Clinical trials: Muscle Disuse Atrophy
Atrophy, Disuse, Muscle Atrophy
Molecular Mechanisms Underlying Anabolic Resistance to Protein Intake During Muscle Disuse
This study will characterize intramuscular molecular mechanisms underlying anabolic resistance to protein ingestion during muscle disuse.
- Conditions
- Atrophy, Disuse, Muscle Atrophy, Muscular Disorders, Atrophic, Disuse Atrophy
- Trial name
- NCT06228742
- Testing
- Unilateral leg immobilization, Contralateral active leg
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- United States Army Research Institute of Environmental Medicine
Hip Fractures, Muscle Atrophy
The Role of Blood Flow Restriction Therapy in Postoperative Elderly Patients With Hip Fracture
The investigators aim to study the use of blood flow restriction therapy (BFR) to augment routine post-operative physical therapy in elderly patients (age >= 65) after recovering from surgical treatment of hip fractures.
- Trial name
- NCT04809714
- Testing
- Blood Flow Restriction with Delfi Tourniquet System Cuff, Routine Post-operative Physical Therapy
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Alabama at Birmingham
Muscle Wasting
The Effect of Repeated Whole-body NMES Sessions With or Without Protein Intake on Muscle Protein Synthesis During 3 Days of Bed Rest in Healthy Young Volunteers
The goal of this clinical trial is to examine the effect of whole-body electrostimulation with protein intake on muscle protein synthesis, muscle mass and function during bed rest in healthy young adults (18-35 years).
- Trial name
- SPRINT (NCT07062562)
- Testing
- NMES, Protein bolus (20g), Standard nutrition
- Where
- Netherlands
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Wageningen University
Immobilization, Muscle Disuse Atrophy
Neuromuscular Electrical Stimulation During Immobilization Due to Ankle Fractures
Rationale: Situations such as fractures of the lower extremity can necessitate a prolonged period of immobilization in otherwise healthy individuals.
- Trial name
- ANKL-ES (NCT02469506)
- Testing
- Neuromuscular Electrical Stimulation (NMES)
- Where
- Netherlands
- Volunteers
- 1 people
- Sponsor
- Maastricht University Medical Center
Muscle Atrophy, Muscle Weakness
Evaluating Muscle Function After Ankle Surgery
Patients who are forced to rest or reduce activity as a result of illness, injury, or surgery often experience resulting muscle weakness.
- Conditions
- Muscle Atrophy, Muscle Weakness, Fractures
- Trial name
- NCT00060970
- Testing
- Physical Therapy
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Disuse Atrophy
The Efficacy of Protein Supplementation on Attenuating Muscle Atrophy Following Disuse in the Collegiate Population
Following orthopedic surgery and/or injury, a significant loss of muscle mass is generally observed. While this loss of muscle mass appears to be the norm, it causes significant problems in both the athletic and general…
- Trial name
- NCT03454347
- Testing
- Profile Perform, Lower Limb Suspension
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- South Dakota State University
Sarcopenia, Skeletal Muscle Atrophy
Prehabilitative Exercise Prior to Immobilization
This is a 10-week human study involving 24 younger (20-35 y) and 24 older (65-85 y) healthy individuals. All participants will undergo unilateral immobilization of a knee for 7-10 days, followed by 4 weeks of heavy resistance…
- Conditions
- Sarcopenia, Skeletal Muscle Atrophy, Disuse Atrophy
- Trial name
- PREHAB (NCT06205784)
- Testing
- Prehabilitative exercise
- Where
- Denmark
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Bispebjerg Hospital
Atrophy of Muscle Due to Disuse, Rehabilitation
Sex-specific Determinants of Early-phase Recovery From Skeletal Muscle Disuse
This project is a 2-phase, randomized clinical trial that includes 7 days of unilateral leg disuse (Phase 1), immediately followed by 1 week of bilateral leg rehabilitation (Phase 2).
- Trial name
- MAC (NCT04151901)
- Testing
- Resistance Exercise Rehabilitation, Walking-based rehabilitation
- Where
- 2 sites in United States
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center at San Antonio
Muscle Disuse Atrophy, Nutrition, Healthy
Effect of a Natural Source Supplementation on Muscle Mass
Periods of muscle disuse are commonly experienced in young and elderly individuals as a result of short-term hospitalization or leg casting after injury.
