Clinical trials: Muscle Disorders
Stroke
Strength Training for Skeletal Muscle Adaptation After Stroke
Chronically disabled stroke survivors experience accelerated skeletal muscle atrophy and other detrimental changes to muscle and surrounding tissues on the paretic side.
- Trial name
- NCT00827827
- Testing
- Exercise- Strength Training, Exercise- Stretching Control
- Where
- United States
- Volunteers
- 38 people
- Sponsor
- VA Office of Research and Development
Temporomandibular Joint Disorders, Bruxism
Botox for Treatment of TMJ Disorder With Bruxism
Hypothesis: Myofascial temporomandibular joint disorder and related symptoms are associated with mandibular condyle and temporal fossa overloading secondary to temporalis and masseter muscle hyperactivity and spasm This study…
- Conditions
- Temporomandibular Joint Disorders, Bruxism, Temporomandibular Joint Dysfunction Syndrome, Myofascial Pain Dysfunction Syndrome, Temporomandibular Joint
- Trial name
- TMJ (NCT02202070)
- Testing
- onabotulinumtoxinA
- Where
- United States
- Sponsor
- Washington University School of Medicine
Fibromyalgia, Primary
Fibromyalgia During the COVID-19 Pandemic
On 12 January 2020, the World Health Organization (WHO) confirmed that a novel coronavirus was the cause of a respiratory illness in a cluster of people in Wuhan City, Hubei Province, China, which was reported to the WHO on 31…
- Trial name
- NCT04422522
- Where
- Egypt
- Volunteers
- 45 people
- Sponsor
- Al-Azhar University
Chondromalacia Patellae
Temporal Activation of Core Muscles and Vasti in Isolated Patellofemoral Osteoarthritis
Objective: To compare the temporal muscle activation between females with PF OA and normal controls during stair ascent. Methods: An observational comparative study was conducted with thirty-one females with PF OA and 11 healthy…
- Trial name
- NCT04589702
- Where
- Egypt
- Volunteers
- 42 people
- Sponsor
- Cairo University
Critical Illness, Sarcopenia
Effects of Frailty, Sarcopenia and Muscle Wasting on Outcomes of Patients in the Surgical Intensive Care Unit
The primary aim of the study is to evaluate consequences of frailty in critically ill patients. We hypothesize that a higher frailty index (based on published questionnaires) predicts a longer surgical intensive care unit and…
- Conditions
- Critical Illness, Sarcopenia, Muscle Wasting
- Trial name
- NCT02270502
- Testing
- Ultrasound Philips CX50, Frailty Index Questionnaire, Muscle strength tests
- Where
- United States
- Volunteers
- 111 people
- Sponsor
- Massachusetts General Hospital
Insulin Sensitivity
Acute Effects of an Oral Fat Load on Skeletal Muscle and Hepatic Insulin Sensitivity
The development of type 2 diabetes is based on a combination of insulin resistance and beta cell dysfunction. In the last years, elevated FFA were recognized as a key players in the pathogenesis of insulin resistance and type 2…
- Trial name
- FLAME (NCT01736202)
- Testing
- fat orally
- Where
- Germany
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- German Diabetes Center
Efficacy, Self, Fatigue; Muscle, Heart
Neuromodulation of the Autonomic Nervous System in Athletes
There are few studies in the literature that have evaluated the effects of using percutaneous stimulation of the auricular branch of the vagus nerve for sports purposes (to accelerate recovery after physical exertion).
- Conditions
- Efficacy, Self, Fatigue; Muscle, Heart, Fatigue, Mental, Fatigue; Combat
- Trial name
- NANSA (NCT06281795)
- Testing
- tVNS
- Where
- Russia
- Volunteers
- 121 people, healthy volunteers welcome
- Sponsor
- Bakulev Scientific Center of Cardiovascular Surgery
Vitamin D Deficiency
The Effect of Vitamin D Supplements on Vitamin D Status, Cardiometabolic Health and Immune Defense in Danish Children
The main purpose of this study is to investigate whether and in which doses vitamin D intake is needed in order to maintain an adequate vitamin D status in 4-8 year-old Danish children during wintertime.
- Trial name
- ODIN Junior (NCT02145195)
- Testing
- Vitamin D3 (cholecalciferol)
- Where
- Denmark
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
Limb-Girdle Muscular Dystrophy
Genetic Characterization of Individuals With Limb Girdle Muscular Dystrophy
The objective of this study is to identify and maintain a registry of well-characterized limb-girdle muscular dystrophy (LGMD) patients.
- Trial name
- NCT00457912
- Where
- United States
- Volunteers
- 277 people
- Sponsor
- Nationwide Children's Hospital
Lateral Epicondylitis
Kinesiotaping in Lateral Epicondylitis
The aim of this study is to compare the effects of kinesiology taping with exercise, sham taping with exercise and exercise alone for lateral epicondylitis.
