy β-methylbutyrate (HMB) supplement, Protein supplement
- Where
- 3 sites in Hong Kong
- Volunteers
- 200 people
- Sponsor
- Chinese University of Hong Kong
Lumbar Disc Herniation, Lumbar Degenerative Disease
Multivariate Analysis and Risk Factors Were Used to Predict the Short-term Postoperative Pain of Degenerative Lumbar Spine
The objective of this retrospective clinical study wasto study the risk factors for short-term low back and leg pain after PLIF in patients with lumbar Degenerative disease, and to establish a risk prediction model for short-term…
- Conditions
- Lumbar Disc Herniation, Lumbar Degenerative Disease, Sarcopenia
- Trial name
- NCT06628583
- Testing
- Magnetic Resonance Imaging with Contrast
- Where
- China
- Volunteers
- 936 people, healthy volunteers welcome
- Sponsor
- Hao Liu
Mitochondrial Myopathies, Mitochondrial DNA Mutation
Genomic Profiling of Mitochondrial Disease - Imaging Analysis for Precise Mitochondrial Medicine
This study is an observational longitudinal study involving the use of MRIs and video recordings taken at home of patients completing basic tasks.
- Conditions
- Mitochondrial Myopathies, Mitochondrial DNA Mutation, Mitochondrial Diseases, Chronic Progressive External Ophthalmoplegia With Myopathy
- Trial name
- NCT05012358
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- Mayo Clinic
Hip Osteoarthritis, Osteoarthritis, Hip
Gluteal Sling Release on Gluteal Dysfunction After in Primary Total Hip Arthroplasty
This study investigates the effects of gluteal sling release during total hip arthroplasty (THA) on gluteal muscle function and hip joint performance.
- Conditions
- Hip Osteoarthritis, Osteoarthritis, Hip, Gluteus Maximus Muscle Atrophy, Muscle Weakness Condition
- Trial name
- NCT06850155
- Testing
- Sling release, Sling release and repair
- Where
- Turkey (Türkiye)
- Volunteers
- 144 people
- Sponsor
- Ankara City Hospital Bilkent
Bone Resorption
The Novel Unloading Device "HEPHAISTOS" and Its Effects Upon Bone, Muscle and Vasculature
The present study aimed to investigate the importance of gravitational induced forces that appear during normal ambulation for the health of muscles, bones and blood vessels.
- Trial name
- HEP (NCT01576081)
- Testing
- HEPHAISTOS
- Where
- Germany
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- DLR German Aerospace Center
Incomplete Spinal Cord Injury, Spasticity, Muscle
Activating Spinal Circuits to Improve Walking, Balance, Strength, and Reduce Spasticity
For many people with spinal cord injury (SCI), the goal of walking is a high priority. There are many approaches available to restore walking function after SCI; however, these approaches often involve extensive rehabilitation…
- Trial name
- NCT05429736
- Testing
- Motor Skill Training (MST), Transcutaneous Spinal Stimulation (TSS)
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- Shepherd Center, Atlanta GA
Temporomandibular Joint Disorders
Intra-articular Injection in Arthroscopic Management of Temporomandibular Diseases
The aim of this study is to evaluate the efficacy of intra-articular injection of platelet rich plasma versus hyaluronic acid following diagnostic arthroscopy in the management of patients suffering from degenerative…
- Trial name
- NCT04936945
- Testing
- Temporomandibular joint arthroscopy plus intra-articular injection
- Where
- Egypt
- Volunteers
- 20 people
- Sponsor
- Sohag University
Muscle Degeneration, Body Weight Changes
Enforced Reduction in Physical Activity and Recovery in Older Adults
Apparently healthy and well-functioning community dwelling 70-80 year-olds will be recruited to the study. All subjects undergo pre-screening for suitability and a physicians examination, as well as 7-day habitual daily steps are…
- Conditions
- Muscle Degeneration, Body Weight Changes, Walking, Difficulty
- Trial name
- ENDURE (NCT04997447)
- Testing
- Step-reduction/Exercise Rehab
- Where
- Finland
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- University of Jyvaskyla
Amyotrophic Lateral Sclerosis, Frontotemporal Dementia
TRIAL READY (Clinical Trial Readiness)
This study, being conducted under the auspice of the CReATe Consortium, will enroll patients with ALS and related disorders as well as healthy controls, with the goal of facilitating clinical validation of leading…
- Conditions
- Amyotrophic Lateral Sclerosis, Frontotemporal Dementia, ALS-Frontotemporal Dementia, Primary Lateral Sclerosis
- Trial name
- NCT03912987
- Where
- 3 sites in United States
- Volunteers
- 610 people, healthy volunteers welcome
- Sponsor
- University of Miami
Spine Injuries and Disorders
Which Markers of Musculoskeletal Health Can Explain Complications in Spinal Surgery?
