Clinical trials: Muscle Disorders
Muscle Weakness
Maximal Strength Training in Patients Undergoing Total Hip Arthroplasty
Conventional rehabilitation after total hip arthroplasty (THA) does not seem to restore muscular strength or walking speed. Three-5 years after surgery patients are still not fully rehabilitated.
- Trial name
- NCT02498093
- Testing
- Maximal strength training, conventional rehabilitation
- Where
- Norway
- Volunteers
- 60 people
- Sponsor
- Norwegian University of Science and Technology
Fecal Incontinence
Autologous Muscle Fiber Fragment Injections
To regenerate functional anal sphincter muscle using muscle fiber fragments that contain muscle precursor cells (MPCs)
- Trial name
- NCT05396456
- Testing
- Muscle Fiber Fragment (MFF) Injections
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Wake Forest University Health Sciences
Overweight and Obesity, Insulin Resistance
Insulin and Muscle Fat Metabolism
Our objective in this study is to identify the extent to which insulin drives the accumulation of lipids in skeletal muscle of humans.
- Conditions
- Overweight and Obesity, Insulin Resistance, Metabolic Disease, Mitochondrial Metabolism
- Trial name
- NCT04759872
- Testing
- Hyperinsulinemic-euglycemic Clamp
- Where
- United States
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- Oregon State University
Musculoskeletal Pain, Neck Pain
Pain Modulatory Profiles in Massage for Individuals With Neck Pain
One in ten adults experience widespread pain. Neck pain, for example, is a prevalent condition with a high rate of recurrence that affects between 10.4% and 21.3% of the population annually.
- Trial name
- NCT03534739
- Testing
- Pain Inducing Massage, Light Touch Massage, Coldpressor
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- University of Florida
Inclusion Body Myositis, Sporadic Inclusion Body Myositis
Safety and Tolerability of Phenylbutyrate in Inclusion Body Myositis
This is a pilot study (phase 1 clinical trial) to evaluate the safety and tolerability of phenylbutyrate in IBM. In this open label study, 10 patients with sporadic inclusion body myositis will be treated with phenylbutyrate (3…
- Trial name
- NCT04421677
- Testing
- Phenylbutyrate Oral Tablet
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of Kansas Medical Center
Obesity, Metabolic Syndrome
Effect of Resvida, a Comparison With Calorie Restriction Regimen
The purpose of this study is to compare the effects of the antioxidant "resveratrol" to a diet intervention (Calorie Restriction) to determine how each of them affects the following: gene expression profile, cholesterol (lipids)…
- Conditions
- Obesity, Metabolic Syndrome, Diabetes, Aging
- Trial name
- Resvida (NCT00823381)
- Testing
- resveratrol, Calorie Restriction
- Where
- United States
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Type 2 Diabetes
Dynamic in Vivo PET Imaging and ex Vivo Biopsies From Skeletal Muscle and Adipose Tissue to Investigate the Effects of Exercise on Insulin Resistance and Mitochondrial Energetics in Type 2 Diabetes
The overall aim of this pilot study is to investigate the effects of exercise training on skeletal muscle and adipose tissue insulin resistance in subjects with Type 2 Diabetes (T2D).
- Trial name
- EXPET (NCT04754581)
- Testing
- Maximal ATP Production (ATPmax), Exercise Testing (VO2max), Muscle Biopsy
- Where
- United States
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- AdventHealth Translational Research Institute
Occupational Diseases, Muscle Pain
Musculoskeletal Problems and Strategies Developed by Physiotherapists to Cope With Them
The aim of this study is to investigate whether there is a difference in areas such as occupational musculoskeletal injuries and strategies developed by physiotherapists working in different fields, burnout and occupational…
- Trial name
- NCT06006481
- Testing
- Survey
- Where
- Turkey (Türkiye)
- Volunteers
- 255 people, healthy volunteers welcome
- Sponsor
- Uskudar University
Subacromial Pain Syndrome, Rotator Cuff Related Shoulder Pain
Predictive Model for PENS Response in Subacromial Pain Syndrome
Subacromial pain syndrome (SPS) is one of the most common causes of shoulder pain, leading to significant disability and socioeconomic burden.
