Clinical trials: Muscle Disorders
Asthma
Fatty Acids in Airway Smooth Muscle of Asthmatics
In this proof of concept study, the investigators aim to determine if supplementation with coconut oil causes an increase in cholecystokinin and cholecystokinin receptor expression in the airway smooth muscle of lean asthmatics…
- Trial name
- NCT02809235
- Testing
- coconut oil
- Where
- United States
- Sponsor
- Brigham and Women's Hospital
Systemic Lupus Erythematosus, Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis
Safety and Efficacy Study of CD19-CAR-DNT Cells in Autoimmune Diseases
To evaluate the safety and efficacy of CD19-CAR-DNT cells in subjects with relapsed/refractory autoimmune diseases
- Conditions
- Systemic Lupus Erythematosus, Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis, Idiopathic Inflammatory Myopathies, Systemic Sclerosis
- Trial name
- NCT06316076
- Testing
- CD19-CAR-DNT cells
- Where
- China
- Volunteers
- 48 people
- Sponsor
- RenJi Hospital
Patellofemoral Pain Syndrome
Activation of Hip Muscles in Runners With Patellofemoral Syndrome
Introduction: Hip motor control deficit and neuromuscular disorders of the gluteus medius influence the mechanics of patellofemoral joints through increased dynamic knee valgus and can lead to Patellofemoral Pain Syndrome (PFPS).
- Trial name
- NCT02837289
- Testing
- Therapy taping
- Where
- Brazil
- Volunteers
- 15 people
- Sponsor
- Universidade Estadual de Londrina
Tennis Elbow
Comparing Arthroscopic Tennis Elbow Release With Arthroscopic Debridement
We propose a randomized, double-blind controlled trial comparing arthroscopic release with arthroscopic debridement for the management of chronic tennis elbow in an effort to definitively determine whether arthroscopic tennis…
- Trial name
- NCT02236689
- Testing
- Non operative, Arthroscopic tennis elbow release
- Where
- Canada
- Volunteers
- 68 people
- Sponsor
- Ottawa Hospital Research Institute
Idiopathic Inflammatory Myopathies
Clinical Characteristics and Mechanism Research of Inhibitors of Janus Kinase in the Idiopathic Inflammatory Myopathies
This study aims to explore the clinical characteristics and mechanism of inhibitors of janus kinase in the treatment of idiopathic inflammatory myopathies
- Trial name
- NCT05400889
- Testing
- tofacitinib
- Where
- China
- Volunteers
- 10 people
- Sponsor
- Peking University People's Hospital
Scoliosis; Adolescence, Myofascial Pain Syndrome
Prevalence of Myofascial Pain Syndrome in Adolescent Idiopathic Scoliosis
this is an observational and cross-sectional prevalence study. 10-18 years aged participants with adolescent idiopathic scoliosis were recruited in the study. Myofascial pain syndrome will be questioned to the participants.
- Conditions
- Scoliosis; Adolescence, Myofascial Pain Syndrome, Trigger Point Pain, Myofascial, Physical Medicine and Rehabilitation
- Trial name
- NCT05185050
- Testing
- physical examination and measurement of spinal alignment
- Where
- Turkey (Türkiye)
- Volunteers
- 168 people
- Sponsor
- Kanuni Sultan Suleyman Training and Research Hospital
Urinary Retention, Urinary Incontinence
Autologous Muscle Derived Cells for Underactive Bladder
This is a prospective, open-label, Phase 1, single center study evaluating the safety and efficacy of Autologous Muscle Derived Cells as a treatment for chronic Underactive Bladder.
- Trial name
- NCT02463448
- Testing
- Autologous Muscle Derived Cells
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- Jason Gilleran
Cervical Cancers
The Effects of Immunonutrition Therapy on Locally Advanced Cervical Cancer Patients
The goal of this open-label randomized control trial is to study the effect of immunonutrition in locally advanced cervical cancer (LACC) with standard concurrent chemoradiotherapy.
- Trial name
- NCT06349148
- Testing
- enteral immunonutrition, standard oral enteral nutrition
- Where
- China
- Volunteers
- 50 people
- Sponsor
- SHUANG ZHENG JIA, PhD
Musculoskeletal Pain
Effects of Pain Neuroscience Education on Pain Attitudes and Beliefs in Physiotherapy Assistant Students
The goal of this educational trial is to learn whether Pain Neuroscience Education (PNE) improves pain-related attitudes and beliefs in physiotherapy assistant (PTA) students in Turkey compared to traditional pain education.
- Trial name
- NCT07005778
- Testing
- Traditional pain education, PNE-based education
- Where
- Turkey (Türkiye)
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Akdeniz University
Depressive Disorder, Musculoskeletal Pain
Multicomponent Program for the Integrated Management of Chronic Pain and Depression in Primary Care
This study evaluates whether the implementation of an integrated clinical program for chronic musculoskeletal pain and depression behave better clinical outcomes than the usual approach in primary care
- Conditions
- Depressive Disorder, Musculoskeletal Pain, Chronic Pain
- Trial name
- DROP (NCT02605278)
- Testing
- Clinical program for pain and depression, Control
- Where
- Spain
- Volunteers
- 330 people
- Sponsor
- Fundacio d'Investigacio en Atencio Primaria Jordi Gol i Gurina
Chronic Obstructive Pulmonary Disease, Muscle Weakness Conditions
Effects of Inspiratory Muscle Training on Breathing Pattern in Patients With Chronic Obstructive Pulmonary Disease
The improvement in inspiratory muscle function might result in beneficial changes in breathing pattern during whole body exercise.