- Trial name
- NCT03074500
- Testing
- Kinesiotaping, Exercise
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Marmara University
Patellar Tendinopathy
Effects of HMB and Rehabilitation Program in Athletes With Patellar Tendinopathy
This randomized, double-blind, placebo-controlled clinical trial evaluates the effects of oral beta-hydroxy-beta-methylbutyrate (HMB) supplementation combined with an eccentric exercise and extracorporeal shockwave rehabilitation…
- Trial name
- HMB_TEN (NCT07466407)
- Testing
- Eccentric exercise and extracorporeal shock wave therapy, Beta-hydroxy-beta-methylbutyrate (HMB)
- Where
- Spain
- Volunteers
- 30 people
- Sponsor
- Universidad Complutense de Madrid
Obesity & Overweight
Effect of 8 Weeks of Resistance Training With Blood Flow Restriction on Muscle Strength, Clinical Parameters, Biochemical Biomarkers, and Perceived Exertion in Adults With Obesity
To analyze the effect of 8 weeks of resistance training with blood flow restriction on muscle strength, clinical parameters, biochemical biomarkers, and perceived exertion in adults with obesity.
- Trial name
- NCT07444736
- Testing
- Intervention
- Where
- Mexico
- Volunteers
- 30 people
- Sponsor
- Centro Universitario de Tlajomulco, Universidad de Guadalajara
Bladder Cancer
Study on the Effects of Drugs That Modulate the Endocannabinoid System on Spontaneous and Induced Contractility of the Human Detrusor Muscle
The goal of this observational, in vitro study is to evaluate the effects of drugs that modulate the endocannabinoid system on spontaneous and neuronally induced contractility of the human detrusor.
- Trial name
- NCT07545694
- Where
- Italy
- Volunteers
- 65 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Blepharospasm, Hemifacial Spasm
Post Marketing Surveillance Study of Dysport
The purpose of this study is to provide further information regarding the risks and benefits of Dysport in marketed indications.
- Conditions
- Blepharospasm, Hemifacial Spasm, Cervical Dystonia, Spasmodic Torticollis
- Trial name
- NCT00210431
- Where
- 36 sites in France, Germany and 1 more
- Volunteers
- 783 people
- Sponsor
- Ipsen
V Pattern Esotropia, Monocular Exotropia With V Pattern
Correction of V-pattern Strabismus by Graded Recession of Inferior Oblique Muscle .
V pattern strabismus is the commonest of alphabet pattern. Its identification is essential to plan a proper surgical management. Graded recession is a very logical approach to treat inferior oblique overaction (IOOA).
- Trial name
- Pattern (NCT05786053)
- Testing
- graded recession of inferior oblique muscle
- Where
- 2 sites in Egypt
- Volunteers
- 40 people
- Sponsor
- Tanta University
Postmenopausal Osteoporosis
Impact of Ultraviolet Radiation on Bone Density and Muscle Strength in Postmenopausal Women
70 postmenopausal women, aged 50 to 60, who are vitamin D deficient and diagnosed with osteoporosis or osteopenia with T score of DEXA of lumbar spine (L1 to L4) was less than or equal -1 and their body mass index between 25 and…
- Trial name
- NCT05650437
- Testing
- Ultraviolet Radiation, Aerobic exercise, Vitamin D supplementation
- Where
- Egypt
- Volunteers
- 70 people
- Sponsor
- Cairo University
Muscular Disorders, Atrophic, Muscular Diseases
Managed Access Program for Del-zota in Participants With DMD Mutations Amenable to Exon 44 Skipping
The purpose of this Managed Access Program is to allow access to delpacibart zotadirsen (AOC 1044) for eligible patients diagnosed with DMD mutations amenable to exon 44 skipping.
- Conditions
- Muscular Disorders, Atrophic, Muscular Diseases, Musculoskeletal Diseases, Neuromuscular Diseases
- Trial name
- NCT07250737
- Testing
- delpacibart zotadirsen
- Where
- 22 sites in United States
- Sponsor
- Avidity Biosciences, Inc.
Atrophy, Muscular
31P MRS Ischaemic Exercise Optimisation and COPD
An MRI study to develop a reliable methodology for 31P MRS ischaemic exercise in order to obtain a consistent standard of measurement of muscle metabolism while maintaining an acceptable level of subject comfort and use optimised…
- Trial name
- NCT01476072
- Testing
- MRI scan
- Where
- United Kingdom
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
ME/CFS, Long COVID
Is Swimming a More Tolerable Form of Movement for Individuals With Myalgic Encephalomyelitis/ Chronic Fatigue Syndrome?
Individuals with ME/CFS experience profound exercise intolerance and post-exertional malaise. This remote (app-based) pilot study explores whether light, fully self-paced, swimming may be a tolerable form of movement for people…
- Conditions
- ME/CFS, Long COVID, Post- COVID-19 Syndrome, POTS - Postural Orthostatic Tachycardia Syndrome
- Trial name
- ME/CFS (NCT07454395)
- Testing
- Swimming, Cycling
- Where
- Canada
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Simon Fraser University
Myofascial Pain Syndrome
Massage of the Low Back Muscles Assessed With Ultrasound Scanning
The aim of the study is to use diagnostic ultrasound to compare the thickness of soft tissues in the low back in a group of patients with chronic low back pain treated with massage to a control group of non-treated patients.
- Trial name
- NCT01174667
- Testing
- Specific massage for fascial release, Quiet non-instructed rest for 3 minutes
- Volunteers
- 70 people
- Sponsor
- Anglo-European College of Chiropractic
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