The present study is related to the project "ORTHOSPINE FITNESS: WHICH MARKERS OF MUSCULOSKELETAL HEALTH CAN EXPLAIN COMPLICATIONS IN SPINE SURGERY?", winner of the Ministry of Health Call, financed by the European Union…
- Trial name
- NCT06736106
- Testing
- screening
- Where
- 2 sites in Italy
- Volunteers
- 200 people
- Sponsor
- Istituto Ortopedico Rizzoli
Low Back Pain, Muscle Strength
Back Squat Exercise Treatment for Low Back Pain: Clinical Trial
Summary: Low back pain is the leading cause of deficiency and loss of productivity worldwide. No evidence of any particular exercise was more effective than another for treating nonspecific low back pain.
- Conditions
- Low Back Pain, Muscle Strength, Visceral Obesity, Spine Disease
- Trial name
- NCT04691258
- Testing
- Experimental: Complete Group, Active Comparator: Restricted Group
- Where
- 3 sites in Brazil
- Volunteers
- 32 people
- Sponsor
- Universidade Federal de Goias
Inclusion Body Myopathy With Early-onset Paget Disease and Frontotemporal Dementia, Paget Disease of Bone
Characterization of Inclusion Body Myopathy Associated With Paget's Disease of Bone and Frontotemporal Dementia (IBMPFD)
The investigators are researching families with inherited inclusion body myopathy (IBM) and/or Paget disease of bone (PDB) and/or dementia (FTD) which is also called IBMPFD. IBMPFD is caused by mutations in the VCP gene.
- Conditions
- Inclusion Body Myopathy With Early-onset Paget Disease and Frontotemporal Dementia, Paget Disease of Bone, Frontotemporal Dementia, Myopathy
- Trial name
- NCT01353430
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of California, Irvine
Mitochondrial Diseases, Mitochondrial Respiratory Chain Deficiencies
A Phase Ia/Ib, SAD and MAD Study of of KL1333 in Healthy Subjects and Patients With Primary Mitochondrial Disease
This will be a double blind, randomised, placebo controlled, single and multiple oral dose study conducted in 3 parts: Part A, Part B and Part C.
- Conditions
- Mitochondrial Diseases, Mitochondrial Respiratory Chain Deficiencies, MELAS Syndrome, Mitochondrial Myopathies
- Trial name
- NCT03888716
- Testing
- KL1333
- Where
- 2 sites in United Kingdom
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Abliva AB
Motor Neuron Disease, Amyotrophic Lateral Sclerosis, Motor Neuron Disease Progressive Spinal Muscle Atrophy
Non-invasive Spinal, Cortical, and Sensorimotor Biomarkers in Motor Neurone Disease
Substantial variability exists in the onset, and rate of degeneration across individuals with Motor Neurone Disease (MND) or Amyotrophic Lateral Sclerosis (ALS).
- Conditions
- Motor Neuron Disease, Amyotrophic Lateral Sclerosis, Motor Neuron Disease Progressive Spinal Muscle Atrophy, Primary Lateral Sclerosis, Multiple Sclerosis
- Trial name
- NCT06320444
- Testing
- 232 Electrode Electrophysiology (EEG-ECG-EMG-EXG)
- Where
- Ireland
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- University of Dublin, Trinity College
Achilles Tendinopathy, Achilles Tendonitis
Achilles Tendinopathy, Treatment With eXercise Comparing Men and Women
This study will evaluate if there is a difference in recovery of tendon structure and mechanical properties between males and females with Achilles tendinopathy receiving exercise treatment.
- Conditions
- Achilles Tendinopathy, Achilles Tendonitis, Achilles Tendon Pain, Achilles Degeneration
- Trial name
- ATX (NCT03523325)
- Testing
- Exercise treatment
- Where
- United States
- Volunteers
- 182 people
- Sponsor
- University of Delaware
Neurodegenerative Disorders
Development of IPS from Donated Somatic Cells of Patients with Neurological Diseases
Human fibroblasts and possibly other human somatic cells may be reprogrammed into induced pluripotent stem (iPS) cells by the forced expression of transcription factors (1-5).
- Trial name
- NCT00874783
- Where
- Israel
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Hadassah Medical Organization
Degenerative Lumbar Diseases, Cage
Development and Validation of Interpretable Machine Learning Models Incorporating Paraspinal Muscle Quality for to Predict Cage Subsidence Risk Followingposterior Lumbar Interbody Fusion
The study focuses on identifying risk factors for cage subsidence after posterior lumbar interbody fusion (PLIF) and developing an interpretable machine learning model to predict these risks.
- Conditions
- Degenerative Lumbar Diseases, Cage, Machine Learning
- Trial name
- NCT06888739
- Testing
- MR4
- Where
- China
- Volunteers
- 720 people, healthy volunteers welcome
- Sponsor
- Hao Liu