Clinical trials: Muscle Disorders
Pediatric Oncology
A Phase I Dose Finding Study in Children With Solid Tumors Recurrent or Refractory to Standard Therapy
Dose escalation phase of the study : To define the safety profile, maximum tolerated dose (MTD) and recommended phase II dose (RP2D) of regorafenib administered orally as a single agent in a 3-weeks-on/1- week-off schedule in…
- Trial name
- NCT02085148
- Testing
- Regorafenib (BAY73-4506), Vincristine (Cellcristin®), Irinotecan (Irinotecan Cell pharm®)
- Where
- 12 sites in France, Italy and 2 more
- Volunteers
- 62 people
- Sponsor
- Bayer
Osteo Arthritis Knee, Knee Arthroplasty
Effects of Motor Imagery Intervention on Functional Recovery Following Total Knee Arthroplasty
The knee osteoarthritis becoming a leading cause of disability among older adults' population. When conventional treatments fail, a total knee arthroplasty (TKA) is suggested.
- Trial name
- KSV2017 (NCT03684148)
- Testing
- Motor imagery practice
- Where
- Slovenia
- Volunteers
- 34 people
- Sponsor
- Science and Research Centre Koper
Ultrasound, Muscle Disease
Role of Ultrasound in Diagnosis of Muscle Diseases
The study aims to provide a timely update on the role of combining clinical and neuromuscular ultrasound assessments in diagnosis and follow-up of various muscle diseases in clinical practice over 12 months period, and…
- Trial name
- NCT04233255
- Testing
- Neuromuscular Ultrasound (US), Electrophysiological studies, Seum CPK, CK-MM levels, Lactate dehydrogenase and alanine aminotransferase.
- Where
- Egypt
- Volunteers
- 128 people, healthy volunteers welcome
- Sponsor
- Assiut University
Inherited Mitochondrial Disease
A Safety Study for Previously Treated Vatiquinone (PTC743) Participants With Inherited Mitochondrial Disease
The primary objective of this study is to assess the safety of vatiquinone in participants with inherited mitochondrial disease who had prior exposure to vatiquinone in a PTC/BioElectron sponsored (previously Edison) clinical…
- Trial name
- NCT05218655
- Testing
- Vatiquinone
- Where
- 26 sites in United States, France and 5 more
- Volunteers
- 101 people
- Sponsor
- PTC Therapeutics
Duchenne Muscular Dystrophy (DMD)
A Remote Study Using Technology to Assess Outcomes in DMD
Every year, 100 boys are born in the UK with a rare muscle disease called Duchenne muscular dystrophy. These boys cannot make an important muscle protein called dystrophin.
- Trial name
- TODDLER (NCT07423026)
- Where
- United Kingdom
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Strabismus, Comitant
Single Minimal Conjunctival Incision for Strabismus
The purpose of this investigation is to study the feasibility and inflammatory response of surgery for rectus muscles using a small single bulbar conjunctival incision posterior and parallel to the muscle insertion.
- Trial name
- NCT05987878
- Testing
- single minimal conjunctival incision
- Where
- Spain
- Volunteers
- 25 people
- Sponsor
- Universidad Autonoma de Madrid
Healthy
Evaluation of Skeletal Muscle Lipid Content by Magnetic Resonance Spectroscopy
Type 2 diabetes is a growing public health issue and one component of Type 2 diabetes is 'insulin resistance" - the ability of insulin to work less well.
- Trial name
- NCT00786578
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Minnesota
Autosomal Dominant Hypocalcemia (ADH)
Efficacy and Safety of Encaleret Compared to Standard of Care in Participants With ADH1
The primary purpose of the study is to understand the effectiveness, safety, and tolerability of encaleret when compared to standard of care (SoC) treatment in participants with Autosomal Dominant Hypocalcemia Type 1 (ADH1).
- Trial name
- CALIBRATE (NCT05680818)
- Testing
- Encaleret, Standard of Care
- Where
- 25 sites in United States, Australia and 8 more
- Volunteers
- 67 people
- Sponsor
- Calcilytix Therapeutics, Inc., a BridgeBio company
Duchenne Muscular Dystrophy (DMD), Cardiomyopathy
Modeling Mortality in Duchenne Muscular Dystrophy Cardiomyopathy: Identification of Surrogate Outcome Measures for DMD Drug Trials
Dystrophin associated heart dysfunction is a leading cause of death in patients with Duchenne and Becker Muscular dystrophy (DMD/BMD) and Duchenne and Becker muscular dystrophy carriers (MDC); however, the evolution of heart…
- Conditions
- Duchenne Muscular Dystrophy (DMD), Cardiomyopathy, Becker Muscular Dystrophy, Carrier of Duchenne Muscular Dystrophy
- Trial name
- NCT07674758
- Where
- 9 sites in United States
- Volunteers
- 1,000 people
- Sponsor
- Vanderbilt University Medical Center
Acute Myeloid Leukemia, Myelodysplastic Syndrome
Phase I Trial of Universal Donor NK Cell Therapy in Combination With ALT803
The purpose of this study is to find the number of natural killer (NK) cells from non-HLA matched donors that can be safely infused into patients with cancer. NK cells are a form of lymphocytes that defend against cancer cells.