- Trial name
- NCT02186340
- Testing
- Inspiratory muscle training
- Where
- Belgium
- Volunteers
- 50 people
- Sponsor
- KU Leuven
Studying Efficacy of dTMS in FM
dTMS as a Treatment for Patients With Fibromyalgia
Purpose: The purpose of the study is to explore the efficacy of H1 deep TMS for the treatment of FMS. Design: Prospective randomized sham controlled trial Study Population \& sample size:forty (40) FMS subjects between 18-80…
- Trial name
- NCT03460340
- Testing
- prefrontal deep rTMS of H1 Coil
- Volunteers
- 40 people
- Sponsor
- Shalvata Mental Health Center
Duchenne Muscular Dystrophy
A Long-term Observational Study Evaluating Eteplirsen, Golodirsen, or Casimersen in Routine Clinical Practice
This is a phase 4, multicenter, prospective, observational study designed to collect both medical history data and prospective data on Duchenne Muscular Dystrophy (DMD) treatment outcomes in participants receiving eteplirsen…
- Trial name
- EVOLVE (NCT06606340)
- Testing
- Eteplirsen, Golodirsen, Casimersen
- Where
- 23 sites in United States
- Volunteers
- 300 people
- Sponsor
- Sarepta Therapeutics, Inc.
Panniculitis, Dermatomyositis
Panniculitis in Dermatomyositis
Adipose tissue involvement is rare in dermatomyositis. The occurrence of partial or diffuse lipodystrophy is a rare but well-characterized manifestation, particularly in juvenile forms of dermatomyositis.
- Trial name
- PANNICUL (NCT07345949)
- Where
- France
- Volunteers
- 20 people
- Sponsor
- University Hospital, Strasbourg, France
Hemorrhage, Surgical, Myoma;Uterus
Comparison Effectiveness of Rectal Misoprostol & Intravenous Tranexamic Acid Reducing Hemorrhage in Myomectomy
Fibroids are the most commonly encountered tumors in the female reproductive system. In patients, fibroids most often lead to abnormal uterine bleeding and the resulting anemia.
- Conditions
- Hemorrhage, Surgical, Myoma;Uterus, Effect of Drug, Postoperative Hemorrhage
- Trial name
- NCT06114758
- Testing
- Cytotec 200Mcg Tablet, Transamine
- Where
- Turkey (Türkiye)
- Volunteers
- 75 people
- Sponsor
- Ankara Etlik City Hospital
Schizophrenia
Injection Site Tolerability of Multiple Dose Treatment With Long-acting Injectable Risperidone Administered Via Deltoid Muscle in Chronic Schizophrenia Patients.
The purpose of this study is to examine the discontinuation rate of schizophrenia patients receiving multiple sequential 2 mL injections of long acting injectable risperidone (an atypical antipsychotic medication) when…
- Trial name
- NCT00828958
- Testing
- Risperidone long-acting injectable
- Volunteers
- 53 people
- Sponsor
- Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
Muscle Strain, Neuromuscular Diseases
Posterior Chain EMG Patterns in Athletes With and Without Hamstring Injury
This cross-sectional observational study investigated posterior chain muscle activation patterns in football players with and without a history of hamstring strain injury.
- Conditions
- Muscle Strain, Neuromuscular Diseases, Athletic Injuries
- Trial name
- NCT07171385
- Testing
- Nordic Hamstring Curl (NHC), Kettlebell Swing (KS), Supine Sliding Single-Leg Curl (SSLC)
- Where
- Turkey (Türkiye)
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Ankara Yildirim Beyazıt University
Osteoarthrosis
Effect of Methylprednisolone on Quadriceps Muscle Function in Patients Undergoing Total Knee-arthroplasty
This study evaluates the pathophysiological effects of a single dose Methylprednisolone administered prior to total knee-arthroplasty (TKA).
- Trial name
- NCT02319343
- Testing
- Methylprednisolone, Isotonic Sodium Chloride
- Where
- Denmark
- Volunteers
- 70 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Gastro-Esophageal Cancer
Cancer-associated Cachexia in Patients With Incurable Gastroesophageal Cancer
Patients with incurable gastroesophageal cancer are at high risk of cancer cachexia with an estimated prevalence of 60-80%. Cancer cachexia is defined as ongoing loss of skeletal muscle mass with or without loss of fat mass and…
- Trial name
- NCT06137508
- Where
- Denmark
- Volunteers
- 125 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Temporomandibular Joint Disorders, Orofacial Pain
Occlusal Adjustment as Treatment for Chronic Orofacial Pain
The purpose of this study is to determine whether occlusal adjustment by selective grinding and/or occlusal addition is an effective treatment of chronic temporomandibular joint disorders.
- Trial name
- NCT00899717
- Testing
- Occlusal adjustment
- Where
- 2 sites in Spain
- Volunteers
- 21 people
- Sponsor
- University of Santiago de Compostela
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