- Trial name
- NCT07063641
- Testing
- Percutaneous Electrical Nerve Stimulation (PENS)
- Volunteers
- 269 people
- Sponsor
- Néstor Requejo Salinas
Duchenne Muscular Dystrophy
A Study to Evaluate the Safety and Tolerability of PF-06939926 Gene Therapy in Duchenne Muscular Dystrophy
This is a first-in-human/first-in-patient, multi-center, open-label, non-randomized, ascending dose, safety and tolerability study of a single intravenous infusion of PF-06939926 in ambulatory and non-ambulatory subjects with…
- Trial name
- NCT03362502
- Testing
- PF-06939926
- Where
- 22 sites in United States
- Volunteers
- 23 people
- Sponsor
- Pfizer
Diabetes Mellitus, Type 2, Frailty
Power Strength Training in Type 2 Diabetic Mellitus Older Adults
Diabetes is a disease with a high impact in the population older than 65 years old. Some indications suggest that diabetes in the old age aggravate the negative effects of ageing, as the loss of muscle mass and strength, bringing…
- Trial name
- DIAPOW (NCT04332302)
- Testing
- Power resistance training
- Where
- Spain
- Volunteers
- 41 people
- Sponsor
- Technical University of Madrid
Dermatomyositis
Biomarkers of Cancer-Associated Myositis
The project is about dermatomyositis (DM), an autoimmune disease characterized by inflammation in the skeletal muscles and skin. Patients with DM have an increased risk of cancer, with a cancer incidence between 5.5% and 42%.
- Trial name
- MIOSURFACE (NCT06808672)
- Where
- 2 sites in Italy
- Volunteers
- 50 people
- Sponsor
- Azienda USL Reggio Emilia - IRCCS
Esophageal Cancer
Effect of Concurrent Chemoradiation Therapy on Respiratory Muscle Performance, Lung Function and Functional Capacity in Patients With Local Esophagus Cancer
The purpose of this study is to investigate the effect of concurrent chemoradiation therapy on respiratory muscle performance, lung function and functional capacity in patients with local esophagus cancer.
- Trial name
- NCT03120572
- Where
- Taiwan
- Volunteers
- 45 people
- Sponsor
- Mackay Memorial Hospital
Intraabdominal Hypertension, Breast Neoplasms
DIEP Flap Surgery and Intraabdominal Pressure
Aim: The primary aim of this study is to test if closure of the abdominal donor site increases the Intraabdominal Pressure (IAP) in women undergoing secondary Deep Inferior epigastric perforator (DIEP) flap breast reconstruction.
- Trial name
- NCT05764577
- Testing
- DIEP flap surgery
- Where
- Denmark
- Volunteers
- 13 people
- Sponsor
- Aalborg University Hospital
Stroke, Cerebrovascular Accident
Source of Hand Weakness After Stroke
The purpose of this study is to determine whether neural block and neuromuscular electrical stimulation are effective in treating finger impairment due to stroke.
- Trial name
- NCT00907829
- Testing
- lidocaine, muscle stimulator
- Where
- United States
- Sponsor
- US Department of Veterans Affairs
Heart Failure
Inspiratory Muscle Training in HFpEF
This study is being done to determine how inspiratory muscle training impacts inspiratory muscle function during exercise in heart failure patients.
- Trial name
- NCT06510231
- Testing
- Inspiratory Muscle Training
- Where
- United States
- Volunteers
- 68 people
- Sponsor
- Mayo Clinic
Fibromyalgia
Tools for the Differential Diagnosis of Fibromyalgia Based on Cognitive Tasks
The goal of this observational study is to test for behavioural and neurophysiological biomarkers in fibromyalgia patients. The main questions it aims to answer are: Is there a measurable decline in working memory? Could these…
- Trial name
- NCT05910372
- Testing
- Color Comparison Task, N-back Task
- Where
- Argentina
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- National Council of Scientific and Technical Research, Argentina
Fatigue Syndrome, Chronic, Myalgic Encephalomyelitis
Oral Melatonin Plus Zinc Supplementation in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis (CFS/ME)
The purpose of this study is to evaluate the effects of oral melatonin plus zinc supplementation in relieving self-reported fatigue in CFS/ME
- Trial name
- MELATOZINC (NCT03000777)
- Testing
- melatonin plus zinc
- Where
- Spain
- Volunteers
- 60 people
- Sponsor
- Laboratorios Viñas, S.A.
Cancer, Skin Fibroblasts
Nicotinamide Riboside on Mitochondrial Function in Li-Fraumeni Syndrome
Background: Nicotinamide riboside (NR) is a vitamin B3 dietary supplement. It may help improve muscle function, that may in turn may improve a person s exercise capacity.
- Conditions
- Cancer, Skin Fibroblasts, Muscle Weakness
- Trial name
- NCT03789175
- Testing
- Nicotinamide Riboside (NR)
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
COPD
Sit-to-stand and Peripheral Muscle Strength in COPD
Background: Individuals with COPD may present reduced peripheral muscle strength, which leads to impaired mobility. Comprehensive pulmonary rehabilitation (PR) should include strength training, in particular to lower limbs.
- Trial name
- NCT02487875
- Testing
- rehabilitation
- Where
- Italy
- Volunteers
- 60 people
- Sponsor
- Maugeri Foundation
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