Clinical trials: Muscle Disorders
Peripheral Artery Disease
Static Muscular Stretching for Treatment of PAD
Patients with peripheral arterial disease (PAD) often have walking impairment due to insufficient oxygen supply to skeletal muscle.
- Trial name
- NCT04222751
- Testing
- Ankle Splint
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- Florida State University
Spinal Muscular Atrophy Type 2
GCB-001 in Treatment of Patients With Type II (SMA) Spinal Muscular Atrophy
This study explored dose escalation of single-arm, open, single intrathecal injection in patients with delayed onset type 2 SMA. The investigator plans to conduct 2 cohorts.
- Trial name
- GITOPWTSMA (NCT06772402)
- Testing
- GCB-001
- Where
- China
- Volunteers
- 6 people
- Sponsor
- Genecombio Ltd.
Elderly, Muscle Loss
Effect of Lactobacillus Paracasei PS23 on Improving Aging and Muscle Loss in the Elderly
This study refers to the supplementation of PS23 in human experiments to help the elderly maintain muscle mass, delay muscle loss, promote physical activity, and delay the occurrence of disability and debilitation in elderly…
- Conditions
- Elderly, Muscle Loss, Depression, Anxiety
- Trial name
- NCT06062472
- Testing
- Probiotics, heat-treated of Lactobacillus paracasei HT-PS23
- Where
- Taiwan
- Volunteers
- 119 people, healthy volunteers welcome
- Sponsor
- Chi-Chang Huang
Female, Older Adults
Effect of Green Tea Supplementation in Older Adult Women
Introduction: One of the consequences of aging is the decrease in physical performance which can affect the quality of life of older people.
- Conditions
- Female, Older Adults, Sarcopenia
- Trial name
- GTAW (NCT06289439)
- Testing
- Green tea (Camellia sinensis) 1000 mg as extract
- Where
- Spain
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of Valladolid
Mitochondrial Diseases, Drug Resistant Epilepsy
A Study to Evaluate Efficacy and Safety of Vatiquinone for Treating Mitochondrial Disease in Participants With Refractory Epilepsy
This is a parallel-arm, double-blind, placebo-controlled study with a screening phase that includes a 28-day run-in phase to establish baseline seizure frequency, followed by a 24-week, randomized, placebo-controlled phase.
- Conditions
- Mitochondrial Diseases, Drug Resistant Epilepsy, Leigh Disease, Leigh Syndrome
- Trial name
- MIT-E (NCT04378075)
- Testing
- Vatiquinone
- Where
- 27 sites in United States, Canada and 7 more
- Volunteers
- 68 people
- Sponsor
- PTC Therapeutics
Trigger Finger
Effect of Steroid Injection Which is Added to Percutaneous Trigger Finger Release: a Double-blinded Randomized Controlled Trial.
Background Present treatment strategies for trigger finger when conservative management including steroid injection was failed include percutaneous or open A1 pulley release, but some people showed prolonged swelling and delay of…
- Trial name
- NCT01781130
- Testing
- Steroid injection
- Where
- South Korea
- Volunteers
- 112 people
- Sponsor
- Samsung Medical Center
Chronic Obstructive Pulmonary Disease
Transdiaphragmatic Pressure and Neural Respiratory Drive Measured During Inspiratory Muscle Training in COPD
Inspiratory muscle training（IMT）was an rehabilitation therapy for stable patients with chronic obstructive pulmonary disease(COPD).
- Trial name
- NCT03017300
- Testing
- Threshold IMT®, PFLEX®
- Volunteers
- 12 people
- Sponsor
- Guangzhou Institute of Respiratory Disease
Obesity, Sarcopenia
Evaluation of Physical Performance in Old Adults With Sarcopenic Obesity
The primary objectives of the present study are to estimate the sarcopenic proportion in a cohort of obese older subjects who have been hospitalized.
- Trial name
- PREFISAR (NCT06299241)
- Where
- Italy
- Volunteers
- 80 people
- Sponsor
- Istituto Auxologico Italiano
Obesity, Weight Loss
Hormonal Regulation of Body Weight Maintenance
The investigators here propose to perform a collaborative clinical research effort including a randomized controlled trial investigating the mechanisms of weight maintenance and their relation to a lifestyle intervention in…
- Conditions
- Obesity, Weight Loss, Weight Gain, Hormone Disturbance
- Trial name
- NCT00850629
- Testing
- multimodal lifestyle intervention
- Where
- Germany
- Volunteers
- 286 people, healthy volunteers welcome
- Sponsor
- Charite University, Berlin, Germany
Chinese Version, Fibromyalgia
Chinese Version of Fibromyalgia Criteria and Severity Scales Study
Up to now, there is no Chinese version of fibromyalgia diagnosis criteria and severity assessment scales. The aim of this study is to translate, adapt, and validate the Chinese version of the 2011 modification of the 2010 ACR…
- Conditions
- Chinese Version, Fibromyalgia, Diagnosis, Fibromyalgia Impact Questionnaire
- Trial name
- NCT03381131
- Where
- China
- Volunteers
- 327 people
- Sponsor
- Guang'anmen Hospital of China Academy of Chinese Medical Sciences
Fibrodysplasia Ossificans Progressiva
Saracatinib Trial TO Prevent FOP
This is a phase 2 study, designed as a European multicentre 6-month double blind random-ized controlled trial (RCT) of AZD0530 versus matched placebo, followed by a 12 month trial comparing open-label extended AZD0530 treatment…
- Trial name
- STOPFOP (NCT04307953)
- Testing
- AZD0530 Difumarate
- Where
- 3 sites in Germany, Netherlands and 1 more
- Volunteers
- 20 people
- Sponsor
- Amsterdam UMC, location VUmc
Low Back Pain
Effects of Bilateral Asymmetrical Limbs Proprioceptive Neuromuscular Facilitation on Multifidus Muscle in CLBP.