- Trial name
- NCT05369026
- Testing
- Single leg immobilization
- Where
- Canada
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- McMaster University
Knee Osteoarthritis, Disuse Atrophy
Effects of Kneehab 12-week Peri-operative Total Knee Arthroplasty
Determine the efficacy of neuromuscular electrical stimulation (NMES, Kneehab) in promoting accelerated recovery of quadriceps function in patients recovering from total knee arthroplasty (TKA) as measured by increases in…
- Trial name
- KneehabTKA (NCT01096524)
- Testing
- Standard Physiotherapy, Kneehab
- Where
- United Kingdom
- Volunteers
- 200 people
- Sponsor
- Bio-Medical Research, Ltd.
Disuse Atrophy, Immobilization
Cross-education of Skill and Strength in Healthy People Subjected to an Upper-limb Disuse Model
This randomized controlled trial aims to compare manual dexterity and strength between a group undergoing a contralateral manual dexterity training program and a no-intervention control group in healthy, physically inactive…
- Trial name
- IMMO-CROSS (NCT07615062)
- Testing
- Contralateral Manual Dexterity Training
- Where
- Chile
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Universidad Catolica de Temuco
Muscle Disuse, Muscle Disuse Atrophy
Muscle Response to Different Amounts of Dietary Protein During Leg Immobilization
Individuals who sustain musculoskeletal injuries (MSKI) can experience a rapid loss of muscle mass due to declines in muscle loading and activation that occur post-injury (i.e., disuse atrophy).
- Trial name
- NCT07069426
- Testing
- 20 grams protein, 40 grams protein
- Where
- United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- United States Army Research Institute of Environmental Medicine
Muscle Atrophy
n3 PUFA and Muscle-disuse Atrophy in Young Women
This study will examine the influence of n3 PUFA supplementation on the rate of muscle atrophy in women undergoing 2 weeks of unilateral limb immobilization.
- Trial name
- NCT03059836
- Testing
- n3 PUFA-enriched fish oil
- Where
- Canada
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- McMaster University
Muscular Atrophy
A Study of LY2495655 in Older Participants Undergoing Elective Total Hip Replacement
The primary objective of this study is to test the hypothesis that appendicular lean body mass (aLBM) will increase after 12 weeks of LY2495655 treatment versus placebo in older participants undergoing elective total hip…
- Trial name
- NCT01369511
- Testing
- LY2495655
- Where
- 45 sites in United States, Austria and 9 more
- Volunteers
- 400 people
- Sponsor
- Eli Lilly and Company
Muscle Loss, Disuse Atrophy
Preventing Bed-rest Induced Muscle Loss in the Elderly
Episodes of inactivity due to hospitalisation, as short as 5 days, are associated with rapid muscle and strength loss in the elderly.
- Conditions
- Muscle Loss, Disuse Atrophy, Protein Metabolism, Prehabilitation
- Trial name
- NCT04422665
- Testing
- Resistance exercise
- Where
- United Kingdom
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Birmingham
Atrophy, Muscular, Atrophy, Disuse
Blood Flow Restricted Electrical Stimulation During Immobilisation
Following injury or surgery to a limb, it is often immobilised to allow tissue healing. Short periods of disuse cause loss of muscle size and strength and impaired mechanical properties of tendons, which leads to reduced…
- Trial name
- NCT05093985
- Testing
- Neuromuscular electrical stimulation with blood flow restriction
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- St Mary's University College
Muscle Atrophy, Muscle Disuse Atrophy
n3 PUFA and Muscle-disuse Atrophy in Older Women
This study will examine the influence of n3 PUFA supplementation on the rate of muscle atrophy in older women undergoing 1 week of unilateral limb immobilization.
- Conditions
- Muscle Atrophy, Muscle Disuse Atrophy, Sarcopenia
- Trial name
- NCT03808519
- Testing
- n3 PUFA-enriched fish oil
- Where
- Canada
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- McMaster University
Muscle Atrophy, Muscle Weakness
FIT Exercise in 30d of ULLS-induced Muscle Disuse
This study aims to determine how flywheel-based inertial training (FIT) implemented according to principles of velocity-based training (VBT) and High-Intensity Interval Training (HIIT) affects disuse-induced physical…
- Trial name
- NCT06631053
- Testing
- velocity-based FIT (VBFIT), No Exercise
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Lance Bollinger
Muscle Disuse Atrophy
Can Supplemental Leucine Offset Disuse-induced Muscle Atrophy?
Ageing is associated with a gradual decline in muscle mass that is detrimental to both physical function and metabolic health, increasing the risk of morbidity and mortality.
- Trial name
- LEU-DIMA (NCT03762278)
- Testing
- Leucine
- Where
- United Kingdom
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Birmingham
Multifidus Disuse Atrophy
Short Arc Multifidus Study
Patients will be performing Logan short arc banding protocols to see the effect on multifidus size
- Trial name
- NCT00846664
- Testing
- Logan Short Arc Banding
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Logan College of Chiropractic