- Conditions
- Acute Myeloid Leukemia, Myelodysplastic Syndrome, Acute Lymphoblastic Leukemia, Chronic Myeloid Leukemia
- Trial name
- NCT02890758
- Testing
- Natural Killer (NK) Cells, ALT803
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- Brenda Cooper, MD
Duchenne Muscular Dystrophy
Prognostic Factors Affecting Duchenne Muscular Dystrophy
Determination of prognostic factors affecting ambulation of duchenne muscular dystrophy
- Trial name
- NCT03372655
- Volunteers
- 82 people
- Sponsor
- Assiut University
COPD, COPD Exacerbation
Evaluation of Utility Quadriceps Magnetic Stimulation in COPD (Chronic Obstructive Pulmonary Disease) Patients After Hospital Exacerbation
The aims of this study are:1.To evaluate the utility of quadriceps RMNMS (repetitive magnetic neuromuscular stimulation) in the evolution of COPD patients after hospital admission for acute exacerbation.2 To evaluate the time…
- Trial name
- COPD (NCT01264978)
- Testing
- Repetitive magnetic stimulation of the quadriceps muscle
- Where
- Spain
- Volunteers
- 32 people
- Sponsor
- Hospital de Cruces
Muscle Injury, Pulsed Electromagnetic Therapy
Investıgatıon of The Effıciency of Pulsed Electromagnetıc Field Therapy and Stretching Exercises
In this study, a total of 69 Wistar Albino rats were used, five of which were in the preliminary study. The preliminary study was planned to determine the ideal PEMF treatment time.
- Conditions
- Muscle Injury, Pulsed Electromagnetic Therapy, Muscle Stretching Exercise
- Trial name
- NCT05988476
- Testing
- Exercise, Pulsed Electromagnetic Field Therapy
- Where
- Turkey (Türkiye)
- Volunteers
- 64 people
- Sponsor
- Suleyman Demirel University
Muscular Atrophy, Spinal
A Study to Collect Blood Samples From Patients With Spinal Muscular Atrophy for Biomarker Analysis
In this single center study blood samples for biomarker analysis will be collected from patients with spinal muscular atrophy. Up to 21 mL blood will be drawn from eligible patients at a single visit.
- Trial name
- NCT01910168
- Where
- 2 sites in United States
- Volunteers
- 36 people
- Sponsor
- Hoffmann-La Roche
Chronic Disease, Glucocorticoid Therapy, Response to
Efficacy Study of Recombinant Growth Hormone on Muscle Function in Children Long-term Treated With Glucocorticoid
Children suffering from chronic disease and receiving long-term glucocorticoid therapy suffer over years from severe growth retardation and profoundly altered body composition.
- Conditions
- Chronic Disease, Glucocorticoid Therapy, Response to, Growth Retardation
- Trial name
- NCT00813189
- Testing
- GH treatment
- Where
- France
- Volunteers
- 30 people
- Sponsor
- Association REMEDE
Critical Illness Myopathy, Respiratory Paralysis
ICU Acquired Neuromyopathy and Diaphragm Function
Critical illness neuromyopathy is a common disease acquired during ICU stay leading to a deep weakness involving the respiratory muscle work which result in a delayed weaning of mechanical ventilation.
- Trial name
- NCT01968889
- Testing
- Non invasive phrenic nerve stimulation
- Where
- France
- Volunteers
- 60 people
- Sponsor
- University Hospital, Montpellier
Mental Retardation, Spasticity
Prevalence of Spasticity in Adults With Mental Retardation Living in the Community
This survey aims to investigate the prevalence of spasticity among adults who live in community settings in Davidson County, Tennessee.
- Trial name
- NCT00282191
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- Vanderbilt University
COPD, Hypercapnia
The Effect of Non-invasive Ventilation on the Oxygenation of Peripheral Muscle in Hypercapnic COPD Patients
In this study, 20 hypercapnic COPD patients will perform two constant workrate endurance cycle tests. One test will be while using non-invasive Ventilation (NIV) support, one without in a randomized cross-over design.
- Trial name
- NCT02877290
- Testing
- non-invasive ventilation (NIV)
- Where
- Germany
- Volunteers
- 20 people
- Sponsor
- Schön Klinik Berchtesgadener Land
Trigger Finger
A1 Pulley Stretching Along With Tendon Gliding Exercises in Post-operative Patients of Trigger Finger
The study was conducted to determine the synergistic effects of A1 pulley stretching along with tendon gliding exercises on pain, range of motion, and hand grip strength in post-operative patients of trigger finger
- Trial name
- NCT07482397
- Testing
- A1 pulley stretching, Tendon Gliding exercises, Standard physiotherapy treatment
- Where
- Pakistan
- Volunteers
- 30 people
- Sponsor
- Riphah International University
Musculoskeletal Pain, Flexibility
Effects of a Four-Week Active Break Program on Musculoskeletal Pain and Spinal Mobility in Office Workers
This study was designed as a two-arm, parallel-group randomized controlled trial with a 1:1 allocation ratio. A total of 55 office workers were randomly allocated to an experimental group (n = 28) or a control group (n = 27).
- Conditions
- Musculoskeletal Pain, Flexibility, Well Being
- Trial name
- NCT07865143
- Testing
- Active Break
- Where
- Slovenia
- Volunteers
- 55 people
- Sponsor
- Julia Wegener
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