The low back pain is a leading cause to limit individual functional activities worldwide and 60%-80% of adults are probable to get low back pain at least once in life time.
- Trial name
- NCT04206137
- Testing
- Group A (PNF rhythmic initiation group ), Group B (Swiss ball exercises)
- Where
- Pakistan
- Volunteers
- 150 people
- Sponsor
- University of Karachi
Stroke, Proprioceptive Disorders
Combined Effects of PNF and Electrical Muscle Stimulation on Spasticity and Hand Function in Stroke Patients.
To determine the combined effects of proprioceptive neuromuscular facilitation and electrical muscle stimulation on spasticity and hand function in stroke patients.
- Conditions
- Stroke, Proprioceptive Disorders, Balance; Distorted
- Trial name
- NCT05916872
- Testing
- experimental group, control group
- Where
- Pakistan
- Volunteers
- 30 people
- Sponsor
- Riphah International University
Muscle Atrophy, Disuse Atrophy (Muscle) of Lower Leg
The Regulation of Human Skeletal Muscle Mass by Contractile Perturbation
It is well known that periods of weight training lead to increases in skeletal muscle size and strength. In contrast, periods of inactivity such as bed rest or immobilization result in losses of skeletal muscle size and strength.
- Trial name
- HYPAT (NCT03046095)
- Testing
- Unilateral Resistance Exercise, Immobilization
- Where
- Canada
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- McMaster University
Bladder Cancer
Vicinium Treatment for Subjects With Non-muscle Invasive Bladder Cancer Previously Treated With BCG
Because of the high risk for development of muscle invasive disease, cystectomy is recommended for CIS, high-grade Ta and T1 patients who experience disease recurrence following intravesical therapy.
- Trial name
- VISTA (NCT02449239)
- Testing
- Vicinium
- Where
- 70 sites in United States, Canada
- Volunteers
- 133 people
- Sponsor
- Sesen Bio, Inc.
Osteoporosis, Sarcopenia
Bone Microstructure by Using HR-pQCT in Long Courses After Gastrectomy
Osteoporosis after gastrectomy, which is characterized by both the loss of bone mass and the deterioration of bone architecture, is a serious complication in the long course after gastrectomy.
- Conditions
- Osteoporosis, Sarcopenia, Gastric Cancer
- Trial name
- NCT03251430
- Testing
- gastrectomy
- Where
- Japan
- Volunteers
- 114 people, healthy volunteers welcome
- Sponsor
- Kobayashi Shinichiro
Osteoarthritis
Overcoming TWEAK Signaling to Restore Muscle and Mobility After Joint Replacement
This single-blind, randomized, controlled trial is designed to test the effect of an intensive, 16 week exercise rehabilitation program (progressive resistance training + functional mobility training) vs.
- Trial name
- TWEAK (NCT02628795)
- Testing
- PRT + FM, Usual Care
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- University of Alabama at Birmingham
Bladder Cancer
Diagnostic Performance and Predictive Capacity of Immediate Urine Cytology After Transurethral Resection of Non-Muscle Invasive Bladder Cancer; A Prospective Study
The current study aimed at prospectively assessing the performance of IUC as a predictive tool for residual tumor after primary TURBT of NMIBC, and possible future recurrence.
- Trial name
- NCT04194112
- Testing
- immediate urine cytology
- Volunteers
- 198 people
- Sponsor
- Mansoura University
Fibromyalgia
Prevalence of Fibromyalgia in Israel
The prevalence of fibromyalgia syndrome in the Israeli population is of importance fro planning resource allocation of medical expenditure as well as for identifying demographic and ethnic differences of this unique population…
- Trial name
- NCT01203865
- Where
- Israel
- Volunteers
- 1,200 people, healthy volunteers welcome
- Sponsor
- Tel-Aviv Sourasky Medical Center
Severe Acute Pancreatitis, Intra-abdominal Hypertension
Efficacy and Safety of Da-Cheng-Qi Decoction in Severe Acute Pancreatitis
This single-center prospective randomized controlled trial evaluated Da-Cheng-Qi Decoction (DCQD) as the acute-stage intervention of an integrated traditional Chinese and Western medicine whole-stage treatment protocol for severe…
- Trial name
- NCT07816900
- Testing
- Da-Cheng-Qi Decoction Plus Standard Western Treatment, Standard Western Treatment
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Shanghai Jiao Tong University School of Medicine
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